Klimadinon - peace of mind for women's health during menopause

Klimadinon is a plant-based drug that has an estrogen-like effect on the woman’s body. This remedy is widely used to eliminate menopausal and premenopausal disorders in women. Klimadinon is also prescribed in the postoperative period in case of bilateral ovarian removal in a woman of reproductive (childbearing) age.

The active components of the drug (based on black cohosh) are similar in mechanism of action to estrogens - they interact with the same receptors of the hypothalamus. This drug against the background of menopausal syndrome has the following effects:

• estrogen-like effect; • sedative effect; • therapeutic effect on the autonomic nervous system; • minimizing the manifestations of malaise associated with menopause.

The effect of taking this drug appears gradually, a noticeable result is usually achieved in the 3rd week from the start of using the drug.

What do women who have taken it think about climadinone? Let's get a look.

METHODOLOGY

The competitive group of the drug CLIMADINON® was formed within the framework of the ATC classification of the 3rd level of group G03X “Other sex hormones and drugs affecting the sexual sphere.” Indications for their use were used as a criterion for selecting drugs in this group; in particular, drugs intended for the treatment of menopausal syndrome were selected.

Contraindications

Klimadinon drops and tablets should not be used if a woman is overly sensitive to any of the components of the drug.

Also a contraindication is a diagnosed or possible history of estrogen-dependent tumors of different locations.

beware of using the drug Klimadinon if you have :

• Liver diseases;
• Epileptic syndrome;
• Brain illnesses/injuries.

In these cases, consultation with a doctor is necessary. He will be able to assess what will come from use more - benefit or harm.

Tablets should not be used by people who are lactose intolerant, and the oral solution should not be used by people with alcoholism.

Treatment of menopause

Hormonal disorders associated with menopause lead to the occurrence and/or complications of many diseases (degradation of the mucous membranes of the genital organs, osteoporosis, cardiovascular diseases). Therefore, do not underestimate the possible consequences of this physiological process in the absence of therapy.

There are several methods of treating menopause: hormone replacement therapy and therapy with herbal remedies. In addition to the above-mentioned methods of treating menopausal syndrome, folk methods are also used, which use various medicinal plants (valerian root, St. John's wort, etc.). It should be noted that the severity of menopause symptoms is often a marker that determines which treatment will be most appropriate.

The meaning of hormone replacement therapy is that the female body receives hormones that it lost after menopause, namely estrogens. The regimen for such treatment is selected by the doctor individually, taking into account indications and contraindications and assessing the risks and benefits.

The emergence of herbal remedies containing estrogen-like substances has allowed women a new way to cope with menopausal syndrome. Patients also receive herbal medicine therapy through medical prescriptions. Herbal preparations are considered promising because there is convincing evidence that the use of certain herbal extracts reduces the severity of menopausal symptoms and improves bone metabolism in postmenopausal women. One of these herbal preparations is an extract from the rhizomes of black cohosh (Cimicifuga racemosa, black cohosh). Its effectiveness has been proven by the results of clinical trials (Wuttke W. et al., 2006).

Let's sum it up

As a conclusion, we can say that “Klimadinon”, according to most positive reviews, is quite effective in eliminating the painful manifestations of the menopause. For some it completely eliminated unpleasant symptoms, for others it only reduced their severity. There is also a certain number of negative reviews, which is associated either with side effects of the drug or with its ineffectiveness in a certain case.

Thus, to successfully eliminate the signs of menopause, it is necessary to consult an experienced gynecologist who will select and prescribe the most effective drug for the woman individually.

THE MAGIC OF COMICIFUGA

Since ancient times, the medicinal plant black cohosh (Cimicifuga racemosa) has been known for its healing properties. The active substances of the plant act on the central nervous system, cardiovascular and reproductive. Cohosh is a plant with a pronounced hormonal effect: it has an estrogen-like effect and selectively acts on the anterior lobe of the pituitary gland. Cohosh preparations have a wide spectrum of action; they are prescribed for menopause and hot flashes, migraines and nervous tension, rheumatoid arthritis, to lower blood pressure, cholesterol levels, for dysmenorrhea, to restore the normal menstrual cycle, for infertility, etc.

It is the extract of black cohosh rhizomes that is the main active ingredient of the drug CLIMADINON®, which is used to treat neurovegetative disorders during menopause (hot flashes, increased sweating, sleep disorders, increased excitability, mood swings, apathy, etc.). The drug has an estrogen-like effect on the vaginal mucosa, eliminates the symptoms of menopause and has a positive effect on bone tissue.

MARKET DEVELOPMENT

Ukrainian consumers have been familiar with the drug CLIMADINON® for many years. Over the years, its popularity has increased, which is confirmed by the market development of the drug - a permanent increase in pharmacy sales in monetary terms (Fig. 1). In physical terms, sales of the drug CLIMADINON® showed active growth before the onset of the crisis in 2009. At that time, the negative impact of the crisis was felt by the entire pharmaceutical market, and CLIMADINON® was no exception. But it should be noted that subsequently the market dynamics of CLIMADINON sales in physical terms began to recover and gradually return to the pre-crisis level. Already at the end of 2011, CLIMADINON® strengthened its position in the competitive group of drugs and took a share of 18% in monetary and 17% in physical terms. The strengthening of the market position of the drug CLIMADINON® was facilitated by the faster growth rates of its pharmacy sales volume compared to those of the competitive group. Thus, at the end of 2011, the volume of pharmacy sales of the CLIMADINON® brand compared to 2010 increased by 15.4% in monetary terms and 6.1% in physical terms, while the sales volume of drugs from its competitive group decreased by 6 .9 and 18.4%, respectively (Fig. 2, 3).

Rice. 1

Dynamics of the volume of pharmacy sales of CLIMADINON in monetary and physical terms in 2004–2011.

Rice. 2

Dynamics of the volume of pharmacy sales of CLIMADINON and medicines of the competitive group in monetary terms based on the results of 2009–2011. indicating the rate of growth/loss compared to the same period of the previous year

Rice. 3

Dynamics of the volume of pharmacy sales of CLIMADINON and medicines of the competitive group in physical terms based on the results of 2009–2011. indicating the rate of growth/loss compared to the same period of the previous year

CLIMADINON® is presented in several dosage forms - CLIMADINON® film-coated tablets, No. 60, CLIMADINON® oral drops, 50 ml bottle, as well as CLIMADINON® UNO, film-coated tablets, No. 30. They contain different amounts of black cohosh extract. CLIMADINON® is taken one tablet 2 times a day. The course of therapy is determined individually and lasts 3–6 months. Accordingly, 1 package of CLIMADINON® film-coated tablets, No. 60 will be enough for patients to use for almost 1 month. Also, CLIMADINON® is prescribed 30 drops (equivalent to 1.5 ml) 2 times a day. Accordingly, 1 package of CLIMADINON® 50 ml bottle is enough for approximately 17 days of therapy. CLIMADINON® UNO, film-coated tablets, No. 30, is designed for use for 1 month. It is important that the therapeutic course should not exceed more than 3 months without consulting a doctor.

The greatest demand among consumers is in the solid form of release - CLIMADINON® UNO film-coated tablets, No. 30 and CLIMADINON® film-coated tablets, No. 60, which in total accumulate a share of about 80% in the overall sales structure of the brand in monetary and physical terms. Accordingly, the share of the liquid form - CLIMADINON® oral drops, 50 ml bottle, is about 20%. But in some regions - Volyn and Kirovograd - this share is much higher - 44.5 and 39.8%, respectively (Fig. 4). The maximum volume of pharmacy sales of the drug CLIMADINON® is concentrated in large regions - Dnepropetrovsk region, Kyiv, etc. (Fig. 5).

Rice. 4

The share of various dosage forms of CLIMADINON in the overall structure of brand sales in physical terms by region based on the results of the first quarter. 2012

Rice. 5

The volume of pharmacy sales of various dosage forms of CLIMADINON in physical terms by region based on the results of the first quarter. 2012

Possible side effects and negative consequences of use

According to statistics, in general the drug is well tolerated, side effects occur quite rarely.

Contraindications:

• uterine fibroids;
• estrogen-dependent tumor;
• allergy to the components of the drug;
• lactose intolerance (tablets);
• alcohol addiction (drops).

Use with extreme caution, or better under medical supervision, for:

• disruption of liver function;
• brain injury;
• epilepsy.

Use during pregnancy and lactation: use of the product by pregnant and lactating women is not recommended.

If the medication was used before pregnancy, once pregnancy is established, use should be discontinued immediately.

Interaction with other drugs: compatibility with other types of medications has not been clarified to this day.

Release forms:

• Round, convex pink tablets with a hint of brown.
• Light brown drops, transparent, smelling of wood.

Storage conditions: the drug must be stored in a dry, dark place. Keep away from children, protect from light, avoid dampness, recommended temperature is not higher than 24-25 C. The drug is valid for 3 years from the date of release.

Dispensing conditions from pharmacies and price:

• produced by the Bioronica SE plant, registered in Germany;
• available without a prescription;
• can be purchased both in regular pharmacies and online pharmacies;
• price in drip form - varies between 290 - 420 rubles;
• tablet form from 330 to 380 rubles.

Doctors and pharmacists about Klimadinon

The quality and high effectiveness of the drug CLIMADINON® were appreciated by a professional audience. Their loyalty to the brand is formed thanks to visits from medical representatives, memories of which demonstrate stable positive dynamics. Thus, at the end of 2011, the total number of memories of doctors and pharmacists about promotions of medical representatives for the drug CLIMADINON® increased by more than 50% (Fig. 6). Based on the results of the first quarter. this year, the total number of his appointments/recommendations by the professional audience increased by 29.4% (Fig. 7).

Rice. 6

The number of memories of doctors and pharmacists about visits by medical representatives to promote the drug CLIMADINON based on the results of 2010–2011. indicating the growth rate compared to the previous year

Rice. 7

The number of memories of doctors and pharmacists about the prescriptions/recommendations of the drug CLIMADINON based on the results of the first quarter. 2011–2012, indicating the growth rate compared to the previous year

Drug interactions

Such drug interactions can only be prescribed by a doctor under his own supervision.
There is no information about the interaction of the drug Klimadinon in the instructions from the manufacturer.

It has been established that when combined with other products that contain estrogen, they enhance each other’s effects.

Many patients are interested in whether it is possible to use Klimadinon and Mastodinon at the same time, since both drugs are prescribed for mastopathy and have the same effect, their independent use is not recommended.

Sales of KlimadinonA in various retail outlets

There is no seasonality in the sale of CLIMADINON, therefore, pharmacies should have approximately the same amount of inventory of the drug, regardless of the time of year. When forming inventory, you should take into account a number of external and internal factors that influence the needs and sales capabilities of retail outlets, including their format - pharmacies, pharmacy kiosks and pharmacy points, and their financial characteristics. The market potential of CLIMADINON can be assessed by analyzing the dynamics of its sales in various types of retail outlets (pharmacies, pharmacy kiosks and pharmacy points), grouped according to their financial characteristics. Data for February and the first quarter were used as the analyzed period when calculating the volume of pharmacy sales of the drug CLIMADINON® and the monthly sales of pharmacies. 2012 Minimum number of CLIMADINON® packages sold in retail outlets with different turnover in February and based on the results of the first quarter. is 1 (Fig. 8 and 9). The average number of packages sold is comparable to the minimum and ranges from 1 to 2. The maximum number of packages sold of the CLIMADINON® brand varies depending on the average turnover of the outlet. In February 2012, this figure was in the range of 3–15 packages and in the first quarter. — 4–15. At the same time, the maximum number of CLIMADINON packages sold in different retail outlets is uneven. In one outlet with a profit of 400–600 thousand UAH. in February 2012, 6 packages of the drug were sold, and in the first quarter. - 9 (see Fig. 8). At the same time, with a profit of 600–800 thousand UAH. the maximum number of sold packages of the CLIMADINON® brand was lower - 5 packages in February, and in the first quarter. - 8.

Rice. 8

Minimum, average and maximum number of CLIMADINON packages sold in various retail outlets, grouped by financial characteristics, in February 2012.

Rice. 9

Minimum, average and maximum number of CLIMADINON packages sold in various retail outlets, grouped by financial characteristics, in the first quarter. 2012

PS

Warm spring notes can prevent the awakening of a romantic mood in women suffering from menopausal syndrome. It would seem that menopause is not such a serious illness, and a woman can cope with it on her own, using her own strength. But why suffer from insomnia, be irritable and waste precious moments of spring awakening, if you can see a doctor, buy medicine and fully enjoy the delights of spring, and then, already in a positive mood, prepare for the main event of the coming summer - a resort vacation.

Today, herbal preparations can be an alternative to hormonal therapy for menopausal syndrome. Herbal medicines have found their niche of application in many areas of medicine (therapy, surgery, dentistry, ophthalmology, etc.); in gynecology they are used to treat menopausal syndrome, accompanying conditions, as well as other nosologies. CLIMADINON®, , is popular among consumers . The effectiveness of its use and favorable safety profile have been proven by clinical studies. He is trusted by a professional audience - doctors and pharmacists, as evidenced by the increasing number of their prescriptions/recommendations. CLIMADINON® is successfully developing in the market and demonstrates advanced development in its competitive environment. In general, these factors act as the best guarantor of the further promising market development of the drug CLIMADINON® .

Oksana Sergienko

medicinal properties of black cohosh

The main active ingredient of the drug CLIMADINON® is extract of black cohosh rhizomes. Black cohosh extract contains organoselective and highly specific phytoestrogens with a pronounced dopaminergic, estrogen-like and organoselective effect on the female body. The active substances in black cohosh extract have an affinity for estrogen receptors in the hypothalamus. When these receptors are stimulated, the release of luteinizing hormone releasing factor decreases with a further decrease in the secretion of luteinizing hormone in the anterior pituitary gland.

Composition of the drug

The main active ingredient of the medicine is the rhizome of cohosh (Cimicifuga racemosa), also called Black cohosh. The results of numerous studies show that the components of these rhizomes act through estrogen receptors and are their modulators, without affecting the vaginal epithelium and endometrium.

Since this medication is available in three different forms, its composition is relatively different:

1. Klimadinon tablets. The main substance is cohosh extract at a concentration of 20 mg per 1 piece. Additional substances are potato starch, calcium hydrogen phosphate dihydrate, talc, yellow and red iron oxide, titanium dioxide, sorbic acid, macrogol 6000, ammonium methacrylate copolymer, ethanol.
2. Klimadinon UNO tablets. The main substance is cohosh extract at a concentration of 32.5 mg per 1 piece. Excipients are potato starch, corn starch, calcium hydrogen phosphate dihydrate, magnesium stearate, yellow and red iron oxide, titanium dioxide, sorbic acid, macrogol 4000, hypromellose, sodium carboxymethyl starch, lactose monohydrate.
3. Klimadinon drops. The main component is liquid cohosh extract in a concentration of 12 g. per 100 gr. Excipients are 96% ethyl alcohol, peppermint oil, pure water, sodium saccharinate dihydrate.

Considering that the composition of Klimadinon is plant-based, one can note its very gentle effect on the body in comparison with other medications in this group.

CLIMADINON®: effect on bone metabolism

The use of CLIMADINON helps to increase bone mineral density (BMD), which is confirmed by the results of the study (Table 2). An increase in this indicator indicates a decrease in the risk of developing osteoporosis. Also, according to other studies, the use of CLIMADINON demonstrated a positive effect on the level of bone turnover markers and femoral bone mineral density (Wuttke W. et al., 2006).

*Significance difference relative to the control group

**The difference is significant between subgroups