Impaza: instructions for use of the drug

• Compound
• Indications

Impaired potency, lack of sexual desire, and fear of sexual impotence worry any man. After all, sex is an integral part of their life.

Everyone has thought about sexual failure at least once, and some are already seriously interested in issues of increasing potency.

Modern lifestyle: poor environment, physical inactivity, unhealthy diet and unhealthy lifestyle increases the percentage of men with one or another intimate problem. Therefore, new, more advanced methods and medications are being developed to treat sexual disorders.

Erectile dysfunction occurs for various reasons, which only a doctor can correctly determine. Usually men are embarrassed to talk about this disease and go to the clinic, trying to solve the problem on their own. This is where the drug Impaza comes to the rescue. This is a safe method of restoring potency and can be purchased at a pharmacy without a prescription.

Impaza eliminates the main cause of erectile dysfunction, which is vascular endothelial dysfunction. As a result of the drug's action, problems with potency are solved for a long time, unlike other drugs that have only a one-time stimulating effect.

note

It should be remembered that self-medication in some cases can be both useless and harmful. Therefore, treatment with Impaza must be carried out according to the instructions for use.

The drug Impaza is a homeopathic remedy. It is a white, flat, cylindrical tablet. To protect against counterfeiting, each tablet is labeled MATERIA MEDICA on one side and IMPAZA on the other.

Official medicine is skeptical about homeopathic medicines. Since the principles of homeopathy and the scientific approach to treatment are different in many ways. Homeopathy is based on the principle: like cures like. Thus, homeopathic remedies are extreme dilutions of substances that cause the same symptoms as the disease being treated.

It is worth noting

Alternative medicine, in this case homeopathy, has both supporters and opponents. But even those for whom any treatment other than that approved by official medicine is absolutely unacceptable, agree that homeopathic remedies do not cause any harm.

But despite the fact that homeopathy is not officially recognized, it is used all over the world because it really helps. And students of medical educational institutions are given lectures on this type of treatment.

According to the instructions, Impaza is used in two cases:

• as a therapeutic and prophylactic agent during the recommended course;
• as a stimulant for stable erection (one-time use before sex).

For the purpose of treatment and prevention, the drug is taken daily for 12 weeks.

The number of tablets taken per day may vary. This depends on the severity of the symptoms of erectile dysfunction.

• In case of slight impairment of potency, the number of tablets is 1 pc. Reception - evening. The tablet is absorbed by the body by dissolving in the mouth. When taking the medicine, it is not recommended to eat or drink water.
• To treat more severe sexual dysfunction, the number of tablets per day can be increased to two. In this case, you need to take the drug in the morning and evening. At the end of the course, take a break for 3-4 months and repeat the treatment again.
• For the purpose of prevention , for persons most at risk of erectile dysfunction, 1 tablet is prescribed every other day.

Risk groups include the following diseases:

• chronic prostatitis;
• diabetes.

For a stimulating effect, Impaza is used before intended sexual intercourse . The first tablet dissolves 2 hours before intimacy, the second - an hour later. It is important to remember that daily intake cannot exceed 2 tablets. Therefore, if a man is undergoing treatment with a double dosage, but needs an occasional dose for a stimulating effect, then the morning dose of the drug should be skipped.

The convenient form of release in the form of lozenges allows you to take the drug on time in any conditions: at work, in a vehicle, during a planned meeting. The tablets are easily absorbed without causing heartburn or other discomfort from the gastrointestinal tract.

The manufacturer of the drug is NPF Materia Medica Holding LLC.

Release form and composition

The drug is produced in the form of lozenges: from white with a creamy tint to white, flat-cylindrical, chamfered and scored, with a uniform, smooth surface; on one side there is the inscription “MATERIA MEDICA”, on the other - “IMPAZA” (in polymer cans of 10, 20 or 40 pcs., 1 can in a cardboard pack; in strip packs of 20 pcs., 1 package in a cardboard pack pack).

1 tablet contains:

• Active substance: mixture of homeopathic dilutions of C12, C30, C200 antibodies to endothelial nitric oxide synthetase (affinity purified) – 3 mg;
• Auxiliary components: magnesium stearate, lactose, microcrystalline cellulose.

Impaza price

You can purchase the drug at any pharmacy. This homeopathic medicine belongs to the category of inexpensive medicines for the treatment of impotence, which makes it accessible to many patients. If you wish, you can order Impaza through an online pharmacy, then the drug will be delivered to you by courier directly to your home. The price of tablets varies depending on the region of purchase and pricing. The average cost of Impaz in Moscow pharmacies is presented in the table:

Pharmacological properties

Pharmacodynamics

Impaza is a homeopathic drug that increases the activity of the endothelial enzyme NO synthase. The use of the drug in the presence of sexual stimulation ensures activation of the production of nitric oxide in endothelial cells, increases the concentration of cyclic guanosine monophosphate in the smooth muscles and causes its relaxation. This action promotes a rush of blood to the cavernous bodies of the penis, causing a fairly strong and long-lasting erection.

A course of treatment with Impaza, as well as a single dose of the drug, increases libido in men and facilitates sexual intercourse. At a sufficiently low concentration of testosterone in the body, regular use of the drug leads to a significant increase in its concentration in the blood serum.

Description

Flat-cylindrical tablets with a score and a bevel, from white to almost white. On the flat side with a notch there is the inscription MATERIA MEDICA, on the other flat side there is the inscription IMPAZA.

pharmachologic effect

According to the manufacturer, it increases the activity of endothelial NO synthase, restores endothelial production of nitric oxide (NO) during sexual stimulation, increases the content of cGMP in smooth muscles and promotes their relaxation, which leads to an increase in blood supply to the cavernous bodies. These effects provide sufficient strength and duration of erection.

It is believed that the pharmacological property is based on the placebo effect. Due to the fact that this medicine is classified as homeopathic, the concentration of the active substance in it is extremely low, and in some cases approaches several molecules per 1 gram of the drug. As a result, the concentration of impurities significantly exceeds the content of the main substance.

The biological result of antibodies to nitric oxide synthetase has not been shown in any serious study.

Effectiveness of use for erectile dysfunction

Data from a randomized, placebo-controlled trial In terms of its ability to improve erectile function, Impaza was significantly superior to placebo (see Table 3, Fig. 3). Moreover, in contrast to placebo, the effectiveness increased with increasing duration of administration from 4 to 12 weeks.

Table 1. Treatment effectiveness in the impaza and placebo groups according to the main study criteria.

* — significant difference from the placebo group, p<0.05; ** — p<0.01.

Contraindications, side effects

Contraindication is increased individual sensitivity to the components (lactose, cellulose, magnesium stearate). When used according to recommended indications and in recommended dosages, no side effects were identified.

In case of accidental overdose, dyspepsia may occur due to the excipients included in the dosage form.

The composition contains lactose, and therefore it is not recommended for use in patients with congenital galactosemia, impaired absorption of glucose or galactose, or congenital lactase deficiency.

FAQ

How to use?

Taken as a course for three months, 1-2 tablets per day, without drinking water. If necessary, the course can be repeated after some time.

What is the price ?

In Russia, the cost is approximately 250 rubles. up to 350 rub. for one package.

Can I buy it without a doctor's prescription?

Yes, because it is an over-the-counter medicine.

Is it sold in other countries?

It is currently registered and can be purchased in the following countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Tajikistan, Turkmenistan, Uzbekistan, Ukraine, Vietnam.

Can I order through your website?

No. This site is for informational purposes only.

Where can I buy it?

You can buy it in pharmacies in your city or in online pharmacies.

How does it work

During the experiments, it was found that the ability of blood vessels to expand is associated with the production by the endothelium (the inner lining of blood vessels) of a universal vasodilator factor - nitric oxide (NO).

Disruption of the functioning of this enzyme occurs in many common diseases: atherosclerosis, hypertension, diabetes mellitus, etc. It is the dysfunction of NO synthase that is largely responsible for the decrease in potency.

Safety in ED

In the group, there were 3 cases (2%) of headaches and 1 case (0.7%) of nausea in the first week of the study, which were associated with taking the drug. In the placebo group there was 1 case (3.3%) of headaches.

There were no drug-related serious adverse reactions reported in the impaza and placebo groups. In those taking the medicine for the underlying disease (including nitrates for coronary heart disease), no undesirable drug interactions with it were registered.

Thus, the present study proved the effectiveness and safety of impaza in the treatment of erectile dysfunction. Moreover, the result is maximum with long-term course administration (for 12 weeks or more).

Conclusions on the effect of impase on total testosterone levels

Long-term use is accompanied by an increase in the level of total testosterone in the serum (in approximately 50% of cases), mainly in men with an initial relative decrease in this indicator.

Among patients with an initial level of total serum TC >14 nM, this indicator does not change in 50%, increases in 20%, and decreases in 30%. At the same time, a decrease in the level of TC is associated with a more frequent positive response to treatment, a more pronounced (compared to the average) increase in orgasmic function, libido and overall satisfaction.

The cause-and-effect relationship between impase and a decrease in TC levels needs to be clarified.

The overall result of impotence depends on the relative contribution of the central and peripheral components to the disturbance of potency in a given individual.

The change in androgen status in this case is most likely secondary to the correction of the central links of erectile function. Thus, it can be assumed that the effect of impase on androgen status is mediated by the central links in the regulation of androgen biosynthesis.

Currently, the Clinic of Urology and Operative Nephrology of the Russian State Medical University (Moscow) is conducting a study of the effect of the drug on the level of free testosterone in patients with erectile dysfunction.

Place and role in the treatment of impotence

The effectiveness and safety in the treatment of impotence of various etiologies has been confirmed in accordance with the principles of evidence-based medicine.

The most effective is a long course of use.

In terms of its mechanism of action, therapeutic activity and safety profile, and effect on androgen status, Impaz differs from all existing methods of pharmacotherapy for impotence.

Data from preclinical and clinical studies indicate the pathogenetic nature of the action in ED, including restoration (increase) of nitric oxide production by the endothelium (a key process in the implementation of erectile function).

The pathogenetic nature of the action explains the relatively slower development of the clinical effect than other oral agents.

It is advisable to use an individual approach to the dosage regimen for a particular patient, taking into account all factors that influence the clinical effect.

High effectiveness in men with a predominance of psychogenic factors and with vascular arterial ED, as well as a favorable combination with nitrates in patients with coronary heart disease, allows us to recommend it as a “first-line” remedy for impotence in these groups.

Taking into account the mechanisms of action of impase and oral phosphodiesterase type 5 inhibitors, their combined use is advisable to improve the clinical outcome.

Based on the results of combination therapy, the following algorithm for the treatment of impotence was formulated

If a man has psychogenic, isolated neurogenic (osteochondrosis), compensated and subcompensated arteriogenic ED of mild or moderate degree, is young, or has coronary artery disease and receives nitrates; Given the sufficient effectiveness in this group of patients, you can start with taking impaza.

In case of ineffectiveness, as well as severe or moderate impotence with veno-occlusive ED, the prescription of PDE-5 inhibitors is indicated.

When choosing, you need to take into account your sexual habits. If the possibility of combining sexual activity with food or alcohol intake is not important to him, i.e. romantic setting, dinner, other additional attributes of sex, then he can be prescribed Viagra, which is weakened by fatty foods or alcohol.

If these factors are important, then you need to find out whether the possibility of repeated sexual intercourse during the day or morning sexual intercourse is necessary, if so, then Cialis will be the drug of choice in this case.

If one of the PDE-5 inhibitors does not help, then you will need to use another rather than abandon this type of pharmacotherapy. If PDE-5 inhibitors are insufficiently effective, a combination with impase is necessary.

This combination therapy also makes it possible to reduce the severity of the side effects of monotherapy by reducing the dose of PDE-5 inhibitors, while maintaining the same effectiveness; preserves the patient’s chances of using future therapy due to the ineffectiveness of existing pharmacotherapy.

After selecting therapy, the doctor must monitor the patient and conduct dynamic monitoring of treatment. It is advisable to prescribe it from the first days together with PDE-5 inhibitors. In addition to the above advantages, this combination allows you to increase the intervals between the use of these products, while maintaining the ability to have successful sexual intercourse.

With the course of use of impase and PDE-5 inhibitors, there is a restoration of adequate and spontaneous erections, both in the opinion of the person being treated and in the increase in cavernous blood flow during ultrasound Dopplerography of the penis with audiovisual sexual stimulation and cavernous electrical activity recorded with EMG of the male penis.

It becomes possible to reduce the minimum effective dose and gradually discontinue PDE-5 inhibitors, transferring the patient to impase monotherapy, and subsequently even discontinuing it.

The proposed scheme of combination pharmacotherapy using Iimpaza allows achieving a positive effect in more than 90% of patients, increasing the safety of treatment and significantly reducing its cost.

Instructions for use of Impaza: method and dosage

Impaz tablets are taken orally, held in the mouth until completely dissolved. The interval between taking the drug and eating should be observed.

Single dose – 1 tablet.

To stabilize sexual potency, regular use of the drug is recommended. The duration of the treatment and prophylactic course is at least 3 months. The frequency of taking the drug is determined by the severity of erectile dysfunction: from daily intake of 1 tablet 2 times a day to 1 tablet 1 time in 2 days (preferably in the evening). If necessary, the course of treatment can be repeated after 3-6 months.

To stimulate an episodic erection, Impaza should be taken before sexual intercourse: 60-120 minutes before the expected intimacy, 2 tablets.

Side effects and overdose

Reviews about Impaza are mostly positive. Patients note that all the characteristics specified in the instructions, when taking the tablets correctly, appear after a month of active treatment. There are no side effects from taking Impaz, except in cases of individual intolerance to the components of the drug, in which case reactions such as:

• stool disorder;
• rarely - vomiting and nausea;
• allergic reactions - redness of the skin, rashes, itching, scabies, burning.

Before starting treatment for disorders, you should carefully study the instructions for use, paying attention to the section with clearly indicated dosages. Failure to comply with the manufacturer's recommendations may lead to an overdose and the appearance of unpleasant symptoms. In cases of accidental use of a large number of tablets, it is necessary to drink enterosorbents and consult a doctor. No specific antidote has been developed for these cases.

Reviews of Impaza

Today there are numerous positive reviews about Impaza. Experts consider it one of the most effective drugs used in the treatment of erectile dysfunction and leading to the body's production of antibodies in response to NO synthase. Doctors who prescribe a course of treatment with this drug to increase male potency say that it is highly effective and has almost no side effects. They note a smooth increase in the positive effect of Impaza on “male strength” throughout the entire treatment period. The best results are usually achieved in the 12th week of therapy.

Reviews from patients about a single dose of tablets immediately before sexual intercourse are ambiguous. Some of them were satisfied with the results obtained, others claim that the use of Impaza did not affect their potency in any way.

Impaza and alcohol

The homeopathic medicine is compatible not only with almost all medicines and food ingredients, but also with alcoholic beverages. However, during treatment it is worth considering that alcohol itself negatively affects libido, reduces male desire and potency. For these reasons, doctors recommend, if possible, avoiding the consumption of strong drinks or reducing their total amount.

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