Klion D vaginal tablets: instructions for use and what they are needed for, price, reviews, analogues

Very often, the female body becomes vulnerable to pathological processes that are caused by pathogenic microflora. Vaginal Trichomonas, fungi of the genus Candida can cause serious diseases, which are accompanied by pain and itching.

They create a risk of infecting a sexual partner, and at the time of birth they can infect a newborn. To eliminate these pathologies, medications are prescribed in the form of suppositories, which are used topically in gynecology and are called Klion-D.

Compound

Klion-D vaginal tablets contain the following components in equal proportions:

1. Metronidazole (a drug that suppresses bacterial microflora and has an antiprotozoal effect).
2. Miconazole (antifungal agent)

Additional components included in this substance include:

1. Silicon Acid.
2. Magnesium sterate.
3. Monohybrid lactose.
4. Povidone.

These additional ingredients ensure good absorption and tolerability of this drug.

What kind of drug?

Klion-D 100 are biconvex white suppositories for vaginal use. On one side there is an engraving “100”. The shape is oval with a pointed tip for ease of intravaginal insertion. The therapeutic effect of the combined drug is due to the active substances (metronidazole, miconazole) in the composition:

• improves 5-nitro groups inside infection cells;
• blocks RNA and DNA synthesis;
• provokes the death of anaerobic microbes, trichomonas, yeast fungi and dermatophytes, without modifying the pH, acidity, and normal vaginal microflora.

Klion-D is often prescribed after the first trimester of pregnancy for thrush. Reviews about the use of candles are mostly positive.

Pharmacological effects of Klion-D

Due to the fact that this drug optimally combines two potent dosage forms, the therapeutic effect in the treatment of fungal pathologies of various origins is achieved very quickly.

1. Miconazole affects pathogenic microflora at the cellular level , it destroys their membrane, after which they lose their ability to reproduce and the microorganisms die. The good qualities of this ingredient include the extent to which its use does not increase the concentration in the human bloodstream.
2. The maximum peak of its effect is observed 8 hours after a single use.
3. The good therapeutic effect of metronidazole is based on the ability of this chemical compound to penetrate the DNA structure of microorganisms, this disrupts the process of cell division, inhibits their growth, and prevents them from reproducing.
4. After the period of treatment with Klion-D has expired , its half-life products are excreted along with the urine (the color of the urine may change to brown or reddish).

Pharmacokinetics and pharmacodynamics

Metronidazole is quickly absorbed into tissues through the mucous membranes of the vagina, then into the systemic circulation. Reaches maximum concentration in the blood (approximately 50% of the administered dose) after 6-12 hours. It is broken down and oxidized in the liver. It is excreted mostly by the kidneys, forming a water-soluble pigment during metabolism, which is why the urine turns reddish-brown. The degree of excretion through the intestines is insignificant (no more than 15%). Communication with plasma proteins – up to 20%.

Miconazole, as the second active substance, accumulates in the vagina gradually, up to 90% of the taken therapeutic dose after 7-8 hours. But its systemic absorption with intravaginal local administration is weak. 8 hours after administration, most of the substance still remains in the vagina, then is quickly destroyed in the liver. The substance does not penetrate the kidneys and blood. This means that it is not detected in urine and blood plasma unchanged.

The active components in tandem begin to affect the vaginal microflora. Metronidazole exhibits antimicrobial and antiprotozoal properties, restores 5-nitro groups at the biochemical level, interacts with DNA cells of anaerobic microorganisms and protozoa, provoking their death. Its antifungal and bacteriostatic activity has been proven by studies against many strains of gram-negative and gram-positive microorganisms. In particular, in combination with antibiotics in case of detection of mixed flora (aerobes, facultative anaerobes), acting against infection according to a synergistic principle.

Miconazole nitrate reduces the biosynthesis of ergosterol and lipid components in the membrane of yeast fungi and dermatophytes. It has an exclusively antifungal effect. It also helps prevent vaginal mycosis, which often develops in women during long-term treatment with metronidazole.

Mode of application

Before using Klion-D vaginal suppositories, you must perform the following procedure:

1. A woman is recommended to do a good wash. In this case, it is necessary to use soft soapy substances that do not disrupt the normal acid-base balance. For this purpose, you can use a gel that does not contain dyes, or soap for children.
2. After this, the hands, especially the nail phalanges, must be treated with an alcohol-containing solution using a cotton swab.
3. Before inserting a vaginal suppository, you must take a lying position , moisten it in cool water, and insert it with the pointed end as deeply as possible into the vagina.

All these manipulations must be done quickly, since under the influence of the warmth of human hands, suppositories can lose their shape and consistency.

The use of Klion-D suppositories may be accompanied by an increase in vaginal discharge. This is not a dangerous sign, but the resulting stains on laundry can create problems during washing. To prevent this from happening, women are recommended to use sanitary pads throughout the course of treatment.

Method of use of the combination drug

You already know that the medicine is inserted into the vagina. The dosage of the medication is determined by the doctor. Usually prescribed 1 tablet per day. The course of treatment must be at least 10 days. Before administering the product, wash your hands well. Remove the tablet from the seal and hold it under running water for a few seconds. After this, take a comfortable position and administer the drug. The use of the medication in pregnant women does not imply a reduction in the dose or duration of therapy. The instructions do not recommend using the medicine only in the first trimester. Doctors say that the medication does not have a teratogenic effect on the fetus if doses are observed in the second and third part of pregnancy.

Indications for use

Gynecological infection is the main area of ​​application of Klion-D.

He is appointed:

• When infected with Trichomonas.
• In the case of candidal infections with a fungus of the genus candida.
• Vaginitis of various etiologies.
• Gardnerellosis.

Use of Klion-D suppositories during pregnancy

During the first trimester of pregnancy, the formation and formation of the internal organs of the future newborn occurs. Therefore, during this period, the use of candles should be avoided.

During subsequent pregnancy, the use of the drug is possible. But before this, the doctor carefully weighs all the pros and cons of this drug. Its appointment occurs in extreme cases, when a woman in labor really needs to eliminate the pathology that is caused by fungal microflora.

Also, Klion-D vaginal suppositories can be used before childbirth to cleanse the birth canal of pathological mycelium. This helps prevent infection of the newborn.

The ingredients of Klion-D suppositories pass into breast milk in small quantities, which makes it impossible to use this medicine. If an appointment nevertheless occurs, breastfeeding is temporarily stopped.

Using Klion-D for thrush

The course of treatment for this pathological disease should not exceed ten days. The recommended dose is a single use of vaginal suppositories before bedtime. Treatment is not carried out in the morning.

After 1 month, if necessary, the course of treatment can be repeated. If treatment is ineffective, a laboratory test must be performed.

Make a bacterial culture of vaginal contents and establish the tolerance of a drug that can resist bacterial microflora.

Use for trichomoniasis

The course of treatment, dosage, and method of application are exactly the same as for the treatment of thrush. It is also possible, if necessary, to extend the course after a month.

Use during menstruation

During the menstrual cycle, women experience bleeding from the vagina.

If you put a suppository with this drug at this time, it may partially dissolve in them, and as a result, it makes no sense to treat the disease, since its therapeutic effect is reduced, which leads to an incomplete cure from the pathological process of the disease.

It is necessary to interrupt the course of treatment for the entire period of menstruation, and after it ends, resume it again.

Use of Klion-D for kidney and liver diseases

As noted earlier, Klion-D suppositories are not prescribed for severe liver damage (cirrhosis, hepatitis of various etiologies).

Renal failure, in the final stages, also precludes the use of this drug.

Possible complications and consequences

As mentioned above, often when undergoing medical therapy, women notice discharge after Klion D, which frightens them very much. In this case, most often patients complain of the presence of bloody, pink, white, yellow or green discharge from the genital tract.

But it should be said right away that this drug does not have any effect on hormonal levels and does not contribute to disruption of the vaginal microflora, and therefore its use simply cannot provoke the appearance of premature menstruation or the appearance of discharge associated with a violation of the acid-base balance in the vagina.

Since Klion D is used to treat infectious and inflammatory diseases, the appearance of vaginal discharge is quite natural, and many women detect it even before taking the drug.

Bloody issues

Bloody discharge during the use of vaginal tablets is quite often associated with inflammation of the cervical canal, in which the walls of the vessels begin to lose their elasticity and become prone to damage. Moreover, the appearance of bloody discharge may be associated with the development of tumor diseases or hormonal disorders that a woman already has (they can occur both against the background of pathologies of the reproductive system and disturbances in the functioning of the endocrine system). Therefore, the occurrence of such discharge is not a reason to stop therapy, but a doctor’s consultation will still be required.

Pink discharge

Pink discharge during the course of treatment is also not a reason to refuse further use of Klion D. Their appearance may also be associated with decreased vascular tone or erosive lesions of the cervix.

It is worth noting that pink and brown discharge often appears due to mechanical damage to the mucous membranes in the vagina due to improper administration of tablets. If there are no abdominal pains or other unpleasant symptoms, then there is also no cause for concern.

It is necessary to study the instructions in more detail, paying special attention to the method of introducing the drug into the vagina

White curd discharge

The appearance of copious white discharge after Klion, similar in appearance to cottage cheese, emitting an unpleasant sour odor and provoking the appearance of itching and burning in the intimate area, indicates the development of candidiasis. In this case, you should also not stop using Klion D tablets, since they, on the contrary, will help suppress the growth of Candida fungi, which are the causative agent of this disease.

Yellow discharge and leucorrhoea

Abundant yellow discharge and leucorrhoea while taking the drug are normal. Their appearance is caused by the removal of excess tablets from the vagina, which is why the mucous secretion turns yellowish or white.

Green discharge

Green discharge is always a sign of the development of infectious diseases in the organs of the reproductive system. They give off an unpleasant odor and are accompanied by itching and burning in the intimate area.

The appearance of these discharges while taking Klion D indicates the active removal of pathogenic microorganisms from the vagina. But if they continue for 7-10 days after starting to use the tablets, you should also visit a doctor.

Contraindications

Klion-D candles have few restrictions on use. This is due to the fact that they are poorly absorbed into the blood, and their concentration in the body is insignificant.

But it should still not be taken in the following cases:

• Pronounced leukopenia.
• Acute form of renal or liver failure.
• Severe forms of epilepsy, which are accompanied by frequent seizures and convulsions.
• Pathological processes leading to disruption of the central nervous system.
• The disease results from impaired blood circulation.
• Forms of diabetes mellitus at the last stage.
• The appearance of an allergy and its symptoms to any ingredients of vaginal suppositories.
• It is unacceptable to carry out therapy with these suppositories while simultaneously taking alcohol, since alcohol significantly reduces the effectiveness of using Klion-D.

Side effects of Klion-D

Compared to other drugs of this pharmacological group, Klion-D suppositories are considered low-toxic and cause few side effects.

Sometimes the following symptoms may appear:

• The appearance of local discomfort. The patient may experience redness, a feeling of the presence of a foreign body in the vaginal area, the genitals may be very itchy, burning, and swelling of the genitals.
• Increased vaginal discharge.
• Sometimes severe migraines occur.
• On the part of the digestive system , taste disturbances, dryness of the mucous membranes of the oral cavity, nausea, cramping pain in the lower abdomen, increased gas formation, and diarrhea may be observed.
• on the skin , and in very severe cases, but extremely rarely, Quincke's edema can develop.
• The blood formula and the color of urine may change.

Overdose

When using Klion-D suppositories, the appearance of overdose symptoms is reduced to almost zero.

But if the drug is taken for a very long time, and the patient has a history of allergic reactions, then the body may be poisoned by this medication.

Also, the clinical picture of overdose may appear if additional, oral use of metronidazole occurs in the treatment of pathological conditions.

Patients experience:

• Nausea, which is accompanied by vomiting, and a metallic taste appears in the mouth.
• There may be pain on palpation of the liver.
• In rare cases, seizures and paresthesia may occur.
• The most severe manifestation of an overdose is the appearance of Quincke's edema or anaphylactic shock.

At the first signs of an overdose, the patient must:

1. Rinse the stomach using a sufficient amount of water, at least 2 liters.
2. Cleanse the intestines. To do this you need to give an enema.
3. Be sure to take enterosorbent, it can be Polysorb, Enterosgel, Sorbex, white activated carbon.
4. It is advisable to put the patient to bed and, due to dehydration, give a warming drink.

If the symptoms of an overdose do not disappear, it is advisable to contact a medical facility.

Oronazole tablets

The active ingredient in these pills is ketoconazole. The drug belongs to antifungal agents. But he is unable to cope with the bacterial infection. This distinguishes it from the “Klion-D” product, the price of which was stated in the article.

The indication for use of the medication is thrush and other fungal pathologies of the female genital tract. The medication is not used for liver and kidney diseases, during pregnancy and lactation, as well as in young children. Note that Oronazole is available only in the form of tablets for oral administration. You will not be able to purchase candles. The prescription of the medication and the selection of the dose are made by the doctor in accordance with the instructions.

Action with alcohol

This medicine cannot be combined with the use of alcohol.
Alcohol suppresses the effect and positive effect of Klion-D suppositories, and also, in tandem with this medicine, has a negative effect on the liver.

And very often it can cause increased side effects, ultimately serving as a reason to discontinue this medication.

Sometimes, under the influence of alcohol, a patient may experience a disulfiram-like reaction.

It is accompanied by the appearance of acute, paroxysmal pain in the lower abdomen, the occurrence of uncontrollable vomiting, the appearance of headaches, and sudden flushes of heat and blood to the face.

special instructions

To prevent unwanted side effects, you must follow certain rules when using this drug:

• If there are clear contraindications, then the use of suppositories is excluded.
• Concomitant use with alcoholic beverages is not allowed.
• When breastfeeding, young mothers are advised to take a break if this drug is prescribed.
• Combining this medicine with antibacterial therapy requires special care to avoid unwanted side effects.
• If anticoagulant therapy occurs simultaneously, treatment should be carried out under the supervision of a doctor. This will avoid sudden bleeding.
• Be careful when driving vehicles. Since this drug can influence a person’s reaction and behavior in emergency situations.

A good, correct effect from the use of Klion-D suppositories can only be achieved if all the rules and regulations for their use are followed.

Therefore it is necessary:

1. If treatment is prescribed, the instructions provide for therapy of the sexual partner. Otherwise, re-infection may occur.
2. During treatment, if work is associated with complex automatic processes, it is better to abstain from it; you must take sick leave for the entire period of treatment.
3. Having sex during therapy is unacceptable.
4. It is imperative to monitor, with the help of laboratory tests, the clinical state of the blood (monitor the number of leukocytes and the state of the leukocyte formula).

Is it possible to have sex while treating thrush with the drug?

It is better to avoid intimacy while using suppositories. In principle, even if thrush or another type of inflammation of the genital organs is detected, it is worth interrupting sexual relations and returning to them when treatment is successful. If signs of the disease also appear in a sexual partner, then treatment should be simultaneous. Simply refusing to be close to your partner will not save you.

The drug can give side effects that do not contribute to the development of libido, which will protect the patient from rash actions, even if she does not know that sex is prohibited during the treatment period.

Interaction

Klion-D suppositories are often used in combination with other medications:

• A good effect is observed when they are combined with antibacterial therapy , broad-spectrum antibiotics, and sulfonamides. However, the route of drug administration may be different.
• If taken simultaneously with Disulfiram, side effects may occur, which manifests itself in the form of impaired consciousness. There is no compatibility between these drugs.
• The use of suppositories is contraindicated in cases of use of muscle relaxants.
• Drugs that prevent blood clotting (anticoagulants) can increase the prothrombin index, which provides grounds for reducing their dose.
• A group of pharmacological agents that can enhance microsomal oxidation in the liver (finitol, phenobarbital) are not combined with taking Klion-D suppositories, as they help reduce their effectiveness.
• Cimetidine can significantly reduce the elimination of metronidazole components, as a result of which this leads to the development of side effects.
• Vaginal suppositories Klion-D significantly increase the level of lithium in the blood ; therefore, it is advisable to reduce their dosage or completely eliminate it.
• In the case of treatment of pathological processes with these drugs, it is undesirable to concurrently use and use local antiseptics and solutions that are used for douching. This combination of drugs can suppress the positive effects of vaginal suppositories.

general information

Klion D 100 is a broad-spectrum drug that has the following properties:

• antibacterial;
• antiseptic;
• antifungal;
• anti-inflammatory;
• regenerating;
• antiprotozoal.

The drug is available in the form of tablets and suppositories for intravaginal use; they dissolve quickly and begin to exert their therapeutic effect almost instantly. Its high effectiveness is due to the presence of substances such as metronidazole and miconazole. Each of them has its own characteristics.

For example, metronidazole, even when used vaginally, is quickly absorbed into the systemic bloodstream and remains high in it for 6-12 hours. Through the bloodstream, metronidazole penetrates into all structures of the female body - mammary glands, placenta, brain and spinal cord. However, it must be said that when using vaginal tablets, its effect on these structures is two times lower than when taking metronidazole orally.

Once this substance passes through the body, it enters the kidneys and most of it is excreted along with the urine, turning its color reddish or brown. The rest of metronidazole is excreted in the intestines along with feces. At the same time, it is metronidazole that suppresses the growth of protozoan microorganisms and bacteria.

Miconazole does not have the ability to be absorbed into the bloodstream, and therefore does not affect either the composition of the blood or the composition of urine. It acts directly on the vaginal mucosa, having a detrimental effect on fungal-like microorganisms (has an antifungal effect) for another 8-10 hours after administration.

Thanks to the properties of metronidazole and miconazole, Klion D suppositories have found their use in the treatment of pathogenic microorganisms such as:

• Candida fungi;
• trichomonas;
• amoeba;
• guardia;
• Garderella;
• bacteroides;
• fusobacteria;
• prevotella;
• vilonella;
• peptococci;
• clostridia, etc.

Analogs

There are a very large number of substitutes for the drug Kliona-D.

They can be conditionally divided according to their chemical composition. That is, have an identical chemical composition, or be based on an ingredient that, in the instructions for use, will be similar in action to candles with Klion-D.

Let's consider several analogues:

1. Metromicon Neo. Its composition almost completely corresponds to the components of Klion D. It has a wider spectrum of action, as a result of which it can replace the drug Klion D in the treatment of amebiasis and giardiasis, pathological processes that are caused by anaerobic infection.
2. Vagiferon. This drug has indications similar to Klion-D, but unlike it, it is active against mixed infections, herpes simplex virus, mycoplasma. Contraindications mainly apply to pregnant women and girls under 18 years of age.
3. Metrovagin. A medication based on metronidazole, with a pronounced antibacterial and antimicrobial effect. The main condition for achieving the full therapeutic effect is use by both sexual partners and complete abstinence from sexual intimacy for the entire period of treatment. The medicine is available only in the form of ointment, helium or vaginal suppositories. Its big disadvantage is its many contraindications.
4. Vagisept. A good analogue, with a good chemical composition (Fluconazole, Metronidazole).
5. Genisol. A medicine containing miconazole nitrate (100 mg). Effective against gram-positive microorganisms and fungal infections. Not used in the second and third trimester of pregnancy. Renal failure is a reason to discontinue the drug.
6. McMiror. It is a good remedy for the treatment of pathologies caused by vaginal trichomonas or candida fungus. Its use is limited only to cases of hypersensitivity. This is the main criterion when the drug is contraindicated. In some cases, instead of suppositories, you can use vaginal cream, which is sold along with a convenient applicator.

McMirror

Metromicon Metrovagin

Vagiferon

Vagisept

Ginesol
In any case, you should adhere to the prescription made by the doctor. But sometimes, due to financial problems, it is impossible to buy medicine in this price category. In this case, you can use cheaper substitutes.

These include:

• Difluzol (price does not exceed 70 rubles ).
• Itrakon ( 100 rubles ).
• Econazole ( up to 90 rubles ).
• Polygynax ( 90 rubles ).
• Pimafucin ( up to 150 rubles ).
• Santequin ( no more than 130 rubles ).

Itracon

Pimafucin

Polygynax

Santequin

Difluzol

Main settings

Klion D suppositories have antifungal, antibacterial, and antiprotozoal effects. The main active component is metronidazole, the action of which is to restore the intracellular transport protein of protozoa and anaerobic microorganisms in the process of biochemical reduction of the nitro group. When interacting with DNA cells, the reduced 5-nitro group begins to have an inhibitory effect on nucleic acids, which leads to the death of various microorganisms. Also, at the same time, the active substance begins to suppress ergosterol in fungi, affects changes in the composition of various lipid components in membranes, which leads to the disappearance of fungal infections.

The active substances of the drug are absorbed into the systemic circulation. Approximately 8-12 hours after use, the maximum cmax in the blood is observed, after a single use. It is excreted from the body unchanged and is not found in feces or blood plasma.

The drug has a wide spectrum of action, as it is active against most microbes and fungi, in particular: Eubacterium, Trichomonas vaginalis, Peptostreptococcus spp, Entamoeba histolytica, Clostridium spp, Lamblia intestinalis, Fusobacterium spp, Bacteroides vulgatus, Peptostreptococcus spp and many others . Insensitive to facultative anaerobes.

Has a wide spectrum of antifungal action. When applied, unpleasant itching caused by dermatophytes or yeast is eliminated as quickly as possible. There is no change in the normal pH level of the vagina, as well as the natural microflora of the vagina.

Indications for the use of Klion D suppositories

• For local treatment of vaginal infections;
• For inflammatory and infectious diseases of the vagina, which are caused by various anaerobic bacteria and fungi;
• For preventive purposes after surgery, to prevent the occurrence of infectious diseases in the pelvic organs;
• Trichomonosis.

The course of treatment is prescribed depending on the nature of the disease. Suppositories are inserted once a day, deep into the vagina, before going to bed. The course of treatment usually does not exceed ten days. In severe forms of infection, simultaneous treatment with Klion D tablets or solution is prescribed.

Possible side effects

• Mucous discharge that has no odor;
• Burning or itching in the vagina;
• If you are intolerant to the drug, allergic reactions manifest as skin rashes, urticaria;
• Frequent urination;
• The sexual partner may experience irritation of the penis during sexual intercourse;
• Rarely – headaches;
• Leukopenia;
• Extremely rare - changed urine color (brown-red color, which changes due to the metabolism of metronidazole and the presence of pigment).

Contraindications for use

• In case of microcirculation disorders;
• In case of individual intolerance to derivatives and main components of the drug;
• History of leukopenia;
• In childhood;
• In the first trimester of pregnancy;
• With impaired coordination of movements;
• During the lactation period;
• In acute form of liver failure;
• For various blood diseases.

When treated with Klion D suppositories, treatment of the sexual partner is also prescribed to avoid re-infection, regardless of whether he has signs of the disease or does not have them. While using the medication, you should refrain from sexual intercourse.

For longer courses of treatment, blood tests may be necessary for medical reasons.

During the onset of the menstrual cycle, treatment with a drug of this group is suspended; treatment with similar tablets is possible, but after the recommendation of the attending physician.

The drug is not prescribed to children under the age of eighteen; there is a special form of the drug in the form of a solution for internal use.

Price

In the pharmacy chain, this medicine has a cost that ranges from 270 to 500 rubles for 10 pieces. Candles are produced in cardboard packaging. They are accompanied by an annotation on the use of this medicine.

Substitutes can be purchased at the following prices:

1. Neo-Penotran in the amount of 14 candles can be purchased for 930 rubles.
2. A Metrovagin pack with ten suppositories will cost from 420 to 500 rubles.
3. Metromicon-Neo. The cardboard packaging contains 2 blisters of 7 pieces. The price of this dosage form does not exceed 450 rubles.

The price in a pharmacy is higher than in an online store.

But this does not mean that when purchasing a medical drug outside a pharmacy network, you will be provided with insurance that will allow you to avoid purchasing a counterfeit.

Therefore, it is recommended to buy medicines only in a pharmacy chain; to confirm their quality when purchasing from a pharmacist, you can ask for a certificate.