Furazolidone: instructions, composition, indications, action, reviews and prices

Furazolidone is used in the treatment of bacterial pathologies of the digestive tract. The action of the drug prevents the production of bacterial toxins and stops the spread of the infectious process. The substance acts in the cavity of the gastrointestinal tract and has virtually no effect on other anatomical structures. Prescribed to patients over three years of age.

Antimicrobial medications for the treatment of intestinal infections often act only within the organ cavity. This property helps reduce the severity of adverse reactions.

Composition and release form

Furazolidone is an active component with medicinal properties. The standard tablet form contains fifty milligrams of this chemical compound. The tablet also contains starch, milk sugar, calcium salt of stearic acid, sucrose, and Tween-80.

Package

Produced in tablet form.

Furazolidone - instructions for use and reviews

Furazolidonum (Furazolidonum, Furazolidone) in tablets is an antimicrobial drug, that is, an antibiotic. Its therapeutic effect is to disrupt the vital systems of harmful bacteria. It is actively excreted from the body through the kidneys.

• Description of the drug
• Indications for use
• How to take the drug depending on age
• Treatment of children with the drug
• Treatment with the drug in adults

• Pregnancy and breastfeeding
• Mechanical transport management

Have you been trying to get rid of PARASITES for many years?

Head of the Institute: “You will be amazed at how easy it is to get rid of parasites by taking every day...

Read more "

The drug is ineffective in treating purulent infections, but there are no prohibitions on its use in these cases. In addition to killing bacteria, the use of furazolidone helps restore the immune system. These tablets also treat fungal diseases. Their range of applications is wide. Reviews about the effectiveness of its action are only the most positive. In this article we will look in more detail at what can be cured with the help of this drug.

Description of the drug

Furazolidone is sold in pharmacies strictly according to a doctor's prescription, like any other antibiotic. , Lvov, Ukraine. 1 yellowish tablet contains 0.05 g of the active ingredient furazolidone. Excipients are:

1. Calcium stearate;
2. Milk sugar;
3. Potato starch.

Tablets are sold in blisters, which are packaged in cardboard boxes. Depending on the disease for which antibiotics are purchased, namely on the dose and course of treatment prescribed by the doctor, the drug can be purchased from 1 to 10 blisters of 10, 20 or 25 pieces each.

When used orally, the drug is slightly inactivated and absorbed into the intestinal wall. Only 5% of the active substance is excreted from the organs in the urine in the form of metabolites or unchanged. The urine is brown in color.

Indications for use

Furazolidone is used to treat various gastrointestinal infections. These are:

• Enteritis;
• Diarrhea;
• Paratyphoid;
• Giardiasis.

Diseases of the genitourinary system:

1. Urethritis;
2. Bladder infections;
3. Inflammation of the kidneys, vaginal mucosa;
4. Trichomonas colpitis.

Children are prescribed the drug for the treatment of:

• Dysentery;
• Paratyphoid;
• Toxic poisoning.

Due to its antimicrobial effect, it is also used in the treatment of burns, wound infections, and for poisoning.

Furazolidone is most often used for cystitis. Everything in the human body is closely interconnected. Furazolidone actively fights bacteria in the intestines, which often cause inflammation in the bladder. The drug inhibits pathogenic bacteria and does not harm the kidneys.

How to take the drug depending on age

Furazolidone tablets are used as an emergency treatment for childhood diarrhea and indigestion; there is no better remedy for the prevention of helminths. Resourceful housewives write reviews that even cats manage to cure diarrhea with the help of furazolidone.

Take furazolidone tablets after meals with water as a whole. Both adults and children can be treated with this antibiotic, but it must be taken in appropriate doses.

Treatment of children with the drug

1. Children under one year old take it 4 times a day, the dose is calculated at 10 milligrams per 1 kg of the child’s weight. They take the medicine for three days, then take a break for the same period and continue to take the pills for another 3 days;
2. Children under 8 years of age should take the drug after meals with plain water. For diseases such as: dysentery, foodborne toxoinfection paratyphoid in a dose of 0.1-0.15 g. Treatment lasts from 5 to 10 days with medication taken 4 times a day. Furazolidone can be taken in cycles of 3-6 days with a break of 3-4 days;
3. For children over 8 years of age, the drug is prescribed at the rate of 6-7 mg per 1 kg of weight, which must be divided into 4 doses.

Treatment with the drug in adults

Adults are prescribed to drink 2 tablets 4 times for 3-6 days, depending on the severity of the disease. After a three-day break, the course is repeated. The tablets are washed down with plenty of water, and the tablets are combined with the consumption of B vitamins.

When treating genitourinary infections, vaginal suppositories with furazolidone are prescribed. Do not exceed the daily dose of 16 tablets. If a cure has not been achieved and there is no desired effect, you should try analogues of the drug.

Since Furazolidone is an antibiotic, taking it for more than 10 days is highly not recommended.

Attention! This antibiotic should be prescribed strictly by the attending physician, despite its safety.

What are the dangers of overdose?

An overdose, namely, taking a large amount of an antibiotic or increasing the duration of taking the drug, threatens:

• Liver intoxication;
• Toxic hepatitis;
• Polyneuritis.

In case of overdose, you urgently need to rinse your stomach, take a laxative and enterosorbent. Reviews from patients indicate that this happens extremely rarely and there is no reason to refuse treatment.

When is furosalidone contraindicated?

Furazolidone is used as an antibiotic for many diseases; it is almost universal. But, nevertheless, there are contraindications to its use in the following cases:

1. The body does not accept the components of the drug;
2. Insufficient levels of glucose and lactose in the blood;
3. Acute renal failure;
4. Cardiovascular diseases;
5. Diseased liver;
6. Psychoneurological diseases;
7. Under the age of one year.

Pregnancy and breastfeeding

It is not advisable to take furazolidone while pregnant or breastfeeding, as it is an antibiotic. If only there is a real threat to the mother's health or the impossibility of treatment in other ways, then this drug can be taken for a short time.

While taking furazolidone tablets, like any other antibiotic, you should stop breastfeeding, no matter the cost, carefully expressing milk during this period. This milk contains active drug components that can harm the baby. Therefore, it should not be given to the baby.

Mechanical transport management

During treatment with the drug, you should refrain from driving vehicles, because furazolidone reduces the activity of the function responsible for concentrating.

Dietary restrictions during drug treatment

A certain diet will increase the effectiveness of the drug. You should say “no” to the use of spices, smoked meats, and pickles. It is useful to combine furazolidone tablets with diuretic decoctions (from lingonberries, cranberries).

Side effects

Side effects, as evidenced by patient reviews, are insignificant. This:

• Manifestation of allergic reactions - itching, skin rash;
• From the gastrointestinal tract - nausea, vomiting.

If such reactions occur, you should immediately stop treatment and consult a doctor.

Drug interactions

Furazolidone is a monoamine oxidase inhibitor. Caution must be exercised throughout treatment, as with any other monoamine oxidase inhibitors.

The antimicrobial effect of Furazolidone tablets is enhanced by tetracyclines and aminoglycosides. Compared to Ristomycin and Chloramphenicol, the drug increases the inhibition of hematopoiesis.

Attention! Furazolidone is not compatible with alcohol!

Analogs

Furazolidone is an active antibiotic. There are a number of medicines that have a similar effect on the body. Doctors mostly prescribe expensive drugs (originals) to their patients, despite the fact that there are cheaper analogues - unadvertised drugs with a similar spectrum of action and the same active ingredient - they are called generics, for which the patent protection period has expired.

However, there are also significant circumstances when certain medications are required to be taken, be they analogues or originals - this is due to contraindications for each person’s body individually. So, the analogues of Furazolidone are as follows:

• BEFUNGIN (suspension) - prescribed for gastrointestinal diseases: gastric ulcer, gastritis, intoxication;
• NEGRAM (capsules, tablets) is an antibiotic that is prescribed for urethritis, pyelonephritis, cholecystitis and other diseases;
• FINER (syrup) - the medicine is used for constipation and skin problems. It helps remove toxins and cholesterol, cleanses the blood;
• HEPAR COMPOSITUM (tablets) - the drug increases the detoxification function of the liver organs, has choleretic, hepatoprotective and antioxidant effects, and is indicated for the treatment of the gastrointestinal tract and liver diseases;
• BI-TOL (suspension) – used for infectious diseases of the respiratory system, sinuses, ear, kidneys, genitals, gastrointestinal tract caused by Shigella, salmonella strains;
• CONFIZIM (tablets) is a medicinal complex used to normalize and maintain digestion. Promotes the digestion of carbohydrates, fats, proteins;
• NORBACTIN (tablets) - an antibiotic indicated for patients suffering from infectious diseases caused by sensitive microorganisms to norfloxacin;
• VIS-NOL (capsules) – used for peptic ulcers of the stomach and duodenum, functional dyspepsia not associated with organic gastrointestinal diseases.

The listed drugs can completely replace Furazolidone. As an analogue, we can also recommend the drug “OFOR”, which treats infections of the genitourinary system, respiratory tract, gastrointestinal tract, giardiasis, and one type of prostatitis.

In terms of their effectiveness, analogues may sometimes not be as good as the originals - this is mainly due to the credibility of the manufacturer, the quality of purification of chemical compounds from impurities, as well as adherence to technology in the manufacture of the drug.

Better quality drugs are produced by manufacturers in developed European countries, Japan and the USA, which are more consistent with the original in their clinical effectiveness than companies from East Asia, India, and China.

Analogues belong to the group of drugs that have a lower cost - this factor is their main advantage.

Reviews about the drug "Furazolidone"

Marina 35 years old, Moscow

Furazolidone has been familiar to me since childhood. At that time we had a private house with a plot where many fruit and berry trees grew. I often loved to eat unripe apples and cherries straight from the trees, unwashed, which is why I suffered from stomach pain, diarrhea and intestinal colic. When the first symptoms of problems in the body appeared, my mother gave me 2 tablets of this drug at once and reminded me that before eating fruits, they should always be washed, but it was useless. I remember that the medicine always helped me very well.

Elvira 28 years old, St. Petersburg

Health comes first for me. I want to tell you from my own experience how I cured cystitis. For those who don’t know what it is, let me explain: cystitis is an inflammatory process that occurs in the bladder. Somehow it turned out that I caught a cold, and as a result, cutting pains appeared while going to the toilet. Only those who have experienced it can understand what kind of torment this is. I began to look for salvation and, as usual, the first thing I did was go online to decide on the choice of drug.

I saw that Furazolidone had positive reviews and decided to go with it. Naturally, I couldn’t buy it at the pharmacy without a prescription, since it’s an antibiotic, I had to make an appointment with a doctor, after which he wrote me a prescription and gave me some instructions regarding taking it. The result was excellent, cystitis receded. Therefore, if anyone encounters this disease, know that Furazolidone is what is needed in this case. Be healthy!

Action of furazolidone

A drug with antimicrobial properties belonging to the nitrofuran group. Has little effect on infectious agents causing purulent and anaerobic infectious processes. The active substance inhibits monoamine oxidase. Antimicrobial properties are due to disruption of oxidative processes and the formation of nucleic acids in pathogens. The cell membrane is gradually destroyed. The metabolic effect of the drug helps pathogenic microorganisms release fewer toxic substances. Because of this, symptom relief occurs before the drug's effect on pathogen numbers.

Activity spectrum

The active substance reduces the number of infectious agents and eliminates the toxic effect on the body. A unique property of the drug is considered to be its ability to improve the functioning of the body's defense systems. The active component stimulates the cellular and humoral mechanisms of immunity. Resistance to the action of a chemical compound in infectious agents develops very slowly.

Overdose

When large doses of Furazolidone are taken orally, the patient develops toxic liver damage, including acute toxic hepatitis. According to reviews, Furazolidone in large doses can lead to the development of hematotoxic and neurotoxic effects.

There are no specific antidotes. Gastric lavage and oral administration of sorbents and saline laxatives are indicated. B vitamins and antihistamines are prescribed. If necessary, infusion therapy is carried out aimed at maintaining water and electrolyte balance.

In case of severe poisoning, hemodialysis is performed.

Side effects

Drug therapy using the drug is well tolerated. Adverse reactions occur rarely. The body may be sensitive to the components contained in the tablet in some patients.

Main side effects:

• Decreased or lack of appetite.
• Vomiting.
• Inflammation of the nerves.
• Skin rashes.
• Redness of the skin.
• Swelling of the covering tissues.
• Itching of the skin.
• Quincke's edema.

If allergic reactions occur during treatment, you need to stop taking the pills and undergo a medical examination. You should also make an appointment with a specialist if you experience side effects not described in the article.

pharmachologic effect

Furazolidone is a synthetic derivative of 5-nitrofurforol. According to reviews, Furazolidone is most effective in the treatment of inflammatory diseases caused by gram-negative aerobic bacteria. Aerobic gram-positive microorganisms, fungi and protozoa are less sensitive to it. Anaerobic pathogens are insensitive to Furazolidone.

The pharmacological effect of Furazolidone largely depends on the doses taken: at low doses the drug has a bacteriostatic effect, and when they increase, it has a bactericidal effect. The mechanism of antimicrobial action is that the nitro groups included in the Furazolidone molecules, under the influence of microbial enzymes, are reduced to amino groups, which are very toxic to bacteria. Amino groups disrupt the integrity of bacterial cell membranes and block many biochemical processes in them. As a result, microorganisms lose their ability to further grow and reproduce.

According to reviews, Furazolidone also has a slight immunostimulating effect. It lies in the ability of the drug to increase the phagocytic activity of white blood cells (leukocytes) and the compliment titer.

Furazolidone increases the sensitivity of the human body to ethyl alcohol. Therefore, when taking this drug and alcoholic beverages simultaneously, nausea and vomiting develop.

Resistance (resistance) to Furazolidone in bacteria develops quite slowly.

After oral administration, Furazolidone is quickly and almost completely absorbed from the intestine. Therapeutically significant concentrations in the blood remain for 5–6 hours after taking a single dose. The drug penetrates into the cerebrospinal fluid, where its concentration is the same as in the blood. There is also a high concentration of Furazolidone in the intestines.

It is excreted mainly by the kidneys, partly unchanged, partly in the form of metabolites.

Absorption and excretion

The active component works well within the intestines. Noticeable concentrations of the substance are created in the blood and cerebrospinal fluid, but there are no significant systemic effects. Antimicrobial properties are predominantly manifested within the intestinal cavity, so the product is used to eliminate infectious processes in this area. In the liver tissue, the active component changes to form a metabolite that does not have medicinal properties.

The chemical compound is almost completely removed from the body in the urine. A small part of the substance is excreted in the feces.

Furazolidone for children - video

This video provides general information on the drug Furazolidone and in what cases it is prescribed. It also talks about contraindications, side effects and other nuances associated with this medicine, which you should definitely read before taking this drug.

Furazolidone is a nitrofuran drug that quickly inhibits many pathogens in the child’s intestines. In addition, it stimulates the body's natural immune response to disease. Two types of dosage forms make it possible to use it for very young children from one year old, kindergarteners, and schoolchildren. However, only a qualified specialist can prescribe such a drug, as well as regulate its dosage, fully taking into account the clinical picture, anamnesis, individual characteristics of the young patient and the results of children's tests. Only in this case the drug will be as effective and safe as possible for the baby.

Have you ever given Furazolidone to your child? What dictated this need? Have there been any adverse reactions? Did you get the desired effect? Share your experience in the comments, this is important for those parents whose children were prescribed Furazolidone for the first time. I wish you healthy babies and good digestion!

Indications for the use of furazolidone

The drug is used in gastroenterological practice to eliminate infectious processes in the intestines. The activity of the chemical compound mainly in the intestinal area determines the specificity of the prescriptions. Prescribed only by a doctor after identifying signs of the disease. It is used in the treatment of pathologies caused by pathogens sensitive to the active component.

Examination before treatment

Main indications

• Dysentery infection.
• Bacterial infectious process against the background of food poisoning.
• Inflammation of the kidney tissue.
• Inflammation of the urethra.
• Cholera.
• Trichomonas infection.
• Paratyphoid.
• Giardiasis.

Only a specialist can competently assess the patient’s condition and prescribe medication. In modern practice, the medicine is usually prescribed only for intestinal bacterial infections.

Indications

This drug is used to treat inflammatory and infectious diseases of the genitourinary system, gastrointestinal tract and skin. According to the instructions, Furazolidone is used to treat the following diseases:

• Typhoid and paratyphoid;

• Bacillary dysentery;

• Giardiasis;

• Enterocolitis;

• Diarrhea caused by infectious causes, in particular food poisoning;

• Trichomonas infection;

• Cystitis, urethritis;

• Infected burns and skin wounds.

Contraindications

There are restrictions on use due to the possibility of severe complications in some people. During the examination, the patient's attending physician excludes allergies or intolerances. Allergic manifestations can be associated with any component of the tablet, so you need to study the composition.

Main contraindications:

• Carrying a child.
• Lack of the enzyme G6PD in the body.
• Age up to three years.
• Lactic sugar intolerance.
• Sensitivity of the body to nitrofuran medications.
• Breastfeeding period.
• Severe renal impairment.

Therapy is strictly controlled by a specialist when the following conditions are detected: chronic pathologies of renal tissue with impaired organ function, pathologies of liver tissue, diseases of the nervous system.

Analogs

If for some reason the original drug does not suit the baby, you can always choose an alternative after consulting with a specialist who is observing the child. We will give only an approximate list of such drugs:

• Phthalazol;
• Loperamide;
• Ersefuril;
• Stopidar suspension for children;
• Furadonin;
• Furagin;
• Levomycetin;
• Nemozol for children;
• McMiror;
• Furacilin.

Instructions for use of furazolidone

Drug therapy is prescribed by a gastroenterologist, pediatrician, therapist or other doctor. The specialist must examine the patient’s medical history and make a diagnosis. Infectious processes in the intestines are often manifested by loose stools, abdominal discomfort, fluid loss, bleeding in the stool and other unpleasant symptoms. If such complications occur, it is imperative to undergo a medical examination to select safe and effective therapy.

The medicine is taken orally only. The tablets should be swallowed whole and taken with plenty of liquid. The product should be taken after eating to improve absorption. The maximum single dose for adult patients is two hundred milligrams. The maximum daily dose for adults is eight hundred milligrams.

Dosages

• Dysenteric infection, paratyphoid fever, bacterial pathology due to food poisoning: one hundred or one hundred and fifty milligrams four times a day. Duration of treatment is from five to ten days.
• Giardiasis: one hundred milligrams four times a day for adults. For a child, the daily dose is selected based on body weight, ten milligrams per kilogram of weight. The resulting value is divided into three or four doses per day.

The patient’s attending physician selects an individual treatment regimen, assessing the patient’s condition and medical history. The above diagrams are described for reference purposes. Self-medication is prohibited.

Additional Information

• The use of doses not specified in the instructions (overdose) may be complicated by the formation of the following negative consequences: toxic damage to liver tissue, inflammation of liver tissue, inflammation of nerve tissue due to the action of the substance, toxic effect on the blood. You need to seek medical help as soon as possible. Specialists rinse the stomach cavity, prescribe adsorbents and laxatives. The ratio of electrolytes and fluid in the body is maintained. B vitamins and antihistamines are sometimes used. Dialysis may be prescribed.
• Effects of mutual use of several drugs are possible. If the patient plans to use other medications together with furazolidone, you should consult your doctor. It is forbidden to take the product together with ethyl alcohol due to the high risk of developing disulfiram-like complications. Blood pressure increases when used together with antidepressants, tyramine, amphetamine, ephedrine, phenylephrine and medications that inhibit monoamine oxidase. Use together with the listed medications is prohibited.
• Strengthens the suppression of hematopoietic function when used together with chloramphenicol or ristomycin. Medicines that change the urine environment to the alkaline side weaken the medicinal properties of the drug. Medicines that change the urine environment to the acidic side improve the medicinal properties of the drug. Medicines of the aminoglycoside and tetracycline groups increase the antibacterial effect of the active component.
• During treatment, the doctor must monitor the patient's condition. Negative consequences similar to complications of the use of substances that inhibit monoamine oxidase are possible. It is important to remove foods rich in tyramine from your diet, including legumes, cheese products, cream, herring, and coffee. To reduce the risk of inflammatory processes in the nerves during long-term therapy, you need to take B vitamins.

More accurate and detailed information can be found in the official instructions.

Side effects

Furazolidone is considered a low-toxic drug, but can still lead to the development of side effects: nausea, vomiting, lack of appetite, pain in the epigastric region. According to the instructions, Furazolidone rarely leads to the development of allergic reactions: Quincke's edema, urticaria, itching, skin rash. To prevent the development of adverse reactions, it is recommended to take each dose of Furazolidone with plenty of liquid, take antihistamines and B vitamins.

With long-term use of Furazolidone, especially in infants, the development of methemoglobinemia and hemolytic anemia, hyperthermia, cough, shortness of breath and a neurotoxic reaction is possible.

Analogues of the product

There are no other trade names for the active ingredient. You can purchase other intestinal antibiotics as prescribed by your doctor.

Indirect analogues:

• Alpha Normix.
• Ersefuril.

Other intestinal antimicrobial agent

The above medications are based on other active ingredients. Medicinal properties differ. Take only as prescribed by a specialist.

How to give furazolidone to children

The daily dose of the drug is determined by the weight of the young patient. Per 1 kg of weight, the daily norm is 10 mg of the active substance. That is, if your child weighs 15 kg, then he needs 150 mg of furazolidone per day. Depending on the dosage form of Furazolidone itself, this amount of active substance determines the amount of suspension or tablets.

In any case, the dosage, whether in tablets or in suspension, of Furazolidone for children with diarrhea of ​​bacterial etiology is strictly regulated by a doctor. It is the specialist who determines the daily dosage of the drug. Parents can only divide this amount into 3-4 doses.

The medicine should be given strictly after meals. If these are tablets, they must be washed down with plenty of water. Thus, their irritating effect on the walls of the stomach is reduced. The suspension must be prepared according to the attached instructions. It is also important not to forget to shake the bottle before each use of the product.