The drug Piroxicam is produced by pharmaceutical companies in the form of a gel for external use and in capsule format intended for oral use. Medicines Piroxicam belong to the group of non-steroidal anti-inflammatory drugs. Regardless of the form of production, the compositions have a pronounced anti-inflammatory, analgesic, analgesic and antipyretic effect.
Indications for use
The drug "Piroxicam" is prescribed for the treatment of joint problems, injuries of soft tissues, tendons, as well as for the treatment of certain systemic ailments.
- For pain syndrome (pain in tissues, muscles, tendons; sprains, bruises, fractures; inflammation of soft tissues; nerve damage; to reduce postoperative pain
- For rheumatic diseases and joint problems (arthritis, osteoarthritis, gout, tendonitis, ankylosing spondylitis, extra-articular rheumatism, lupus erythematosus, acute lower back pain, pinched sciatic nerve
- For systemic use (painful menstruation in patients over 12 years of age; preparation for IVF; inflammatory diseases of the pharynx, appendages; cystitis.
The drug "Piroxicam" is available in 4 forms:
- Pills
- Gel
- Capsules
- Injection
- Rectal suppositories.
The average price is from 10 to 30 rubles.
Reviews
There are a lot of comments about Piroxicam gel, ointment and cream.
In their reviews, people often write that this product often saves them after sports training, when they accidentally stretch certain muscle groups. As noted in the comments, immediately after using Piroxicam, people report immediate improvement, and their swelling and pain disappear. At the same time, as consumers say, the swelling goes away completely or is significantly reduced.
Thus, many patients write in their reviews that they really like this medication. It is often prescribed to patients with lupus erythematosus. Doctors periodically prescribe a course of Piroxicam for such patients for treatment. It is noted that in this case, this remedy helps a lot, and patients regain their taste for life.
The use of the drug is also praised by those patients who suffer from psoriasis and psoriatic arthropathy. It is reported that while taking Piroxicam, there is actually a result from the treatment. Joint pain disappears, and the ability to move the joints is normalized. As can be seen from the reviews about this drug, almost all of them are positive, which only proves its effectiveness.
Piroxicam tablets
One tablet contains 20 mg or 10 mg of the active substance (piroxicam). Auxiliary components are: lactose, cellulose, starch, magnesium stearate, sodium zucrin, silicon dioxide, sodium starch glycolate, polyvinylpyrrolidone, water.
Round tablets are white or yellowish in color, flat, have a dividing strip.
Mode of application
The tablets inhibit platelet adhesion and phagocytosis. The pills are well absorbed from the gastrointestinal tract, their maximum concentration is achieved after 5 hours. Over the course of 12 days, the concentration of tablets in the blood is balanced. The half-life is about 50 hours. The tablets are excreted through the intestines and kidneys. Does not accumulate in the body. The tablets eliminate pain and swelling of the joints. Taken orally from 1 to 4 tablets at a time.
Average price from 90 to 150 rubles.
Gel "Piroxicam"
The gel has antipyretic, anti-inflammatory, analgesic effects. Equilibrium concentration is obtained after 7–12 days.
0.5 g of piroxicam per 100 g of gel. Additional elements: carbomer, propylene glycol, trolamine, ethanol, water, methyl parahydroxybenzoate.
The color is transparent, from light yellow to greenish. Has a characteristic smell.
Mode of application
The ointment (gel) is applied to the skin over the problem area up to 4 times a day and rubbed in gently. Duration of application – no more than 2 weeks. It has a quick local effect, bypassing the gastrointestinal tract and, thus, does not negatively affect internal organs.
The average price is from 30 to 70 rubles.
Piroxicam capsules
Contains: piroxicam, wheat starch, magnesium stearate, talc, glycine, colloidal silicon dioxide, MCC
Looks like hard gelatin. The body is creamy orange, inside the capsule is white powder
Mode of application
Inside from 1 to 4 pieces at a time. The duration of treatment is from 1 week to 4 months. A distinctive feature is that the drug is quickly absorbed into the stomach without negative consequences.
Capsules have the same properties as tablets. The result is achieved 30 minutes after administration. Prolonged action – 24 hours after taking 1 capsule.
The average price is from 40 to 70 rubles.
For liver dysfunction
Capsules
- Liver failure or any active liver disease: therapy is contraindicated;
- Hepatic porphyria: Piroxicam should be used with caution.
Tablets and suppositories
In severe liver failure, the use of Piroxicam is contraindicated.
Gel for external use
In case of exacerbation of hepatic porphyria, severe liver failure or active liver disease, the drug is prescribed under medical supervision.
Rectal suppositories "Piroxicam"
Rectal suppositories are yellowish-green in color and cigar-shaped. Contains 20 mg of active substance in 1 suppository. Other components: semi-synthetic glycerides.
Mode of application
Rectally. 1 suppository once a day after a colon cleansing enema. Before insertion, wet the candle with water and lubricate the anus with cream. Duration of treatment – from 1 to 2 weeks
Suppositories increase the excretion of uric acid from the body. Concentrates in blood plasma within 3 hours after administration. They are eliminated within 30–86 hours.
special instructions
Before you start taking Piroxicam capsules, you need to carefully study the instructions for the product. The patient should pay attention to a number of special instructions presented in the following list:
- The drug is not recommended for use in acute pathologies associated with intestinal disorders.
- For elderly patients, dose adjustments are made.
- During use of the product, you should exclude the possibility of drinking alcoholic beverages.
- when using the drug orally, activities that require increased concentration of attention from the patient should be limited.
The drug is released to the public through a network of pharmacies for free sale, however, patients should remember that uncontrolled use can cause a sharp deterioration in their health.
Solution for injections "Piroxicam"
The average price is from 25 to 50 rubles.
The injection solution contains 20 mg of active substance per ml. The ampoule itself is dark glass, volume 1 ml. Packed in contour cells of 10 pieces and in cardboard packs.
Mode of application
Inject the drug once a day. If the pain symptom is severe, then 40 mg of the substance; for moderate pain, 20 mg. The maximum amount of substance to be administered is 40 mg.
Injections are carried out for 1-2 days. Then they switch to tablets or capsules.
Pharmacological effect
The use of Piroxicam allows for a comprehensive effect:
- reduces pain in the postoperative and post-traumatic period,
- reduces discomfort during painful menstruation,
- reduces swelling of the tissue around the damaged vertebra or joint,
- stops inflammation
- reduces pain in orthopedic diseases and rheumatic manifestations,
- helps reduce skin temperature in the affected area,
- relieves fever and fever during inflammation,
- helps improve joint mobility during the recovery period,
- prevents the production of substances that provoke the occurrence of inflammatory processes in infectious and rheumatic diseases of the spine and joints.
The active substance is absorbed in a short period of time: the maximum concentration of piroxicam is observed after 3-5 hours. Plasma concentration reaches 98%. Metabolized in the liver, metabolic products are excreted in the urine.
Contraindications
You should not take the medicine in the following cases:
- If you have impaired renal or liver function, you should not take tablets or capsules. Gel and suppositories should be used with caution
- Children under 12 years of age (and in any form of release)
- In case of individual intolerance to the drug
- For ulcers and open wounds where the gel is applied
- 3rd trimester of pregnancy.
You should take the drug with caution in the following cases:
- During lactation, as well as in the 1st and 2nd trimester of pregnancy
- Together with other anti-inflammatory medications
- For ulcers, erosions in the gastrointestinal tract
- Elderly people
- Patients with bronchial asthma
- For chronic kidney diseases
- If you have a tendency to bleed
- With hemorrhagic diathesis.
During pregnancy and breastfeeding
- In the 3rd trimester, the drug is contraindicated in any form of release.
- In the 1st and 2nd trimesters, the issue of using the medicine can only be decided with a doctor
- Tablets and capsules are excreted in breast milk. During therapy, you need to stop feeding the baby or stop taking the medication.
Overdose
If the recommended therapeutic dose of Piroxicam capsules is exceeded, the patient may experience signs of intoxication. The list of possible symptoms includes the following:
- nausea ending with vomiting;
- darkening of the stool;
- manifestation of tinnitus;
- muscle cramps;
- hemorrhagic diathesis;
- the appearance of a rash on the skin;
- confusion;
- anemia.
In severe cases, bleeding may occur in the digestive tract. Therapy consists of gastric and intestinal lavage. To eliminate the symptoms of intoxication, sorbents are used. Symptomatic therapy is determined in a hospital setting.
When using Piroxicam in gel form, the risk of overdose is minimized.
Interaction with other drugs
The simultaneous use of Piroxicam with certain drugs leads to:
- The development of side effects from the gastrointestinal tract, as well as allergic reactions, if the patient takes glucocorticoids along with the described medication
- Weakening the effect of diuretics if they are taken together with the drug Piroxicam
- An increase in the concentration of lithium in the blood plasma if Piroxicam tablets or capsules are taken in parallel with lithium medications
- Increased risk of bleeding when taking Piroxicam and anticoagulants.
Side effects
Side effects associated with the use of the drug composition are quite rare.
From the gastrointestinal tract:
- nausea;
- loss of appetite;
- stomatitis;
- epigastric pain;
- diarrhea or constipation;
- flatulence.
Allergic reactions:
- Quincke's edema;
- generalized skin itching;
- hives;
- redness;
- bronchospasm;
- serum sickness;
- Lyell's syndrome.
From the side of the central nervous system:
- dizziness;
- headache;
- drowsiness;
- sleep disorders;
- depression;
- nervousness;
- hallucinations;
- mood changes;
- weakness.
Piroxicam in IVF: truth or myth?
IVF is in vitro fertilization, carried out in a test tube. Indications for IVF include ovarian diseases, obstruction of the fallopian tubes, male infertility, etc. IVF is prescribed to couples who have already tried all possible methods of treating infertility, but none have brought results.
Some reproductive specialists prescribe the drug "Piroxicam" for the transfer of fetuses (embryos). It is noted that the tablets can reduce the contractile activity of the uterus. And this can lead to a high probability of pregnancy. Doctors who prescribe the drug to infertile couples prescribe it to women 1 pill three times a day, before the procedure (one day before embryo transfer) and on the day of IVF (1 tablet in the morning).
Piroxicam may improve the rheological properties of blood. This means that the pills can increase blood flow in the uterus, which can have a positive effect on the attachment of embryos during IVF.
Not all clinics where IVF is performed, doctors prescribe Piroxicam. There is no reliable data on the positive effect of this drug on pregnancy. Studies have been carried out and the results have shown that Piroxicam tablets can reduce the contractile activity of the uterus. This may increase the chance of pregnancy, but does not guarantee it. And the study, which was conducted a long time ago, did not receive any official confirmation over the next 5 years. Only in 2009, scientists conducted a repeat study, which refuted the assumption regarding the effect of the drug on embryos.
Taking the pill before the IVF procedure has no effect on pregnancy in patients who take progesterone in the luteal phase after IVF.
For impaired renal function
Capsules
- Severe renal failure (creatinine clearance less than 30 ml/min), progressive kidney disease, confirmed hyperkalemia: therapy is contraindicated;
- Renal failure with creatinine clearance 30–60 ml/min: Piroxicam is prescribed with caution.
Tablets and suppositories
In severe renal failure, the use of suppositories and Piroxicam tablets is contraindicated.
Gel for external use
- Severe renal failure with creatinine clearance less than 30 ml/min: therapy is contraindicated;
- Progressive kidney disease: Piroxicam should be used with caution.
Analogs
There are plenty of substitutes for the drug Piroxicam. Among the analogues are the Finalgel gel and Revmoxicam tablets.
Gel "Finalgel"
Boehringer Ingelheim Pharma, Germany. Price from 300 to 400 rubles.
The main substance of the drug is piroxicam. The gel is sold in tubes of different volumes: 35 or 50 g. It appears light yellow with a slight odor of isopropyl alcohol.
pros
- Fast absorption into the skin
- Economical spending
Minuses
- High price
- Helps only with minor injuries (bruises, minor injuries). For more serious problems it does not always help
- Name. Many people confuse it with Finalgon. Both drugs relieve pain, but act differently. Finalgon burns the skin. On the contrary, Finalgel cools it down. If you confuse 2 drugs with similar names, the result can be disastrous.
Tablets "Revmoxicam"
JSC Farmak, Ukraine. Price from 270 to 320 rubles.
The active ingredient of the drug is meloxicam. Available in various forms: tablets, solutions, suppositories. Not approved for use in Russia.
pros
- Quickly relieves inflammation and pain
- Can be purchased without a prescription
Minuses
- A large number of side effects
- This is a drug that is not gentle on the stomach (may cause abdominal pain, cramps)
- High price. If you take 2 tablets a day, then a pack costs 300 rubles. enough for only 5 days.
Storage conditions
Piroxicam in capsule form should be stored at a temperature of no more than 25 degrees out of the reach of children. The shelf life is 3 years from the date of production.
Piroxicam in gel form for external use should be stored in a dry place, protected from children, at a temperature of 15 to 25 degrees. Shelf life is 3 years from the production date indicated on the tube.
It is impossible to use drugs after the expiration date; their use can cause harm to the human body.
