Photo: Pimafucin suppositories, tablets, cream: instructions for use, price
Broad-spectrum antibiotics do not always have the desired effect. In most cases, such drugs cause a number of side effects and include a number of contraindications. Also, such products have a fairly high cost, which raises questions about the profitability of their purchase.
Thus, many consumers have a need to purchase a high-quality and affordable product that will allow them to cope with a number of microbes and parasites in a completely safe way.
One of these drugs is Pimafucin. This product is relatively new, but it has already gained popularity among buyers. The main advantages of Pimafucin are safety and effectiveness.
- What is Pimafucin?
- Release form and manufacturer
- Compound
- Indications for use Pimafucin
- Instructions for use of Pimafucin
- Contraindications
- Side effects
- Features of Pimafucin Suppositories
- Pills
- Cream
Mechanism of action
Natamycin irreversibly binds to ergosterol contained in the cell membrane of the fungal cell, which causes a violation of its integrity, loss of cytoplasmic contents and cell death.
The substance is active against most pathogenic molds and yeasts, including those belonging to the genera Penicillium, Candida, Fusarium, Cephalosporium and Aspergillus. P. boydii and dermatophytes demonstrate less sensitivity to natamycin. No cases of drug resistance have been reported to date. Pimafucin in the form of enteric tablets acts only in the intestinal lumen.
Clinical trials
Clinical trials of the antifungal drug Pimafucin included women with various types of vaginitis caused by protists, fungi and opportunistic microorganisms.
The effectiveness of the drug was confirmed in all tests conducted. The best results were obtained in the treatment of vaginitis caused by Candida albicans infection (83-95%). Test results showed the high effectiveness of Pimafucin in the treatment of recurrent forms of candidiasis and a decrease in the number of Candida fungi in the rectum after using the oral form of the drug.
Patients received one vaginal capsule (0.1 g of natamycin) once a day before bedtime. The duration of the course was 6 days. In parallel, women took Pimafucin in tablet form - 4 tablets per day, for 5 days. All women were contraindicated from having sexual intercourse for 15-20 days. On days 2-3 of treatment, all patients noted an improvement in their well-being and a decrease in the severity of symptoms. At the end of treatment, the main symptoms of vaginitis were eliminated in 30 patients: vaginal discharge, vascular congestion, swelling of the mucous membrane, itching and burning. Final microbiological studies of vaginal discharge showed the absence of fungal cells and spores.
This study was conducted by the Scientific Center for Obstetrics, Gynecology and Perinatology of the Russian Academy of Medical Sciences (Moscow).
What is Pimafucin?
Pimafucin is an antifungal agent that belongs to the broad-spectrum polyene antibiotics. This drug is notable for its ability to suppress a number of pathogenic microorganisms and be used to treat such unpleasant diseases as thrush, nail candidiasis, and fungal diseases of the gastrointestinal tract.
The product exhibits active fungicidal activity, which allows you to block the proliferation of microorganisms and eliminate the fungus even in the progression phase. The positive effect of Pimafucin was noted against Candida fungi, yeast-like fungi, and dermatophytes.
The peculiarity of the drug Pimafucin is its harmlessness. Modern pharmaceutical technologies have made it possible to ensure that the drug can be used on pregnant women, children and even infants.
The presence of various forms of release of Pimafucin allows you to choose the optimally convenient version of the drug. The substance does not have any side effects on the body, but acts directly on the problem itself.
Indications for the use of suppositories
The drug in the form of vaginal suppositories is prescribed for fungal diseases caused by pathogenic yeast fungi of the genus Candida.
Natamycin in this form is often prescribed to women for thrush. Throughout the course of therapy, patients do not complain of irritation or discomfort when applied topically. Among other things, over the years of using medicine for fungal infections, not a single woman has complained that she experienced symptoms of a drug overdose or had quite serious allergic reactions.
Due to the safety of the drug, it is often prescribed for the treatment of thrush during pregnancy and lactation.
Side effects
Statistics show that side effects from the use of this drug are rare. Most often they manifest themselves in the form of local allergic reactions and are expressed in the form of burning and itching. In more complex cases, the side effects of Pimafucin suppositories cause redness of the mucous membrane and the appearance of swelling.
The above symptoms have a temporary effect and disappear a few hours after using the medications. It is not recommended to interrupt the course of treatment if side effects occur. When using suppositories and tablets simultaneously, negative body reactions such as nausea and diarrhea may occur. These symptoms completely disappear at the end of the course of treatment.
Directions for use and dosage
Pimafucin suppositories, instructions for use. Vaginal suppositories are used once a day at night.
Pimafucin suppositories for thrush are inserted deep into the vagina in a lying position, 1 piece, course - 3-6 days. If necessary (severe vaginitis caused by Candida albicans), an additional oral form of natamycin is prescribed - 1 tablet 4 times a day, for 10-20 days.
For the treatment of candidiasis of the partner's genital organs, it is recommended to use Pimafucin cream.
How to use the cream?
For external use. The ointment should be applied to the affected areas one to several times a day for balanoposthitis, vulvovaginitis and vulvitis.
If symptoms persist, suppositories or tablets are prescribed. For dermatomycosis (including diaper rash in children and candidiasis of the nails and skin), the suspension should be applied to the nails and skin up to 4 times a day.
Cost of the drug
The pharmaceutical product Pimafucin, available in the form of suppositories for vaginal administration, can be purchased at the pharmacy. This medication is freely available and there is no need to provide a prescription when purchasing it. It should be noted that Pimafucin is one of a number of expensive medications. The cost of the medicine depends not only on the form of release and the number of suppositories in the package, but also on the country of the manufacturer of the medicine.
The average cost of a package containing three candles varies from two hundred fifty to three hundred rubles. A package with two strips of suppositories costs from five hundred and fifty rubles.
Due to the relatively high cost of the drug, many people prefer cheaper analogues. Knowing what Pimafucin suppositories are for, you can choose a more affordable medication with a similar therapeutic effect. People also resort to choosing analogues if there are contraindications to the use of the medicine. That is why, in order to choose a suitable analogue based on the individual characteristics of the body, it is recommended to consult a specialist.
Each medication used in the treatment of fungal diseases has its own advantages and disadvantages. Ignorance of the nuances associated with use significantly increases the risks of complications and side effects.
The drug pimafucin is one of the most gentle for the human body, there are almost no side effects
Pregnancy and breastfeeding
Pimafucin is one of the antifungal drugs approved for use during pregnancy and lactation. The active component of the drug, natamycin, is practically not absorbed in the gastrointestinal tract, through the skin and mucous membranes. It is also not detected in blood and other biological fluids (including breast milk).
However, doctors often differ in their opinions regarding the use of this drug during pregnancy. Many gynecologists consider Pimafucin to be an outdated and ineffective drug in comparison with newer antifungal agents, and some even consider it dangerous and recommend resorting to it only in case of emergency. In addition, it does not help many women at all, and in rare cases, it worsens the course of the disease.
And yet, most gynecologists recommend Pimafucin as one of the safest antifungal drugs, in particular for pregnant and lactating women. As a rule, doctors recommend vaginal suppositories as the most convenient and safe dosage form of the drug.
Compound
Due to its universal composition, Pimafucin provides clear results within a few days after the start of treatment.
Pimafucin contains the main component – natamycin. Natamycin is a broad-spectrum macrolide antibiotic that can resist a number of fungal microorganisms.
This substance is not able to be absorbed into the blood and into the walls of the digestive tract. Nitamycin is also not absorbed from the skin and mucous membranes.
Additional components improve the clinical effect of the drug. In each type of drug, the additional ingredients differ from each other.
Composition of Pimafucin tablets
Main components:
- Natatsimin.
Additional:
- Potato starch;
- Magnesium stearate;
- Lactose;
- Gelatin;
- Acacia;
- Methyl p-hydroxybenzoate;
- Calcium carbonate;
- Kaolin;
- Talc;
- Cellulose acetate phthalate;
- Triacetin;
- White beeswax;
- Titanium oxide;
- Sucrose.
Vaginal suppositories
Main components:
- Natamycin.
Additional:
- Cetyl alcohol;
- Solid fat;
- Sorbitol;
- Polysorbate;
- Sodium bicarbonate;
- Aipinic acid.
Photo: Cream Pimafucin
Cream Pimafucin
Main component:
- Natamycin.
Additional:
- Decyloleate;
- Wax based on cetyl esters;
- Cetostearyl alcohol;
- Sodium lauryl sulfate;
- Methyl parahydroxybenzoate;
- Propyl parahydroxybenzoate;
- Propylene glycol;
- Purified water.
special instructions
Cetyl alcohol, which is part of the suppositories, can cause a burning sensation in the genital area. Candle therapy should be interrupted during menstruation.
There is no need to avoid sexual intercourse during treatment with suppositories. However, it is necessary to examine both sexual partners and carry out a course of therapy if candidiasis is detected. In addition, barrier contraception should be used.
Under the influence of body temperature, vaginal suppositories quickly dissolve, forming a foamy mass, due to which the active substance is distributed evenly. For recurrent or chronic infections, therapy can be supplemented with cream or tablets.
According to indications, the drug can be used during pregnancy and lactation.
Features of Pimafucin
Suppositories
Pimafucin can be used during lactation and pregnancy. There is no evidence of a negative effect of the drug on the fetus.
Pills
Pimafucin can be used during pregnancy, as well as during breastfeeding. It is not recommended to use the drug when treating infants. This is due to the possible difficulty in swallowing tablets in newborns.
Cream
The drug can be used during breastfeeding and during pregnancy. There is no data on the adverse effects of Pimafucin crepe on the fetus. The cream is prescribed for children and newborns.
Reviews from women
Reviews of Pimafucin indicate that most patients experience a positive treatment effect after a course of treatment.
- Svetlana. During late pregnancy, terrible thrush appeared. The doctor advised me to buy Pimafucin. I bought it and didn’t regret it. In three days everything went away, and there were no consequences, I’m glad.
- Margot. Very good Pimafucin suppositories. They helped me cope with thrush, otherwise it was just a disaster... Such discomfort, everything itches... it knocks me out of the rhythm of everyday life, I had to forget about sports, I generally keep quiet about my personal life. The suppositories helped quite quickly, at least on the second day the symptoms immediately somehow became much less, and after 4 days everything went away.
- Lyudmila. With the advent of menopause, a lot of sores piled up. So the thrush is still attached. On the advice of the doctor, I put on Pimafucin suppositories. They quickly cured the “infection”. I recommend it to all women over 50.
- Inna. A course of pimafucin tablets and suppositories, and I forgot about thrush for like 2 years. In general, thrush is an insidious thing, and we still need to look for what will help each woman specifically. Before pimafucin, I tried different drugs, but I finally found one that definitely helped and didn’t have any side effects. After all, it is even prescribed to pregnant women, and this is a good sign.
Feedback from women with thrush is positive due to:
- the possibility of additional therapy with other types (tablets, cream);
- strong antifungal effect;
- Possibility of use as a prophylactic drug;
- lack of resistance (resistance) to the active substance natamycin in pathogens of fungal infections;
- lack of addictive effect;
- Possibility of use during pregnancy and during the lactation period;
- possibilities for treating various forms of candidiasis, including chronic ones;
- lack of strict regulations regarding the time of use of the drug.
Among the disadvantages of Pimafucin, patients include the high cost of suppositories, the need to interrupt the course of treatment during menstruation, and the use of pads to protect against leakage.
Contraindications
Pimafucin is completely safe for the patient’s health and is not capable of causing radical complications of the existing disease, nor does it provide the expected results. The only nuance with which you need to be extremely careful is hypersensitivity to the components of Pimafucin. If allergic reactions are suddenly detected, the use of Pimafucin should be stopped and go to the hospital to receive the necessary therapy.
Photo: Contraindications for the drug Pimafucin
Pimafucin, as an antifungal antibiotic, is a broad-spectrum drug. The active ingredient of Pimafucin, Natamycin, has a fungicidal effect and leads to the death of fungal cells.
Most pathogenic yeast fungi are sensitive to the active substance of Pimafucin. Dermatophytes are weakly sensitive to the component.
What is thrush and what are the causes of its occurrence?
Thrush, or, as it is called in medicine, “Candidiasis” is a disease of a vaginal nature. It is classified as a type of fungal infection caused by fungi called Candida. They live in the microflora of every person, but in large quantities they often lead to the development of thrush. Characterized by thick white discharge. This disease mainly affects women, and in rare cases, men and children.
The reasons for the occurrence of this disease in female representatives can be various factors:
- Weakened immunity;
- Antibiotics;
- Unhealthy diet;
- Synthetic underwear;
- Disruption of metabolic processes in the body;
- Use of hormonal drugs;
- Diabetes;
- Dysbacteriosis;
- Hygiene problems;
- Stress.
The main symptoms of thrush
The main symptoms of thrush in women can be considered:
- Feeling of burning and itching in the vagina;
- Discharge with lumps of bright white color (looks like cottage cheese);
- Unpleasant odor;
- Increased volume of vaginal discharge;
- Redness in the intimate area;
- Swelling in the intimate area;
- Feeling of pain during urination;
- Feeling of pain during intercourse with a partner;
- Weakness and increased body temperature;
- Feeling of pain during bowel movements;
- Microcracks on the walls of the anus.
It is not necessary that you may have all of the above symptoms. Moreover, symptoms may go away on their own during menstruation. At this time, the vaginal environment becomes highly alkaline, which has a detrimental effect on the development of Candida.
Analogs
If for some reason the drug is not suitable for the patient, it is replaced with another drug that has the same effect. The drug has no absolute analogues, but according to the main active substance there are corresponding similar medicinal products.
The main assets include:
- natamycin;
- Primafungin.
These products contain the same substance, the healing effect is similar.
These analogues have the same method of action and eliminate infected microflora.
Both drugs are absolutely safe, and therefore they are prescribed for pregnant women.
There are no adverse reactions observed, and there is only one contraindication - personal intolerance to the elements of the composition.
Pharmacies offer less expensive drugs, including:
- clotrimazole;
- Livarol.
All these means are inferior to the main one in their effectiveness. The latter drug is the best analogue with a similar therapeutic effect. The active component of the analogue is ketoconazole, which copes with various groups of fungal infections and dermatophytes.
Its difference from Pimafucin is that it cannot be used in the first trimester of pregnancy. It has a higher number of adverse reactions than the main drug. There is another analogue, similar in composition to Pimafucin - Ecofucin, in which natamycin acts on microorganisms.
The different compositions and indications of similar drugs oblige the patient to consult a doctor before replacing the main medication with it.
