Many pathological conditions in neurology are caused by impaired cerebral circulation. The combined drug "Fezam" is intended to improve microcirculation in the cranium and increase the functionality of the brain. With its help you can fight the consequences of strokes, traumatic brain injuries, infectious diseases, and vascular diseases. According to the instructions for its use, the drug can be used even in childhood. The main thing is to follow the rules given in the annotation to avoid potential negative consequences.
pharmachologic effect
The abstract indicates that Phezam is a combined agent that provides nootropic, antihypoxic and vasodilating effects. There is a mutual potentiation of a decrease in cerebral vascular resistance, improving blood flow in these vessels.
As Wikipedia informs, the therapeutic effect and its mechanism are determined by the main active substances that are part of the drug Phezam. The main effect observed after taking the medicine is improvement of blood circulation in the brain and metabolic processes in nerve fibers and brain cells.
The substance piracetam has a nootropic effect, activating brain activity and positively affecting metabolism in the body. Under the influence of the substance, the rate of consumption of glucose, which is the main nutrient for the brain, increases. Thus, under the influence of piracetam, more active nutrition of cells occurs, which leads to the production of more energy and activation of brain function. Piracetam helps increase the speed of impulse transmission between neurons. As a result, memory increases, concentration improves, which leads to increased intellectual function.
Piracetam also helps improve blood flow in those areas of the brain where there are damaged vessels, and ischemia , that is, oxygen starvation. Since microcirculation improves, ischemic zones that arise due to lack of oxygen disappear, and the entire volume of neurons participates in brain function.
In addition, there is an indirect effect of this component, which helps to activate blood flow. It is ensured by inhibiting the process of platelet adhesion, which essentially prevents the formation of blood clots. The piracetam component not only activates blood flow, but also improves its properties. Thus, blood circulates more actively through microvessels.
hypoxia increases . Piracetam improves the integrative function of the brain, activates intellectual work, facilitates the process of assimilation of new material, and ensures restoration and support of brain functions in older people.
The substance cinnarizine has a pronounced effect directly on the blood vessels of the brain, dilating them. Also, under the influence of this substance, the tone of smooth muscles decreases, their response to active substances that constrict blood vessels decreases. Due to the fact that the substance dilates blood vessels, blood flow is activated, and more oxygen and nutrients enter the brain. Due to improved blood flow, the resistance of brain tissue to oxygen deficiency also increases. Moreover, despite the vasodilating effect, cinnarizine does not affect blood pressure and intracranial pressure .
The presence of these two components in Phezam simultaneously ensures a mutual enhancement of the effects of the active components. Consequently, the severity of the effect of the drug is more pronounced compared to taking these components separately.
When taking Phezam, there is a predominance of the sedative effect of cinnarizine, from which the medicine does not lead to the manifestation of psychomotor agitation, as happens when taking piracetam.
Pharmacokinetics and pharmacodynamics
After the patient has taken Phezam tablets orally, the active substances are completely absorbed from the gastrointestinal tract. The highest concentration of piracetam in plasma is observed after 2-6 hours, cinnarizine - after 1-4 hours. The bioavailability level of piracetam is 100%.
Piracetam does not bind to plasma proteins, cinnarizine binds 91%. Penetrates the BBB, is detected in all tissues and organs, and passes through the placental barrier. Its selective accumulation in the cerebral cortex is noted.
The substance piracetam is not metabolized, the metabolism of cinnarizine occurs in the liver.
The half-life of piracetam is 4-5 hours from the blood, 8.5 hours from the cerebrospinal fluid. Mainly excreted through the kidneys. The half-life of cinnarizine is 4 hours. Metabolites are excreted mostly in urine and also in feces. In people with renal failure, the half-life of piracetam is increased.
Indications for use of Phezam
Before using the medicine Phezam, you should definitely take into account the indications for use. The drug is prescribed in the following cases:
- with insufficiency of blood flow in the brain (in the case of vascular atherosclerosis , during the recovery period after an ischemic or hemorrhagic stroke , with encephalopathy of various origins, after a TBI);
- in case of intoxication;
- in diseases of the central nervous system, in which there is a decrease in intellectual-mnestic functions, that is, deterioration of attention, memory, mood;
- with psychoorganic syndrome, in which signs of asthenia and adynamia ;
- consequences of traumatic brain injury;
- labyrinthopathy (tinnitus, dizziness, nausea and vomiting);
- asthenic syndrome associated with psychogenic origin;
- Meniere's syndrome;
- for the purpose of preventing migraine , kinetosis ;
- in the complex therapy of children who have a psychoorganic syndrome, which has led to low learning ability.
For children
In childhood, the drug begins to be used at the age of five.
In extreme cases, doctors allow such therapy to be performed on children over one year old. A direct indication for it is perinatal damage to the central nervous system. The treatment also shows increased effectiveness during the period of the baby’s recovery from an infectious disease or traumatic brain injury.
Results of taking the product by a child:
- improving sleep quality by making it easier to fall asleep, eliminating nightmares, reducing the number of night awakenings;
- reducing fatigue, increasing physical and intellectual endurance;
- elimination of moodiness and irritability against the background of emotional instability;
- reduction in the frequency of headaches due to fatigue or overexertion;
- facilitating the adaptation process in a new team;
- stabilization of blood pressure, eliminating its changes;
- stimulation of mental abilities, simplification of the process of mastering the school curriculum;
- accelerating the development of basic social skills, in particular speech;
- reducing the risk of developing negative consequences of organic or functional brain damage.
Today, the product is increasingly being included as part of complex therapy for autism. In some cases, the drug helps to get rid of mild neurological disorders or reduce the severity of their clinical picture.
Contraindications
Phezam should not be taken in the following cases:
- in severe forms of renal and liver failure;
- during periods of increased psychomotor agitation;
- with Huntington's chorea ;
- during pregnancy and breastfeeding;
- when the patient is under 5 years of age;
- with high sensitivity to the components of the product.
The medicine is prescribed with caution to those patients who have been diagnosed with Parkinson's disease , hemostasis disorders, impaired liver or kidney function, and severe bleeding .
What is the drug "Sesame"?
I would like to warn you right away that you will not find such a name in Russian. In pharmacies you can purchase the drug SEZAM produced in China. Mostly women are interested in it, since this product is a test cassette to determine whether there is a pregnancy or not, and in just 7 days.
The material for research is urine. There are no tablets inside the package. “Sesame” is a kit that includes a pipette, a container for collecting urine and a super-sensitive scale that can show that fetal development has begun even before the menstrual cycle is delayed. The action of the scale indicator is based on sensitivity to the hormone human chorionic gonadotropin. It is produced by the future placenta of a woman's fertilized egg. In small quantities, this hormone appears in the urine already on the 5th day, but more often on the 7th day after conception has occurred. Using the Sesame test is very simple - you just need to use a pipette to place a couple of drops of your urine in a special window on the scale.
Side effects of Phezam
The following side effects are possible during treatment:
- Nervous system: nervousness, feeling of drowsiness, hyperkinesia. In rare cases - headaches, dizziness , insomnia , ataxia , agitation, anxiety.
- Allergic manifestations: in rare cases - skin rash, dermatitis , swelling, itching, photosensitivity.
- Digestive system: severe salivation, nausea, vomiting, abdominal pain, diarrhea .
- Other manifestations: increased libido.
Phezam tablets, instructions for use (Method and dosage)
The instructions for use of Phezam, which are provided in the annotation for the drug, indicate that the medicine should be taken 1-2 capsules three times a day for one to three months. The duration of treatment depends on the severity of the disease. The drug is usually taken in courses - 2-3 courses annually.
Children over 5 years old are advised to take 1-2 capsules 1-2 times a day. Capsules are used for one and a half to three months. Capsules should be taken by swallowing them whole, without violating the integrity of the capsule. The tablet should be taken with half a glass of non-hot water.
Many users ask about capsules and how to take them - before or after meals. The instructions say that there is no particular difference in whether to take the product before or after meals. But it is optimal to drink capsules 20-30 minutes after eating. It is advisable to take the medicine at the same time every day.
Doctors warn that you cannot take the medicine for longer than 3 months - a break is necessary between courses.
Use in pediatrics
The instructions for use of Sesame tablets indicate that this drug is prescribed for children over 5 years of age, but in special cases it is permissible to prescribe it to children aged only 1 year. Indications for taking Sesame in children are the same as in adults. In addition, for this category of patients the drug is used in the following cases:
- neurological pathology in a mild form (restlessness, poor memory, difficulties at school with memorizing material, poems, texts, poor concentration);
- inability to clearly express one’s thoughts or formulate an answer;
- when there is a lag in intellectual development, as one of the components of a comprehensive teaching methodology;
- autism;
- past infectious diseases;
- restlessness, tearfulness, anxiety;
- headache;
- Down syndrome;
- hysteria, mood instability;
- frequent night awakenings.
Interaction
Not all medications can be taken with Phezam tablets at the same time, so the interaction of this medication with other medications should be taken into account.
When taking medications simultaneously with Phezam that depress the action of the central nervous system, ethanol , tricyclic antidepressants , their sedative effect may increase.
When taking Phezam, the effect of nootropic and antihypertensive drugs is potentiated.
Vasodilator medications enhance the effect of Phezam.
Due to the presence of cinnarizine in the drug, the activity of hypertensive drugs .
When taking Phezam simultaneously, there is an increase in the activity of thyroid hormones , which can lead to tremor and anxiety.
Due to the antihistamine effect, cinnarizine can mask the manifestation of positive reactions in relation to factors of skin reactivity during skin tests. To avoid this effect, you must stop using the medication 4 days before such tests.
Phezam may enhance the effect of oral anticoagulants .
Overdose
Despite the increased chemical activity, the medicine is well accepted by the body even when therapeutic doses are exceeded. An overdose of Phezam has been recorded only a few times over the entire period of its use. The condition does not pose a health hazard. In adults, it usually manifests itself in the form of abdominal pain, which does not require symptomatic therapy or discontinuation of the product. In childhood, the consequences of an overdose can be irritability, tremors of the limbs or convulsions, and problems with sleep.
There is no antidote to the drug. If severe symptoms appear when the recommended dose of the drug is exceeded, it is necessary to carry out standard first aid measures. The patient is given gastric lavage, absorbents are given, and symptomatic therapy is performed. In severe cases, hemodialysis is indicated.
special instructions
If Fezam is prescribed to patients with impaired liver function, liver enzyme levels should be monitored.
The medicine activates the functions of thyroid hormones, which is why patients undergoing treatment may experience anxiety and tremors .
Since cinnarizine can cause drowsiness, during treatment you should drive carefully and work with precise and dangerous machinery.
When treating elderly people, it is necessary to regularly monitor kidney function indicators and, if necessary, adjust the dose.
Active components are able to penetrate the filter membranes of hemodialysis .
The medication should be avoided in case of porphyria .
When taking Phezam, a false positive result may occur during doping control in athletes, also due to the presence of iodine-containing dyes in the capsule shell. A false positive result may occur in the radioiodine test .
Since piracetam reduces platelet aggregation, it should be prescribed with caution when hemostasis is impaired in patients, as well as in conditions accompanied by hemorrhages. You should not take the medicine during complex surgical operations, with severe bleeding and a history of hemorrhagic strokes
Phezam can provoke irritation in the epigastric region; when used after meals, a decrease in the severity of gastric irritation may be observed, for which purpose the medicine should be used with caution in patients suffering from gastrointestinal diseases.
lactose as an auxiliary component .
During pregnancy and lactation
The drug is contraindicated for use during pregnancy, despite the absence of signs of negative consequences for the fetus during animal experiments.
Theoretically, the use of medication can cause increased anxiety in a woman, mood swings, and changes in psycho-emotional mood. This may adversely affect the development of the child or complicate the course of pregnancy. The active components of the drug can pass into breast milk, so its use during lactation is also prohibited. If the product is prescribed to a nursing mother, the child is transferred to artificial formula.
Phezam's analogs
Level 4 ATX code matches:
Bravinton
Acefen
Carnicetine
Pyracesin
Nooclerin
Semax
Piracetam
Olatropil
Vinpocetine
Cerebrocurin
Cavinton Forte
Calcium Hopanthenate
Glutamic acid
Cephabol
Olanzapine
Cerebrolysate
Pramistar
Sidnocarb
Vinpotropil
Glycine Ozone
Phezam and its analogues should be prescribed by a doctor after an accurate diagnosis. Active components similar to those contained in the drug Fezam are included in the following drugs: Combitropil , Piracezin , Omaron , NooKam . The price of analogues depends on the manufacturer of the drug and its packaging.
Medicines also have a similar pharmacological effect on the patient’s body: Acefen , Vinpocetine , Demanol , Memotropil , Combitropil , Pantogam , Pyriditol , Cellex , Encephabol , etc.
Omaron or Fezam - which is better?
Omaron drug and has the same indications for use, contraindications and causes similar side effects. At the same time, the price of the drug Omaron is lower compared to Fezam.
Release form
Phezam tablets are actually gelatin capsules - today this is the only form of release of the product. The drug is intended for oral administration. It cannot have a different composition or a different ratio of active components.
Phezam capsules look like white cylinders, dense to the touch. If you separate the halves, you will find a crumbly white or cream-colored powder inside. The presence of small lumps is allowed; they easily fall apart when pressed with a dense object. Capsules are packaged in boxes of 60 pieces.
Reviews of Fezam
Most often, reviews about Phezam on forums are positive, they talk about improving the condition of patients when taking this medicine. Users write that after taking it, memory normalizes, attention and performance improve. Also, under the influence of the medicine, stress and anxiety .
Similar positive reviews appear when capsules are used for children.
On forums where the drug Phezam is discussed, reviews from doctors are also often positive. However, there are also negative comments that the drug causes drowsiness, as well as the lack of positive effects during treatment.
Undesirable effects
Reviews of Phezam indicate that in most cases the drug is well tolerated by patients. The most common side effect in the first days of treatment was drowsiness, which went away as the body adapted to the medicine.
In addition, in some patients the drug can cause dyspeptic symptoms: nausea, vomiting, diarrhea, dry mouth. In rare cases, allergic skin reactions are possible. They occur mainly in patients with hypersensitivity to the ingredients of the capsules.
Phezam price, where to buy
The price of Phezam capsules in Moscow is on average 270 rubles for 60 pieces. You can buy them at any pharmacy with a doctor's prescription.
The price of Phezam in Ukraine (Kyiv, Kharkov, etc.) is from 200 UAH. per pack 60 capsules.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Fezam capsules 400mg+25mg 60 pcs.Balkanpharma/Zdravle HFZ
267 rub.order
Pharmacy Dialogue
- Phezam (cap. No. 60)Zdravlje
RUB 284 order
- Phezam (caps. No. 60) ZiO-Zdorovye CJSC
RUB 303 order
- Phezam (caps. No. 60)Balkanpharma
RUB 267 order
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Pharmacy24
- Phezam No. 60 capsules Pharmaceutical and Chemical Industry, Zdravle AT, Serbia
199 UAH.order
PaniPharmacy
- Phezam capsule Phezam capsules No. 60 Bulgaria, Balkanpharma-Dupnitza
223 UAH order
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What is the drug Phezam?
This is exactly the product that people want to buy when they ask for Sesame tablets in pharmacies to improve memory, insomnia, headaches and other similar conditions. It is mainly of interest to people engaged in mental work, students about to take exams, and older citizens who have developed symptoms of impaired brain activity. This drug is produced in Bulgaria at the Balkanfarma - Dupnitsa enterprise, as well as in a branch in Serbia. It goes on sale in the form of capsules, 10 pieces in a blister (plate) and 6 blisters in a package, that is, 60 capsules in 1 pack.
Phezam is a nootropic drug that provides neurometabolic stimulation of brain functions. It is sold with or without a prescription in any pharmacy in Russia. The price varies from 170 to 260 rubles per 1 package. The difference in cost does not affect the quality and depends on transport, purchasing and other expenses of the seller.
