Pragisan 200 during early and late pregnancy, for which it is prescribed

Forms of release and composition of the drug Prajisan 200

Prajisan is available in 3 forms:

Pragisan 200 during pregnancy is prescribed for its deficiency.
The main substance of the drug is the hormone progesterone. Other ingredients include peanut butter, glycerol, sorbitol solution, gelatin. Given the form of the drug, the components may be supplemented or changed.

It is important to remember: changing one form of the drug to another is undesirable.

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Pharmacodynamics and pharmacokinetics

The drug works as follows:

1. Gestagen comes into contact with receptors, enters the nucleus and activates DNA there. As a result, rapid RNA production begins.
2. The uterine mucosa enters the secretory phase.
3. Fertilization occurs.
4. Gestagen reduces the excitability and contraction of the uterine muscles.
5. When protein lipase is stimulated, fat reserves increase and the rate of glucose excretion increases. Glycogen accumulates in the liver. Aldosterone synthesis increases.

The active substance has different effects on the production of pituitary hormones. It depends on the dose: a small one helps to accelerate, and a large one – suppression. Prajisan 200 is often prescribed during pregnancy. It has pharmacokinetic properties that depend on the form and route of administration.

For example, if capsules are used, the substances they contain will be well absorbed in the gastrointestinal tract: more of the main active substance will penetrate into the blood. It will take approximately 120 minutes for the concentration to reach its maximum. Sometimes the highest concentration can be observed after 1 hour, sometimes after 3 hours. The substance is synthesized in the liver.

The main metabolites detected in blood plasma:

• 20-alphahydroxydelta;
• 4-alphapregnanolone;
• 5-alphadihydroprogesterone.

Metabolic products are excreted in the urine. Otherwise, the absorption and excretion of the drug occurs if it is used vaginally. The product is absorbed quickly. The main substance accumulates in the uterus. The maximum concentration can be achieved 60 minutes after administration. The decrease in the main active ingredient begins after approximately 4 hours.

If the drug is administered vaginally three times a day, 100 mg, the concentration will remain at an average level around the clock.

When progesterone is metabolized in the body, 3-alpha, 5-betapregnanediol are formed. The saturation of the latter in the blood does not increase. Metabolic products are excreted in the urine.

Pharmacological action of Prajisan

Progesterone (the active component of Prajisan) is a hormone of the corpus luteum that causes the transition of the uterine mucosa from the proliferation phase to the secretory phase.

Prajisan promotes:

• Reducing the excitability and contractility of the muscles of the uterus and fallopian tubes;
• Increased glucose utilization;
• Development of normal endometrium;
• Increased aldosterone production;
• Accumulation of glycogen in the liver.

When Prajisan is used vaginally, progesterone binds to the vaginal mucosa and is continuously released for at least three days.

Indications for use during pregnancy

Prajisan 200 during pregnancy and in its absence is indicated for low progesterone levels.

The hormone progesterone is prescribed to pregnant women who are prone to miscarriage due to:

• pathologies of the endocrine system;
• uterine fibroids;

  

• problems with the cervix, which cannot hold the fetus in the uterus;
• thrombophlebia;
• antiphospholipid syndrome (APS).

Prajistan is prescribed in the following cases:

Prajisan has no contraindications during pregnancy, but there is a danger to the child, especially if the birth of a boy is expected in the first half of the entire term. The main substance in the 2nd and 3rd trimesters can contribute to the occurrence of liver diseases.

According to the results of a large number of studies, no cases of abnormal fetal development were found. Nothing is known about the effect the active substance may have on a born baby who is fed breast milk.

When is it prescribed?

On numerous forums, women share their experiences of prescribing and taking medications. Based on this, we can conclude that in any case, the use of the drug is based on problems with progesterone. However, there is a difference in purpose between the tablets and the vaginal gel.

The doctor prescribes capsules:

• with premenstrual syndrome;
• in case of cycle disorders caused by anovulation and ovulation;
• with mastopathy of fibrocystic type.

And also, as I already said, for problems that arise during menopause.

Candles are most often in demand for the following pathologies:

• to prolong the luteal phase, which is necessary when preparing for IVF;
• in the absence of the luteal phase for the treatment of infertility;
• as prevention in the presence of uterine fibroids and endometriosis.

The instructions for the drug describe in detail the factors under which the drug should be used. But it’s better to ask the doctor who will prescribe the drug in more detail about this. He must not only prove the necessity of using the drug, but also explain what side effects there may be.

Prajisan 100 mg N30 is the most common dosage option for the drug. The annotation gives advice on the correct administration of the drug into the vagina.

I recommend that you familiarize yourself with it to avoid mistakes. Each disorder has its own characteristics of administration; this is described in detail, as well as on what days of the menstrual cycle you should start taking capsules.

Contraindications

Prajisan is contraindicated for women:

• having individual intolerance to the substances present in the composition;
• in early pregnancy;
• having problems with the circulatory system;
• suffering from asthma, diabetes.

The drug is also contraindicated if there are:

• vaginal discharge of unknown nature;
• tumors of the reproductive system;
• thrombophlebitis;

  

• disturbances in the functioning of the liver;
• hypersensitivity to progesterone.

If the drug is taken, the following symptoms may appear:

• allergy;
• contact dermatitis;
• prostration;
• increased drowsiness.

If these or other side effects occur, you should visit a specialist. He will recommend a different form or a different remedy.

When not to use the product

There is no need to rush to buy Prajisan without studying the contraindications for its use.

The most common include:

• if there is vaginal discharge of unknown origin;
• if there are malignant tumors of the woman’s reproductive system or if there is suspicion of oncology;
• if there are problems with thrombophlebitis.

It is clear that if a woman is hypersensitive to progesterone, then she is prohibited from taking the drug. And this is not a complete list of pathologies for which you should not take the drug. For example, if you have liver problems, then this is also a contraindication.

Instructions for use, dosage of the drug

The duration of therapy is determined by the doctor, which depends on the patient’s health and her individual characteristics.

In the early stages

Prajisan 200 in capsule form is taken orally during pregnancy. Most often, the daily dose does not exceed 300 mg. The first half of this dose is taken in the morning, and the second in the evening.

The dose may be higher, for example, if the prescription was for luteal phase deficiency, it can reach up to 400 mg. The course of therapy will last 1.5 weeks: it starts on the 17th day of the cycle and ends on the 26th day.

In the later stages

The gel is applied vaginally. The applicator contains 90 mg of the main substance. If it is necessary to cure infertility, the treatment lasts 1.5 weeks and is carried out every day. It usually starts on the 18th, 19th, 20th or 21st day of the cycle. To maintain the luteal phase, use 1 applicator every day. After pregnancy, treatment continues for another 3 months.

The gel is used as follows:

1. The applicator is removed, then held so that it is positioned between the thumb and middle finger, and the index finger is placed over the plunger.

   

2. You will need to lie on your back and bend your knees slightly.
3. Carefully insert the applicator and press down on the plunger. The contents will end up in the vagina.
4. You will need to discard the applicator even if there is gel left in it.

Method of application for gel

Gel "Prajisan" is intended for intravaginal use. For added convenience, it is packaged in an applicator that cannot be reused.

To insert the gel into the vagina, you need to follow a simple procedure:

1. Open the package and take out the applicator.
2. Unscrew the cap.
3. Hold the applicator between your middle and thumb and place your index finger over the plunger.
4. The gel is inserted into the vagina while lying on your back. The knees should be slightly bent.
5. In order for the medication to enter the vagina, you must press the piston of the applicator.

After pressing, a small amount of the drug may remain inside the applicator. There is nothing critical about this. There is no need to try to somehow get it out or store it for the next use. The manufacturer has provided for this point, so the patient does not have to worry that an insufficient amount of progesterone has entered the body.

Side effects

Prajisan 200 during pregnancy in various forms can lead to side effects.

If you take capsules, the following symptoms are possible:

• excessive sleepiness;
• dizziness;
• nausea;
• bleeding;
• reduction in the duration of the menstrual cycle;
• tension in the mammary glands.

To eliminate or reduce side effects, you should reduce the dose or use a different type of drug.

If Prajisan is administered vaginally, an allergic reaction such as hives or anaphylactic shock may occur.

Side effects when taken orally

1-3 hours after using Prajisana capsules, dizziness or drowsiness may occur. This side effect can be reduced by reducing the dose (after consulting a doctor), switching to the intravaginal route of administration, or taking the drug before bed.

If the course of treatment was started earlier than the 15th day of the cycle, this can lead to acyclic bleeding or premature onset of menstruation.

In addition, the following side effects may occur:

• allergic reactions (including urticaria and anaphylactic shock);
• amenorrhea;
• headache;
• bloating;
• mammalgia;
• depression;
• cholestatic jaundice;
• itching, acne;
• chloasma;
• insomnia;
• hyperthermia;
• tension in the mammary glands;
• change in libido;
• joint pain;
• change in body weight;
• fluid retention;
• increased blood pressure;
• increased sweating at night;
• hirsutism;
• alopecia;
• acute pancreatitis;
• thromboembolic complications and thrombosis (when used in conjunction with estrogens).

Overdose

If the amount of the drug taken exceeds the dose prescribed by the doctor, the following symptoms may be observed:

• increased drowsiness;

  

• frequent dizziness;
• reduction of the menstrual cycle.

If any of the symptoms are observed, you need to reduce the dose or adjust the regimen.

For example, if:

• frequent dizziness and sleepiness, a dose of 200 ml should be taken before bed in the last 3 days of the 2nd week of the cycle. In this case, the vaginal method is acceptable;
• as a result of an overdose, the duration of menstruation decreases; use should be started a little later: not from the 18th day, but from the 20th. If necessary, symptomatic treatment is carried out.

Dosage and course of treatment with gel

The required dosage and duration of treatment depend on the chosen form of the drug, the characteristics and nature of the disease.

Instructions for the use of "Prajisan" in the form of a gel provide the following dosages and course of treatment:

1. For replacement therapy in combination with estrogens during the postmenopausal period, 1 applicator of the drug (90 mg) twice a week.
2. For dysfunctional uterine bleeding and secondary amenorrhea - 1 applicator of the drug every other day, starting from the 15th and ending with the 25th day of the menstrual cycle. If necessary, the course of treatment can be adjusted up or down on an individual basis.
3. During ART, to maintain the luteal phase, the use of gel begins on the first day after embryo transfer. Dose – 1 applicator per day. After confirmation of pregnancy, therapy continues during the first trimester.
4. When treating infertility, therapy begins on the day of confirmed ovulation or between days 18 and 21 of the cycle and lasts 10 days. The dose remains the same as in all previous cases - 1 applicator per day.

special instructions

Before taking Prajisan, you should familiarize yourself with its special instructions:

• The product cannot be used as contraception.
• With long-term treatment based on taking the hormone progesterone, you need to undergo regular medical examinations, including liver tests. The appointment must be canceled if deviations in the work of this body are discovered.
• Dosage should be stopped if cholestatic jaundice occurs.
• When taking medications that contain estrogen and progestogen, in some cases patients develop chloasma. In women who are predisposed to developing chloasma, the disease may appear more quickly or worsen when the skin is exposed to ultraviolet rays. Therefore, it is not recommended to frequently stay in the sun, especially in clear weather.
• Patients with depression should be closely monitored. If it develops and enters a severe stage, use should be discontinued.
• Patients with problems with the circulatory and cardiovascular systems should be under the supervision of a specialist.
• Women who drive a car and who operate certain mechanisms by occupation must remember: the active component affects the ability to drive.

Side effects with intravaginal use

The number of adverse reactions of the body in this case is reduced to a minimum. Some patients experience local reactions, indicating individual intolerance to the components of the drug. In particular, these are:

• oily discharge;
• itching;
• burning;
• hyperemia of the vaginal mucosa.

Dizziness and drowsiness, characteristic of oral use of Prajisan, are not observed with intravaginal use.

Drug interactions

Based on the method of application, the medication interacts differently with other drugs. Prajisan 200 during pregnancy with simultaneous use of barbiturates loses its effectiveness. The same applies to taking Prajisan and Carbamazepine, Hydantoin, Rifampicin.

Capsules may enhance the effect of the following substances:

• cyclosporine;
• theophylline;
• troleandomycin.

If Prajisan is used in the form of suppositories or gel, you should not administer other intervaginal agents. This will prevent possible absorption of progesterone.

Interaction with other drugs

Suppositories should not be used together with other intravaginal medications.

Interaction reactions with other drugs and the use of Utrozhestan in the vagina have not been studied. When taken orally, please note that the medication:

• helps enhance the effect of anticoagulants, diuretics and antihypertensive drugs,
• reduces the effectiveness of oxytocin and its analogues,
• accelerates its metabolism while using barbiturates, spironolactone, rifampicin and antiepileptic drugs,
• has less effectiveness when used with antibiotics,
• has greater bioavailability when used with ketoconazole,
• reduces the effectiveness of bromocriptine,
• increases the need for insulin.

The effectiveness of Utrozhestan is reduced in smoking patients and women who abuse alcohol.

Analogs

Drugs whose effect is based on the hormone progesterone include:

Use of Prajisan during pregnancy and lactation

The use of Prajisan during pregnancy is not contraindicated, however, the instructions indicate the existing risk when taking the medication in the first four months of pregnancy. Based on the results of numerous epidemiological studies, no cases of abnormalities in child development were identified.

However, it should be borne in mind that Prajisan during pregnancy in the second and third trimesters can cause the development of liver diseases in the expectant mother.

There is no reliable data on the effect of the medication on a child during breastfeeding.

Progesterone levels during pregnancy

Progesterone is produced by the body during menstruation and increases in the middle of the cycle, during ovulation. During pregnancy, its amount constantly increases. The adrenal glands are responsible for producing the hormone.

Progesterone is responsible for the restructuring of the female body before pregnancy.

It affects:

• cell division and growth of fetal tissues;
• enlarged uterus;
• expansion of the pelvic bones;
• enlargement of the mammary glands;
• psycho-emotional state.

Its rate varies depending on the period of pregnancy:

If fertilization occurred through IVF, the norm should not differ from the indicators during a natural pregnancy, but the woman must keep this indicator under control, because its deficiency is often traced.

When the hormone is higher, this may indicate pathologies of the fetus or diseases of the woman, for example, diabetes, problems with the kidneys or adrenal glands.

If the hormone level is low, there may be a risk of miscarriage.

It could be:

• inflammatory process in a woman;
• delay in fetal development;
• frozen or ectopic pregnancy.

Clinically, progesterone deficiency may not be noticeable, so diagnosing it will require the following examination:

• basal temperature measurements;
• Ultrasound of the genital organs;
• Dopplerography and Doppler ultrasound;
• blood test to determine hormone levels;
• endometrial biopsy.

Only when determining the exact causes of changes in progesterone levels is it permissible to use Prajisan, but only under the supervision of a leading specialist.

In addition to taking it to adjust the hormone level, pregnant women should adhere to a certain diet. To reduce its level, do not consume nuts and dairy products, and reduce protein intake. To increase your intake, include legumes, nuts, avocados, eggs, fatty cheeses and fish and fish oil in your menu.

It is also important:

• maintaining routine and sleep;
• exclusion from food of canned foods rich in vitamins E, C;
• drinking clean water;
• exclusion of hair dyeing;
• maintaining an active lifestyle.

Prajisan is recommended during pregnancy if there is a risk of carrying a child. The product is sold in the form of capsules, suppositories and gel. The active component is the hormone progesterone, which is responsible for reproductive function.

Article design: Vladimir the Great

Storage conditions

To purchase the drug, you need a prescription.

Tablets are stored at a temperature not exceeding 25 degrees in a cool, dry place.

Gel - at a temperature of 15 to 25 degrees.

Keep away from children.

Tablets must be stored in a room where the temperature does not exceed 25 °C. The gel must be stored at a temperature of 15-25 °C. The shelf life is 2 years.

Store in a place protected from moisture and light, out of reach of children. Storage temperature: capsules – no higher than 25 °C; gel – from 15 to 25 °C.

Shelf life – 2 years.

Reviews from doctors

The use of Prajisan has received positive reviews from doctors. Here are some of them:

Candidate of Medical Sciences, gynecologist Anna Tishkova:

We prescribed the use of Prajisan vaginal gel to our patient with endometriosis, and already halfway through the course she noted the effectiveness of the prescribed treatment. The patient is now 2 months pregnant. There was no trace left of the disease.

Gynecologist Elena Smirnova:

The drug is relatively new, but has already proven itself. I prescribed it to several patients, I can only talk about its positive effect, no side effects were noticed.

Head of the Department of Gynecology, Gordykina Lyubov:

The patient had an underdeveloped endometrium. Prescribed by Prajisan. According to the ultrasound results, a positive effect is noticeable. The endometrium is healthy and grows normally.

Ph.D., gynecologist Polina Chistyakova:

Treatment of endometriosis with the drug Prajisan began to be prescribed to patients recently. It works quickly and effectively, I can confidently recommend it.

Experienced gynecologists recommend the drug Prajisan to their patients . Experience of successful use proves its effectiveness. The drug copes well with the tasks assigned to it.

Contraindications for the use of Prajisan.

The drug should not be used in cases of impaired renal and liver function (including hepatitis), vaginal bleeding for an unknown reason, or breast carcinoma (unless progesterone is used to treat this disease).

The medicine is quickly and almost completely absorbed. The drug is excreted with bile and kidneys, with feces.

Regular visits to the gynecologist - once every six months - will allow you to keep your health under control.

An overdose of prajisan can be detected by the following unpleasant symptoms: dizziness, drowsiness, the menstrual cycle becomes shorter than usual.

To eliminate the consequences of an overdose, consult your doctor, reduce the dose, and increase food intake. The doctor will tell you how to adjust the course taking into account the days of the cycle. If necessary, symptoms can be treated separately with other medications (in consultation with your doctor).

Compatibility with other drugs:

• Prajisan reduces the effectiveness of bromocriptine and glucose tolerance . In the presence of diabetes mellitus, the need for insulin increases.
• Smoking and excessive alcohol consumption reduce the effectiveness of progesterone.
• The drug cannot be used to protect against unwanted pregnancy; it is not a means of contraception.
• The medication is taken separately from meals.
• Now you have comprehensive information about the medicine, and it will be easier for you to understand your health issues.
• Before using the drug, consult your doctor.

Prajisan price in Moscow from 328 rubles, buy Prajisan, reviews and instructions for use

The cost of Prajisan is on average 298 rubles. Prices range from 216 to 419 rubles.

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357.00 rub.

328.00 rub.

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Gestagen

The price of Prajisan is about 250 rubles for 10 capsules with a dosage of 200 mg.

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ZdravCity

• Prajisan caps. 100mg n30SUN Pharmaceutikal Industries Ltd.
• Prajisan caps. 200mg n10SUN Pharmaceutikal Industries Ltd.

Reviews about Prajisana

There are generally good reviews on the Internet about the medicine if you use it according to your doctor's recommendations.

Reviews of Prajisana on forums:

• “I took the drug to get rid of pain before my period. The medicine significantly relieved all my pain. I advise you to buy...”
• “After I took the first pill, I felt bad, dizzy, nauseous, and there was a vacuum in my ears, I felt unwell all day...”
• “My sister took pills during pregnancy. I carried and gave birth, everything is fine...”

Interaction

When combining the drug with Carbamazepine , Rifampicin , barbiturates or Hydantoin , the effectiveness of the drug may be reduced.

Also, Griseofulvin and enterosorbents may reduce the effectiveness of the drug.

The medicine is combined with caution with Troleandomycin , Theophylline and Cyclosporine .

When administered intravaginally, the drug cannot be combined with various suppositories and vaginal tablets.