Pharmacodynamics and pharmacokinetics
Pharmacodynamics
This is an antiviral agent, the main mechanism of which is inhibition of the early stage of virus reproduction after its penetration into the cell, blocking the transfer of the genetic material of the virus into the cell cytoplasm.
Pharmacokinetics
Slowly but completely absorbed into the gastrointestinal tract. 40% binds to blood proteins. The concentration of the active substance in nasal secretions is 50% higher than the plasma concentration. Metabolism occurs in the liver. The half-life is 24-30 hours, excreted by the kidneys. In patients with renal failure, it accumulates in toxic concentrations in the absence of dose adjustment.
Indications for use of Remantadine
What are these pills for? Affects influenza A and tick-borne encephalitis ( arbovirus ). It is effective when taken at the initial stage of infection (6-7 hours), which reduces the incidence of influenza and the severity of symptoms.
Main indications:
- treatment of influenza in the early stages;
- prevention of influenza during epidemics;
- prevention of encephalitis caused by ticks.
What is it needed for
The drug is prescribed at the first signs of illness:
- weakness;
- dizziness;
- chills;
- sore throat;
- headache;
- temperature above 37.5°C;
- profuse purulent discharge from the nose;
- redness of the skin;
- cough.
The main indications for taking Remantadine are:
- early and late therapy of viral diseases caused by strains of microorganisms:
- group A, including A2;
- group B;
- H1N1 groups;
- maintenance therapy for colds;
- prevention of encephalitis during tick activity;
- treatment of herpes caused by the pathogen Herpes simplex;
- prevention of viral diseases and influenza during epidemics.
Instructions for use of Remantadine (Method and dosage)
Remantadine tablets, instructions for use for adults
The tablets are taken orally after meals. For the treatment of influenza, take according to the following scheme: 1st day - 100 mg three times, on the 2nd and 3rd days - 100 mg twice, 100 mg on the 4th day. For the purpose of prevention - 50 mg per day for 10 to 15 days.
How to take the drug if you are bitten by a tick? During the first 72 hours, take 100 mg 2 times a day.
Instructions for Remantadine for children
- Children 7-10 years old are prescribed tablets - 50 mg twice, from 10 years old - 50 mg three times a day.
- In severe cases, it can be given to children 3–7 years old, but at a dose of 1.5 mg/kg in 2 divided doses.
Children from 1 year of age are prescribed rimantadine in syrup. Syrup for children is produced under the names Orvirem and Algirem .
Algirem syrup alginate matrix carrier ) can be used in children from 1 year of age. Sodium alginate has an adsorbent and detoxification effect, which enhances the antitoxic activity of the drug. A longer circulation time of Algirem in the blood allows reducing its dosage and reducing the risk of adverse reactions. A teaspoon of syrup contains 10 mg of rimantadine, take it after meals, according to the scheme.
The dosage method is as follows:
- From 1 to 3 years: 2 tsp. syrup three times a day on day 1; 2 tsp each twice a day on days 2 and 3; Day 4 – 2 tsp. syrup 1 time.
- From 3 to 7 years: 3 tsp. three times a day on day 1, 3 tsp. twice a day on days 2 and 3; Day 4 – 3 tsp. 1 time. Effective when taken in the first two days from the onset of the disease. Combines well with Viferon (ointment, gel, rectal suppositories).
Antiviral drugs of other groups: Tamiflu can be prescribed to children over one year old - 2 mg/kg 2 times, and Arbidol is approved for use in children over 3 years of age.
Instructions for use Remantadine STI
For the treatment of influenza, take according to the following scheme: 1st day - 100 mg three times, on the 2nd and 3rd days - 100 mg twice, on the 4th day - 100 mg 1 time. For the purpose of prevention - 50 mg per day for 10 to 15 days. Remantadine Actitab has the same indications and is used in the same dosage regimen.
Contraindications
You should stop taking Remantadine:
- children under 1 year old;
- with renal or liver failure;
- severe forms of hypertension;
- for epilepsy;
- thyrotoxicosis;
- individual intolerance;
- at all stages of pregnancy and during pregnancy.
The drug should be taken with caution in patients with atherosclerosis and cerebrovascular accidents. Rimantadine increases the risk of hemorrhagic stroke.
Interaction
Adsorbents and enveloping drugs reduce the absorption of the active substance.
Agents that acidify urine reduce the effectiveness of rimantadine, while agents that alkalize urine increase the effectiveness. The clearance of rimantadine is reduced when taking cimetidine .
Rimantadine reduces the effect of antiepileptic drugs.
The maximum concentration of the active substance in the blood is reduced by the simultaneous use of paracetamol and acetylsalicylic acid .
Side effects
In some cases, while taking the drug, the following are likely:
- dyspepsia: loss of appetite, dry mouth, nausea, stomach pain;
- impaired concentration, increased drowsiness, anxiety;
- headache.
In case of overdose, the body's negative reactions intensify. Acute intoxication leads to a metallic taste, uncontrollable vomiting, confusion, panic attacks, and hallucinations. In such cases, urgent gastric lavage and drug detoxification are required.
Analogs
Level 4 ATC code matches:
Rimantadine
Orvirem
Remavir
Analogs that have the same active ingredient and a similar antiviral effect: Orvirem , Rimantidine Actitab , Rimantadine-STI , Polyrem , Algirem ,
Similar antiviral drugs: Arbidol , Kagocel , Tamiflu .
Price issue
Every time you are prescribed a drug, you wonder how much it will cost you. Many employees of Russian pharmacies say that the patient often begins to choose a cheaper substitute for the drug prescribed to him. However, there are situations when this should not be done, because a cheaper analogue does not always have the same effect as the original drug, and if you take a cheap analogue, the consequences for you may be sad.
Reviews about Remantadine
Remantadine tablets - what are they taken for?
This is an antiviral drug that suppresses the replication of the virus. It is a “long-liver” on the antiviral drug market - it has been used since 1975. Its preventive use is effective during influenza epidemics in closed groups, as reported in many reviews. However, in recent years, the majority of influenza A viruses (up to 50%) have acquired resistance to this drug, so it has lost its relevance. It is not effective against other respiratory viral diseases and the A/H1N1 virus , which causes pandemics, is resistant to it. In this connection, the Ministry of Health and Social Development of the Russian Federation does not recommend the use of Remantadine during the pandemic period.
The sensitivity of viruses to class II drugs remains: oseltamivir , zanamivir , peramivir . Class III drugs ( aprotinin , camostat) have appeared recently and occupy a leading position in the treatment of influenza.
Reviews of Remantadine also include its use for weight loss. This is based on the fact that one of the side effects of the drug is a decrease in appetite, even anorexia . It should be noted that the indications for use of Remantadine do not include its use for this purpose. The presence of side effects, including kidney and liver damage, neuropsychiatric disorders (in 45.5% of cases), anemia , does not justify its use for weight loss. So you can pay a high price for lost kilograms.
special instructions
During treatment with Remantadine, there is a possibility of exacerbation of concomitant chronic diseases. In elderly people with arterial hypertension, the risk of developing hemorrhagic stroke increases; in patients with a history of epilepsy or simultaneously receiving anticonvulsant therapy, the risk of developing an epileptic seizure increases. In the latter case, the daily dose of rimantadine should not exceed 100 mg.
Prophylactic use of the drug is effective in cases of high risk of disease during an influenza epidemic, contacts with sick people, or the spread of infection in closed groups.
For influenza caused by virus B, rimantadine has an antitoxic effect. Viruses resistant to the drug may emerge.
Due to the likelihood of developing side effects from the central nervous system during treatment, it is recommended to exercise caution when driving vehicles and performing potentially dangerous types of work that require increased attention and high speed of mental and/or physical reactions.
Remantadine price, where to buy
This drug can be easily purchased at any pharmacy. The price of Remantadine depends on the manufacturer, so tablets No. 20 from Biokhimik (Russia) can be purchased for 50 - 60 rubles, and Remantadine from the manufacturer Usolye-Sibirsky CFC (Russia) is in the same price range. A similar number of tablets from the manufacturer Olainfarm (Latvia) costs 150 - 170 rubles. You do not need a prescription to purchase the drug.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Remantadine capsules 100 mg 10 pcs. Olainfarm JSC
194 rub. order - Remantadine tablets 50 mg 20 pcs. BiokhimikBiokhimik OJSC
67 RUR order
- Remantadine tablets 50 mg 20 pcs. Olainfarm JSC
RUB 169 order
Pharmacy Dialogue
- Remantadine tablets 50 mg No. 20Olainfarm OA
175 rub. order
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Pharmacy24
- Remantadine-KR 0.05 g No. 20 tablets PAT "Khimpharmzavod" Chervona Zirka", Kharkov, Ukraine
25 UAH. order
PaniPharmacy
- Remantadine tablets Remantadine-KR tablet. 50 mg No. 20 Ukraine, Red Star OJSC
30 UAH order
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Where should the consumer focus in the fight for health?
You learned about the medications “Rimantadine” and “Remantadine. The difference between the compositions is described above. What is better to choose for treatment and prevention?
Doctors report that the drug Rimantadine has not undergone the same tests as its analogue. That is why its instructions contain many side effects and special instructions. The drug "Remantadine" in this sense is safer and can be used for children and women during lactation.
If you still haven’t made your choice, then ask your doctor: “Rimantadine” and “Remantadine” - what’s the difference?” The doctor will tell you about the effectiveness of each medication, and also give valuable advice. Be healthy!
