Mifepristone is an effective and safe drug for medical abortion.

Mifepristone tablets are a synthetic steroidal antiprogestagenic drug that does not have gestagenic activity, the main purpose of which is medical abortion. As the main active ingredient, it is included in the following drugs: Mifegin, RU-486, Pencrofton, Mifolian, Mifeprex, Miropriston, Ginepriston, Zhenale, Ginestril, Agesta.

International name: Mifepristone Group affiliation: Antiprogestogen Description of the active substance (INN): Mifepristone Dosage form: tablets

Which method of abortion is less traumatic?

Three methods are used for artificial termination of pregnancy in Russia. The most common method is dilatation and curettage (curettage). The World Health Organization considers it the most dangerous, and therefore recommends its use in extreme cases. In second place is mini-abortion (vacuum aspiration), which has been used in our country since 1989. And only third place is occupied by medical abortion. But this is the most effective and safe method of terminating an unwanted pregnancy.

Medical abortion regimens and drug dosages were approved in most countries of the world in 2012. As a result of the use of drugs, the death and rejection of the embryo occurs.

The drug with the active ingredient mifepristone is generally accepted for medical abortion. The original drug Mifegin (mifepristone 200 mg) was officially registered and approved for use in the Russian Federation in 1999. Since then, mifepristone in combination with misoprostol has been successfully used for medical termination of pregnancy.

Of course, when a woman decides to have an abortion, she must understand that termination of pregnancy, in principle, cannot be absolutely safe. And there is nothing good in this action. But if such a need arises, you need to contact a gynecologist at the earliest possible date and choose a minimally traumatic method.

Abortion with Mifegin

If you have decided to terminate your pregnancy with French mifegin, an abortion in our clinic is performed subject to the following conditions:

1. correct dosage
2. timely intake of support medication at stage 2,
3. optimal (short) terms of conception, compliance with recommended restrictions.

Our medical center carries out pregnancy termination with Mifegin (France) using only those methods and schemes that are approved by government authorities regulating activities in the field of healthcare. We use only original, imported tablets, certified and approved for use in the Russian Federation!

Prices for services

Only certified tablets from France

Characteristics of the drug Mifepristone

Contains the active ingredient mifepristone. Release form: tablets containing mifepristone 200 mg, 3 pcs. Registration certificate holder: Nizhpharm JSC, Russia. Manufacturer: JSC Obninsk Chemical and Pharmaceutical Company, Russia. Clinical and pharmacological group: antigestagen.

A drug that increases the activity and tone of the myometrium. Pharmacotherapeutic group: antiprogestogen. Pharmacological action: synthetic steroid antigestagenic drug. Does not have gestagenic activity. Blocks the action of progesterone at the receptor level. It is an antagonist of glucocorticosteroids (GCS) due to competition at the level of connection with receptors.

Stimulates the release of interleukin-8 in choriodecidual cells and increases the sensitivity of the myometrium to prostaglandins, resulting in increased myometrial contractility. As a result of the action of the drug, desquamation (falling off) of the decidua and expulsion of the fertilized egg occurs. Used in combination with a synthetic prostaglandin analogue.

Release form, composition and packaging

Tablets are light yellow or light yellow with a greenish tint.

Excipients: lactose, potato starch, carboxymethyl starch, microcrystalline cellulose, polyvinylpyrrolidone, magnesium stearate.

3 pcs. — polymer cans (1) — cardboard packs. 3 pcs. — contour cell packaging (1) — cardboard packs. 3 pcs. — contour cell packaging (2) — cardboard packs. 6 pcs. — polymer jars (1) — cardboard packs. 6 pcs. — contour cell packaging (1) — cardboard packs. 6 pcs. — contour cell packaging (2) — cardboard packs.

Dosage regimen and regimen for use of Mifepristone for medical termination of pregnancy

For medical termination of pregnancy in the early stages, Mifepristone is prescribed in a dose of 600 mg (3 tablets) once.

Features of taking the drug:

• used only in specialized licensed medical institutions with the necessary equipment;
• taken orally 1-1.5 hours after eating a light meal, washed down with 100 ml of boiled water;
• it is necessary to monitor the absence of vomiting, as this will lead to malabsorption and a reduction in dosage;
• the patient should be under the supervision of medical personnel in a medical facility for at least 2 hours after taking the drug. Since the maximum concentration of Mifepristone in the blood is reached 1.3 hours after administration, this is necessary to provide emergency medical care in the event of an allergic reaction.

36-48 hours after taking Mifepristone, the patient should come to the hospital for an ultrasound examination of the uterine cavity. At the same time, she takes a second drug, misoprostol at a dosage of 400 mg. Misoprostol stimulates contraction of the smooth muscles of the uterus and dilates the cervix, increasing the frequency and strength of myometrial contractions. As a result of the combination of two drugs, bleeding, rejection of the fertilized egg and termination of pregnancy occur.

Ultrasound examination of the uterine cavity

After 10-14 days, a clinical examination and repeated ultrasound control are repeated; if necessary, the level of hCG (chorionic gonadotropin) is determined to confirm spontaneous abortion. If the examination results indicate that an incomplete abortion has occurred or the pregnancy continues, fetal tissue is removed using a vacuum aspirator.

Special instructions for the use of Mifepristone for medical termination of pregnancy
:

• if a woman has a negative blood type, and the partner from whom conception occurred is positive, she is recommended to administer anti-Rh immunoglobulin to prevent the development of Rh conflict in the next pregnancy;
• Women with artificial heart valves or infective endocarditis should receive prophylactic antibiotic therapy when using Mifepristone;
• it is necessary to inform the patient that the pregnancy must be terminated in another way if there is no effect from the use of the drug on days 10-14, since there is a risk of congenital malformations in the fetus;
• within 8-12 days after taking the drug, it is necessary to avoid taking non-steroidal anti-inflammatory drugs; for pain relief it is allowed to take antispasmodics;
• it is necessary to inform the patient about the decrease in the effectiveness of the method as the woman’s age increases;
• it is necessary to warn about the possibility of prolonged bleeding from the vagina, lasting on average about 12 days, sometimes more. A woman should receive clear instructions that if severe bleeding occurs, with or without pain, she must go to the clinic;
• The decision to use the drug for women with hemostasis disorders and anemia is made together with a hematologist and after his consultation.

Side effects

Mifepristone can lead to the development of uterine bleeding, fever caused by retention of discharge in the uterus (lochiometra), slowdown of postpartum processes (uterine subinvolution), pain and discomfort in the lower abdomen, exacerbation of uterine infections and urinary tract infections.

There are also reviews of Mifepristone, which causes headache, weakness, diarrhea, nausea, hyperthermia, dizziness, and chills.

The combination of the drug with misoprostol can provoke dyspepsia, asthenia, leg pain, anemia, vaginitis, anxiety, leucorrhoea, fainting, and a decrease in hemoglobin levels.

Drug interactions

Interaction studies have not been conducted with mifepristone. However, it must be taken into account that cytochrome P4503A4 (CYP3A4) is involved in the metabolism of mifepristone. Cytochrome P450 dependent monooxidases (enzymes) catalyze many reactions involved in the metabolism of drugs. Specifically, CYP3A4 is responsible for the metabolism of drugs and steroids. Therefore, it is possible that grapefruit juice, ketoconazole, itraconazole, erythromycin, when used together with mifepristone, can increase its concentration in the blood plasma.

Dexamethasone, preparations of St. John's wort, phenytoin, phenobarbital, carbamazepine, rifampicin, when used together, can reduce the concentration of mifepristone in the blood plasma.

Caution should be exercised when concomitantly using mifepristone with drugs that are CYP3A4 substrates, including drugs for general anesthesia. With the simultaneous use of Mifepristone and glucocorticosteroids, it is necessary to increase the dosage of GCS.

Contraindications to the use of Mifepristone

• ectopic pregnancy;
• pregnancy for more than 42 days, as well as not confirmed by clinical studies;
• pregnancy during the use of intrauterine contraceptives or after discontinuation of hormonal contraception;
• inflammatory diseases of the female genital organs;
• smoking in women over 35 years of age without prior consultation with a physician;
• adrenal insufficiency;
• acute or chronic renal and/or liver failure;
• porphyria;
• long-term use of glucocorticoids;
• anemia;
• impaired hemostasis (including previous treatment with anticoagulants);
• the presence of severe extragenital pathology;
• a history of hypersensitivity to Mifepristone and/or auxiliary components.

Anemia

Early pregnancy

Complications after taking Mifepristone

It is important not to confuse the concept of a side effect of a drug and complications after taking it. A complication is a pathological process that is attached to the underlying disease or develops as a result of therapeutic or diagnostic measures. Complications arise when the rules for taking the medication or regimen are violated, as well as due to the pathological reactivity of the body.

To prevent the development of complications during medical termination of pregnancy using Mifepristone, it is very important to examine the woman, determine the presence of diseases, contraindications for the procedure, the exact duration of pregnancy, and check the rules of admission. The main condition for a favorable outcome of a medical abortion is that it is carried out by specialists in a medical institution.

One possible complication is bleeding. If the bleeding is heavy, more than 2-3 pads in one hour, accompanied by severe intolerable pain, you should immediately consult a doctor. Significant blood loss requires medical intervention. To stop, vacuum aspiration or curettage and blood transfusion are performed. Without going to the clinic, the risk of death as a result of heavy bleeding increases.

In some cases, the fertilized egg does not completely leave the uterine cavity. In the case of an incomplete abortion, the remains of the embryo cause an inflammatory process, intoxication of the body, the spread of infection can lead to blood poisoning and the death of the woman. Emergency medical care is required - curettage of the uterine cavity after an ultrasound examination, a course of detoxification and antibacterial therapy in a hospital setting.

Partial or complete absence of abortion occurs in 5-15% of women, due to the individual reaction of the body and depends on the duration of pregnancy (the longer the period, the higher the risk). If, after taking Mifepristone, pregnancy continues to develop (incorrect dosage of the drug and late term), termination of pregnancy is necessary, since the risk of having a child with serious malformations is very high.

How to use

Mifepristone is a synthetic medicine that provokes active contractions of the uterus. The action of the medicine is aimed at the tone of the uterus, increasing the contractility of the muscle layer - the myometrium. After the medicine is taken, the effect of progesterone on the receptors is stopped.

To terminate a pregnancy

How to take it depends on the indications. For an abortion, a woman drinks 200 mg of the drug orally, followed by 150 ml of water (no less). In the next 24-48 hours, minor bleeding and aching pain in the lower abdomen, which is not pathological, may appear.

To induce labor

To prepare the uterus for childbirth during a full-term pregnancy, a single dose of 200 mg of Mifepristone is prescribed. A day later, you need to take it again in the same dosage. After 2-3 days, the doctor assesses the condition of the birth canal, its readiness for childbirth, and may also prescribe oxytocin or prostaglandins.

Overdose

Taking Mifepristone in a dosage of up to 2 g does not cause an undesirable reaction in the body. There is no specific antidote. In cases of drug overdose, adrenal insufficiency may develop. In case of suspected development of acute adrenal insufficiency, the use of dexamethasone is recommended (at the rate of 400 mg of mifepristone - 1 mg of dexamethasone).

The high effectiveness and safety of medical abortion using the drug Mifepristone has been proven. The recommended regimen for using Mifepristone in combination with misoprostol is widely used not only in Russia, but throughout the world and has the following advantages:

• high efficiency 96-99%;
• minimal risk of developing serious complications;
• no surgical intervention or general anesthesia is required;
• there is no risk of infection and development of the inflammatory process;
• completely eliminates the risk of infection with hepatitis B and C, HIV;
• psychologically well tolerated.

Time-tested experience with the use of Mifepristone proves its good tolerability and effectiveness.

MAKE AN APPOINTMENT

Abortion and contraception clinic in St. Petersburg - department of the medical gynecological association "Diana"

Make an appointment, tests or ultrasound via the contact form or by calling +8 (812) 62-962-77. We work seven days a week from 09:00 to 21:00.

We are located in the Krasnogvardeisky district, next to the Novocherkasskaya, Ploshchad Alexander Nevsky and Ladozhskaya metro stations.

The cost of a medical abortion in our clinic is 3,300 rubles. The price includes all pills, an examination by a gynecologist and an ultrasound to determine the timing of pregnancy.

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