Instructions for use of Menopur and special instructions

To learn more

Consultations are conducted by professional doctors who have significant experience in solving infertility problems.

Compound

The drug is used to treat various problems of the reproductive system in men and women.
One bottle contains the active substance - menotropin 75 ME. The medicine comes with a special solvent (sodium chloride solution 0.9%). Medicinal substances:

• lactose monohydrate - 20 mg;
• polysorbate-20 - 0.1 mg;
• sodium hydroxide - 0.0008–0.003 mg;
• hydrochloric acid - 0–0.0005 mg.

Solvent:

• sodium chloride - 9 mg;
• hydrochloric acid - 0.007–0.02 mg;
• water for implementation - up to 1 ml.

Menopur price, where to buy

The price of Menopur 75 IU No. 10 varies around 12,000-14,000 rubles. You can buy Menopur in Moscow in the same price range.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine

LuxPharma* special offer

• Menopur Liof.
  75ME 10pcs 23,000 rub. order

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pharmachologic effect

The medicine is a hormonal drug that is produced in a woman’s body during pregnancy, is later excreted in the urine, and has a high degree of purification. Menopur belongs to the group of menothoropins, which contains follicle-stimulating and luteinizing hormones in equal proportions.

Women need to use the drug to increase the level of the hormone estrogen in the blood and stimulate its growth, as well as the maturation of follicles in the ovaries, for the growth of the functional layer in the production of female hormones.

Men are recommended to take the drug to increase the amount of testosterone in the blood and stimulate spermatogenesis in azoospermia. Menopur affects the sperm cells in the semen.

Analogs

Level 4 ATX code matches:
Pergoveris

Puregon

Horagon

Ovitrel

Chorionic gonadotropin

Decayed

Gonal-F

• Alterpur;
• Gonal-F;
• Ovitrel;
• Luveris;
• Decayed;
• Follitrope;
• Puregon;
• Horagon;
• Pergoveris;
• Ecostimulin;
• Bravelle;
• Elonva.

Indications for use

The drug Menopur has a number of main indications for use.

Women:

• inability to conceive a child due to hypothalamic-pituitary disorders;
• to stimulate the growth of the dominant lobe of the lymph gland;
• to stimulate and accelerate the action of auxiliary procedures that promote pregnancy.

Men:

• Stimulation of the development of male germ cells. Used in the presence of male infertility.

Reviews about Menopur

Women who have ever been prescribed this remedy mostly leave positive reviews about Menopur on forums created to discuss problems of conception . Reviews of Menopur for IVF characterize this drug as quite effective and in most cases not causing any side effects.

Many patients who underwent egg stimulation with Menopur achieved a long-awaited pregnancy, which led to the birth of a healthy child. Naturally, such therapy requires clear indications, serious preparation, consultations with a competent doctor and does not provide an absolute guarantee of conception, and for some women it will not be suitable in principle. But in the absence of contraindications and pathologies incompatible with pregnancy, it significantly increases the chance of motherhood.

Contraindications

The drug Menopur has a number of main contraindications:

• cyclic enlargement of the ovaries;
• the presence of neoplasms in the ovaries;
• the presence of abnormal pathologies in the development of the genital organs;
• irregular bleeding of the uterus not associated with menstruation;
• malignant neoplasms in the ovaries, uterus and/or mammary glands;
• malignant neoplasms of the prostate gland, testicular tumors;
• high concentration of follicle-stimulating hormone;
• pregnancy and the period of natural breastfeeding;
• intolerance to the drug or its individual components.

If you discover the presence of one of the listed diseases, you should immediately consult a doctor for advice before taking the drug.

Drug interactions

It is worth saying that no drug interaction studies have yet been conducted with the drug Menopur.

Although when combined with Clomiphene, you may encounter an increased reaction of the follicles.

You can learn more about the drug Clomiphene in this article.

If you take the drug "Menopur" with agonists, you will have to increase the dosage of the first drug in order to achieve the desired ovarian reaction and stimulate follicle growth.

Regarding combined use with alcohol, drugs for epilepsy and tuberculosis, no negative reactions were identified.

Side effects

Possible negative effects

Genitourinary system:

• Ovarian hyperstimulation.
• Drawing pain in the lower part of the body.

Nervous system:

• Migraine.

Digestive system:

• Feeling nauseous.
• Pain in the abdominal part of the body.
• Bloating.

At the injection site:

• Painful sensations.
• Swelling.
• Tissue irritation.

A side effect in men may be enlargement of the mammary gland with hypertrophy of the glands and adipose tissue.

A serious negative effect in women can be ovarian hyperstimulation syndrome, which carries with it a number of complications: ovarian torsion and thromboembolic syndrome.

If these side effects or others not listed in the instructions occur, you should definitely consult a doctor.

Use of the drug (dosage and method of administration)

The drug should be administered intramuscularly or subcutaneously. The solution for injection should be prepared before administration.

If there are no contraindications, the injection should be performed based on the recommended effective treatment regimen.

Women

In the absence of the ability to naturally conceive a fetus due to hypothalamic-pituitary disorders, in order to activate the growth of the lymphatic gland lobule

The dosage method of the drug is established taking into account the individual characteristics of the woman’s body. The dose required to achieve optimal performance is determined by ultrasound examination of the ovaries. In addition, it is necessary to conduct an examination and determine the level of presence of the main female hormones - estrogens - in the blood. Achieving optimal follicle size also determines the amount of estrogen present in the patient's blood. To identify the full picture of the disease and make effective recommendations for treatment, long-term clinical observation is necessary.

The recommended dose of Menopur is 75–150 IU (1–2 bottles/day). If the ovaries do not show a pronounced reaction, the dosage of the drug should be gradually increased (up to 225–450 IU per day). If there is a sharp and rapid increase in estrogen hormones at the initial stage of the drug’s action, the dose is immediately reduced.

Men

To achieve the goal of stimulating the formation and development of sperm in the testicles, 1000–3000 IU of hCG should be administered 3 times a week.

Doses for anovulation

For anovulation, including that which is a manifestation of polycystic ovary syndrome, Menopur is usually prescribed at a starting dose of 75 or 150 IU per day. The purpose of using the drug in this case is the maturation of one follicle. The drug is used for 7 days. If the follicles do not grow, the dose may be increased. You can increase it by 37.5 or 75 IU per week. If there is no response within 4 weeks, stimulation is stopped. Then a new cycle should be started with higher dosages of Menopur.

The size of the dominant follicle is constantly monitored. As soon as it matures, the doctor prescribes an injection of human chorionic gonadotropin (hCG) to the patient. It is prescribed once in a dose of 5 or 10 thousand IU. HCG is administered the day after the last dose of Menopur. The next day, the patient is recommended to have sexual intercourse or perform artificial insemination.

special instructions

Before starting treatment, it is recommended to analyze the seminal fluid of the sexual partner. If necessary, treat hypothyroidism, adrenal insufficiency, tumors of the pituitary gland or hypothalamus.

When the ovaries become enlarged, cysts may rupture, so the gynecologist should conduct the examination as carefully as possible.

Once stimulation of follicle maturation and ovulation is completed, there is a risk of pregnancy with multiple fetuses.

The risk of ectopic pregnancy especially increases in the presence of pathologies in the fallopian tubes. In addition, the presence of a large number of early pregnancies and abortions that occurred after treatment with the drug increases in comparison with the medical history of previously healthy patients.

As a result of research, it was not possible to establish a direct connection between the formation and development of neoplasms in the organs of the reproductive system of the female body and the use of the drug Menopur.

Congenital abnormalities in children are detected more often than in cases of natural conception. It is probably possible to establish a connection between these deviations and the unique characteristics of the parents, these include age and characteristics of seminal fluid.

The likelihood of thromboembolic complications increases in patients with a body mass index ≥30 kg/m2.

Conducting health programs with drugs with gonadotropic pharmacological action can contribute to the development of menotropins and lead to the development of ovarian hyperstimulation syndrome. The effect of the drug is manifested in the formation of large cysts in the ovaries. In addition, fluid accumulates in the abdominal area. The volume of urine output decreases, blood pressure levels drop, and blood vessels become clogged.

The day of onset of ovarian hyperstimulation syndrome established by a number of studies is 7–10 after the mature cell leaves the ovary.

Among the signs of ovarian hyperstimulation syndrome there is pain in the lower abdomen, which appears during palpation by a doctor, or is established using ultrasound examinations.

In this case, treatment is stopped. If a woman is carrying a child, the symptoms are especially acute and can become a threat to the health and life of the patient.

Doses for IVF

The purpose of using Menopur may be the maturation of a large number of follicles in order to obtain eggs. The drug in a short IVF protocol is prescribed from the second or third day of the cycle. The starting dose is 150 or 225 IU. It is supported for the first 5 days. If the ovarian response is insufficient, the dose can be increased, but not more than 150 IU at a time. The maximum daily dose is 450 IU. The maximum course of stimulation lasts 20 days.

Menopur is also used in long IVF protocols. They involve the administration of GnRH agonists in the cycle that precedes the stimulated one. In this case, stimulation begins approximately 2 weeks after the start of the protocol. The dosages used are similar.

After the follicles reach their optimal size, which is determined by ultrasound, the doctor prescribes an injection of 10,000 IU of hCG. This allows the final maturation of the eggs to be achieved. Then the follicles are punctured. Observation of the patient is required for at least 2 weeks in order to detect possible ovarian hyperstimulation syndrome in time.

If the dose of Menopur is excessive, pregnancy should be avoided in the current cycle. Firstly, this can lead to late hyperstimulation syndrome, which is much more severe than early hyperstimulation syndrome. Secondly, there is a high probability of multiple pregnancy. Moreover, there can be more than two fruits. Therefore, the administration of hCG is canceled, and the use of barrier contraception or refusal of sexual activity is required until the next cycle.