Omacor - instructions for use of capsules, indications, side effects, analogues and price

Omacor tablets

The drug Omacor belongs to the group of anti-sclerotic agents based on eicosapentaenoic and docosahexaenoic acids, which are Omega-3 acids. They regulate glyceride and lipid levels, helping to prevent the risk of myocardial infarction and other diseases associated with triglyceride concentrations. Omacor has its own application characteristics.

Composition of the drug Omacor

The drug is available in the form of transparent gelatin capsules containing a yellowish oily liquid. They are packaged in polyethylene bottles of 28 and 100 pieces. The composition of the contents of the capsule and shell is presented in the table:

Pharmacodynamics and pharmacokinetics

The drug reduces triglyceride levels by reducing the concentration of very low density lipoproteins (VLDL), as well as actively influencing hemostasis, reducing the synthesis of thromboxane A2. The medication inhibits the synthesis of triglycerides in the liver, since docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) suppress the esterification (reaction of ester formation) of fatty acids, interact with the enzymes creatine phosphokinase (a participant in the process of energy metabolism) and lactate dehydrogenase (a participant in the formation of lactic acid) .

A decrease in triglyceride levels is affected by a decrease in the level of free fatty acids, which are involved in the synthesis of triglycerides. Medical statistics show that patients taking 1 g of the drug per day significantly reduce the risk of mortality, stroke and non-fatal myocardial infarction. Omega-3 fatty acids are absorbed in the small intestine and metabolized in three ways:

1. They are transported to the liver, where they become part of various categories of lipoproteins and replenish peripheral lipid reserves.
2. Phospholipids of cell membranes are replaced by phospholipids of lipoproteins, fatty acids are precursors of eicosanoids.
3. Most fatty acids undergo β-oxidation to meet the body's energy needs.

Indications for use of Omacor

The drug is recommended by cardiologists as a therapeutic agent for angina pectoris. Direct readings:

• Prevention of secondary myocardial infarction in combination therapy with other standard treatments: antiaggregation drugs, statins, angiotensin-converting enzyme (ACE) inhibitors, beta-blockers.
• Endogenous hypertriglyceridemia type IV in the form of an addition to a lipid-lowering diet, provided that it is of low effectiveness.
• Endogenous hypertriglyceridemia type ll b or type III in combination with statin inhibitors, if triglyceride levels are unsatisfactorily controlled by the use of statins.

Composition and release form

The drug is available in capsule form. They are packaged in a plastic bottle of 28 or 100 pieces. The shell is straw-yellow in color, the contents are transparent.

Table 2 - Composition of the drug Omacor

special instructions

Patients over 70 years of age, people with impaired liver function, hemorrhagic diathesis, surgical interventions or severe injuries should take the medication with caution. Due to the effect of large doses on bleeding time, monitoring of patients diagnosed with bleeding disorders and being treated with anticoagulants is necessary. Patients receiving drugs that affect hemostasis and leukocytes require special attention.

If undesirable side effects are identified when combining the drug with anticoagulants, the dosage of the latter must be adjusted. In some cases, the use of the drug may cause an increase in the activity of aspartate aminotransferase, transaminase and alanine aminotransferase, but there are no precedents for an increased risk of taking the drug in patients with liver dysfunction. The drug can cause dizziness, so increased caution is required when driving.

Special instructions for the use of the drug Omacor

Due to a moderate increase in bleeding time (when using the drug in a high dose, that is, 4 capsules per day), it is necessary to monitor the condition of patients receiving anticoagulant therapy and, if necessary, appropriately adjust the dose of the anticoagulant. The possibility of increased bleeding time should be considered in patients with an increased risk of hemorrhage (due to severe trauma, surgery or other reasons). Omacor is not indicated for the treatment of exogenous hypertriglyceridemia (hyperchylomicronemia type I). The available experience with the use of the drug in secondary endogenous hypertriglyceridemia (especially in decompensated diabetes) is limited. There is no experience in the treatment of hypertriglyceridemia with Omacor in combination with fibrates. In patients with liver failure (especially when taking the drug in high doses), regular monitoring of liver function (ALT and AST) is necessary. During pregnancy and breastfeeding. There is no experience with the use of Omacor during pregnancy. Animal studies have not revealed a toxic effect of the drug on the fetus and the mother. The potential risk for humans is unknown, therefore Omacor can be prescribed during pregnancy only after a thorough assessment of the benefit/risk ratio. There are no data regarding the excretion of Omacor into breast milk, therefore Omacor is not recommended for use during breastfeeding. Children. Due to the lack of data regarding the effectiveness and safety of Omacor in children, its use in children is not recommended.

During pregnancy

To date, there is no objective and authoritative data on the peculiarities of taking the drug during pregnancy. For this reason, the use of the medication is possible with caution, and only if there is an understanding that the likelihood of benefit to the mother will be greater than the possible risk to the unborn child. During lactation, taking the medication is prohibited.

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pharmachologic effect

The ratio of essential fatty acids EPA and DHA is 1.2/1. PUFAs are in the form of ethyl esters, which increases the shelf life of the supplement.

DHA and EPA contained in Omacor capsules have a hypolipidemic effect: they reduce the level of triglycerides and LDL to a greater extent. Acids slightly increase the content of HDL in the blood plasma, which is beneficial for the body, as it reduces the risk of progression of atherosclerosis. The positive effect of omega acids on lipid metabolism is produced due to the interaction of active substances with liver cells - omega-3s inhibit the synthesis of new PUFAs and enhance the destruction of harmful fats already present in the body.

The drug also affects blood clotting parameters and reduces the formation of thromboxane A2, which is responsible for normal hemostasis processes.

After oral administration, omega undergoes 3 metabolic pathways:

• transportation to the hepatic parenchyma, where substances undergo breakdown and are transported to peripheral lipid stores;
• integration into the phospholipid layer of cell membranes, due to which omega-3 acids enter into metabolic reactions in the form of eicosanoids;
• oxidation processes to provide the body with energy substrates.

Side effects

When using Omacor capsules, various side effects may occur. Common conditions include:

• hypersensitivity reactions;
• gout, hyperglycemia, dry skin, rash on it;
• dizziness, headache, increased cholesterol levels;
• decreased blood pressure, nosebleeds;
• bloating, abdominal pain, constipation;
• flatulence, dyspepsia, belching, nausea, muscle pain;
• vomiting, gastroesophageal reflux disease, gastrointestinal bleeding, liver dysfunction, gastritis, gastroenteritis;
• skin rashes on the neck, urticaria, allergic reactions, erythema.

Side effects of the drug Omacor

The frequency of side effects according to studies is distributed as follows: often (1/100, ≤1/10); uncommon (1/1000, ≤1/100); rare (1/10000, ≤1/1000); very rare (≤1/10000), including isolated cases: infections and infestations: uncommon: gastroenteritis. From the immune system: uncommon: hypersensitivity. Metabolic disorders: rarely: hyperglycemia. From the side of the central nervous system: infrequently: dizziness, dysgeusia; rarely: headache. From the cardiovascular system: very rarely: hypotension. From the respiratory system and thoracic organs: very rarely: dry nasal mucosa. From the gastrointestinal tract: often: dyspepsia, nausea; uncommon: abdominal pain, gastritis, epigastric pain; rarely: gastrointestinal pain; very rarely: bleeding from the lower gastrointestinal tract. From the hepatobiliary system: rarely: liver dysfunction. From the skin and subcutaneous tissues: rarely: acne, skin rash accompanied by itching; very rare: urticaria. General disorders and symptoms at the injection site : rarely: increased symptoms of the underlying disease. Laboratory indicators are very rare: leukocytosis, increased LDH in the blood; Moderate increase in the activity of liver transaminases in patients with hypertriglyceridemia. Spontaneous reports of side effects Metabolic and nutritional disorders: increased need for insulin. From the hepatobiliary system: increased activity of liver enzymes. From the skin and subcutaneous tissues: rosacea, rash, redness/erythema, urticaria in the chest, neck and upper arms. Laboratory indicators: increased CPK levels in blood plasma, increased activity of ALT, AST. Weight gain, myalgia.

Contraindications

Taking Omacor has a number of contraindications due to its pharmacological action. Among them are the following factors:

• children and adolescents up to 18 years of age;
• old age over 70 years;
• liver dysfunction;
• diabetes;
• combination with fibrates, oral anticoagulants;
• period after surgery, severe injuries (strictly at the discretion of the doctor);
• exogenous hypertriglyceridemia, hyperchylomicronemia;
• breast-feeding;
• hypersensitivity to components.

Use of the drug Omacor

After myocardial infarction, 1 capsule per day. Hypertriglyceridemia Initial dose – 2 capsules per day (in 1-2 doses). In case of insufficient effect, the dose can be increased to 4 capsules per day. Treatment should be continued until a therapeutic effect is achieved. To prevent gastrointestinal disorders, take capsules with meals. Experience with the use of Omacor in children, patients over 70 years of age and patients with liver failure is absent, and in patients with renal failure is limited.

Omacor price

The cost of the drug varies depending on the pricing policy of the pharmaceutical chain. The approximate cost of the medicine and its analogues in Moscow and St. Petersburg is indicated in the table:

Instructions for use

Omacor must be taken with food, water or juice. Capsules should not be chewed or squeezed out. The dosage for adults is selected based on the indications and general well-being:

• 1 capsule – reducing the risk of cardiovascular crises and myocardial infarction;
• 2 – treatment of initial and moderate hyperlipidemia;
• 4 – therapy of resistant forms of hypertriglyceridemia.

It is recommended to drink no more than two pieces at a time, so the larger daily dose is divided into two doses: morning and evening. The course of treatment is selected by the doctor individually based on test results and medical history.

Customer Reviews

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Omacor Omega-3 Abbott

Average rating: Number of reviews: 0

Pros:

• reduction in the level of total cholesterol and atherogenic fractions of lipoproteins;
• relief of arrhythmia.

Minuses:

• No.

Special cases

When prescribing high dosages, it is necessary to regularly conduct a coagulogram and monitor changes in blood clotting. Patients who take anticoagulants and antiplatelet agents as basic therapy may need to reduce the daily dose of these medications.

People with severe liver disease and liver failure should undergo periodic tests for ALT and AST (cytolysis enzymes) during the course of taking Omacor. An increase in these values ​​is an indication to reduce the dosage.

Indications for use of Omacor

The drug is successfully used to prevent the development of a heart attack: Omacor is prescribed in combination with ACE inhibitors, statins, antiplatelet drugs, and beta-blockers.

There are many good reviews about Omacor, which is used for endogenous hypertriglyceridemia. Moreover, if type IV of the disease is diagnosed, only Omacor can be taken, but if the patient has hypertriglyceridemia of types IIb or III, and a high level of triglycerides is observed, statins are additionally prescribed.

Where can I buy

You can purchase a drug with omega acids at a regular pharmacy. But we recommend saving money and time and ordering medications on the Zdravcity website:

Omacor capsules 28 pcs

from 1660 ₽

Buy

The store offers a wide range of medical products. Medicines are also delivered free of charge to any pharmacy within 1-2 days. Payment occurs only after receiving the parcel.

Table 3 – Prices for Omacor in Moscow