Candidiasis is one of the most common diseases, the fight against which is necessary to victory. This kind of disease causes great discomfort to women whose immunity is weakened.
To treat this infection, it is necessary to use not only antifungal drugs, also called antimycotic drugs, but also comprehensive therapy. The drug Zalain has a global range of qualities, expressed in the destruction of a huge number and varieties of fungi.
Moreover, it should be noted that Zalain treats not only candidiasis, but also diseases such as fungus on parts of the body, as well as gardnerella. What is Zalain, in what form is it available and how can the drug help in treatment?
Compound
1 gram of cream contains 20 mg of sertaconazole nitrate .
Additionally: 20,000 mg ethylene glycol and polyethylene glycol palmitostearate, 5,000 mg saturated polyglycolyzed glycerides, 2,000 mg glycerol isostearate, 8,000 mg paraffin oil, 100 mg sorbic acid, 100 mg methyl p-hydroxybenzoate, up to 100,000 mg purified water.
1 suppository includes 300 mg of sertaconazole nitrate .
Additionally: 1305 mg suppositir, 1305 mg witepsol, 90 mg colloidal anhydrous silicon dioxide.
Pharmacodynamics and pharmacokinetics
Zalain suppositories and ointment are an antifungal remedy whose active ingredient is a derivative of benzothiophene and imidazole . Local application of therapeutic dosages of the drug is characterized by fungicidal and fungistatic effectiveness. The central mechanism of action is aimed at suppressing the processes of ergosterol and increasing the permeability of mycotic cell membranes , which is actually the cause of lysis of the fungal cell .
The antifungal activity of the drug extends to strains of fungi of the genus Candida . Antibacterial effectiveness is manifested against gram-positive microorganisms ( Staphylococcus and Streptococcus ).
When applied topically, sertaconazole nitrate is not detectable in blood or urine. When used intravaginally, absorption of the active ingredient of the drug is not observed.
Indications for use
Zalain cream is indicated for use for the treatment of superficial skin mycoses , including: mycoses of the hands , feet and legs ; mycoses of the beard ; mycoses of the trunk ; pityriasis versicolor ; candidiasis .
Zalain suppositories are prescribed for local treatment of infections of the vaginal mucous membranes caused by strains of fungi of the genus Candida ( thrush / vulvovaginal candidiasis ).
Contraindications
Like any other drug, Zalain has a number of contraindications that must be observed before starting therapy with this drug:
- A contraindication for use is hypersensitivity to individual components that form the basis of the medicinal product or the possibility of an allergic reaction to the components that make up this medicinal product.
- Hypersensitivity to sertaconazole , which is a derivative of imidazole and benzotifene, is a contraindication.
- It is also worth noting that in pregnant women and during lactation there are no contraindications to the use of such suppositories or Zalain cream.
Side effects
When using the cream, the formation of local reactions, manifested in the form of contact dermatitis . They also allow for the possibility of developing transient erythematous phenomena that do not require cessation of treatment.
Suppositories for thrush occasionally led to allergic manifestations , as well as burning / itching sensations in the vagina , which did not require discontinuation of the drug and disappeared on their own with further therapy. These side effects are classified as classic effects observed with the use of local vaginal dosage forms and reflect the effectiveness of the drug.
Benefits of using candles
If the problem occurs during lactation, doctors consider suppository medications to be the most effective for thrush during breastfeeding. You should not ignore the problem, because without proper hygiene rules it is easy to transmit a fungal infection to your baby.
The main advantage of using suppositories is local application. The active substances of the suppositories act directly at the site of inflammation, without penetrating into the general bloodstream and without causing adverse reactions on the part of the child’s body. A woman breastfeeding does not need to worry about changes in the composition of her milk.
Also, the use of suppositories does not require additional therapeutic measures; as a rule, after a course of treatment prescribed by a doctor, the signs of thrush quickly disappear. Modern anti-yeast drugs are highly effective and easy to use. Therefore, during the breastfeeding period, a woman will not have problems eliminating the unpleasant symptoms of the disease.
Suppositories are the most effective and safe in the treatment of thrush
Instructions for use of Zalain
Cream Zalain, instructions for use
Proper use of the cream involves applying it evenly in a thin layer to the infected areas of the skin, covering about 1 cm of healthy skin around the problem area. The recommended frequency of use of the drug is 2 times every 24 hours, with the duration of therapy depending on the etiology of the pathogen and the infectious localization (most often 4 weeks). Disappearance of symptoms of infection is usually observed after 2-4 weeks.
It is not recommended to simultaneously use other local antifungal drugs (ointments, solutions, gels, etc.).
Zalain suppositories, instructions for use
Vaginal suppositories of the drug are intended for single use. One suppository, previously removed from the blister, should be inserted deep into the vagina. This procedure is recommended to be performed before going to bed in a horizontal (lying on your back) body position. of thrush persist, you can repeat the procedure for introducing a suppository after 7 days.
Immediately before inserting the suppository, hygiene of the external genital organs should be carried out using alkaline or neutral soap .
How to promptly recognize candidiasis
Symptoms of thrush are the same for all women – pregnant or not. The first sign is discomfort in intimate places after sex. Often this is a burning sensation, a feeling of tightness that intensifies when the bladder is emptied.
The second symptom indicating the progress of the disease is itching. Unpleasant sensations appear in the area of the labia minora and labia majora. They weaken after hygiene procedures, but appear after a couple of hours.
An obvious sign of thrush is a change in the nature of vaginal discharge. In pregnant women, they become thicker than usual and cloudy. With candidiasis, white inclusions can be detected among the mucus. They are similar to curdled milk (hence the name “thrush”). The secret comes out in increased volume. Severe itching is accompanied by thick, lumpy vaginal discharge. An unpleasant sour-milk odor appears in intimate areas.
Inflammation and vaginal discharge due to thrush are provoked by colonies of candidobacteria
Thrush may also have less severe symptoms. Some women periodically experience itching and burning with scanty discharge. Their consistency is thick, but there are no curdled inclusions. These are manifestations of chronic thrush, which a woman could have had even before pregnancy.
Any set of symptoms similar to vaginal candidiasis should be contacted by your obstetrician-gynecologist. The specialist will conduct an examination and take swabs. Based on the test results, it will be possible to say exactly what the nature of the unpleasant sensations in the expectant mother is. Delay is not only discomfort for the pregnant woman, but also poses a threat to the fetus.
special instructions
The drug cream is not intended for use in ophthalmic practice.
When applying the cream, the use of acidic hygiene products , due to the increased proliferation of Candida fungal strains in an acidic environment.
In the case of suppository therapy with a parallel observed infection of the labia and surrounding areas of the skin ( candidal vulvitis ), additional local use of Zalain cream is recommended.
Administration of suppositories of the drug during menstruation .
During the therapeutic effect of the suppository, sexual intercourse is undesirable.
In order to prevent urogenital reinfection, the issue of parallel therapy of the sexual partner should be considered.
The possibility of damage to contraceptive barrier devices (rupture of the diaphragm or condom) increases during the action of the active ingredient of the suppository.
Description of the drug
Perhaps many have also heard that a disease such as thrush can be cured with a one-time use of the drug. Zalain is one of those drugs that needs to be taken once.
As noted earlier, this drug is available not only in suppository form, but also in creamy form. A medicine such as Zalain is intended for the treatment of diseases caused by groups of Candida fungi.
According to the manufacturer, using one candle is enough to eliminate the disease due to its composition. This drug in the form of suppositories, as well as in the form of a cream, was developed and produced by a pharmaceutical corporation in Hungary. However, to date, the production of this drug has been taken over by a pharmaceutical corporation in Spain.
Zalain also exhibits a fungistatic effect, the purpose of which is to destroy the ability of the fungus to reproduce in the future.
Zalain also exhibits a fungicidal effect, the essence of which is to disrupt the conditions in which fungi live and reproduce. In conclusion, the fungus dies. The essence of this drug is to destroy fungi that multiply and live in a woman’s body.
This drug acts both fungistatically and fungicially.
The mechanism for killing fungi itself is that the drug Zalain disrupts the synthesis of ergosterol.
This is a substance necessary for the cell membrane of fungal-type microorganisms.
Without ergosterol, the membrane acquires a fragile foundation that is unable to protect itself from negative environmental influences.
In conclusion, the fungus begins to die. Zalain is also capable of not only penetrating the cell membrane of the fungus, but also displacing a substance such as tryptophan.
As a result, the cell membrane undergoes a process of disorganization, and subsequently increases permeability to water and salts, which have free access to fungi and can disrupt their further development in life.
In all cases, the fungus, under the influence of these components, begins to undergo destruction and subsequently dies. This is exactly what patients suffering from candidiasis need to achieve.
In addition, Zalain is able to effectively destroy streptococci of the gram-positive variety. In addition, staphylococci and trichomonas vaginalis, gardnerella, enterococci, as well as bacteroides.
Therefore, it can be understood that the spectrum of action of a drug such as Zalain is quite wide. This is what makes it possible to use medications for candidiasis and the treatment of fungal infections of the skin and vagina.
Zalain is also approved for use in combination in the treatment of bacterial vaginosis. The great advantage of this drug is that when applying either a cream or a suppository, the active substances in the drug do not come into contact with the blood and do not have any negative effects on human health.
A big advantage is also that this drug can be used to treat women who are pregnant and for nursing mothers. The active substance will not affect the baby or mother’s milk in any way.
Zalain's analogues
Level 4 ATX code matches:
Gainomax
Sertaconazole
Ornisis
Metrogil Plus
Livarol
Flagyl
Ginofort
Ketoconazole
Candide B6
Candide
Gyno-Travogen Ovulum
Kanizon
Metromicon-Neo
Lomexin
Klion-D 100
Neo-Penotran
Gyno-Pevaril
Ginesol
Antifungol
Below are preparations for topical use, which are the most popular analogues of the remedy Zalain.
For cream (ointments, sprays, creams, powders, gels, solutions):
- Amyclone;
- Kandibene;
- Bifonazole;
- Clotrimazole;
- Dermazol;
- Candide;
- Mycozoral;
- Funginal;
- Mycospor;
- Nizoral , etc.
For suppositories (vaginal capsules, suppositories, creams, tablets):
- Ginalgin;
- Clotrimazole;
- Ginofort;
- Kandibene;
- Livarol;
- Candide;
- Metrogil;
- Pimafucin;
- Metronidazole;
- Neo-Penotran;
- Trichopolum;
- Mikogal;
- Klion-D , etc.
Zalain during pregnancy (and lactation)
The instructions for the drug allow the use of Zalain cream and suppositories during pregnancy and lactation , only after an individual assessment by a doctor of the risk/benefit ratio for the woman/child (fetus), which is confirmed by both positive and negative reviews about Zalain during pregnancy and lactation of women, when - have been treated with this drug. It is impossible to predict in advance and with accuracy the response of the female body to the action of the active ingredient of the drug and its effect on the fetus/child, and therefore during these periods it is better to do without the use of “chemistry”.
Can I take a pill?
Thrush tablets for one-time use should not be taken by expectant or nursing mothers. These are drugs based on fluconazole, a broad-spectrum antifungal substance. When testing this compound, its ability to disrupt the development of the fetus and cause mutations was revealed.
Antifungal tablets should not be taken by breastfeeding women. In breast milk and other body fluids, concentrations of the substance equal to plasma concentrations are achieved. This means that the active component will enter the baby’s body along with breast milk, albeit in small quantities. The only drug whose safety during lactation has been proven is Diflucan.
Gynecologists and pediatricians believe that during pregnancy and breastfeeding it is better to abandon any systemic medications except life-saving ones.
Reviews about Zalain
In comparison with other creams and ointments that have a similar antifungal effect, reviews of Zalain cream are significantly more positive. Many patients who have experienced several similar local preparations give the best assessment of the effectiveness, duration of action and safety of Zalain and recommend this cream to all their friends suffering from the same infectious diseases .
Reviews about Zalain suppositories are also in most cases positive and often speak of the effective treatment of thrush using only one suppository. In turn, comparing analog drugs in terms of safety and frequency of recurrence of infection and based on their own experience, some women advise using these suppositories during pregnancy , but warn against self-prescribing such treatment in favor of a mandatory decision on the possibility of antifungal therapy by a doctor.
Is there any harm to the baby?
While breastfeeding, a woman suffering from thrush should not self-medicate so as not to harm the baby. Despite the relative safety of drugs in the form of suppositories, they need to be selected wisely, based on the absence of side effects. And only specialists have such information.
Therefore, at the first symptoms of thrush, in order not to interrupt feeding and minimize the risk of a baby’s negative reaction to the drug (allergies, digestive disorders, intoxication), you need to visit a doctor. If the disease has just begun, the doctor may recommend using folk remedies. In case of actively developing inflammation, when it is not possible to cure thrush using improvised methods, a specialist will select suppositories that do not change the composition of milk and are allowed during the feeding period.
Zalain price, where to buy
If we compare the cost of other local antifungal drugs analogues (including ointments, sprays, creams, solutions, etc.), as well as other similar suppositories for thrush, the purchase of any of the dosage forms of Zalain may seem like a waste of money, which is most often offset by the high efficiency and cost-effectiveness of drug use.
Today, the price of Zalain cream varies between 450-550 rubles, and the price of Zalain suppositories fluctuates around 500-600 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
Pharmacy Dialogue
- Zalain cream (tube 2% 20g) Ferrer Inter.
RUR 575 order - Zalain suppositories (sup. vag. 300 mg No. 1) Egis
RUR 544 order
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Pharmacy24
- Zalain 2% 20 g cream Ferrer International, S.A., Spain/ZAT Pharmaceutical Plant EGIS, Ugorshchina
126 UAH.order - Zalain ovula 300 mg No. 1 suppositories ZAT FZ EGIS/Trommsdorff Gmbh i Co KG, Ugorshchina/Nimechchina
192 UAH order
PaniPharmacy
- Zalain cream Zalain cream 2% 20g Spain, Ferrer Internacional
145 UAH order
- Zalain ovuli suppository Supp. zalain ovuli vag. 0.3g No. 1 Hungary, Egis
201 UAH order
- Supp. vag. zalain ovuli 0.3g No. 1 Ukraine, Teramex Laboratory
241 UAH order
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Should I stop feeding?
As already mentioned, doctors try to prescribe effective and safe drugs for thrush to women who breastfeed. So that there is no need to wean the baby from the breast, especially if we are talking about a newborn baby. But the use of the suppositories described above is possible more in the initial stages of a fungal infection.
If the inflammation has gone far, the nursing mother does not follow the rules of treatment with suppositories, or even with proper therapy the disease returns again - additional measures are required. For example, prescribing antibacterial, antifungal and anti-inflammatory drugs orally. But here, most doctors recommend interrupting feeding until recovery, so as not to harm the baby.
