Glucophage, 1000 mg, film-coated tablets, 30 pcs.

• July 8, 2019
• Other drugs
• Savelyeva Victoria

Let's look at the instructions and reviews for Glucophage Long 1000 mg. It is an oral hypoglycemic drug. Part of the biguanide group.

The dosage form of Glucophage Long is tablets with prolonged action. They are biconvex, white or almost white in color, with “500”, “750” or “1000” engraved on one side (this depends on the dosage); Merck engraved on the back. There are 7 pieces in a blister; a cardboard pack contains 4 or 8 blisters; sometimes there are 10 pieces in a blister, then a cardboard pack contains 3 or 6 blisters; There are also 15 pieces in a blister, in this case the pack contains 2 or 4 blisters. To protect against counterfeiting, the blisters and packaging are marked with the “M” symbol.

pharmachologic effect

"Glucophage Long" refers to oral hypoglycemic drugs included in the biguanide group. While taking it, there is a decrease in basal and postprandial plasma sugar levels in the blood. Metformin does not stimulate insulin secretion, and hypoglycemia does not develop. Sensitivity to insulin from peripheral receptors and glucose utilization by cells increases. Since gluconeogenesis and glycogenolysis are inhibited, liver glucose production is reduced. The process of absorption of this substance in the intestines occurs more slowly.

Metformin affects glycogen synthetase and stimulates glycogen production. The transport capacity of membrane glucose transporters increases. According to the instructions for use for "Glucophage Long" 1000 mg, under the influence of the active substance, lipid metabolism is carried out favorably: the content of triglycerides decreases, and low-density lipoproteins and total cholesterol become less. During treatment, the patient's weight remains at the same level or decreases moderately. We will read reviews of those who have lost weight using Glucophage Long 1000 for weight loss at the end of the article.

ATX

According to the international classification of medicinal products (ATC), Glucophage 1000 has the code A10BA02. The letters A and B present in the code indicate that the drug affects metabolism, the functioning of the digestive tract and hematopoietic activity.

Glucophage is a highly effective drug for lowering blood sugar levels and maintaining them at an acceptable level.

Pharmacokinetics of the drug

In accordance with the instructions for use for Glucophage Long 1000 mg, the absorption process of metformin after ingestion of this drug, compared to pills with a regular release, occurs at a slower pace. The maximum concentration of the active component is detected seven hours after taking a tablet at a dosage of 500 mg (if you take 1500 mg - after 4-12 hours), the same indicator for tablets whose usual release is 2.5 hours.

The absorption of metformin from extended-release tablets does not depend on food. The substance binds to plasma proteins to a small extent.

The process of cumulation does not occur against the background of repeated doses of up to 2000 mg per day. Metabolites of the substance are not detected. The half-life after oral administration is approximately 6.5 hours. The active ingredient is excreted from the body unchanged by the kidneys. The renal clearance of the substance is more than 400 ml/min (tubular secretion and glomerular filtration ensure the excretion of metformin). Metformin clearance in cases of renal impairment decreases in proportion to creatinine clearance; the half-life in this group of patients is longer.

Glucophage price, where to buy

The price of Glucophage 1000 mg varies between 300-350 rubles.

The price of Glucophage 850 mg is from 205 rubles.

You can buy 500 mg tablets for 170-200 rubles.

The medicine Glucophage, intended specifically for weight loss, is not available.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Glucophage long tablets prolong.
  500 mg 60 pcs. Merck Sante S.A.S./Nanolek LLC RUB 354 order
• Glucophage long tablets prolong. 750 mg 30 pcs. Nanolek LLC

  RUB 295 order

• Glucophage Long tablets with prolong release. 1000 mg 60 pcs. Nanolek LLC

  RUR 657 order

• Glucophage Long tablets with prolong release. 750 mg 60 pcs. Merck Sante s.a.s./Nanolek LLC

  RUB 487 order

• Glucophage Long tablets with prolong release. 1000 mg 30 pcs. Nanolek LLC

  RUB 339 order

Pharmacy Dialogue

• Glucophage long (tablet ret. 500 mg No. 60) Merck Sante/Nanolek

  RUR 387 order

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• Glucophage long (tablet ret. 750 mg No. 60) Merck Sante/Nanolek

  RUR 507 order

• Glucophage long (tab.pl/vol. 1g No. 30) Merck Sante

  RUR 348 order

• Glucophage long (tab.pl/vol.1g No. 60)Merck Sante

  RUR 681 order

• Glucophage long (tablet ret. 750 mg No. 30) Merck Sante/Nanolek

  RUB 303 order

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Pharmacy24

• Glucophage 500 mg N30 tablets Merck Sante S.A.S., France/Merck, SL, Spain
  67 UAH. order
• Glucophage 500 mg N60 tablets Merck Sante S.A.S., France/Merck, SL, Spain

  127 UAH order

• Glucophage XR 500 mg N60 extended-release tablets Merck Santé, France

  270 UAH. order

• Glucophage 1000 mg N60 tablets Merck Sante S.A.S., France/Merck, SL, Spain

  255 UAH order

• Glucophage 850 mg No. 30 tablets Merck Sante S.A.S., France/Merck, SL, Spain

  96 UAH order

PaniPharmacy

• Glucophage tab. p/o 1000 mg No. 30 France, Merck Sante

  130 UAH order

• Glucophage tablets 500 mg No. 30 Australia, Nycomed

  80 UAH order

• Glucophage XR tablet prol. valid 500 mg No. 60 France, Merck Sante

  261 UAH. order

• Glucophage tablets, coated 850 mg No. 30 France, Merck Sante

  90 UAH order

• Glucophage film-coated tablets 1000 mg No. 60 France, Merck Sante

  255 UAH order

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In what cases is the drug not prescribed?

So, the medication is contraindicated for:

• impaired renal function or in the presence of renal failure (if creatinine clearance is less than 45 ml/min);
• diabetic precoma, diabetic ketoacidosis, coma;
• clinically expressed manifestations of chronic/acute stages of diseases, against the background of which tissue hypoxia can occur (we are talking about acute myocardial infarction, acute heart failure, breathing problems, chronic heart failure with unstable hemodynamic parameters);
• acute conditions accompanied by a risk of renal dysfunction, including dehydration (the patient has severe/chronic diarrhea, repeated bouts of vomiting), shock, severe infectious diseases (we are talking about urinary and respiratory tract infections);
• liver dysfunction, liver failure;
• injuries and major surgical operations when insulin therapy is prescribed;
• lactic acidosis, including those with a complicated history;
• acute alcohol poisoning, chronic alcoholism;
• with a hypocaloric diet (when a person consumes less than 1000 kcal per day);
• radioisotope/x-ray studies during the administration of iodine-containing contrast agent (before/after within 48 hours);
• pregnancy;
• under 18 years of age;
• individual sensitivity to the components of the drug.

Relative contraindications (“Glucophage Long” is prescribed, but taken under the supervision of a doctor) include:

• renal failure (with creatinine clearance in the range of 45–59 ml/min);
• lactation;
• old age from 60 years, when heavy physical work is performed (lactic acidosis may occur).

Benefits and harms

The drug can cause harm to the body only if a person takes it with contraindications. When they are not there, you don’t have to worry about your own health.

As for the benefits of the drug, it is undeniable. The drug allows you to keep type 2 diabetes under control and fight excess weight. In addition, taking Glucophage makes it possible to reduce cholesterol levels in the blood, which protects a person from cardiovascular diseases.

Another advantage of the drug is that it reduces the likelihood of developing severe complications of diabetes, which makes it possible to prolong the life of such patients.

The medicine is time-tested. People have been treated with it for 50 years. This allows us to judge the absolute safety of the drug.

Long-term use of the drug can lead to the development of B12 deficiency anemia. Knowing this, the patient should take vitamin B12 in courses. This is done for preventive purposes.

How to determine the dosage and method of administration?

The drug "Glucophage Long" 1000 mg is taken orally, washed down with a small amount of water, it is best to do this in the evening with meals. The tablets are swallowed whole and should not be chewed.

The medication should be taken only once a day. You need to do this every day. If there is a need to stop taking the drug, the patient should notify the doctor. The dose of the medication is determined individually after the results of measuring blood glucose levels are analyzed.

At the beginning of therapy, people who have not previously taken metformin are prescribed Glucophage Long 500 or 750 mg.

Every 10–15 days, the dosage should be adjusted based on the same blood sugar results. With a gradual increase in dose, treatment tolerance in the stomach and intestines improves. The maximum daily dose will be 2000 mg. If glucose levels cannot be controlled, the possibility of taking the daily dose in two doses (in equal parts, during breakfast and dinner) is considered. If adequate glycemic control was not achieved in this case, you will need to switch to metformin in the form of tablets with regular release of the active substance (namely, standard Glucophage), then the maximum daily dose is 3000 mg.

For patients already receiving metformin, Glucophage Long 1000 mg is prescribed at the same dosage as the regular release drug. Patients taking metformin in the form of regular pills at a dose of more than 2000 mg per day should not switch to the long-acting drug.

If there is moderate renal failure (creatinine clearance about 45–59 ml/min), metformin can be used only in cases where there is no likelihood of lactic acidosis. At the beginning of therapy, they are prescribed Glucophage Long 500 mg or 750 mg once, the maximum daily dose will be 1000 mg. Renal function should be monitored every 3–6 months. If creatinine clearance is less than 45 ml/min, therapy is stopped immediately.

In older patients, the dose of metformin should be adjusted based on assessment of renal function, which should be carried out regularly (optimally twice a year). If a dose is accidentally missed, take it as soon as possible. A double dose of the drug is not expected.

We will describe in more detail below how to take Glucophage Long 1000 for weight loss.

Glucophage release form

According to the instructions, Glucophage is produced in the form of round, film-coated, white, biconvex tablets with a homogeneous white mass on the cross section. One Glucophage tablet contains:

• Povidone – 20 mg or 34 mg;
• Metformin hydrochloride – 500 mg or 850 mg;
• Magnesium stearate – 5.0 mg or 8.5 mg.
• The film shell consists of 6.8 mg of hypromellose.

Glucophage is also produced in the form of oval, white, film-coated biconvex tablets with a score line on both sides, an engraving “1000” on one side and a homogeneous white mass on the cross section.

One Glucophage tablet contains:

• Metformin hydrochloride – 1000 mg;
• Povidone – 40 mg;
• Magnesium stearate – 10 mg.
• The film coating consists of 90.90% hypromellose, 4.550% macrogol 400 and 4.550% macrogol 8000.

Glucophage Long is produced in the form of white or almost white capsule-shaped biconvex tablets of prolonged action with an engraving “500” on one side, 15 pieces each. in cellular contour packaging in cardboard packs.

One tablet of Glucophage long contains:

• Metformin hydrochloride – 500 mg;
• Hypromellose 2208;
• Carmellose sodium;
• Microcrystalline cellulose;
• Hypromellose 2910;
• Magnesium stearate.

Glucophage Long is also produced in the form of white or almost white capsule-shaped biconvex tablets of prolonged action with an engraving “750” on one side and the inscription “Merck” on the other side, 15 pieces each. in cellular contour packaging in cardboard packs.

One tablet of Glucophage long contains:

• Metformin hydrochloride – 750 mg;
• Hypromellose 2208 – 294.24 mg;
• Magnesium stearate – 5.3 mg;
• Carmellose sodium – 37.5 mg.

Side effects

While taking the drug "Glucophage Long 1000" according to the instructions, negative reactions may occur:

• On the part of the nervous system, a symptom such as a metallic taste in the mouth appears.
• On the part of the hepatobiliary system, the occurrence of hepatitis or disturbances in liver function cannot be ruled out (when metformin is discontinued, adverse effects completely disappear).
• From the digestive system, symptoms such as vomiting, nausea, abdominal pain, diarrhea, lack of appetite occur (these effects appear at the beginning of treatment and subsequently disappear; if you take Glucophage Long with food, and also gradually increase the dosage, then the likelihood of these adverse reactions will decrease).
• Metabolism may also be affected. The occurrence of lactic acidosis cannot be ruled out; if therapy is long-term, the absorption of vitamin B12 decreases (with megaloblastic anemia this should be taken into account).
• Symptoms such as itching, erythema, and urticaria appear on the skin.

If any unpleasant symptom occurs, you should consult a doctor.

Glucophage during pregnancy

The fact of pregnancy should lead to discontinuation of the drug Glucophage 1000. If pregnancy is only planned, then it is necessary to consider discontinuing the medication. An alternative to metformin is insulin therapy under medical supervision. To date, there is no data on how the drug interacts with breast milk, so taking Glucophage is prohibited while breastfeeding.

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Signs of overdose

According to the instructions for use and reviews of Glucophage Long 1000 mg, if you take 85,000 mg of metformin (which will exceed the maximum daily dose by 42.5 times), there will be no hypoglycemia, but in this case lactic acidosis will manifest itself. In the event of a significant overdose, the presence of associated risk factors will lead to this dangerous pathology. If signs of this condition appear, the medication should be discontinued immediately. The patient should be urgently hospitalized to clarify the diagnosis (after the lactate concentration has been determined).

The most effective measure for removing lactate and metformin from the body is hemodialysis. Symptomatic treatment is also carried out.

Special recommendations for the use of this medicine

As we are told by the instructions for “Glucophage Long” 1000 mg, since accumulation of metformin is not excluded, sometimes a rare but serious complication occurs - lactic acidosis, in which mortality is high in the absence of emergency treatment. Most often, while using the medication, such cases occurred in diabetes mellitus, when the disease was accompanied by severe renal failure. Other risk factors must also be taken into account. We are talking about ketosis, poorly controlled diabetes, prolonged fasting, liver failure, excessive alcohol consumption and any conditions associated with severe hypoxia.

Lactic acidosis causes severe abdominal tenderness, vomiting, acidotic shortness of breath, hypothermia, and muscle cramps followed by coma. The condition is characterized by diagnostic laboratory parameters - a decrease in blood pH (< 7.25), a lactate content in the blood plasma > 5 mmol/l, an increased lactate/pyruvate ratio and an increased anion gap.

If there is a suspicion of lactic acidosis, Glucophage Long should not be taken further. The drug is discontinued 48 hours before planned surgical interventions. Resume therapy after 48 hours if renal function is normal. Before treatment and regularly thereafter, creatinine clearance is determined: if there are no violations - at least once a year, in old age, as well as in patients with creatinine clearance at the lower limit of normal - 2-4 times a year.

When creatinine clearance is less than 45 ml/min, Glucophage Long is not prescribed. Against the background of impaired renal function and when used in combination with antihypertensive drugs, non-steroidal anti-inflammatory drugs and diuretics, elderly patients need to be careful. Hypoxia and kidney problems can develop in patients with heart failure. This group of patients should be regularly monitored for their cardiac function and renal status during treatment.

It is important to find out in advance how to take Glucophage Long 1000 mg. Patients should be on a diet where carbohydrates are consumed evenly throughout the day. When body weight is excessive, a hypocaloric diet is needed (but not less than 1000 kcal per day). Patients should also exercise regularly.

The occurrence of infectious pathologies (respiratory and urinary tract infections) and ongoing therapy should be reported to the doctor. In order to monitor the development of diabetes mellitus, standard laboratory tests are carried out regularly. In the case of monotherapy with Glucophage Long, hypoglycemia is not caused, but caution should be exercised when using it in combination with insulin or if other oral hypoglycemic medications are also used.

Hypoglycemia is characterized by increased sweating, weakness, dizziness, headache, rapid heartbeat, and difficulty concentrating or seeing. The inactive components of Glucophage Long 1000 mg tablets are released unchanged through the intestines, which does not affect the therapeutic activity of the drug.

Indications for use

Glucophage is used in 3 cases:

1. Type 2 diabetes mellitus in adults and children over 10 years of age. Treatment can be carried out using Glucophage alone and in combination with other drugs, including insulin.
2. Prevention of early-stage diabetes mellitus and pre-diabetes in cases where other methods (diet and exercise) do not provide a satisfactory effect.
3. Prevention of the initial stage of diabetes and prediabetes in cases where the patient is at risk - under 60 years of age - and has:
   increased BMI (body mass index) equal to 35 kg/m² or more;
4. history of gestational diabetes mellitus;
5. genetic predisposition to the development of the disease;
6. close relatives suffering from type 1 diabetes;
7. increased concentration of triglycerides;
8. reduced concentration of high-density lipoproteins.

If kidney and liver function is impaired

When creatinine clearance is less than 60 ml/min, when there are acute conditions that occur with a risk of renal dysfunction (dehydration with severe/chronic diarrhea, repeated bouts of vomiting), severe infectious diseases, shock, the drug “Glucophage Long” 1000 mg is contraindicated ; when renal failure is observed (with a creatinine clearance of 45–59 ml/min), therapy is carried out with caution.

According to the instructions for use, the medication is not prescribed for liver disorders.

Interaction of the drug with other drugs

During a radiological examination, when iodine-containing radiocontrast agents are used, lactic acidosis may develop in diabetics with renal failure.

If you take ethanol at the same time, it is possible that lactic acidosis may occur during acute alcohol intoxication, especially if there is liver failure, and while following a diet with a small amount of calories.

It is not recommended to use medications containing ethanol during therapy.

The medication should be combined with caution with diuretics, danazol, beta2-adrenergic agonists, chlorpromazine (in doses of 100 mg per day), drugs that have an indirect hyperglycemic effect (in particular, glucocorticosteroids and tetracosactide for local/systemic use.

Interaction

The simultaneous use of this drug and danazol may lead to the development of hyperglycemic effects. If necessary, such a combination requires dosage adjustment and glycemic control.

Taking high doses of chlorpromazine increases glycemia, reducing insulin release. Any hormonal drugs reduce glucose tolerance, increasing glycemia, and can cause ketosis.

Combination with loop diuretics maintains the risk of lactic acidosis due to functional renal failure.

β2-adrenergic receptor stimulants can increase blood glucose levels. In this case, glycemic control is necessary, and insulin may be prescribed. The combination of Glucophage and sulfonylurea derivatives, insulin, acarbose, and salicylates enhances the hypoglycemic effect.

Using Glucophage Long 1000 for weight loss

Excess weight can be very difficult to lose, and it interferes with your life. Now there are a large number of methods for rapid weight loss, and one of them is taking specially designed drugs for diabetics with metformin in the composition. In Russia, the drug Glucophage Long is popular.

Research shows that metformin helps people lose weight. Why is this happening? This drug blocks the brain center responsible for the feeling of hunger, causing a decrease in appetite. It also changes the distribution of fat and where it is stored in the body. Although Glucophage Long 1000, according to reviews, helps well in losing weight, it is not a quick-acting solution. Weight from metformin decreases gradually over 1-2 years. The amount of weight lost varies from person to person.

When using the drug, it is important to adhere to proper nutrition and exercise regularly. People who follow a healthy diet and exercise while taking Glucophage tend to lose weight faster. Metformin is supposed to increase the number of calories burned during exercise. It is important to get this advantage, and without physical training you will not be able to do this.

Weight is lost only while taking the drug. As soon as you stop using Glucophage and Glucophage Long, you will need to make more efforts not to gain weight again.

One of the advantages of the medication is that even if it does not lead to weight loss, it will prevent even greater weight gain.

Therapy begins with one pill once a day in the evening. The active substance will gradually accumulate in the body, so in order to minimize adverse reactions, the dose is increased extremely slowly.

Reviews of Glucophage Long 1000 mg

Patients consider it an effective medicine that can be used for a long time. According to reviews, side effects develop infrequently. If you are overweight, there is a gradual decrease in weight. This is confirmed by numerous reviews of those who have lost weight from Glucophage Long 1000 mg.

Women praise the drug because it helps to quickly lose weight, while taking it you do not have to exhaust yourself too much with physical exercise. After the first course of therapy, people manage to lose 3-4 kg. True, it’s unlikely to be possible without a diet, according to reviews of Glucophage Long 1000 mg.

Patients are advised not to self-medicate; be sure to consult a doctor for advice so as not to harm their health. The doctor will prescribe the necessary regimen and select a suitable diet. A good result can only be achieved if you take a responsible approach and follow all the recommendations of specialists.

The course can be repeated after a couple of months.

Analogs

Level 4 ATX code matches:
Bagomet

Diaformin

Metformin

Formetin

Gliformin

Glucophage Long

Siofor

The main analogues are represented by the following drugs: Bagomet, Glycon, Gliformin, Gliminfor, Langerin, Metospanin, Metadiene, Metformin, Siafor and others.