Pharmacodynamics and pharmacokinetics
The effective effect of the drug is achieved through the combination of its components.
Diclofenac has a pronounced anti-inflammatory and analgesic effect, and moderately reduces elevated body temperature.
Paracetamol has an analgesic effect, anti-inflammatory and antipyretic effects are weakly expressed. The principle of action of the drug is based on inhibition of prostaglandin .
When taken orally, Dolaren begins to act within an hour. Eating slows down the rate of absorption of the active components of the drug. Metabolites are excreted by the renal and hepatic systems.
Side effects of the drug Dolaren Knight Pain
Arterial hypotension, confusion, dizziness, drowsiness, blurred vision, tinnitus, urinary retention, nasal congestion, chills, dry mouth and throat, nausea, increased excitability, pain in the epigastric region, constipation, diarrhea. Sometimes insomnia, agitation, and tremor are noted. Photosensitivity and changes in muscle tone were detected. Allergic reactions (skin rash, itching), blurred vision, anemia, increased appetite and weight gain have been described. Possible leukopenia, thrombocytopenia, agranulocytosis.
Indications for use
Dolaren is prescribed to relieve pain: lumbago , neuralgia , toothache and headache, rheumatoid arthritis , radiculitis , sciatica , ankylosing spondylitis , osteoarthritis , diseases of the spine and joints.
The drug is effective in the treatment of dysmenorrhea , postoperative pain, bursitis , tendinitis , musculoskeletal disorders in the acute period, febrile conditions, and soft tissue diseases.
Directions for use and doses
The dosage is determined for each patient individually, taking into account the patient’s age, the nature and course of the disease, tolerability and the therapeutic effect of the drug.
For sporadic pain (headache, toothache), Dolaren is used from 1 to 3 tablets per day.
For algodismenorrhea, the initial dosage is 1-3 tablets (up to 4) per day. The duration of use of the drug is 5-7 days and depends on the dynamics of symptoms.
For moderately severe pain or long-term therapy, as a rule, 2 tablets of the drug per day are sufficient - one in the morning and one in the evening. The maximum dose of Dolaren in such cases should not exceed 3 tablets per day.
The drug is administered orally, without chewing, during or after meals (to achieve a quick effect, 30 minutes before meals), with a small amount of water.
Side effects
Gastrointestinal tract: dyspeptic disorders, anorexia , nausea, epigastric pain, stool disorders, flatulence . Long-term use of the drug leads to ulcerative lesions of the gastrointestinal tract, including bleeding.
Central nervous system: depression, drowsiness, headaches.
Urinary system: nephrotic syndrome, hematuria, acute renal failure, proteinuria .
Hematopoietic organs: anemia, thrombocytopenia (rare).
Allergies: erythema, bronchospasm , skin rashes, itching.
Pharmacokinetics
The pharmacokinetics of DOLARENA is determined by the characteristics of the pharmacokinetics of each of its active components. After oral administration, diclofenac and paracetamol are quickly and completely absorbed from the gastrointestinal tract. The concentrations of active substances in the blood plasma have a linear dependence on the dose of the drug, reaching the maximum plasma concentration 60-90 minutes after taking DOLARENA.
After repeated use of DOLARENA, the pharmacokinetic parameters of the active substances do not change. Provided the intervals between administrations are observed, there is no accumulation of the drug.
Interaction
Dolaren reduces the effectiveness of furosemide , antihypertensive drugs.
When taken simultaneously, it increases the level of digoxin in the blood.
Potassium-sparing diuretics increase the risk of hyperkalemia .
Corticosteroid and anti-inflammatory drugs increase the risk of gastrointestinal bleeding.
It is not recommended to combine Dolaren with cyclosporine and methotrexate .
Dolaren Tablets
Name: Dolaren Tablets (Dolaren) Pharmacological action: Dolaren tablets contain 2 substances from the NSAID group - paracetamol and diclofenac sodium. Both agents inhibit the activity of cyclooxygenase, which promotes the formation of cyclic endoperoxides from arachidonic acid. Cyclic endoperoxides serve as the starting material in the formation of prostaglandins, which are involved in the development of inflammation and its clinical manifestations - pain, swelling, fever. Diclofenac suppresses the formation of prostaglandins by inhibiting the activity of both types of cyclooxygenase. Thus, it has a pronounced analgesic and anti-inflammatory effect. The antipyretic effect is moderate. The central mechanism of the analgesic effect of diclofenac is associated with inhibition of the formation of prostaglandins in the nervous system.
Paracetamol has a predominantly central effect, inhibiting the formation of prostaglandins in the nervous system. It is a strong analgesic and antipyretic. The anti-inflammatory effect is weakly expressed. Diclofenac is well absorbed from the digestive tract. The rate of absorption slows down slightly when taking food at the same time. Able to penetrate into synovial fluid. Metabolism occurs primarily in the liver. Some metabolites are pharmacologically active. Excretion of metabolites is carried out mainly by the kidneys, partially with bile. About 1% of diclofenac is excreted unchanged by the kidneys. Absorption of paracetamol in the digestive tract occurs quickly, mainly in the small intestine. Metabolism of paracetamol occurs in the liver. Metabolic products are excreted by the kidneys. Unchanged, the kidneys excrete 5% of the drug.
Indications for use: Dolaren tablets are recommended for the symptomatic treatment of colds, headaches, neuralgia, toothache, lumbago, osteoarthritis, sciatica, rheumatoid arthritis, radiculitis, febrile conditions, bursitis, tendinitis, myositis, dysmenorrhea, postoperative pain.
Directions for use: Dolaren tablets can be used after reaching the age of six. Take Dolaren after meals. Dosing is carried out individually. A single dose of Dolaren is 1 tablet. The frequency of daily doses can be from two to three.
Side effects: - Anorexia, constipation, nausea, abdominal pain, diarrhea; - ulcers of the digestive tract with a possible complication of bleeding (as a rule, occur only with long-term use); - depression, drowsiness, headache; - hematuria, nephrotic syndrome, acute renal failure, proteinuria; - thrombocytopenia, anemia; - allergic reactions.
Contraindications: - Exacerbation phase of peptic ulcer disease; - pregnancy; - kidney diseases; - hypersensitivity; - bronchial asthma; - liver diseases; - lactation period; — hematopoietic disorders; - “aspirin triad” (a combination of nasal and paranasal sinus polyposis, intolerance to NSAIDs and bronchial asthma).
Pregnancy: Dolaren is contraindicated during pregnancy.
Interaction with other drugs: Dolaren reduces the clinical effects of furosemide and antihypertensive drugs, potentiates the effect of potassium-sparing diuretics. Increases plasma digoxin levels. Concomitant administration of corticosteroids increases the risk of developing gastrointestinal ulcers. Increases the toxic effects of methotrexate. Strengthens the nephrotoxic effect of cyclosporine. Potentiation of the action of anticoagulants is possible.
Overdose: Manifestations – renal failure, arterial hypotension, convulsions, dyspeptic symptoms, respiratory disorders. Treatment is symptomatic.
Release form: Tablets without shell, in packages No. 10(10x1), 4(4x1), 100(10x10), 200(4x50).
Storage conditions: Temperature below 25 degrees Celsius, protected from moisture and light.
Synonyms: Diprene.
Ingredients: Paracetamol 0.5g, diclofenac sodium 0.05g. Other ingredients are magnesium stearate, talc, gelatin, starch, sodium methylparaben, sodium starch glycolate, microcrystalline cellulose, sodium propylparaben, dye.
Additionally: During the period of use of Dolaren, monitoring of liver function is required. Medical examination is necessary for persons with kidney and digestive tract diseases.
Attention! The description of the drug “ Dolaren Tablets ” on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
special instructions
For patients with a history of gastrointestinal diseases, Crohn's disease , ulcerative colitis , functional disorders of the hepatic system, additional supervision is recommended.
Taking the drug Dolaren may cause an increase in liver transaminases .
With a long course of treatment, monitoring of the condition of the liver is required.
Dolaren can provoke attacks of hepatic porphyria .
During treatment, it is necessary to monitor the condition of peripheral blood.
The drug can inhibit platelet aggregation; the phenomenon is temporary. Dolaren reduces the speed of psychomotor reactions.
Contraindications
Hypersensitivity (including to other NSAIDs), a combination of bronchial asthma, recurrent nasal polyposis, paranasal sinuses and intolerance to ASA or other NSAIDs (including a history); period after coronary artery bypass surgery; CRF (creatinine clearance less than 30 ml/min), progressive kidney disease, severe liver failure, active liver disease, hyperkalemia, erosive and ulcerative lesions of the gastric mucosa and duodenum, active gastrointestinal bleeding, inflammatory bowel diseases, hematopoietic disorders, pregnancy, lactation period, children's age (up to 12 years).
Carefully. IHD, CHF, cerebrovascular diseases, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral vascular diseases, chronic renal failure (creatinine clearance 30-60 ml/min), ulcerative lesions of the gastrointestinal tract (history), the presence of Helicobacter pylori, liver failure, inducible acute hepatic porphyria, benign hyperbilirubinemia (including Gilbert's syndrome), glucose-6-phosphate dehydrogenase deficiency; long-term use of NSAIDs, simultaneous use of oral ICS (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including ASA, clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fpuoxetine, paroxetine, sertraline), ethanol, nicotine, old age.
Dolaren's analogs
Level 4 ATC code matches:
Voltaren Emulgel
Ultrafastin
Indomethacin
Dicloran
Dicloran Plus
Dolgit
Nise
Ketonal
Ketorol
Febrofeed
Fastum gel
Diclofenac
Finalgel
Bystrumgel
Deep Relief
Butadion
Diklovit
Artrosilene
Olfen
Fanigan Fast
Analogs include the drug Panoxen .
Interactions of the drug Dolaren Knight Pain
Simultaneous use with MAO inhibitors, sedatives, analgesics, antidepressants leads to increased effects of the drug; with tricyclic antidepressants - can lead to an increase in the severity of its side effects. Alcohol while using the drug enhances its effect on the central nervous system. When used simultaneously, the drug reduces the effect of furosemide and antihypertensive drugs. When used with other NSAIDs, the risk of gastrointestinal bleeding increases.
Dolaren price, where to buy
The price of Dolaren tablets is currently unknown. You cannot buy the drug in Moscow, Kharkov or another city.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Dolaren tab.
N100 2600 rub. order
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Pharmacy24
- Dolaren Hit gel 50 g Nabros Pharma Pvt. Ltd., India
111 UAH order - Dolaren Hit 30 g gel Nabros Pharma Pvt. Ltd., India
63 UAH order
- Dolaren No. 100 tablets Nabros Pharma Pvt. Ltd., India
300 UAH order
PaniPharmacy
- Dolaren HIT gel 30g India, Nabros Pharma
78 UAH order
- Dolaren tablets Dolaren tablets. No. 100 India, Nabros Pharma
317 UAH. order
- Dolaren HIT gel 50g India, Nabros Pharma
122 UAH order
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Special instructions for the use of Dolaren Night Payne
Use with caution for glaucoma, prostatic hypertrophy, and peptic ulcers. Not prescribed before anesthesia. During treatment with the drug, it is not recommended to drive vehicles or work with potentially dangerous mechanisms. Use with caution in children, since the drug can cause hallucinations, weakness, agitation, and in the elderly - dizziness, drowsiness, and arterial hypotension are possible. It can be used during pregnancy if the benefit to the mother outweighs the potential risk to the fetus.
