Mercazolil: instructions for use and what it is needed for, price, reviews, analogues

Mercozolil is a drug produced in the form of tablets belonging to the group of thyroid hormone antagonists. The antithyroid properties of the drug are used in modern medicine to treat diseases associated with increased activity of the thyroid gland. The drug is produced in the form of tablets for oral use, which ensures ease of use.

Pharmacodynamics and pharmacokinetics

The active substance is thiamazole . The mechanism of action of the main component is aimed at blocking peroxidase , an enzyme that takes an active part in the process of iodination of thyronine in the tissues of the thyroid gland with the formation of monoiodothyronine, diiodothyronine, and subsequently triiodothyronine and tetraiodothyronine.

The drug interferes with the process of synthesis of hormones in the tissues of the thyroid gland, reduces the internal production of the hormone T4, accelerates the process of removing iodides from the tissues of the thyroid gland, slows down the basal metabolic rate, enhances the reciprocal production and synthesis of the hormone TSH by the pituitary gland, which leads to hyperplasia of the thyroid gland.

In many ways, the rate of development of the therapeutic effect depends on the initial level of hormones T3 and T4. On average, a decrease in hormone levels is recorded a week after the start of treatment with Mercazolil at a dose of 30 mg; or after a month when taking 40 mg.

After stopping treatment, hormone levels may return to previous levels within 5 days.

Pharmacological group

Mercazolil inhibits the production of hormones produced by the thyroid gland, namely triiodothyronine and thyroxine. This effect of the drug is associated with the suppression of the activity of peroxidase, that is, the enzyme that ensures the saturation of triiodothyronine with iodine. As a result, against the background of the above process, the metabolic rate in the human body decreases and the loss of iodine by the thyroid gland is activated. Against this background, the secretion of thyroid-stimulating hormone from the pituitary gland increases, which leads to an increase in the volume of the thyroid gland.

The drug is well absorbed from the gastrointestinal tract and accumulates in the tissues of the thyroid gland. The effect of the drug lasts for 24 hours. After two days, the drug is completely excreted in the urine. It is worth noting that the active component of the drug can be found in breast milk. The use of the drug by women during breastfeeding is prohibited. After oral administration, it is quickly and completely absorbed from the gastrointestinal tract. The half-life is 6 hours. The product is biotransformed in the body. The component is eliminated from the body in the form of metabolites in a volume of 70% within 2 days.

Contraindications

Mercazolil is contraindicated during breastfeeding, with granulocytopenia, with intolerance to the active component thiamazole, with severe leukopenia.

When pregnant, with severe liver pathology, with a very large goiter with concomitant narrowing of the trachea (only in the preoperative period for a short course), the drug is prescribed with caution.

Indications for use

The list of indications for use of the drug includes the following conditions:

• diffuse toxic goiter;
• thyrotoxic crisis;
• mixed toxic goiter;
• as part of complex therapy with radioactive iodine.

for adults

Patients of this age category can use the drug if there is an indication for use. The drug composition is well tolerated; adverse reactions, provided all recommendations are followed, are quite rare. Patients over 75 years of age should be aware of the limitations of the dosage regimen. The use of medications in high doses is not recommended due to the high likelihood of developing hypothyroidism.

for children

The drug can be used in pediatric practice. The drug Mercazolil is well tolerated by patients of this age category, provided that the dosage regimen is carefully planned. If such recommendations are not followed, the drug may cause acute side effects.

for pregnant women and during lactation

During pregnancy and breastfeeding, women are not recommended to use the drug. The active components of the drug penetrate into breast milk and can have a negative effect on the development of the fetus.

Side effects of Mercazolil

Aplastic anemia, thrombocytopenia, allergic reactions in the form of urticaria and skin rashes, granulocytopenia, suppression of myelopoesis, generalized lymphoadenopathy , hypoprotrombinemia (manifested in the form of bleeding and piles), medication, insulin autoimmune syndrome, disorders sialadenopathy , lupus -lane syndrome, polyneuritis, alopecia, hepatitis, periarteritis , vomiting, arthralgia, epigastric pain, cholestatic jaundice, nausea, fatigue, dizziness, paresthesia, myalgia, hyperpigmentation of the skin, headaches, fever, nephritis rarely develops.

Mercazolil, instructions for use (Method and dosage)

Take orally after meals.

Thyrotoxicosis of mild to moderate severity: 3-4 times a day, 5 mg. Upon achieving remission (after about 1-1.5 months), the daily amount of the drug is reduced by 5-10 mg every 5-10 days, until the minimum dosage is gradually reached (once every 3 days, or 1 time per day, 5 mg), which are capable of providing a lasting therapeutic effect.

Severe thyrotoxicosis: 3-4 times a day, 40-60 mg per day, after stabilization of the condition, the dose is reduced to 5-10 mg per day. The course of therapy is designed for 1-1.5 years. The highest dosages: daily – 60 mg, single – 10 mg.

Release form and composition

Mercazolil is produced in the form of tablets: flat-cylindrical, from white with a yellowish or creamy tint to white, round with a chamfer (in plastic containers or polymer jars of 50 or 100 pcs., 1 container or jar in a cardboard box; in blister packs of 10 or 20 pcs., 5 or 10 packages (10 tablets each) or 2 packages (20 tablets each) in a cardboard box).

1 tablet contains:

• Active substance: thiamazole – 5 mg;
• Auxiliary components: calcium stearate monohydrate – 1 mg; talc – 2 mg; potato starch – 98 mg; lactose monohydrate – 94 mg.

Overdose

Manifested by febrile syndrome, nausea, swelling, skin itching, epigastric pain , vomiting, arthralgia.

aplastic anemia may develop .

Nephrotic syndrome , neuropathy, stimulation or inhibition of the central nervous system, hepatitis, and exfoliative dermatitis are rarely recorded

Long-term treatment with high dosages leads to hyperplasia of thyroid tissue.

In case of an overdose of thiamazole, it is necessary to rinse the stomach, prescribe enterosorbents, and carry out syndromic therapy.

Analogs

As analogues of the drug, you can consider other drugs intended for the treatment of thyroid diseases in patients of different age categories.

Thyroxine

The hormonal drug Thyroxine affects the metabolism of fats, proteins and carbohydrates. The product should be taken only as prescribed by a specialist, following a strict dosage regimen. The drug affects the functioning of the cardiovascular and central nervous systems. If there are important indications, the drug can be used in children of different ages.

Propycyl

The drug Propicil is considered as an antithyroid drug used to treat diseases of the thyroid gland that occur against the background of its hyperfunction. The drug is prescribed to children, adult patients, as well as pregnant women according to strict indications in minimal doses.

Interaction

Reserpine, lithium preparations, amiodarone, beta-blockers can increase the effectiveness of Mercazolil, which requires mandatory adjustment of the dosage regimen.

With an excess of iodine, the effect of the drug is weakened, and with iodine , it is enhanced.

The risk of leukopenia increases with treatment with metamizole sodium and sulfonamides .

special instructions

It is important to warn patients about the need to seek medical help if boils , inflammation in the oral cavity, cough, chills, fever, sore throat appear, since the appearance of these symptoms may indicate the development of agranulocytosis .

During the treatment period, mandatory monitoring of peripheral blood parameters is required.

To prevent the growth of goiter with large struma of the thyroid gland with concomitant narrowing of the trachea, courses of treatment with Mercazolil are carried out only for short periods.

jaundice , persistent vomiting or nausea, skin rash and itching, subcutaneous hemorrhages and bleeding of unknown origin, severe epigastric pain appear during therapy If treatment is stopped early, a relapse of the underlying disease is possible.

Mercazolil price, where to buy

The price of Mercazolil can vary significantly depending on the manufacturer. So, 50 tablets of 5 mg each cost from 30 to 150 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Mercazolil tab.
  5mg No. 50 LLC FC Zdorovye 31 rub. order

Pharmacy Dialogue

• Mercazolil (5 mg tablet No. 50)Health/Ukraine

  28 RUR order

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PaniPharmacy

• Mercazolil tablets Mercazolil tablets.
  0.005g No. 100 Ukraine, Health LLC 150 UAH. order

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Mercazolil

Active substance:

Thiamazole*

Pharmgroup:

Thyroid hormones, their analogs and antagonists (including antithyroid drugs)

Average price in pharmacies