Otrivin Complex Otrivin Complex instructions for use

Release form and composition

Dosage form of Otrivin Complex - nasal spray: transparent liquid, colorless or slightly colored, practically odorless (10 ml in a bottle, 1 bottle in a cardboard box).

Composition per 1 ml of solution:

• active ingredients: ipratropium bromide monohydrate – 0.6 mg; xylometazoline hydrochloride – 0.5 mg;
• auxiliary components: glycerol, disodium edetate dihydrate, concentrated hydrochloric acid, sodium hydroxide, water.

Analogs

The use of Otrivin Complex is not intended for children and adolescents under 18 years of age. For this category of patients, manufacturers have provided a different remedy.

Otrivin Baby

The nasal spray is intended mainly for children from 3 months of age, but it can also be used by adults. It is used to irrigate and cleanse the nasal passages, relieve congestion in rhinitis of various origins, flu, allergies and other diseases accompanied by a runny nose. In addition, it is well suited for hygiene procedures, preventing dryness in the nasal passages, as a prophylaxis during seasonal epidemics, as well as for caring for the nasal cavity when living in environmentally unfavorable areas.

Anyone who is not allergic to sea water can use the Otrivin Baby solution for an unlimited time: it is not addictive, and if the instructions are followed, there are no side effects.

Otrivin Baby is an isotonic solution based on sea water. The content of natural salt in 1 ml of the drug is 10.5 mg. The spray has the appearance of a transparent liquid without color or odor. Sold in 20 ml bottles with a built-in dispenser and nozzle.

Price in online pharmacies – 220-250 rubles.

If there are no other instructions from the pediatrician on the use of the product, then Otrivin Baby should be used according to the instructions:

• For children and adults, it is recommended to inject the solution 1 dose (press) into each nostril 2-4 times throughout the day to rinse the nose.

Pros:

• Safe composition
• Naturalness of the product.

Minuses:

• Small volume
• High price.

Pharmacological properties

Pharmacodynamics

Otrivin Complex is a combination drug, the effect of which is determined by the properties of its constituent components:

• xylometazoline is a local vasoconstrictor (decongestant). Has alpha-adrenomimetic effect. Relieves swelling and hyperemia of the nasopharynx mucosa by narrowing the blood vessels. Eliminates congestion and facilitates nasal breathing;
• ipratropium bromide is an anticholinergic substance. Reduces nasal secretion due to competitive inhibition of cholinergic receptors located in the epithelium of the nasal cavity.

When the drug is used in therapeutic doses, it does not cause irritation or hyperemia of the nasal mucosa. The therapeutic effect appears within 5–10 minutes and lasts up to 8 hours.

Pharmacokinetics

Absorption of the active ingredients of the drug when applied topically is insignificant.

Indications

Main indications for use:

• acute respiratory infections, which are accompanied by a runny nose and nasal congestion;
• allergic rhinitis in acute form;
• sinusitis;
• symptomatic treatment for swelling and hyperemia (redness) of the nasal mucosa.

It is noteworthy that Otrivin Complex acts in four directions at once, allowing you to eliminate all manifestations of a runny nose at once. This:

1. Sneezing. A sneeze is a reflex reaction of the nasal cavity to congestion, irritation of the mucous membrane and the accumulation of foreign microorganisms. Sneezing occurs involuntarily, causing not only physical but also psychological discomfort to the patient.
2. Copious nasal discharge. Under normal conditions, a healthy mucous membrane produces a certain amount of secretion to moisturize the nasal cavity. During illness, in the active stage of the inflammatory process, cells increase the production of this secretion. We observe this as a severe runny nose and constant discharge.
3. Congestion. During a cold or upon contact with an allergen, an inflammatory process forms in the nasal cavity, which leads to the expansion of small blood vessels under the mucous membrane. This, together with accumulated mucus, causes nasal congestion and impaired sense of smell.
4. Edema. The principle of the formation of this symptom of a runny nose is the same as that of congestion - inflammation and swelling of inflamed cells and blood vessels occurs. All this interferes with the normal aeration and drainage functions of the nasal cavity, which can lead to congestion in the paranasal sinuses and the development of complications.

Contraindications

Absolute contraindications:

• glaucoma;
• atrophic rhinitis;
• surgical operations on the membranes of the brain (in history);
• pregnancy (first trimester);
• age under 18 years (due to the high content of the active substance, Otrivin is not prescribed to children);
• increased sensitivity to the components of the drug, as well as to atropine and similar compounds (hyoscyamine, scopolamine).

Relative contraindications, in the presence of which a doctor’s consultation is required before using the drug:

• hyperthyroidism;
• diabetes;
• pheochromocytoma;
• angina pectoris III - IV functional class;
• prostatic hyperplasia;
• bladder neck obstruction;
• cystic fibrosis;
• pregnancy (II and III trimester);
• lactation (breastfeeding);
• predisposition to nosebleeds, dizziness, tremor of skeletal muscles, arrhythmias, sleep disorders, increased blood pressure (BP), paralytic ileus.

Interactions with drugs

As a rule, treatment of ENT diseases is carried out comprehensively, so Otrivin is used in combination with other drugs, but it is important to know which of them it is incompatible with. It is not recommended to use the spray with the following products:

• MAO inhibitors.
• Tetra- and tricyclic antidepressants.

The use of Otrivin with these substances can significantly enhance the sympathomimetic effect of xylometazoline. Catecholamines are released, which act as a vasoconstrictor, leading to an increase in blood pressure. It is completely compatible and safe with other drugs.

Despite the positive properties of the spray and its safety, it has certain contraindications, so you should consult your doctor before use.

In the treatment of ENT diseases, the use of Otrivin complex is quite justified. This spray is relatively inexpensive and very effective. Before use, you need to carefully read the instructions to avoid negative consequences.

Instructions for use of Otrivin Complex: method and dosage

Otrivin Complex is used intranasally.

Recommended dosage for adults: 1 injection into each nasal passage 3 times a day.

The duration of therapy should not exceed 7 days due to the risk of swelling of the nasal mucosa and increased secretion caused by increased sensitivity of cells to the drug.

One dose (injection) of the drug contains xylometazoline hydrochloride - 70 mcg, ipratropium bromide - 84 mcg.

Indications

Nasal spray is used for a runny nose. At the first symptoms of swelling of the mucous membranes of the nose and the appearance of mucus, it quickly eliminates them. The drug is safe and, if the instructions are followed, extremely rarely causes adverse reactions.

Indications for use of the drug are:

1. Swelling and hyperemia of the nasal cavity.
2. Acute respiratory infections occurring with a runny nose.
3. Allergic rhinitis in acute form.
4. Sinusitis and hay fever.

As part of complex therapy for acute respiratory viral infections, acute respiratory infections, colds and flu, it is used very often. The active components very quickly eliminate the symptoms of acute runny nose and make breathing easier.

For acute forms of rhinitis, especially those that occur during acute respiratory viral infections and bacterial infections in the nasal cavity, the spray helps to cope with unpleasant symptoms within several days. Eliminates heavy discharge and relieves inflammation of the mucous membranes.

When treating allergic rhinitis, the substance helps to cope with unpleasant symptoms while the patient is undergoing an examination to identify the allergen.

As a rule, for the treatment of chronic runny nose, the spray is used extremely rarely, however, when prescribed by a doctor, it makes it possible to slightly alleviate the patient’s condition.

The use of the drug during nasal congestion is very effective; it helps to avoid various complications, for example, frontal sinusitis and sinusitis. Sometimes it can be prescribed for eustachitis and otitis media.

Side effects

• nervous system: headache, dizziness, insomnia;
• digestive system: dry mouth, nausea, dyspepsia;
• sensory organs: increased intraocular pressure, eye pain, mydriasis, deterioration in patients with angle-closure glaucoma, blurred vision;
• urinary system: difficulty urinating;
• respiratory system: dryness and irritation of the mucous membrane of the nasopharynx, nosebleeds, sneezing, itching and tingling sensation, hypersecretion (nasal), nasal congestion (with prolonged and frequent use);
• cardiovascular system: palpitations, atrial fibrillation, supraventricular tachycardia, arrhythmia;
• skin: itching, skin rash, urticaria;
• allergic reactions: laryngospasm, angioedema (tongue, lips, face), anaphylactic reactions.

You should consult a doctor if the described side effects worsen or if other side effects occur.

Interaction with other drugs

You need to know which drugs Otrivin is incompatible with. Concurrent use may worsen the condition or increase the effect of the drops. Here is a list of all interactions:

Otrivin enhances the effect of MAO inhibitors. Because of this, the patient may experience a hypertensive crisis.

It is important not to use drops for 2 weeks after stopping MAO medications; Tetracyclic antidepressants increase all side effects from Otrivin. Doctors categorically prohibit combining such medications so that the patient does not develop a severe allergy; Use of beta blockers leads to severe asthma

The patient's blood pressure may also drop sharply. Therefore, doctors prohibit combining such drugs with Otrivin drops.

Before using the medicine, be sure to consult your doctor and tell him what other medications you have taken. Then the doctor will determine the dosage of the drops or stop some medications that are dangerous to take in parallel.

Overdose

Due to low systemic absorption, an overdose of Otrivin Complex is unlikely.

Symptoms of xylometazoline overdose: sweating, nausea, decreased body temperature, bradycardia, headache, impaired accommodation, respiratory depression, arterial hypertension, hypotension, coma. Palliative therapy under medical supervision is recommended.

Symptoms of an overdose of ipratropium bromide: dry mouth, difficulty in accommodation, tachycardia; in severe cases, symptoms may develop in the central nervous system caused by the anticholinergic effect of the substance. Palliative therapy is recommended; in case of severe overdose, cholinesterase inhibitors are indicated.

Composition of Otrivin

Produced by a Swiss pharmaceutical company. The main active ingredients of Otrivin are:

• Xylometazoline hydrochloride. Refers to drugs that cause spasms of capillaries. Stimulates alpha receptors. Constricts blood vessels, quickly restores nasal passages and makes breathing easier. This remedy is actively used for various pathological conditions in ENT practice. Used for topical use.
• Benzalkonium chloride. It has a pronounced bactericidal and antiviral effect.
• Sodium chloride. A physiological substance that is an analogue of human intercellular fluid.
• Other additional substances.

Spray Otrivin. Photo: yandex.ru

Also, adult otrivin can be produced with additional additives: levomenthol, eucalyptus, ipratropium bromide or with the addition of sea water.

special instructions

Before using the nasal spray, you should clean your nasal passages. The duration of continuous treatment should not exceed 7 days.

Avoid contact of the drug with the eyes and the skin around them, as this can lead to temporary blurred vision, irritation, pain, redness, as well as exacerbation of angle-closure glaucoma. If Otrivin Complex gets into your eyes, rinse them with cold water. If pain or blurred vision occurs, consultation with a doctor is recommended.

Impact on the ability to drive vehicles and complex mechanisms

In therapeutic doses, Otrivin Complex does not affect the ability to drive vehicles and other complex mechanisms that require rapid psychomotor reactions.

Description of the drug

The manufacturer presents its drug in several forms. You can purchase nasal spray or drops at the pharmacy chain. In addition to this division, medications are also classified into children's and adults.

The cost of the medicine directly depends on its type and composition. The drug "Otrivin" (spray) costs about 150 rubles. When adding additional components to the active substance, the price may increase to 200 rubles. The drops will cost you no more than 300 rubles.

It is worth noting that other products for the treatment of runny nose are also produced under the Otrivin brand. Aspirators from this manufacturer, as well as replacement attachments for them, are widely popular in pediatrics. Such devices are designed to eliminate runny nose and nasal congestion in children.

Rules for using drops

Doctors recommend using a clear sequence of actions at the time of instillation:

• Completely clear your nose of unwanted mucus before using Otrivin;
• Throw your head back as far as possible, but without feeling discomfort;
• Apply the required dosage of Otrivin into each nostril. At the same time, keep your head thrown back for another 2-3 minutes. This is necessary so that the medicine is completely distributed throughout the nasal cavity;
• Disinfect the pipette before returning it to the vial.

It is advisable to use Otrivin before bedtime. Doctors advise using only one vial per patient to avoid infection.