Pimafucin cream is an effective and safe drug with antifungal activity. The active ingredient of the drug exhibits the greatest activity against fungi of the genus Candida (candida), which provoke the appearance of candidiasis. Therefore, the main indication for use in women and men is thrush. The cream must be used on the recommendation of a doctor or strictly according to the instructions.
Features of good stagnation
The presence of methyl parahydroxybenzoate (E 218) and propyl parahydroxybenzoate (E 216) in stock may cause allergic reactions (possibly worsened). Cetostearyl alcohol may cause local skin reactions (such as contact dermatitis). Propylene glycol may cause skin irritation.
Suspension during pregnancy or breastfeeding.
The drug can be taken during pregnancy and breastfeeding.
This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.
Doesn't flow in.
How to use
The drug in the form of suppositories is used intravaginally. Typically, a course of treatment for thrush requires three to six suppositories. Treatment is carried out every day, the candle is placed once, before going to bed, lying down, as deep as possible in the vagina.
If the disease does not go away after treatment with suppositories, you must simultaneously take Pimafucin tablets. The drug is taken one tablet per day for ten days.
At the same time, the partner is treated with Pimafucin cream. Treatment is prescribed purely individually. Sometimes it is extended to twenty days.
Cream "Pimafucin" is used exclusively externally. It is injected into the ear canal for otitis caused by candida. The cream is also used for vaginitis, vulvitis and balanoposthitis. If cream treatment does not help, suppositories and capsules are prescribed. For nail and skin fungi, use the cream up to four times a day.
For mycosis of the inner ear, turundas with cream are administered. After the symptoms of the disease have eased, treatment must be continued for some time.
For intestinal candidiasis, use Pimafucin capsules, swallowing one each four times a day. For children - twice a day. Typically the duration of the course is seven days.
Side effects
| Body system | Rarely (≥1/10,000 - <1/1000) |
| Underworld discord and changes in the place of stagnation | Hypersensitivity reactions, liver sensitivity, teasing. |
Hypersensitivity reactions: the place is stagnant, so the liver and tissues may be affected.
If stench bothers you, you may be hypersensitive to preservatives (parahydroxybenzoates).
Information about adverse reactions
Information about suspected adverse reactions following drug registration is important. In this way, it is possible to gradually evaluate the associated measles/risk for medical purposes.
Doctors are asked to report any suspected adverse reactions through the national reporting system.
Description of the drug
Pimafucin cream is a white product with a yellowish tint with a thick consistency and no characteristic odor. It is intended for the treatment of pathologies caused by yeast-like fungi. These microorganisms belong to opportunistic microflora and do not show themselves for a long time. But with a sharp decrease in immunity, fungi rapidly become more active.
Clinical manifestations of infection include sticking in the corners of the mouth and cheesy discharge from the urethra or vagina. Red spots on the skin indicate a mycotic lesion. All diseases are dangerous, contagious, and require immediate medical intervention. Antifungal drugs are used in therapy, including Pimafucin ointment.
What is the topical application prescribed for:
- mycotic lesions of the skin and mucous membranes;
- fungal infection of the nail plates on the hands and feet;
- bacterial pathologies of the ear, complicated by an associated mycotic infection;
- vaginal candidiasis.
The cream works effectively after the first application to pathological lesions. It helps to quickly get rid of the symptoms of a fungal disease by destroying its pathogens.
When diagnosing an uncomplicated pathology, it is sufficient to use only the cream. When a recurrent disease is detected, other medications are included in the therapeutic regimen. Usually these are tablets of the same name and intravaginal suppositories.
Pimafucin helps well against vaginal candidiasis, but treatment is indicated for both sexual partners. Women are prescribed suppositories or cream, and men only cream.
Clinical and pharmacological group
The cream is an external agent from the clinical-pharmacological group of antimycotic drugs. The active ingredient is a polyene antifungal antibiotic, so Pimafucin can be classified as an antimicrobial agent.
pharmachologic effect
Low concentrations of natamycin have a fungistatic effect.
A polyene antibiotic from the macrolide group inhibits the growth and reproduction of pathogenic fungi. This property is often used for prophylactic purposes to prevent the spread of infection. Natamycin in high concentration exhibits powerful fungicidal activity. It prevents fungi from producing ergosterols, the structural elements of membranes. As a result, the integrity of the entire cell is disrupted, so it quickly collapses.
Pimafucin is a broad-spectrum antimycotic agent. It is active against the following fungal species:
- yeast-like fungi Candida - causative agents of oral candidiasis and thrush;
- dermatophytes that cause severe skin lesions.
Pimafucin is one of the few antimycotics that are used throughout treatment. The fact is that fungi are not capable of developing resistance to natamycin.
Release form and composition
The Pimafucin therapeutic line includes three of its dosage forms. This is a cream for application to the skin and mucous membranes, vaginal suppositories and tablets for oral administration. All drugs contain one active substance with pronounced antifungal activity - natamycin.
The Italian manufacturer packages the cream in a plastic or aluminum tube of 30 g. The secondary packaging for the drug is a yellow cardboard box with attached instructions for use.
In addition to natamycin, Pimafucin cream contains the following auxiliary components:
- macrogol;
- cetostearyl alcohol;
- sodium lauryl sulfate;
- distilled water;
- methylparaben;
- propylparaben;
- wax.
Additional ingredients ensure maximum absorption of the antibiotic into the mucous membranes and skin.
Many of them have weak antiseptic properties, which enhances the therapeutic effect of the drug. The components of the product form protective shells, preventing bacterial infection of tissues affected by inflammation.
Storage conditions and periods
The shelf life of the antimycotic drug is 24 months, after the seal of the tube is broken - 3-4 weeks. It should be stored at room temperature in a dark place out of reach of small children. Freezing Pimafucin cream is not allowed. If the consistency, color changes, or a rancid odor appears, the product is not suitable for treatment.
Hygiene during treatment
When treating with Pimafucin, there are no special recommendations or a separate daily routine. You just need to adhere to the basic rules of general hygiene :
- Wash regularly , carefully treating the damaged areas with a soap solution with a neutral pH, preferably not directly, but using a sponge made of natural fabric.
- Change your underwear more often , giving preference to completely natural, not synthetic fabrics. Clothing should be loose and not tight to areas of fungal infection.
- Sexual activity can only be carried out using barrier contraception in order to minimize the risk of infecting the partner.
Contraindications
Pimafucin cream is not used in case of individual intolerance to antimycotic substances from the group of macrolides. Women during menopause with thinned vaginal mucosa should take special care when treating with Pimafucin.
Literature:
- Algorithm for the management of patients with vulvovaginal candidiasis (VVC) // Gynecology. 2004. – T. 6.-No. 2. – pp. 78-79.
- Arzhakova O.N., Savicheva A.M., Tsybulevskaya N.G. The use of pimafucin in the complex therapy of vulvovaginal candidiasis in pregnant women // Obstetrics and Gynecology.-2004.-No.2.-P.54-55.
- M. Bayramova G.R. Experience in the treatment of vulvovaginal candidiasis // Gynecology. .-2002.-T.4.-No. 2- P. 84-85.
- Ilyukhina T.V., Sideltsev V.V. Vulvovaginal candidiasis: clinical picture, diagnosis, treatment // Obstetrics. and gin. - 1998. - Special. issue — P. 99.
- https://medi.ru/instrukciya/pimafutsin_10656/
- Issues of gynecology, obstetrics and perinatology.-2005.-No.4.-P.13-16.
- Karapetyan T. E., Tyutyunnik V. JT. Modern aspects of the treatment of vulvovaginal candidiasis // Russian Medical Journal. -2004. T.-12.-No.13. – pp. 752-754.
- https://www.rlsnet.ru/tn_index_id_6525.htm
- Kisina V.N., Zabirov K.I. Urogenital infections in women. Clinic, diagnosis, treatment M.: MIA, 2005.- P.33-46.
- https://www.vidal.ru/drugs/pimafucin__5373
- Prilepskaya V.N., Bayramova G.R. Vulvovaginal candidiasis - modern ways to solve the problem // Journal “Difficult Patient”. - 2006. - No. 9. - P. 31-33.
Composition of Pimafucin ointment
The main active ingredient in the product is the antimycotic natamycin. It is contained in the cream in an amount of 2%
This means that 1 g of cream contains
20 mg of active substance
.
This antifungal component is used to combat candidiasis in its various manifestations. It destroys the shell of the fungus and this leads to the death of fungal microorganisms.
In addition to natamycin, the ointment contains auxiliary substances - wax, alcohol, lauryl sulfate, and the preservative propylene glycol. They form the basis and ensure its concentration, fluidity, as well as the safety of the medicinal substance and the smell of the drug.
Note: natamycin acts against most known fungi, but it is more effective against candida and less effective against dermatophytes.
Thrush in men: General information
In men, physiologically, the genital organs are designed in such a way that during urination, all bacteria and fungi come out of the urethra with urine. Therefore, in the male body, Candida fungi and other infections take root much more difficult, unlike the female body . It is for this reason that, as a rule, representatives of the stronger sex do not notice any signs of diseases in the intimate sphere.
Thrush itself in men most often goes away without any discomfort. But when the immune system is weakened or there is a concomitant infection in the body ( trichomoniasis, chlamydia, ureaplasmosis ), then Candida can bring a man many troubles, which usually manifest themselves in the form of:
- the appearance of acne;
- redness;
- burning sensation in the genitals.
In this case, the man is recommended to undergo a thorough and comprehensive examination by a doctor for the presence of STIs, take smears from the urethra for infections and flora, and, if necessary, take a sperm culture and prostate juice. , the urologist prescribes Pimafucin cream for topical use as a very effective and common drug for combating thrush in men .
Reviews
Galina, Salsk
For treatment, you need to use ointment and suppositories together. Ointment treats from the outside, suppositories treat from the inside. Together it works effectively - the fungus goes away and does not appear.
Valentin Semenovich, Arkhangelsk Men do not get thrush, they do not have discharge, redness, or burning. But they can transmit thrush to a woman. Therefore, two people need to be treated. If you have thrush, then your husband definitely has it.
Anastasia, 39 years old, Pavlovo Thrush - recurs every winter during a cold. I have already treated both my husband and myself. First it goes away, then it appears again.
Features of use, recommendations
Despite the minimum of side effects and the absence of the risk of overdose, it is better to use Pimafucin as prescribed by a specialist. He will conduct a thorough diagnosis and select an individual dosage regimen.
In case of chronic or recurrent infection, local treatment can be supplemented with systemic medications. Intravaginal use is contraindicated during menstruation.
If one of the partners is diagnosed with thrush (genital candidiasis), the other also needs to be examined. If the disease is diagnosed, the man and woman should begin a course of antifungal therapy. During the treatment period, it is necessary to use barrier contraceptives (condoms).
The cream is allowed to be used for thrush in pregnant and lactating women. They are prescribed medication strictly according to indications. The drug is also used to treat newborns.
If the cream is accidentally swallowed, the patient is advised to rinse the stomach and consult a doctor. If necessary, symptomatic therapy is carried out.
Pimafucin suppositories
Pimafucin suppositories are used to treat vaginal candidiasis. They are inserted into the vaginal cavity at night. The use of pimafucin locally allows you to limit the growth and development of fungal infection directly at the site of inflammation. What is better to use - pimafucin suppositories or ointment?
Ointment forms of the drug are more convenient to apply to open areas of the body - fingers, nails, skin, glans penis. To treat vaginal candidiasis, it is better to use suppositories (candles).
Analogs
The average cost of Pimafucin cream in pharmacies is 350 rubles. Cheaper analogs are available in the form of vaginal suppositories - Clotrimazole, Nystatin ointment, Hexicon, Chlorhexidine.
Indications for use
Pimafucin tablets are included in complex therapy for diagnosing fungal infections of the gastrointestinal tract. The cause of the disorder can be a long course of antibiotics, a decrease in immune defense, and nutritional errors.
The tablet form is also used for candidal (fungal) otitis media, classic genital thrush and its skin manifestations.
Cream (used in both gender groups) and suppositories (used only in women) are indicated in the following cases:
- fungal infection of mucous membranes, skin, nail plates;
- vulvitis/vaginitis, balanitis/balanoposthitis, caused by active reproduction of the Candida fungus;
- fungal otitis;
- ringworm.
Pimafucin ointment or cream: which is better?
Creams and ointments differ in their base. The cream has a lanolin base, it is quickly absorbed and for a therapeutic effect it must accumulate in the subcutaneous epidermis. Ointments are based on vasiline. It is absorbed for a long time and this ensures the so-called prolonged, long-lasting effect of the drug without concentration in the subcutaneous layer.
Traditionally, Western pharmaceuticals produce creams as more convenient cosmetics. They do not stain clothes and contain auxiliary components and fragrances. Ointments
– traditional products of pharmacies in the post-Soviet space. They contain fewer auxiliary components, they can stain clothes, and at the same time they are less likely to cause an allergic reaction.
Pimafucin is a medicine from a European manufacturer, therefore it is supplied for external use in the form of a fungal cream. There are no ointment preparations called Pimafucin.
Mechanism of action
To a greater extent, the drug has a positive effect due to the presence of a substance such as natamycin. It is capable of destroying even large colonies of yeast. After applying the cream, a biochemical reaction begins to occur, which consists of binding pathogenic lipid compounds from which the membranes of fungal microorganisms are built. As a result, the pathogenic microflora initially has damaged membrane walls that can no longer fully function. The destruction of the strain begins a few hours after the drug hits the surface of the skin or mucous membrane.
Pharmacology
Pimafucin has a local effect .
When applied externally, natamycin does not penetrate deep into the epidermis. The active compound in tablet form works within the intestines without leaking through its walls.
Natamycin is an antifungal substance that eliminates the pathogenic environment caused by the Candida fungus.
The mechanism of action is identical to the fungicidal one, which can be traced in the following stages:
- the substance binds sterols to bacterial cell membranes;
- there is a violation of the integrity of the membranes;
- death of microorganisms is observed.
