Mifolian is a drug used for medical abortion.

Mifolian is a drug (tablets) that belongs to the group of sex hormones and modulators of the reproductive system. The instructions for use highlight the following features:

How to dissolve vascular plaques, normalize blood circulation, blood pressure and forget the way to the pharmacy

• Sold only with a doctor's prescription
• When breastfeeding: contraindicated
• For liver dysfunction: contraindicated
• If renal function is impaired: contraindicated

Pharmacodynamics and pharmacokinetics

Mifepristone is an antagonist of the hormone progesterone at the receptor level. The substance replaces progesterone on specific receptors through a competitive mechanism, eliminating the decidua of the uterus.

The ability of the myometrium to contract increases, the membrane becomes more sensitive to progesterone, the fertilized egg is evacuated from the uterus and the decidual membrane is desquamated.

The drug promotes termination of pregnancy, leads to regression of myomatous nodes dependent on the activity of progesterone.

After oral administration in the recommended therapeutic dosage, the active substance quickly enters the systemic circulation, its bioavailability is about 70%. The drug has a high degree of binding to plasma proteins (up to 98%). The metabolism of the drug highly depends on the individual characteristics of the patient. The half-life is about 18 hours, metabolites are excreted in feces and urine.

Mifolian - description of the drug

Mifolian is a synthetic steroid with antiprogestogenic effects. Used for medical abortion. The medicine is produced in tablet form. The average price of Mifolian in pharmacies at residential complexes is about 1100-2890 rubles.

The antiprogestogenic drug is produced by the Chinese pharmaceutical company Shanghai Hualian Pharmaceutical.

Compound

The active component of the drug is mifepristone. Auxiliary elements are lactose and starchy compounds, magnesium stearate and hypromellose, as well as sodium carboxymethyl starch. Mytholian tablets are light yellow in color and round in shape. They are placed in blisters of 1 or 3 pieces. The package contains one blister.

Operating principle

Mifepristone, which is the active component of Mifolian, is a synthetic substance of steroid origin with antiprogestogenic activity.

It has a blocking effect on progesterone at the receptor level:

• The substance helps eliminate the decidua of the uterine membrane.
• Under the influence of the drug, the contractility of the uterine body increases, and the membrane becomes hypersensitive to the progesterone hormone.
• As a result, the fertilized egg is rejected and evacuated from the uterine body.
• Then the decidua covering the mucous membrane is desquamated.

Under the influence of Mifolian, pregnancy is terminated and myomatous nodular formations, which are progesterone dependent, regress.

After oral administration, the active element of the drug is quickly absorbed into the bloodstream, reaching 70% bioavailability. The metabolism of Mifolian is determined by the individual organic characteristics of the patient. Due to the ability to increase the contractile functions of the myometrial uterine layer, the medication is used to stimulate labor in patients with full-term periods.

Contraindications

The medicine is contraindicated:

• if you are allergic to its components;
• persons suffering from secondary or primary adrenal insufficiency;
• with porphyria;
• after long-term use of anticoagulants or glucocorticosteroids;
• if there are scars on the uterus;
• with anemia (hemoglobin below 100 g per liter);
• people with severe liver or kidney diseases;
• if the patient has lesions of the coronary vessels, cerebral vessels, blood clotting is poor;
• women with severe extragenital pathology, including a history;
• for fibroids whose gestation period is more than 12 weeks;
• patients with severe infectious and inflammatory diseases (with elevated body temperature);
• if intrauterine contraceptives have not yet been removed;
• for eclampsia, preeclampsia, post-term or premature pregnancy.

Women who smoke over the age of 65 should consult a physician before taking the drug.

Mifolian should not be taken if an ectopic pregnancy is suspected, unless the pregnancy has been confirmed clinically or laboratory or occurs after discontinuation of combined oral contraceptives.

Side effects

When using the drug, the following side effects from systems and organs are possible:

• Central nervous system: headache, dizziness;
• Digestive system: diarrhea, vomiting, nausea;
• Allergic reactions: urticaria;
• Reproductive system: disorders of the menstrual cycle, lochiometer, amenorrhea, bleeding from the genital tract, subinvolution of the uterus, exacerbation of inflammatory processes of the appendages and uterus;
• Other: hyperthermia, weakness, pain and discomfort in the lower abdomen.

Instructions for Mifolian (method and dosage)

The drug can be used in the presence of a qualified medical professional. personnel in a hospital setting.

Instructions for use

For abortion, take 600 mg of the drug in the presence of a doctor. It is advisable to take the tablets after meals with water. The patient must be monitored for 120 minutes to avoid the development of undesirable reactions that pose a threat to the life and health of the woman. Usually, 2 days after taking the drug, prostaglandins, Misoprostol, and Gemiprost are additionally prescribed. Also during this period, a sonographic examination should be performed to determine the level of human chorionic gonadotropin to confirm a miscarriage.

To induce labor, it is recommended to take 200 mg of the medicine once. After 2-3 days, the maturity of the birth canal is re-evaluated, and the use of Oxytocin and prostaglandins is indicated.

If emergency contraception is necessary, it is performed within 3 days after unprotected sexual intercourse. Usually 10 mg of the drug is used. It is not recommended to eat food within 2 hours before and after taking the tablets.

For the treatment of uterine leiomyomas, 50 mg of the drug per day is usually prescribed. The duration of treatment is 90 days.

Reviews

In general, patients respond positively to the drug. As a rule, it is more often used for drug interruption. Adverse reactions, according to reviews from those who terminated a pregnancy with Mifolian, are associated with natural bleeding that occurs during an abortion. But in general, the patients’ well-being remains normal, since within a couple of hours after the appointment the woman is allowed to go home.

Doctors note that with a natural abortive reaction to the drug, pain in the uterine area should be of medium or low intensity, sometimes they are cramping in nature. Bloody smear with mucous impurities is also normal.

In general, Mifolian is highly effective, but it should only be taken under the supervision of a doctor, since the reaction to the synthetic hormone can be unpredictable. There were no reviews on the Internet regarding the use of the drug as a stimulant of labor, but doctors consider the drug quite worthy for such a purpose.

It can be difficult to find such a medication in pharmacies, but doctors, knowing about this problem, indicate acceptable mifepristone-based substitutes in the prescription. The video shows the official instructions for using the drug Mifolian:

special instructions

It is strictly forbidden to use the medicine as a permanent method of postcoital contraception.

Almost all women develop vaginal bleeding after taking the medicine.

It is recommended to undergo an ultrasound 2 weeks after using the drug.

If, as a result of treatment with the drug, the pregnancy persists or an incomplete abortion occurs, it is recommended to perform vacuum aspiration and histological control of the resulting material.

Particular caution is required when using the product by women who abuse alcohol and/or smoke more than 10 cigarettes per day.

Analogs

The drug has a number of synonyms that also have mifepristone as an active element. These include:

• Gynepristone;
• Pencrofton;
• Mifepristone;
• Genale;
• Mifegin;
• Miropriston;
• Mifeprex;
• Ginestril, etc.

Similar drugs in the pharmaceutical group include Klimadinon, Angelique, Cyclodinon, Klimadinon UNO.

Features of application

To ensure that Mytholian does not cause negative phenomena, when prescribing it, the indications and contraindications should be strictly observed.

The main indications for taking Mytholian are:

• artificial termination of pregnancy by medication before the 42nd day from the first day of the last menstruation,
• prevention of conception in case of unprotected sexual intercourse or use of a questionable contraceptive agent,
• uterine leiomyoma no larger than 12 weeks of pregnancy,
• stimulation of natural childbirth.

Articles about abortion:

• Abortion pills
• How does an appointment with a gynecologist go?
• Surgical abortion
• Diagnosis of sexually transmitted infections in women
• Diagnosis of gynecological diseases
• Treatment of female diseases
• Pelvic ultrasound
• Vacuum abortion
• Pre-abortion examination
• Medical abortion
• Early abortion
• Late term abortion
• Intrauterine device

Negative effects on the body

• When using mifepristone - headache, discomfort manifested in the lower abdomen, hyperthermia, vomiting, nausea, weakness, dizziness;
• As a result of the therapeutic procedure - exacerbation of inflammatory processes in the uterus and appendages, bloody menstrual-like bleeding from the genital tract, pain in the lower abdomen;
• In case of overdose – adrenal insufficiency.

Mifolian is contraindicated for:

• long-term use of hormonal drugs (glucocorticoids),
• liver or kidney diseases leading to the development of severe renal or liver failure,
• uterine fibroids,
• allergies or hypersensitivity to the components of the drug,
• serious blood diseases, for example, anemia, porphyria, coagulopathy, etc.
• smoking women after 35 years of age due to the high likelihood of developing complications from the cardiovascular system.

It should be remembered that if, after taking Myfolian during a medical abortion, the fertilized egg still remains, the pregnancy will still have to be terminated, since the drug has a teratogenic effect.

Although Myfolian effectively protects a woman from unwanted pregnancy, it is not recommended to be used as a permanent contraceptive. If you use it, you must stop taking NSAIDs, such as paracetamol or aspirin.

Dosage and method of use

Mifolian should be used only in specialized institutions where there is the necessary equipment and medical personnel trained accordingly. The tablets should be used orally. For medical abortion, the following dosage regimen is recommended - in the presence of a doctor, take 3 tablets of 0.2 g at a time. You need to be under the supervision of medical professionals for 2 hours (at least). A woman should undergo an ultrasound 36-48 hours after using mifepristone. After 7-14 days, a clinical examination and ultrasound are repeated, in addition, the hCG level is determined to confirm the absence of pregnancy. If after 2 weeks there is no effect from using the product, then vacuum aspiration is performed, and after that the aspirate is examined histologically.

To prepare for childbirth, as well as for its induction, it is prescribed to take 1 tablet of Mifolian once a day, always in the presence of a doctor. After 24 hours you need to take another tablet. After 48-72 hours, the condition of the birth canal is assessed and, if necessary, the woman is prescribed prostaglandins or oxytocin.

Additional Information

If the desired effect from using Mifolian is not present on the 10-14th day after use (the abortion is incomplete or the pregnancy continues), then the pregnancy must be terminated using another method, because as a result of the use of abortifacient components, the fetus may have developmental defects.

If Mifolian is used in a dose of 2 g, then the woman does not experience any adverse reactions.

Before using the overpayment, general measures accompanying termination of pregnancy should be carried out.

During breastfeeding, you should stop breastfeeding for 2 weeks after taking Mifolian.

How much does Mytholian cost in a pharmacy?

Produces GMP certified tablets. The price of Mytholian in pharmacies starts from 1150 rubles and above.

To avoid risks, the drug should be purchased in specialized institutions:

• Firstly, going there will help you mentally adjust, and if you change your mind, you can always ask the doctor not to perform the intended procedure. In this case, they will only charge you money for the consultation, and you will not have to return the medication.
• Secondly, it is quite difficult to buy a mytholian on your own, despite its low cost. in retail sales, even in large cities of Russia, while it is usually available in antenatal clinics.

Therefore, if you have decided to take action for sure, and time is pressing, turning to specialists is the only right way out. You can leave your review about this drug in the comments below.