Description of herbal preparation for joints - Piascledine

How do doctors respond to the drug?

1. Initially he gave Chondramin to his patients. For a long time I did not observe any positive dynamics in their condition. A short time later, my colleague, who returned at a recent conference, suggested that I prescribe Piascledine 300 to patients. At first I was a little biased, but after a few months I had to notice a significant improvement in the condition of my patients. Since then, if the diagnosis correlates with joint cartilage diseases, I always prescribe Piascledine 300. Thanks to them for that. It is true what they say that everything is learned by comparison.
2. For a long time, I have had Piascledine 300 in my arsenal of medications. Whenever I hear that it allegedly works poorly, I enter into a discussion. I have been giving them to my patients for many months now, and have never made a mistake in my choice. Patients thank their doctor, but do not know what Piascledine treats.
3. Great drug! Piascledine is a very popular drug among patients. In a short time it relieves pain, improves joint movements and generally saves the poor. This drug is especially common among athletes. It is always important for them to keep their joints in good shape, so whenever there is a suspicion of cartilage damage, it is taken.

Side effects

Possible negative reactions of the body to taking the drug:

• allergic manifestations;
• increased activity of liver transaminases, alkaline phosphatase, gamma-glutamyltransferase, and bilirubin levels.

Overdose

There have been no cases of use of Piascledine in excess of the established norm.

Contraindications

The medication should not be taken under the following conditions:

• intolerance to the components of the drug;
• while expecting a baby and breastfeeding;
• under the age of 18.

During pregnancy and lactation

The drug is contraindicated for use by women during pregnancy and breastfeeding..

Analogues of Piascledine

Before replacing Piaskledin cheaper or at the same price, you should first decide on the diagnosis. Since treatment will be effective only if adequately prescribed.

There are no analogues of Piascledine 300 in composition. The drug can be replaced with chondroprotectors that act similarly to Piascledine or by a different mechanism, for example, Structum, Alflutop, Arthroker, Dona and other drugs.

There are analogs that are cheaper than Piascledine, mostly these are dietary supplements that should not be confused with medications, for example, Arthrostop, Stoparthritis, Piacartil and others.

A list of analogues of the drug Piaskledin 300 with prices can be seen in the table.

pharmachologic effect

The action of the drug is to correct the metabolism of cartilage tissue.

It has an analgesic and anti-inflammatory effect on joints. Slows down the degenerative process in the cartilage tissue of joints, helps reduce pain and restore motor function.

During the experiments, it was found that the use of the drug has a regenerating effect on cartilage. Stimulates collagen synthesis in articular chondrocytes.

According to reviews of Piaskledin, thanks to the unsaponifiable compounds it contains, avocado oil and soybean oil:

• They stimulate the production of a plasminogenesis activator inhibitor, thereby reducing cartilage damage directly by acting on it and through stimulation of metalloproteinases. Prevents the destruction of cartilage by activating the degradation of proteglicans.
• Stimulates the effect of IL-1 on collagenase synthesis, increases collagen production.
• Stimulates the synthesis of macromolecules of the intercellular substance of articular cartilage, and also stimulates the synthesis of macromolecules of periodontal tissue and hyaline cartilage, thereby reducing tooth loss.
• Increases the effect of transforming growth factor β1 (TGF) in chondrocytes, which has an anabolic effect.

Use of the drug for osteoarthritis

Osteoarthritis is the leader in the frequency of detection among other joint pathologies. In the world ranking for the detection of this disease, the Russian Federation, like other countries of the post-Soviet space, occupies the top positions: approximately 48% of citizens are diagnosed with this pathology.

An advanced form of osteoarthritis serves as the reason for determining the patient’s disability group and contributes to a deterioration in the quality of his life. Moreover, the treatment of this disease requires significant financial investments, especially when the disease has progressed to a late stage, which is accompanied by damage to cartilage tissue.

Restoration of cartilage and intervertebral discs is possible even in an adult. To achieve this, you need to activate chondrocytes and chondroblasts. If these cells are in sufficient quantity in the articular tissue, and they receive the necessary macro- and microelements in the required volume, regeneration of cartilage from the inside is possible.

However, when the metabolic process in cells is disrupted (due to disease or age-related characteristics of the body), as well as when the production of synovial fluid, the main source of nutrients, decreases, cartilage requires outside help. For this purpose, the drug Piascledine can be used.

Piaskledin or Piacartil - which is better

Manufacturer: Omegapharma, Russia
Release form: capsules

Active ingredient: soy protein isolate, mixture of avocado and soy unsaponifiables, silicon dioxide, mixture of tocopherols

Piacartil is a dietary supplement containing a proprietary blend of AvoVida® containing soy and avocado unsaponifiables, soy protein isolate, silicon dioxide and vitamin E.

The dietary supplement is close in composition to Piascledine, but you need to remember that this is not a medicine and is used for the prevention of joint diseases or in complex therapy together with medications - chondroprotectors and NSAIDs.

Pyacartil is used one capsule per day for at least one month. If necessary, you can take the course or repeat it regularly up to 4 times a year.

Undesirable effects

Thanks to the natural herbal composition of the drug, unwanted effects are extremely rare in people when using it. The following health disorders were recorded:

• allergic conditions - urticaria, Quincke's edema;
• cephalgia;
• difficulty breathing;
• dyspeptic symptoms - diarrhea, nausea, or vomiting.

If there is the slightest deterioration in your health associated specifically with the use of capsules, it is recommended to notify your doctor. They will undergo pharmacotherapy corrections in the future.

Similar means

Piascledine has no absolute analogues, since it is the only one among chondroprotectors of plant origin.

Drugs similar in action include:

• Alflutop;
• Artra;
• Kondronov;
• Rumalon;
• Teraflex Advance.

Alflutop is produced in the form of a solution for injection. The medication improves metabolic processes in cartilage and has an antioxidant effect. Prescribed for osteochondrosis, arthrosis of small joints. Contraindications for use: children, special sensitivity to the components of the product.

Artra are tablets intended for the treatment of osteochondrosis of peripheral joints and the spinal column. The medicine relieves inflammation, protects cartilage tissue from chemical damage, activates the formation of hyaluronan and repair mechanisms. Not recommended for use in case of kidney failure.

Kondronov. The active components of the product are chondroitin sulfate and glucosamine, which help stimulate regenerative processes in cartilage. It is not prescribed in case of special sensitivity to the substances of the drug and dysfunction of liver enzymes. Possible adverse reactions: disruption of the gastrointestinal tract, allergies, tendency to sleep, dizziness.

Rumalon is available in the form of ampoules and is used for intramuscular injections. It is a substitute for Piascledine and has a similar effect on the body. Do not use if you have rheumatoid arthritis. Possible side effects: migraine, digestive upset.

Teraflex Advance fights inflammation, restores cartilage tissue, relieves pain and reduces fever. The drug has a similar effect on the body and indications for use as Piascledine. The medication is contraindicated in pregnant and lactating women under the age of 12, with poor blood clotting.

Reviews from doctors

Experts say that patients who have taken this drug speak positively about it, noting that gradually (one and a half to two months after the start of use) pain in the joints disappears, their mobility is restored, and the quality of life significantly improves. However, it should be noted that some patients experienced complications of diseases of the digestive system after treatment. Therefore, it is important to first study the contraindications and instructions for Piaskledin 300, reviews from doctors and consumers.

Side effects and overdose

The only side effects that can be noted are the likelihood of allergic manifestations in the form of rash, hives, itching, peeling, and swelling.

Since the drug consists of plant components, it has a minimum of side effects.

There is no data on drug overdose; however, if the dose is exceeded, although rare, allergic reactions are possible.

Additional information about the drug Piaskledin 300

The herbal medicine does not cause drowsiness, lethargy and does not have any effect on movement coordination, therefore, when treated with it, you can drive vehicles, perform high-precision work, and also play sports.

No harmful effects of the medication with alcohol have been identified.

The medicine does not interact with other drugs, and at the initial stage of treatment it can be taken together with non-steroidal anti-inflammatory and painkillers, however, with prolonged therapy, the dosage of the latter must be reduced.

Structum

Manufacturer: Pierre FabreMedicine Production, France
Release form: capsules

Active ingredient: Chondroitin sulfate

Synonyms: Chondrogard, Chondrolone, Mucosat, Artradol, Artrafik

The analogue of Piascledine Structum is a prescription French chondroprotector with anti-inflammatory activity.

Structum stimulates metabolism in cartilage tissue, reduces degenerative processes, promotes the synthesis of glycosaminoglycans, reduces calcium loss and promotes the restoration of bone and cartilage tissue.

The Structum analogue is used twice a day, 500 mg, for six months, the treatment effect lasts for another 3–5 months. In the future, the doctor decides whether to repeat the therapeutic course.

Piaskledin 300 or Teraflex – which is better?

Manufacturer: Contract Pharmacal Corporation, USA / Bayer, Russia
Release form: capsules

Active ingredient: Glucosamine + Chondroitin sulfate

Synonyms: ARTRA, Kondronova, Artrafik Pro

The Piascledine substitute Teraflex is produced in the USA, and the rights to the marketing authorization belong to the Russian branch.

The Teraflex analogue is a chondroprotector that promotes cartilage restoration and prevents destruction and chemical damage to cartilage tissue.

The Teraflex analogue is used for osteoarthritis and osteochondrosis, reducing the symptoms of the disease and reducing the need for anti-inflammatory painkillers.

Theraflex should be taken more often than Piascledine: in the first three weeks, three capsules per day, then 1 capsule twice a day. The course of treatment is 3–6 months, depending on the degree of joint damage.