Polyoxidonium® Suppositories, 10 pcs, 6 mg, rectal, vaginal rectal

Polyoxidonium, 6 mg, vaginal and rectal suppositories, 10 pcs.

Pills.

Orally

and
sublingually
, 20–30 minutes before meals, daily 1, 2 or 3 times a day.

Adults - in doses of 12 or 24 mg, adolescents - in doses of 12 mg. The method and dosage regimen is determined by the doctor, depending on the diagnosis, severity and severity of the process.

Sublingual:

- for inflammatory processes of the oropharynx (bacterial, viral and fungal in nature):

1 table each 2 times a day every 12 hours, for 10–14 days. For severe forms of herpetic and fungal infections of the oral cavity - 1 table. 3 times a day every 8 hours for 15 days;

- for chronic diseases of the paranasal sinuses and chronic otitis media:

1 table each 2 times a day every 12 hours, for 5–10 days;

- for chronic tonsillitis:

1 table each 3 times a day every 8 hours for 10–15 days;

- for chronic diseases of the upper respiratory tract:

adults - 2 tablets. (24 mg) 2 times a day, adolescents - 1 tablet. (12 mg) 2 times a day, every 12 hours, for 10–14 days;

- for the prevention of influenza and acute respiratory infections:

immunocompromised persons who suffer from acute respiratory infections more than 4 times a year; in the pre-epidemic period, adults - 2 tables. (24 mg), adolescents - 1 tablet. (12 mg) 2 times a day every 12 hours, for 10–15 days.

Orally:

— for chronic diseases of the upper respiratory tract:

adults - 2 tablets. (24 mg) 2 times a day after 12 hours, for adolescents - 1 tablet. (12 mg) 2 times a day, every 12 hours, for 10–14 days.

Lyophilisate for the preparation of solution for injection and topical use

Adults

Parenteral, intranasal

. Methods of application are selected by the doctor depending on the severity of the disease and the age of the patient.

IM or IV (drip):

the drug is prescribed to adults in doses of 6–12 mg 1 time per day, daily, every other day or 1–2 times a week, depending on the diagnosis and severity of the disease.

For intramuscular administration, the contents of the ampoule or bottle are dissolved in 1.5–2 ml of 0.9% sodium chloride solution or water for injection. For intravenous (drip) administration, the drug is dissolved in 2 ml of 0.9% sodium chloride solution, Hemodez-N, Reopoliglucin or 5% dextrose solution, then sterilely transferred into a bottle with the indicated solutions of 200–400 ml.

The prepared solution for parenteral administration cannot be stored.

Intranasally:

a dose of 6 mg is dissolved in 1 ml (20 drops) of distilled water, 0.9% sodium chloride solution or boiled water at room temperature.

Recommended treatment regimens for adults

Parenterally:

- for acute inflammatory diseases:

6 mg daily for 3 days, then every other day with a general course of 5–10 injections;

- for chronic inflammatory diseases:

6 mg every other day for 5 injections, then 2 times a week for a course of at least 10 injections;

- for tuberculosis:

6–12 mg 2 times a week for a course of 10–20 injections;

- in patients with acute and chronic urogenital diseases:

6 mg every other day for a course of 10 injections in combination with chemotherapy;

- for chronic recurrent herpes:

6 mg every other day for a course of 10 injections in combination with antiviral drugs, interferons and/or inducers of interferon synthesis;

- for the treatment of complicated forms of allergic diseases:

6 mg, course of 5 injections - the first 2 injections daily, then every other day. For acute allergic and toxic-allergic conditions, administer 6–12 mg intravenously in combination with other antiallergic drugs;

- for rheumatoid arthritis:

6 mg every other day - 5 injections, then 2 times a week for a course of at least 10 injections.

In cancer patients:

- before and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapy drugs - 6-12 mg every other day for a course of at least 10 injections, then the frequency of administration is determined by the doctor depending on the tolerability and duration of chemotherapy and radiation therapy;

— for the prevention of the immunosuppressive effect of the tumor, for the correction of immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor, long-term use of the drug Polyoxidonium® is indicated (from 2-3 months to 1 year) - 6-12 mg 1-2 times a week.

In patients with acute renal failure:

prescribed no more than 2 times a week.

Intranasally

6 mg/day is prescribed for the treatment of acute and chronic infections of the ENT organs, to enhance the regenerative processes of the mucous membranes, to prevent complications and relapses of diseases, to prevent influenza and acute respiratory infections. 3 drops in each nasal passage every 2–3 hours (3 times a day) for 5–10 days.

Children

Parenteral, intranasal, sublingual

. Methods of application are selected by the doctor depending on the diagnosis, severity of the disease, age and body weight of the patient.

Parenterally

the drug is prescribed to children from 6 months at a dose of 3 mg (im or intravenous drip 0.1–0.15 mg/kg) daily, every other day or 2 times a week in a course of 5–10 injections (dose calculation is indicated in the table ).

For intramuscular administration, the drug is dissolved in 1 ml of water for injection or 0.9% sodium chloride solution.

For intravenous drip administration, the drug is dissolved in 1.5–2 ml of a sterile 0.9% solution of sodium chloride, Reopoliglucin, Hemodez-N or 5% dextrose solution, sterilely transferred to a bottle with the indicated solutions with a volume of 150–250 ml.

Intranasal and sublingual:

daily at a daily dose of 0.15 mg/kg for 5–10 days. The drug is administered 1–3 drops into one nasal passage or under the tongue after 2–3 hours. To prepare a solution for intranasal and sublingual use, a dose of 3 mg is dissolved in 1 ml (20 drops), a dose of 6 mg is dissolved in 2 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. One drop of the prepared solution (50 μl) contains 0.15 mg of the drug Polyoxidonium®, which is prescribed per 1 kg of child’s body weight.

Store the solution for sublingual and intranasal use in the refrigerator for no more than 7 days. Before use, the pipette containing the solution must be warmed to room temperature (20–25 °C).

Recommended treatment regimens for children:

- for acute inflammatory diseases:

0.1 mg/kg every other day for a course of 5–7 injections;

- for chronic inflammatory diseases:

0.15 mg/kg 2 times a week for a course of up to 10 injections;

- for acute allergic and toxic-allergic conditions:

IV drip at a dose of 0.15 mg/kg in combination with antiallergic drugs;

— for the treatment of complicated forms of allergic diseases in combination with basic therapy:

IM 0.1 mg/kg in a course of 5 injections with an interval of 1–2 days.

Intranasally

administer 1–3 drops into one nasal passage every 2–3 hours (2–4 times a day). For intranasal and sublingual administration, the calculation of the daily dose for children is presented in the table.

Sublingual:

for all indications - daily at a daily dose of 0.15 mg/kg for 10 days, for the treatment of intestinal dysbiosis for 10-20 days. Place 1-3 drops under the tongue every 2-3 hours.

Suppositories

Rectally

or
vaginally
1 supp.
(6 and 12 mg) 1 time per day. The method and dosage regimen is determined by the doctor depending on the diagnosis, severity and severity of the process. Polyoxidonium® can be used rectally
or
vaginally
daily, every other day or 2 times a week.

Polyoxidonium®, suppositories 12 mg

used in adults rectally or vaginally.

Rectally:

1 time per day, 1 sup. (after bowel cleansing).

Vaginally:

for gynecological diseases, 1 supp. Once a day (at night) it is inserted into the vagina in a lying position.

Polyoxidonium®, suppositories 6 mg

used: in children over 6 years old rectally - 1 supp. 1 time per day (after cleansing the intestines), in adults - rectally (after cleansing the intestines) or vaginally (in the vagina in a lying position) as a maintenance dose - 1 supp. 1 time per day (at night).

Standard scheme

use of Polyoxidonium® - 1 supp. (6 or 12 mg) 1 time per day, daily for 3 days, then every other day with a course of 10–20 supp. If necessary, the course of treatment is repeated after 3–4 months.

For patients receiving long-term immunosuppressive therapy, cancer patients with an acquired defect of the immune system - HIV, who have been exposed to radiation, long-term maintenance therapy with Polyoxidonium® is indicated for 2-3 months to 1 year (adults - 12 mg, children over 6 years - 6 mg 1–2 times a week).

Recommended regimens for use as part of complex therapy:

— for chronic infectious and inflammatory diseases:

in the acute stage - according to the standard regimen, in the remission stage - 1 supp. after 1–2 days, the general course is 10–15 supp.;

— in acute infectious processes and to activate regenerative processes (fractures, burns, trophic ulcers):

1 sup. daily, course of treatment - 10–15 sup.;

- for tuberculosis

: according to the standard regimen, the course of treatment is at least 15 supp., then it is possible to use maintenance therapy - 2 supp. per week for a course of 2–3 months;

— against the background of chemotherapy and radiation therapy of tumors

: 1 sup. daily 2-3 days before the start of therapy, then the frequency of suppository administration is determined by the doctor depending on tolerability and duration of chemotherapy and radiation therapy;

— for rehabilitation of frequent (more than 4–5 times a year) and long-term ill persons and for rheumatoid arthritis

: 1 sup. every other day, course of treatment - 10–15 supp.

— for the correction of secondary immunodeficiencies, incl. arising due to aging

: 1 sup. (12 mg) 2 times a week, course - at least 10 supp. 2–3 times a year.

As monotherapy:

- for seasonal prevention of exacerbations of chronic foci of infection, prevention of recurrent herpes infection

: every other day for adults - 6–12 mg, for children - 6 mg. Course - 10 supp.

— for the correction of secondary immunodeficiencies, prevention of influenza and acute respiratory infections

: according to the standard scheme.

— for gynecological diseases
(rectal or vaginal)
: according to the standard regimen.

Release form and composition

Polyoxidonium is available in the form of suppositories for vaginal and rectal use.

One Polyoxidonium suppository contains :

1. Azoximer bromide - 6/12 mg (for children/adults);
2. Mannitol - 1.8/3.6 mg;
3. Povidone K17 - 1.2/2.4 mg;
4. Cocoa butter - 1291/1282 mg.

As can be seen from the composition, the active ingredient of Polyoxidonium is azoximer bromide, all others are auxiliary.

Contraindications

The medicine is not recommended to be taken if:

• The child has hypersensitivity to any component of the product;
• The baby is less than six months old;
• The patient has kidney pathologies.

When using injections, several side effects may occur in the form of:

• Pain in the injection area (disappears after a day);
• Redness and swelling of the injection site (disappears 2-3 hours after the injection).

If you follow the instructions and recommendations of the doctor, the use of suppositories and tablets does not cause side effects.

The course of treatment lasts from 5 to 14 days. Repeated therapy is recommended no earlier than after 4–5 months. If after the first course of treatment the baby begins to get sick less often and feels better, then the medicine is prescribed after six months or a year.

Indications for use

The drug is prescribed for adults, adolescents and children over 6 years of age. Therapists and pediatricians prescribe Polyoxidonich in the following situations:

• colds, viral and infectious diseases such as acute respiratory infections, acute respiratory viral infections and influenza;
• prevention during the season of increased morbidity;
• chronic diseases caused by infections, viruses and bacteria during exacerbation of symptoms or during remission;
• urogenital diseases;
• tuberculosis in various forms of the disease;
• autoimmune diseases;
• allergy;
• oncological diseases;
• rehabilitation of people who suffer from acute respiratory viral infections and acute respiratory infections more than 4 times a year.

special instructions

For patients taking the drug, the manufacturer advises:

• You should stop the drug immediately; you do not need to do it gradually by reducing the dosage;
• if a medication was missed, it is worth continuing treatment according to the prescribed regimen;
• Do not take the drug after the expiration date under any circumstances.

REFERENCE! Polyoxidonium suppositories do not in any way affect attention, memory, thinking, or reaction speed, therefore it is allowed to take the drug while performing dangerous work or while driving a vehicle.

What does it help with?

Polyoxidonium is allowed to be given to children from 6 months of age. Usually prescribed for recurrent herpes infections or as a prophylactic during the autumn and cold season. Before a course of treatment, you should definitely consult a pediatrician.

It is recommended to take the drug in combination with other antiviral agents. Prescribed if the child has:

• Bacterial, viral or fungal infection;
• Chronic diseases periodically worsen;
• Bronchial asthma, hay fever or atopic dermatitis;
• Disruption of the genitourinary system;
• Tuberculosis or rheumatism;
• During chemotherapy;
• The liver and kidneys work poorly;
• Frequent viral diseases are observed (if more than 7 times a year).

Can it be used for babies?

Polyoxidonium is a medicine used for frequent child illnesses.

It shortens the duration of the disease, facilitates its course and protects against new diseases for a long time.

This product is approved for use in children .

According to the instructions, the use of Polyoxidonium suppositories can be carried out for children from six years of age at a dosage of 6 mg.

However, many pediatricians recommend using these suppositories at an earlier age, from 2-3-4 years, only the dosage will be different - 3 mg, for which the suppository is divided in half.

The product is used rectally. However, only a doctor can take into account the reaction of the baby’s body and possible manifestations of allergies.

This is important to consider, since suppositories are a medicinal product. Self-medication is not recommended.

Analogs

There are similar drugs that are similar in therapeutic effect to the original, but their composition differs significantly. Polyoxidonium analogues are as follows:

Solution:

• Actinolysate for intramuscular administration;
• Gepon for oral administration;
• Glutoxim for injection;
• Copaxone-Teva for subcutaneous administration.

Pills:

• Arpetolide;
• Vitanam;
• Galavit;
• Immunorm;
• Phlogenzyme;
• Cycloferon.

Suspension:

• Galavit and Imunofan for administration into the rectum;
• Methyluracil.

Drops:

• Immunal;
• Ruzam;
• Florexil.

pharmachologic effect

According to the instructions for use, Polyoxidonium has a whole range of effects on the human body:

1. Immunomodulatory
2. Anti-inflammatory
3. Antioxidant
4. Detoxifying
5. Membrane stabilizing

Polyoxidonium has an immunomodulatory effect, increases the body's resistance to local and generalized infections. The basis of the mechanism of immunomodulatory action of Polyoxidonium is a direct effect on phagocytic cells and natural killer cells, as well as stimulation of antibody formation. Restores immune responses in secondary immunodeficiency conditions caused by various infections, injuries, burns, malignant neoplasms, complications after surgery, the use of chemotherapeutic agents, including cytostatics, steroid hormones.

Along with the immunomodulatory effect, Polyoxidonium has a pronounced detoxification activity, increases the resistance of cell membranes to the cytotoxic effects of drugs and chemicals, and reduces their toxicity. These properties are determined by the structure and high-molecular nature of Polyoxidonium. The inclusion of Polyoxidonium in the complex therapy of cancer patients reduces intoxication during chemotherapy and radiation therapy, allows treatment without changing the standard therapy regimen due to the development of side effects (cytopenia, vomiting, diarrhea, cystitis, colitis, etc.). The use of Polyoxidonium can increase the effectiveness and shorten the duration of treatment, significantly reduce the use of antibiotics, bronchodilators, glucocorticosteroids, and extend the period of remission. The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.