Instructions for use of vaginal suppositories Polygynax - indications, composition, side effects, analogues and price

Vaginal suppositories Polygynax

Vaginal capsules are widely used in gynecology; they provide an antibacterial and antifungal effect. The effectiveness of the drug is manifested in the fight against gram-positive and gram-negative microorganisms. Polygynax suppositories can be used as a remedy against fungal diseases (they are effective against cryptococcus, candida, histoplasma). In addition, the antibacterial drug normalizes the trophic processes occurring in the vaginal mucosa.

Compound

According to the instructions for use, Polygynax suppositories contain three types of antibiotics:

1. Neomycin. This substance belongs to the group of aminoglycosides. It is effective against gram-positive and gram-negative microbes. The substance fights Proteus, E. coli, staphylococcus, enterococcus, tuberculosis bacteria and other pathogenic microorganisms;
2. Polymyxin B Sulfate. This antibiotic, which is part of the Polygynax suppositories, is active against gram-negative bacteria, it kills Klebsiella, E. coli, enterobacteria, salmonella, and is also effective against dormant and growing microbes;
3. Nystatin. This antibiotic is especially effective against candidiasis, aspergillus, blastomycetes and coccidioidosis.

Pharmacodynamics and pharmacokinetics

Suppositories have a local combined therapeutic effect and have an antibacterial and antifungal effect, therefore they are often prescribed by gynecologists. Polygynax is characterized by high bactericidal activity against various pathogenic organisms. In order for the active substances to reach the vaginal mucosa in large quantities, the capsules are injected deeply. In this case, the components of the drug are practically not absorbed into the bloodstream and therefore do not have a systemic effect.

The central action of the active substances of the drug from a number of antibiotics - neomycin and polymyxin B - is aimed at inhibiting the activity of the bacterial microflora of the vagina. Anaerobic bacteria and streptococci are not sensitive to these effects. Nystatin, which is also included in Polygynax, has a fungicidal effect against fungi of the genus Candida, as a result of which the drug is used to treat thrush.

The medication has a beneficial effect on the trophic processes occurring in the vaginal mucosa. In addition, suppositories have a wide spectrum of action: they treat many diseases, ranging from thrush to inflammatory diseases caused by other fungal microorganisms. When used intravaginally, the active components of Polygynax are evenly distributed throughout the vaginal mucosa, where their antibacterial and fungicidal effects are manifested.

Polygynax - indications for use

If the patient has infectious and inflammatory pathologies of the genital organs caused by pathogenic microorganisms, the doctor prescribes the use of suppositories containing an antifungal antibiotic. Polygynax suppositories are recommended in the following cases:

• the presence of nonspecific fungal vaginitis;
• with vaginal candidiasis;
• if the patient was diagnosed with vulvovaginitis, vulvitis;
• with cervicovaginitis;
• for the prevention of genital organs caused by inflammation or infections;
• during sanitation of the birth canal, abortion;
• as preparation for surgical interventions in the genital area;
• to prepare for diagnosing the space inside the uterus;
• for prevention before childbirth;
• before diathermocoagulation of the cervix and after the procedure.

Sometimes suppositories are prescribed for the treatment of cystitis, especially often in its chronic forms or complications. In addition, the drug can be used to prevent the development of inflammatory processes, which is important before a planned surgical intervention (in the localization of the genital organs), before and after cauterization of uterine cervical erosion, before diagnostic procedures performed intrauterinely and on the eve of childbirth.

Thrush

Almost every woman at least once experiences unpleasant sensations in the intimate area - itching, discharge and pain during sexual intercourse or urination, which significantly worsens the quality of life.
Pregnant women often experience the same symptoms. The cause of the symptoms is vaginal candidiasis, commonly known as thrush, a disease caused by the colonization of microflora by Candida fungi. They are always present in the vaginal microflora, but under certain circumstances their population increases sharply, which leads to the above symptoms.

Favorable factors for the development of fungus:

• Decreased immunity
• Consequences of taking antibiotics
• Poor nutrition (lots of sweets in the diet)
• Diabetes
• Hormonal imbalances
• Wearing tight synthetic underwear
• Pregnancy.

As soon as the population of the fungus increases, it begins to destroy the vaginal epithelium, which causes pain during sexual intercourse. The disease is always accompanied by copious white, cheesy discharge that has a sour odor, which is why it is called “thrush.”

There are many remedies that help get rid of thrush. One of these drugs is Polygynax suppositories.

Polygynax suppositories - instructions for use

Thrush should be treated regularly with Polygynax suppositories. Only through systematic use of the drug can pathogenic bacteria on the vaginal surface be completely destroyed. A single course of therapy, as a rule, is unable to completely rid a woman of bacterial infections. Often, to treat thrush, a 12-day course of using suppositories is needed. The capsules are administered before bedtime, and it is better to do this while lying down, after carrying out hygiene procedures.

For preventive purposes, suppositories are used for 6 days. If a woman has missed taking the drug once or several times, she should resume therapy as soon as possible and continue as usual. Polygynax is administered 1 capsule, and to achieve the expected therapeutic effect, you must follow certain rules:

• Before the procedure, you must wash your hands thoroughly without soap;
• It is better to administer suppositories in a lying position (the recommended depth is equal to the length of a finger, otherwise the drug will flow out after dissolution);
• it is recommended not to change the horizontal position for at least 15 minutes after inserting the suppository to ensure maximum safety of the product;
• After the procedure, you need to wear a sanitary pad so that the released product does not stain your underwear.

special instructions

Exceeding the recommended period of use of Polygynax will negatively affect its effectiveness. This is explained by the fact that pathogens, after the specified period of treatment, develop resistance to the active components of the drug, which creates a risk of re-infection. Another important point is the prohibition of using latex condoms during therapy. Many doctors recommend abstaining from intimacy altogether during this time. During menstruation, treatment should not be interrupted.

Side effects

Allergic manifestations: possible development of allergic

eczema

, both in the area where the drug is applied and in other places (usually with prolonged use of Polygynax).

From the senses: the likelihood of negative effects on the hearing organs is minimal due to the short duration of use of the drug.

From the urinary system: due to the short duration of the course, the likelihood of developing systemic

kidney intoxication

extremely small.

To date, cases of systemic intoxication as a result of the use of Polygynax have not been registered.

During pregnancy

In the first trimester of pregnancy, suppositories are contraindicated; later the doctor may prescribe them if he considers such a measure necessary. Despite the fact that the manufacturer claims that the capsules do not have a negative effect on the fetus, they can be used in a minimal dosage. It is not recommended to use Polygynax suppositories during breastfeeding, however, if there is an urgent need, the child should be weaned off the breast during therapy.

The indication for the use of suppositories is the treatment and prevention of genital inflammatory infections before childbirth, however, such a measure is relevant only if the pregnant woman has pathogenic microflora in the vagina, which was revealed during laboratory tests. In this case, the doctor decides which local drug will be optimal for a particular patient: Polygynax or its analogues.

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Causes

The main reason is banal hormonal changes that affect all girls. The body prepares to become a mother and rebuilds organs, thereby causing inflammatory processes.

Another reason may be hormonal imbalance and endocrine diseases. The cause may also be complications after infectious diseases, injuries, or poisoning.

Some STDs and sexually transmitted infections will complicate the course of inflammation.

Candidiasis is a very unpleasant female disease, and I also suffer from it. No matter what methods I have tried, the symptoms still return.

Another good thing is that the itching and burning disappear literally within 2-3 days of treatment. Although this is only in my case, advanced forms of thrush take longer to treat.

During etiotropic treatment, Polygynax was used in the form of vaginal suppositories. Systemic anti-inflammatory and antifungal treatment was not carried out during Polygynax therapy.

In childhood

For little girls and teenagers, a special form of suppositories is produced - Polygynax Virgo, intended for those who have not yet begun sexual activity. Suppositories have the form of capsules with a pointed end, which, when used, must be pierced and, pressing on the shell, inserted into the vagina. After squeezing out the entire contents of the candle, the capsule itself should be thrown away. Girls need to administer the drug before bed, after the last visit to the toilet. The course of treatment is 6 days without breaks or omissions.

Contraindications

The only contraindication to the use of Polygynax Virgo is intolerance to one of the components.

Precautionary measures

The suspension cannot be used for a long time, since infectious agents may develop resistance to its active ingredients. This increases the risk of recurrence of genital diseases.

If a girl has kidney or liver failure, you must inform your doctor. He will adjust the dose of the drug.

During therapy, the girl should not insert intravaginal tampons.

Interaction with alcohol

The suppositories do not contain antibacterial substances, the combination of which with alcohol can cause a disulfiram-like reaction, which is why ethanol is not broken down into safe elements in the body. In this regard, there is no good reason to prohibit the consumption of alcohol during treatment with Polygynax. However, ethanol can change the effect of drugs, so it is unknown how the active components of suppositories will behave. Based on this, doctors do not recommend combining their use with alcohol.

Analogs

The drug with antifungal substances in its composition belongs to the group of expensive ones, which is largely due to the country of origin of the candles (France). There is a domestic analogue of Polygynax, which is as close as possible to the composition of French suppositories - Terzhinan tablets. The drug also contains nystatin and neomycin sulfate. In addition to these substances, Terzhinan contains ternidazole (has an antifungal effect) and prednisolone (anti-allergic, anti-inflammatory component).

Other analogues of Polygynax candles, which provide a similar effect, but have a different composition:

• Vagiclin;
• Fluomizin;
• Nystatin;
• Vagilak;
• Milagin;
• Klindes;
• Pimafucin, Ave.

Price for Polygynax

Often these suppositories are used for symptoms of thrush. According to reviews from many gynecological patients, Polygynax is an effective drug that not only eliminates the symptoms of the disease, but also prevents further infection. The price of candles depends on their quantity in the package and the pricing policy of a particular point of sale. The table below shows the average cost of Podizhinaks in Russia.