The use of sildenafil has proven to be an effective and safe way not only to treat erectile dysfunction (ED), but also to temporarily support men with psycho-emotional problems that prevent them from achieving a satisfactory erection. After Viagra, the first original drug with sildenafil, expired its patent prohibiting other drug manufacturers from repeating its composition, the situation with the wide availability of cheap and high-quality analogues became much better. Now the pharmaceutical market is replete with sildenophil from different manufacturers, which differ not only in price, but also in the form of release.
How does sildenafil work and is it safe?
In tablet form, the effect of sildenafil begins no later than 30-60 minutes after administration, and depending on the amount (25, 50 or 100 mg), it can last from 4 to 12 hours.
The wide range of available dosages allows you to choose the least effective one, while reducing the likelihood of side effects such as facial flushing or headache - such manifestations are characteristic of sildenafil in approximately 10% of cases. With the exception of these unpleasant, but reversible and harmless effects, long-term experience with use and clinical studies of sildenafil in large populations of men of different ages have demonstrated its high safety profile.
Sildenafil is an effective and well-tolerated treatment for ED regardless of the age of the adult patient, including men under 75 years of age (source).
If the patient does not have severe vascular disorders, heart failure and some other serious diseases (see the full list of restrictions in the instructions), then the use of sildenafil is allowed even in old age.
What analogues of the drug sildenafil exist?
Viagra Soft
The drug differs from the original Viagra in that it does not need to be swallowed. The Viagra Soft tablet must be placed under the tongue and wait until it is completely dissolved. Tablet dosage: 100 mg. You can take Viagra Soft no more than 1 time per day. Due to the fact that the tablet dissolves under the tongue, sildenafil begins to act within 15 minutes. In addition, the tablet has a pleasant taste, which customers will really like.
Viagra Soft retains its effect for approximately 5-6 hours. It is not recommended to use this drug together with fatty foods and alcoholic drinks - side effects may increase.
Viagra Soft should not be used in the following cases:
- diseases of the cardiovascular system;
- priapism;
- severe liver dysfunction;
- renal failure;
- curvature of the penis;
- allergy to medication components;
- leukemia;
- bleeding;
- ulcer;
- heart attack or stroke that occurred in the last 6 months.
Side effects with Viagra Soft are not as common as compared to the original Viagra. However, sometimes a man may experience:
- nausea;
- facial redness;
- dizziness;
- headache;
- tinnitus;
- dry mouth;
- pain in joints, back, muscles.
You can order Viagra Soft at an affordable price on our website.
Sildenafil 20 mg. software
Benefits of Viagra Soft:
- the tablet does not need to be swallowed or washed down with water;
- rapid onset of action of the drug - after 15 minutes;
- Viagra Soft retains its effect for about 5 hours;
- the drug can be taken either on an empty stomach or after meals;
- the tablet has a pleasant taste;
- You can drink it with a small portion of alcohol - no more than 100 ml;
- Viagra Soft has a cumulative effect - after a 3-week course of treatment, the results obtained last for the next 5-6 months;
- there is no addiction to the drug;
- the medicine has a minimal number of side effects;
- improves testosterone production;
- has a positive effect on the reproductive system - used in combination to treat infertility;
- Viagra Soft can be bought without a prescription.
Why is it profitable to buy Viagra Soft in our online store?
- Our pharmacist-consultant will answer all questions of interest to clients;
- There are several options for placing an order - through an operator, independently, by ordering a call back, ordering by phone, quick order;
- We provide clients with a system of discounts - 5, 10, 15%;
- we deliver goods anywhere in the country;
- we guarantee the confidentiality of the client’s contact information, no unauthorized person will know what specific product is in the package;
- Delivery in Moscow and St. Petersburg takes place by courier on the day the order is placed (if it is placed before 17:00). In addition, in these two largest cities, the client has the opportunity to use the pick-up service - that is, pick up the goods at a pre-agreed location after talking with the delivery service;
- the client can track the route of the parcel with the goods using a code sent by email;
- within 1 month the client can return the goods.
Kamagra gel
This analogue of Viagra is available in the form of a tasty gel, which is in sachets. The dosage of one sachet is 100 mg. The client can choose from various flavor options for gel based on sildenafil:
- orange;
- lemon;
- mint;
- a pineapple;
- cherry;
- mango;
- strawberry.
But the advantage of Kamagra gel is not only its pleasant taste. Due to the fact that sildenafil is in the form of a gel, it is more pleasant to use than Viagra in tablets. In addition, the gel begins to act faster - within 15 minutes after administration.
Kamagra gel is taken 15-20 minutes before sexual intercourse. To do this, the man needs to eat the contents of the bag. Viagra in gel form should not be taken more than once per day. The maximum permissible dose is 100 mg. The effect lasts for about 6 hours.
Contraindications for use:
- priapism;
- cardiovascular diseases;
- severe dysfunction of the liver and kidneys;
- allergy to the drug;
- leukemia;
- bleeding;
- heart attack or stroke that occurred in the last 6 months.
Side effects:
- nasal congestion;
- headache;
- dizziness;
- nausea;
- facial redness;
- dyspepsia;
- pain in the back, muscles, joints.
You can buy delicious Kamagra gel on our website.
Sildenafil gel 100 mg - “Delicious” analogue of Viagra
Interesting Facts
A healthy diet, according to the World Health Organization, “Provides protection against a variety of noncommunicable diseases, including...” Details can be found here https://www.who.int/ru/news-room/fact-sheets/detail/healthy-diet
Viagra capsules
Sildenafil in capsule form also begins to act quickly - approximately 20-23 minutes after administration. The dosage of this Viagra analogue is 100 mg. The capsule must be swallowed and washed down with water 20 minutes before sex. The drug acts for approximately 6 hours.
Contraindications:
- diseases of the cardiovascular system;
- priapism;
- curvature of the genital organ;
- leukemia;
- bleeding;
- ulcer;
- severe kidney and liver failure;
- intolerance to the components of the drug.
Side effects:
- dizziness;
- facial redness;
- nasal congestion;
- headache;
- nausea;
- pain in muscles, back and joints.
You can buy Viagra in capsules on our website.
Sildenafil citrate 100 mg. capsules
Viagra 150
This analogue is an enhanced portion of Viagra. Its dosage is 150 mg. In this regard, you can use the drug only after consulting a doctor and getting your body used to a 100 mg portion.
Viagra 150 is available in tablet form. You can take the analogue no more than once a day. The drug should be taken with water 30 minutes before sexual intercourse. The action time is approximately 8 hours.
Contraindications:
- priapism;
- cardiovascular diseases;
- leukemia;
- bleeding;
- peptic ulcer;
- stroke and heart attack suffered in the last 6 months;
- allergy to sildenafil;
- severe disorders of the liver and kidneys.
Side effects:
- facial redness;
- dizziness;
- nausea;
- pain in the back, joints and muscles;
- headache;
- nasal congestion.
You can purchase Viagra 150 on our website.
Super Sildenafil 150 mg.
Female Viagra
Manufacturers also took care of representatives of the fair half of humanity. Female Viagra was created especially for them. It differs from the original drug in its pleasant pink color due to the addition of auxiliary ingredients:
- triacetin;
- calcium hydrogen phosphate;
- lactose;
- titanium dioxide.
The dosage of the Female Viagra tablet is 100 mg. In the female body, the drug increases blood flow to the genitals, resulting in stimulation of the clitoris and increased production of vaginal lubrication. These factors lead to the fact that a woman begins to experience a strong desire for sex.
It is necessary to take Female Viagra in an amount of no more than 1 tablet per day. The tablet is taken with water within 30-40 minutes. The duration of action of Female Viagra is about 6 hours.
Contraindications:
- pregnancy;
- lactation period;
- renal and liver failure;
- allergy to the components of the drug;
- diseases of the cardiovascular system.
Side effects:
- nausea;
- facial redness;
- diarrhea;
- headache;
- disturbance of color perception.
You can order Female Viagra at an affordable price here.
Female Sildenafil 100 mg.
Viagra ODT
This sildenafil-based medicine is manufactured in France. Available in the form of diamond-shaped tablets colored blue. On one side there is the inscription V50, which indicates the dosage of 50 mg. Viagra ODT differs from other Viagra analogues in that, due to the presence of a sweet taste enhancer in the ingredients, it is a pleasant-tasting medicine.
This drug promotes the formation of an erection by relaxing the corpora cavernosa located in the genital organ. Viagra ODT works only if the man is sexually aroused.
The medicine is taken orally 40 minutes before sexual intercourse. The Viagra ODT tablet must be placed under the tongue and held until completely dissolved. If desired, can be taken with water. To enhance the effectiveness of the Viagra analogue, it is advisable to take it on an empty stomach. Sildenafil acts for approximately 7 hours.
Viagra ODT should not be used in the following situations:
- intolerance to the components of the drug;
- severe cardiovascular diseases;
- severe liver dysfunction;
- blood pressure, the level of which is below 90 to 50;
- recovery period after a heart attack or stroke;
- hereditary retinal disease;
- priapism;
- unstable angina;
- combined use with nitric oxide donors, nitrates, guanylate cyclase stimulators;
- penis deformation.
Sildenafil Citrate for Women
Sildenafil, as doctors point out, is a purely male drug that serves to maintain and restore potency in men. Meanwhile, the properties of the main substance of the drug can lower pressure in the pulmonary artery, and therefore the medicine can be prescribed to people suffering from a mild form of pulmonary hypertension. These may also be women, but in such cases the drug will have a slightly different name.
Sildenafil for women is available under the brand names Femalegra , Ladygra and Womenra.
The active substance in these drugs is the same Sildenafil citrate.
When women take the medicine, some side effects are also noted.
These include:
- visual impairment;
- sinus congestion;
- dizziness and headache;
- fear of light.
Sildenafril citrate for the fair sex not only relieves hypertension, but, as experts point out, it also has the same effect as on men - the effect of restoring sexual desire.
Before taking the drug, it is important to consult a doctor.
Contraindications
- hypersensitivity to the drug;
- deformation of the penis;
- simultaneous treatment with nitrates;
- tendency to bleed;
- renal failure and cirrhosis ;
- severe form of hypo- and hypertension ;
- unstable angina ;
- stroke or myocardial infarction (first 6 months);
- arrhythmia.
Interaction
Erythromycin, ketoconazole and cimetidine reduce the excretion of sildenafil with an increase in its content in the blood. Together with sodium nitroprusside the antiplatelet effect is enhanced .
When combined with organic nitrates, their hypotensive effect , which can be fatal.
Concomitant use with hypoglycemic drugs and beta-blockers , which can also be life-threatening.
Sildenafil price, where to buy
You can buy Sildenafil in pharmacies in Moscow and other cities of Russia. The price of Sildenafil in pharmacies depends on the dosage of the drug. The cost of 50 mg tablets ranges from 251 rubles. up to 490 rubles, 100 mg tablets from 412 rubles. up to 728 rub.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Sildenafil-SZ tab.
p/o captivity. 100 mg 14 pcs. Northern Star JSC RUB 391 order - Sildenafil-SZ gran. for oral administration 100 mg pack. 1.2g 4 pcs.NAO Northern Star
RUB 233 order
- Sildenafil-SZ tab. p/o captivity. 50 mg 14 pcs. Northern Star JSC
RUB 314 order
- Sildenafil tablets p.p.o. 50 mg 10 pcs. Ozone LLC
330 rub. order
- Sildenafil-SZ tab. p/o captivity. 100 mg 20 pcs. Northern Star JSC
RUB 619 order
Pharmacy Dialogue
- Sildenafil-SZ granules 50 mg (0.6 g sachets) No. 4Northern Star ZAO
RUB 268 order
- Sildenafil-SZ (tab.p.pl/vol.50mg No. 10)Northern Star ZAO
RUB 311 order
- Sildenafil-SZ (tab.p.pl/vol. 100 mg No. 10) North Star ZAO
RUR 366 order
- Sildenafil-SZ (tab.p.pl/vol.50mg No. 20)Northern Star ZAO
RUR 538 order
- Sildenafil-SZ granules 100 mg (1.2 g sachets) No. 4Northern Star ZAO
148 RUR order
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Release form and composition
The dosage form of Sildenafil is film-coated tablets (25/50/100 mg): diamond-shaped, biconvex, blue on the outside and white or almost white on the break, with an engraving “I” on the other side and “35” (for 25 mg tablets) , “36” (for 50 mg tablets) and “58” (for 100 mg tablets).
Composition of 1 tablet 25/50/100 mg:
- active substance: sildenafil citrate – 35.12/70.24/140.48 mg (in terms of sildenafil – 25/50/100 mg);
- auxiliary components: microcrystalline cellulose, anhydrous calcium phosphate, croscarmellose sodium, magnesium stearate, opadry II blue (lactose monohydrate, hypromellose HPMC 2910, titanium dioxide, triacetin, blue/indigo carmine dye), opadry transparent (hypromellose HPMC 2910, triacetin).
Side effects
- nervous system: headache, dizziness, hypoesthesia, drowsiness, stroke, fainting, transient ischemic attack, convulsions (including recurrent);
- cardiovascular system: hot flashes, palpitations, tachycardia, decreased or increased blood pressure (BP), myocardial infarction, atrial fibrillation, ventricular arrhythmia, unstable angina, sudden death;
- organ of vision: impaired vision and color perception, damage to the conjunctiva, impaired lacrimation, anterior ischemic optic neuropathy, occlusion of retinal vessels, visual field defects;
- organ of hearing: vertigo, tinnitus, nosebleeds;
- gastrointestinal tract (GIT): dyspepsia, nausea, vomiting, dry oral mucosa;
- allergic reactions: skin rash, Stevens-Johnson syndrome, Lyell's syndrome;
- genitals: hematospermia, bleeding from the penis, priapism, prolonged erection;
- musculoskeletal system: myalgia;
- other: chest pain, fatigue.
Special instructions for the use of Sildenafil
Before taking Sildenafil, as a drug that normalizes erectile dysfunction, it is important for the patient to undergo a heart examination, as well as conduct an examination of the vascular system.
Sildenafil is prescribed with extreme caution to men who have anatomical deformities of the genital organ (for example, cavernous fibrosis, etc.), as well as people predisposed to leukemia, sickle cell anemia and multiple myeloma.
Sildenafil should not be taken by men for whom sexual activity is contraindicated for one reason or another.
People should be especially careful when taking the drug:
- prone to frequent bleeding;
- with duodenal disease in the process of exacerbation of the disease;
- with peptic ulcer;
- with retinitis pigmentosa.
Sildenafil citrate should not be taken even in the smallest dose by persons under 18 years of age.
As for driving while taking the medication, doctors note that the drug has no effect on drivers, and therefore Sildenafil tablets can be used by those who are planning to drive.
Precautions when taking Sildenafil
Before you start taking Sildenafil, it is important to consult a doctor.
When a specialist prescribes a drug, he examines the patient’s tests, identifies the reasons that affected the sexual function of the male body, and only then prescribes treatment.
Before prescribing the medicine, a man must undergo a general clinical and urological examination.
The drug may be contraindicated for those who, for a number of clinical (physiological) reasons, have unwanted sexual activity. These can be people with different forms of heart disease, as well as patients with kidney failure, cirrhosis of the liver, men over 70 years old, etc.
When prescribing, the doctor takes into account not only physiological contraindications, but also contraindications for taking Sildenafil with other medications. So, as already noted, the use of this drug with nitrates is not recommended.
Sildenafil is not indicated for use by women, as well as children and adolescents under the age of 18.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
The drug restores the lost response to sexual arousal. Normal erection is impossible without the release of nitric oxide in the corpus cavernosum of the penis, which activates the enzyme guanylate cyclase . Activation of this enzyme leads to an increase in the level of a specific nucleotide - cyclic guanosine monophosphate (cGMP). This nucleotide is necessary to relax the muscles of the corpus cavernosum, resulting in increased blood flow in the penis. Sildenafil is a selective inhibitor of phosphodiesterase 5, which causes the breakdown of cGMP. Thus, Sildenafil citrate increases blood flow in the penis. In studies, 72% of patients had complete sexual intercourse. The effect of this medicine begins after 1 hour and lasts 3-4 hours.
Pharmacokinetics
Absorption: rapidly absorbed, bioavailability is 41%. Maximum plasma concentrations are observed on average 1 hour after administration on an empty stomach. Intake of alcohol and fatty foods slows down absorption.
Distribution: binds to plasma proteins, penetrates evenly into tissues.
Metabolism: metabolized by liver enzymes. The main metabolites are further metabolized, and their half-life is 4 hours.
Excretion: metabolites are mainly excreted in feces (80%) and urine (13%).
