Neo-Penotran - instructions for use in suppositories for the treatment of thrush, analogues and price

Women are interested in how to take Neo-Penotran for thrush. Intrusive itching in the vagina that does not give rest, burning, white cheesy discharge are signs of thrush, or candidiasis. These are yeast-like fungi - part of the normal microflora of the body. A strong and healthy immune system prevents them from reproducing. When it decreases against the background of other diseases or when any infection occurs, a favorable flora is created for candida, and they begin to multiply uncontrollably.

Pharmacological properties of the drug Neo-penotran

Neo-Penotran suppositories contain miconazole for antifungal and metronidazole for antibacterial and anti-trichomoniacal action. Miconazole nitrate has a wide spectrum of action, especially effective against pathogenic fungi C. albicans inclusive, as well as against gram-positive bacteria. Metronidazole is an antibacterial drug effective against protozoa, Gardnerella vaginalis and anaerobic bacteria, Streptococci and Trichomonas vaginalis inclusive. Miconazole nitrate is absorbed to a small extent through the vaginal walls (approximately 1.4% of one dose). The bioavailability of metronidazole when administered topically is 20% compared to its bioavailability when administered orally. Miconazole nitrate is not detected in blood plasma during vaginal administration of Neo-Penotran suppositories. The concentration of metronidazole in the blood plasma at steady state reaches 1.6–7.2 mg/ml. Metronidazole is metabolized in the liver. Hydroxymetabolite is the active substance. The time to reduce the concentration of metronidazole by 2 times is 6–11 hours. Approximately 20% of the dose is excreted unchanged in the urine.

Price in pharmacies in Moscow, St. Petersburg, regions

Comparative prices of vaginal suppositories in different regions of the country:

Sales prices for drugs are the same for all regions, but retail prices vary. The reason is that the drugs are produced by different manufacturers, and also have different prices for the active substance, metronidazole, which depends on the country producing it.

The success of any therapy largely depends on the correct choice of medication. Neo-Penotran suppositories have proven their effectiveness in the fight against pathogenic microorganisms, which is confirmed by many reviews from doctors and their patients.

Use of the drug Neo-penotran

The drug should not be used without consulting a doctor. Unless otherwise prescribed by your doctor, 1 suppository should be inserted high into the vagina at night for 14 days, or 1 suppository at night and 1 in the morning for 7 days. In cases of relapse of the disease or lack of positive clinical dynamics during treatment with other methods, 1 suppository should be inserted high into the vagina at night and in the morning for 14 days. The suppository should be inserted high into the vagina using the disposable finger cap included in the same package as the suppositories. For elderly patients (over 65 years of age): the route of administration and dosage are the same. Children: Not recommended for use in children. The suppository should not be swallowed or administered in any other way.

Instructions

Drug therapy is carried out for seven days. One suppository should be administered before bedtime and one suppository in the morning. If an infection of the vaginal mucosa is diagnosed that is resistant to other medications, the doctor may extend the course of therapy to fourteen days. The package contains devices that make it easier to insert suppositories. The indicated dosages are suitable for patients of all ages (over 14 years old.)

Diagnosis is needed before treatment.

Side effects of the drug Neo-penotran

Occasionally, reactions caused by hypersensitivity to the components of the drug (skin rashes), as well as side effects such as abdominal pain, headache, itching, burning and inflammation of the vagina, are noted. The incidence of systemic side effects is very low because metronidazole is very poorly absorbed through the vaginal wall and its plasma concentration is very low (2–12% of the amount taken orally). Miconazole nitrate may cause vaginal irritation (burning, itching), as do other imidazole-derived antifungals administered intravaginally (2–6%). Due to inflammation of the vaginal mucosa during vaginitis, symptoms of irritation (burning and itching of the vagina) may appear after the introduction of the first suppository or on the third day of treatment. These complaints quickly disappear with continued treatment. If severe irritation occurs, treatment should be discontinued. Side effects with systemic (eg oral) use of metronidazole are: reactions caused by hypersensitivity (rare), leukopenia, ataxia, mental disorders, peripheral neuropathy, in overdose and after long-term treatment, convulsions, sometimes diarrhea, constipation, dizziness, lack of appetite, vomiting , nausea, muscle cramps or abdominal pain, occasionally, disturbance of taste, dryness, metallic or unpleasant taste in the mouth, weakness. These side effects are observed very rarely, since the level of metronidazole in the blood serum after intravaginal administration is very low.

What pharmacological properties does the medicine have?

This remedy is a combination drug with pronounced antiparasitic and antimicrobial properties. In modern medicine, it is widely used to treat protozoal and fungal infections. Some bacteria are also sensitive to the active substances of the drug.

Once in the human body, the active components quickly suppress the vital processes of pathogenic microflora. Metronidazole blocks the process of nucleic acid synthesis, which prevents further proliferation of microorganisms. Miconazole has a detrimental effect on fungal microorganisms, as it destroys their cell walls. By the way, the most sensitive to this substance are cryptococci, candida and aspergillus.

Special instructions for the use of the drug Neo-penotran

After the first trimester of pregnancy, Neo-Penotran suppositories can be used if prescribed by a doctor and under supervision. During treatment with Neo-Penotran suppositories, breastfeeding should be discontinued, since metronidazole passes into breast milk. Feeding can be resumed 24–48 hours after the end of treatment. You should be warned that you should not drink alcohol during treatment and for at least 24–48 hours after the end of the course due to the possibility of reactions similar to the effects of disulfiram. The suppository base may interact with the rubber or latex of the vaginal contraceptive diaphragm, so their simultaneous use is not recommended.

Contraindications

Many women begin treatment with suppositories without waiting for test results.

This should not be done because the vaginal medication should not be used under the following circumstances:

• pregnancy in the first trimester;
• virgin pleura;
• impaired hematopoietic functions;
• disorders of the central and peripheral nervous system;
• biliary-hepatic dysfunction, disrupting pigment metabolism, which is characterized by an increase in porphyrins in tissues and blood;
• lactation period;
• sensitivity to drugs: metronidazole, miconazole;
• alcohol and tobacco consumption;
• age up to 14 years.

Interactions of the drug Neo-penotran

Due to the entry of metronidazole into the systemic circulation, the following interaction reactions may occur when used simultaneously with certain substances: Alcohol: the interaction of metronidazole with alcohol can cause a reaction similar to the effect of disulfiram. Oral anticoagulants: may enhance the anticoagulant effect of the drug. Phenytoin: the concentration of phenytoin in the blood may increase, the concentration of metronidazole may decrease. Phenobarbital: the concentration of metronidazole in the blood decreases. Disulfiram: CNS disorders (psychotic reactions) may occur. Cimetidine: Blood concentrations of metronidazole may increase and the risk of neurotic side effects may increase. Lithium: Increased toxicity from lithium may be observed. Astemizole and terfenadine: Metronidazole and miconazole slow down the metabolism of this drug and increase their concentration in the blood plasma. The effect on the blood concentration of liver enzymes, glucose (hexokinase method), theophylline and procainamide was also noted.

How to use Neo-Penotran for candidiasis?

When using antifungal drugs, the ability to reproduce in fungi is suspended, and recovery occurs. In gynecology, antifungal drugs that are derivatives of the imidazole group are successfully used. Neo-Penotran belongs to them.

This drug contains 2 medicinal substances - metronidazole and miconazole.

The first is successfully used in gynecology as an antimicrobial agent. Reviews from patients and observations from specialists indicate that it copes well with such microorganisms as:

• 
  streptococci;

• trichinella;
• Garderella.

And miconazole fights fungi of the genus Candida. Since both microorganisms are usually present with thrush, it is very convenient to use Neo-Penotran.

The drug is available in the form of suppositories, and therefore can only be used to treat thrush in women.

How to use Neo-Penotran for thrush? Treatment with these suppositories lasts 7 days. If the symptoms of the disease do not disappear completely, you can insert suppositories for another week.

It is advisable to lie down for half an hour after inserting the suppository so that the medicine spreads evenly throughout the vagina and does not leak out.

The package usually contains finger guards. They are provided in order to avoid additional infection. Even despite such precautions on the part of the manufacturer, a woman needs to be careful with long nails so as not to injure the vaginal mucosa.

What if you use Neo-Penotran during menstruation? The fact is that doing this is simply useless. During menstruation, the blood flow will wash away the medicine, and the effect of treatment during menstruation will be minimal.

Overdose of the drug Neo-penotran, symptoms and treatment

If a large amount of the drug accidentally enters the digestive system, gastric lavage should be performed. Treatment must be carried out in cases where 12 g of metronidazole has entered the digestive system. There is no specific antidote; symptomatic treatment is recommended. In case of an overdose of metronidazole, the following symptoms are noted: nausea, vomiting, abdominal pain, diarrhea, itching, metallic taste in the mouth, ataxia, paresthesia, convulsions, leukopenia, dark urine. In case of an overdose of miconazole nitrate, the following symptoms are noted: nausea, vomiting, inflammation of the throat and mouth, headache, diarrhea.

Contraindications for use

Despite all the positive qualities of Neo-Penotran, there are some limitations to its use. They are due to the fact that the substance is very easily absorbed through the vaginal mucosa and penetrates the systemic bloodstream.

Persons with allergic reactions to any of the components of the drug should not use these suppositories for thrush.

If the liver is not functioning properly or is overloaded with other medications, it is not recommended to use Neo-Penotran suppositories.

These suppositories for thrush should not be used during pregnancy (especially in the first trimester) and breastfeeding, as the substance can reach the fetus and affect its development. If there is an urgent need for treatment with this drug, the woman should stop feeding the baby for the entire period of therapy and for several days after it.

If the menstrual cycle is irregular, then a delay in menstruation should alert you. A special test should be performed. During pregnancy, you need to stop treatment and immediately consult a gynecologist.

It is dangerous to use Neo-Penotran in women suffering from candidiasis, prone to seizures or suffering from epilepsy.

Long-term use of metronidazole changes the composition of the blood. Therefore, if side effects occur, treatment with this drug should be stopped.

Metronidazole is not used to treat girls under 16 years of age.

What side effects may occur in the body after using Neo-Penotran:

• vaginal swelling, itching, rashes;
• headache;
• changes in taste (a peculiar metallic taste may appear in the mouth);
• convulsions;
• diarrhea or constipation.

If such manifestations do not last long, then complications will not follow.
If side effects last for a long time (2 days or more), the drug is discontinued. Neo-Penotran Forte suppositories are used for complicated forms of thrush. They differ from regular Neo-Penotran in that they contain a double dose of active ingredients. In any case, it should be selected by a gynecologist, based on the severity of the disease.

Neo-Penotran forte L differs from the previous ones by the addition of lidocaine, which has an anesthetic effect. If thrush is accompanied by pain or discomfort, then a woman can use this form of suppositories.

Contraindication is individual intolerance to lidocaine.

What is important to know? Sexual intercourse should be excluded for the entire duration of treatment.

Both partners must undergo treatment, otherwise the infection may recur.

A condom may break under the influence of these drugs, and unnecessary irritation of the inflamed vaginal mucosa will only worsen the disease.