Xeroform - instructions for use, contraindications, mechanism of action, side effects and analogues

Compound

Xeroform is a yellow powder with a weak specific odor. The powder particles are small and do not have the correct crystalline structure (that is, the powder belongs to the category of amorphous substances ).
Being essentially the main salt of bismuth (Bismutum) - a chemical element of group V of the periodic system of D.I. Mendeleev. tribromophenolate molecule is formed from successive bismuth oxide-hydroxide with tribromophenol radicals at the ends.

In bismuth tribromophenolate , the bismuth oxide-hydroxide serial bonds must consist of three parts.

Xeroform is characterized by poor solubility in water , alcohols , ether and chloroform (it is even difficult to simply wet it with water); it is also slightly soluble in halogenated hydrocarbons and oils. The bismuth oxide content in it ranges from 50 to 55%.

However, some pharmaceutical sources indicate a slightly different percentage of bismuth oxide.

Thus, the 25th edition of the American Pharmacopoeia indicates that the content of bismuth oxide can vary from 44.6 to 54.5% (or from 40 to 49% bismuth), and in the 26th edition of the Martindal Extrapharmacopoeia it is noted that the percentage The bismuth oxide content is approximately 55.74%.

It should be noted that none of the given specifications corresponds to the molar ratio of bismuth to tribromophenolate , since the ideal structure according to the formulas given in the Pharmacopoeias is considered to be the ratio 3Bi/2Tribromophenol.

In cases where the ratio is lower, it will not meet the specification of the substance, but if it increases and approaches the values of 4Bi/2Tribromophenol, the final product will take on a lighter yellow hue. If the ratio is even higher, the final product turns white.

Release form

The drug has several forms of release:

skin powder packaged in containers with a capacity of 7 g;
powder;
xeroform ointment for the treatment of skin lesions containing xeroform in a dose of 10 mg and petroleum jelly in a dose of 90 mg;
xeroform eye ointment (3%).

In addition, Xeroform is an active component of such preparations as balsamic liniment according to A.V. Vishnevsky and suppositories for the treatment of hemorrhoids and anal injuries “ Anuzol ”, which are produced by the pharmaceutical company Nizhpharm OJSC, Russia.

Analogs

Xeroform is included in several medications, so it can theoretically be replaced by them. In addition to them, there are other analogues of the drug with the same effect, but a different composition:

Vishnevsky ointment is an antiseptic liniment containing tar, bismuth tribromophenolate and bismuth oxide complex;
Anuzol - astringent and drying rectal suppositories based on belladonna leaf extract, bismuth tribromophenolate, bismuth oxide complex and zinc sulfate;
Fukortsin is an antimicrobial liquid for treating wounds, containing resorcinol, acetone, boric acid, phenol;
Chlorophyllipt – bacteriostatic and bactericidal tablets, spray, alcohol injection solution, solution for skin treatment, solution in oil based on eucalyptus leaf extract.

Pharmacodynamics and pharmacokinetics

Bismuth salt Xeroform, due to its pharmacological activity, is used as an astringent, disinfectant and drying agent for various types of inflammatory lesions of the skin and mucous membranes.

The disinfecting effect observed when using the drug Xeroform is determined by its bactericidal effect on microorganisms, which is expressed in the ability to bind proteins to their cell membranes. The result of this process is the death of microbial cells.

The astringent effect of xeroform is that when applied to the skin, wound surfaces and mucous membranes, the drug provokes a dehydration and partial coagulation of proteins , which protect tissues affected by the inflammatory process from exposure to irritants.

Like other astringent drugs, Xeroform has a local anti-inflammatory , mild analgesic and hemostatic effect.

The mechanism of action of the drug is due to its ability to interact with proteins of various tissues and form poorly soluble protein compounds albuminates , which, when deposited, like a kind of protective film, protect sensitive nerve endings from irritation.

This process stimulates tissue irritation and provokes the destruction of surface cells, which in turn enhances local blood circulation in the tissues , stimulates cell division , and increases the flow of tissue fluid.

In addition, Xeroform promotes:

narrowing of the lumen of blood vessels;
a decrease in blood vessel permeability and a decrease in the amount of exudate released;
suppression of enzyme activity;
suppression of the activity of pathogenic microorganisms;
drying wound surfaces;
decreased skin sensitivity;
reducing the severity of inflammation;
accelerating the healing processes and regeneration of affected tissues.

In particular, these effects become noticeable in the area of tissues affected by the inflammatory process, which is expressed primarily by a decrease in exudation , limitation (and in some cases even complete cessation) of the release of leukocytes , as well as a decrease in the severity of suppuration.

When astringents come into contact with blood protein and the blood clots. These properties are the basis for the local use of Xeroform and substances similar to it in their action as part of hemostatic and anti-inflammatory drugs.

The antiseptic effect , which is achieved when using Xeroform, is based on the fact that, by acting on tissue, the drug creates conditions unfavorable for the life of pathogenic microorganisms .

data on the pharmacokinetic characteristics of Xeroform. Due to the low toxicity of the drug, irritation of the inflammatory process and wound surfaces is not observed during its use.

Xeroform powder, 7 gr., No. 1

Xeroform is a drug for external use based on tribromophenolate, used primarily in plastic surgery.

Has an antiseptic and disinfecting effect in the treatment of dermatological diseases.

The powder is applied to the skin without tactile contact, which minimizes pain when treating inflamed wounds. No prescription required for purchase.

Main active ingredient	Auxiliary components
Bismuth tribromophenolate – 7 mg	Not applicable

Indications for use

The drug is used as an antiseptic in the treatment of skin diseases accompanied by inflammatory processes. In medical practice it is used in the following cases:

antiseptic treatment of wounds after surgery;
disinfection of purulent wounds (where it is necessary to observe the absence of tactile contact);
trophic ulcers;
eczema of various etiologies;
burns (during final dressing);
lichen;
chicken pox (for spot treatment of the rash site);
weeping wounds (with diabetes mellitus, since the powder has an astringent effect);
skin erosions (of any etiology);
rash and inflammation at the sites of insect bites.

You can also purchase Xeroform at the pharmacy as a means to repel blood-sucking insects (mosquitoes, ticks). Previously, it was used to disinfest clothing and bedding after treating patients with pediculosis (lice).

Reception features

Clinical case	Description
General recommendations	Apply by sprinkling onto a wound or inflamed area of skin, covering the top with a dry, tight bandage made of a sterile bandage.
Combination with other drugs	Can be used to make disinfectant bonds. Mix with medical petroleum jelly, achieving a tribromophenolate concentration of 3%.
Use on children	Approved for outdoor use only. Can be used as a powder for newborns when diaper rash occurs. Previously used to speed up the healing process of a wound on the umbilical cord.
Frequency of use	Dressing is recommended to be carried out 2 times a day. There is no need to additionally treat the wound or remove powder residues, but this can be done with a non-concentrated solution of potassium permanganate (potassium permanganate).

The powder is used externally only. Before application, the wound is treated with hydrogen peroxide, pus and ichor are removed with a napkin. The dosage for a single treatment does not need to be observed; tribromophenolate does not have any effect on the healthy epidermis. The risk of side effects is low, but the following symptoms may occur:

redness of the skin (locally, disappears within 2 days after the end of therapy);
burning (at the time of applying the powder and in the next 15 minutes);
the appearance of swelling (not an allergic reaction);
rash and itching on the treated area of skin.

Any of these side effects is not a prerequisite for the need to stop therapy, but it is advisable to consult with your doctor about this. It also has a disinfecting effect on wounds that are the source of viral infection.

Contraindications

The only contraindication for using the drug is individual hypersensitivity (allergy). The manufacturer states that it occurs in less than 0.0001% of cases and is only local in nature. That is, if an allergic reaction occurs, therapy is canceled and an analogue not based on tribromophenolate is prescribed.

Pregnancy or lactation are not contraindications. Combining Xeroform with other drugs that contain tribromophenolate is also allowed, since an overdose is considered impossible.

You can buy Xeroforms with delivery in our online pharmacy. To place an order, just leave a request or contact the manager by phone. In most cases, dispatch is carried out on the same day. And our price for Xeroform is one of the lowest, since we cooperate directly with drug manufacturers.

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Ambien is an excellent alternative to most drugs. The German medicine allows you to cope with the most advanced diseases and helps in cases where the patient can no longer leave the hospital. In addition, it has an analgesic effect, making the treatment more comfortable.

Available in paired ampoules; one package can contain from three to ten pieces. Particular attention should be paid to the temperature of the preparation. It should not be below 25 degrees when administered.

Main active ingredient	Auxiliary components
Dexamethasone - 0.0035 g.	sodium salicylamide; lidocaine; phenylbutazone; cyanocobalamin.

Indications for use

The drug Xeroform is primarily intended for the treatment of inflammatory diseases of the skin and mucous membranes. It has also proven itself to be an effective remedy:

for skin dermatitis of various origins (including diaper dermatitis in children);
for ulcerative and erosive lesions of the skin and mucous membranes;
with eczematous lesions;
for skin abscesses ;
with boils ;
with inflammatory damage to the lymph nodes ( lymphadenitis );
with acute or chronic inflammation of the lymphatic trunks and capillaries, which is a consequence of purulent-inflammatory processes ( lymphangitis );
for burns ;
for frostbite
;
for bedsores ;
for minor damage to the skin ( scratches and abrasions , for example);
for infected skin lesions;
for diaper rash (both in children and adults);
for postoperative (including purulent and weeping) wounds;
as a repellent to combat mosquitoes and other blood-sucking insects;
for lesions and acute eye diseases ;
for healing the umbilical wound in newborns.

Reviews from patients and doctors

And finally. “Xeroform” (powder), reviews of which you can often find, is indeed a very good and popular product. Those who have used this medicine to combat bedsores and inflammatory processes of the skin are pleased with the results obtained.

According to reviews from doctors and patients, this remedy very well relieves swelling of damaged tissues, reduces the degree of sensitivity, and also eliminates inflammatory processes well. In addition, this drug is able to fight pathogenic microflora. Patients are satisfied with the cost of the powder. For such a small price you can get an incredible effect.

However, doctors recommend comprehensive treatment, using other medications. This way you can get faster results and better therapeutic effects.

The drug "Xeroform" can also cope with severe and advanced stages of damage to the epidermis. All this is due to the very high content of active components in the preparation.

Take charge of your health today. Think about personal safety, and then a drug like Xeroform will not be useful to you at all. Be healthy and take care of yourself.

Side effects

Like most other medicines, Xeroform can cause the development of unwanted side effects, which are expressed in the form of allergic reactions of varying severity.

Most often patients complain of:

redness of the skin;
the appearance of a burning ;
skin rashes
the appearance of edema ;
skin itching at the site of application of the drug.

In some cases, individual reactions may occur.

Any of the listed side effects is a prerequisite for interrupting the course of treatment with Xeroform.

Indications and contraindications

Xeroform is used to heal wounds and accelerate the regeneration of cells in affected tissues. It is non-toxic and does not irritate mucous membranes. According to the instructions, Xeroform is most often prescribed for the treatment of bedsores, purulent and long-term non-healing postoperative wounds, burns and frostbite, dermatitis, eczema, ulcers and diaper rash.

The drug should be used with caution during pregnancy and lactation, and in childhood.

Attention! Xeroform for bedsores should not be used by people who are prone to severe allergic reactions or those who have an individual intolerance to the components of the drug.

Before applying any product to the patient’s skin, it is necessary to test its effect on a healthy area of skin.

Instructions for use Xeroform (Method and dosage)

The drug is intended for external use. In accordance with the instructions for use of Xeroform, all of its dosage forms are recommended to be applied to a previously cleaned affected surface.

The powder or powder is applied to the skin in a thin layer two or three times during the day. Due to their hygroscopicity, they effectively adsorb sweat, exudate , excess sebum, and also increase the evaporation surface and heat transfer rates.

The drug in the form of an ointment or paste is applied to the cleaned wound surface, and then, if necessary, covered with five to six layers of gauze.

Ophthalmic 3% Xeroform ointment is placed under the lower eyelid after thoroughly washing the affected eye.

Treatment options

Xeroform for bedsores can only be used externally. The dosage of the drug is selected by a specialist individually for each patient. This product in any dosage form must be applied to the skin about three to four times a day. Before using the drug, it is necessary to prepare the patient.

Skin toilet

Before water procedures, it is necessary to change the patient’s disposable underwear and clothes, remove all compresses and bandages from bedsores and other wounds. The affected areas of the skin must be washed, dried and cleaned of keratinized masses. You can use saline solution or camphor alcohol.

Antibacterial therapy

After the patient is prepared, the wounds can be treated using medications. To improve blood circulation, agents such as Actovegin or Solkseril are most often used.

To dry wet wounds, speed up the healing process and treat the skin of a bedridden patient, use Xeroform powder for bedsores.

To prevent the development and treatment of stage 1 pressure wounds, you can purchase an ointment. Xeroform for bedsores can be used in any dosage form only as prescribed by the attending physician.

Applying a bandage

Modern dressings are a transparent, breathable, self-adhesive film or patch that provides antibacterial protection, evaporation of excess liquid, and also makes it possible to visually monitor the improvement or deterioration of the condition of the skin. When gluing such patches, excessive tension should be avoided, since small folds form when the patient moves, which can aggravate the condition.

special instructions

If, while using the drug, any problems with the patient’s health are observed or the drug does not have the expected effect and relief of the symptoms of the disease, it is recommended to stop taking it and adjust the further treatment regimen.

Avoid getting the powder or ointment in your eyes. After using Xeroform, you should wash your hands thoroughly.

The drug does not affect the ability to drive vehicles or operate other machinery.

Xeroform price, where to buy

The price of Xeroform in powder form on the Russian pharmaceutical market varies from 75 to 115 Russian rubles. You can buy powder or Xeroform ointment in Moscow in specialized pharmacies that prepare medicines according to mainline (medical) prescriptions.