Sedalgin-Neo – description of the drug, instructions for use, reviews

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Manufacturers: Balkanpharma-Dupnitza (Bulgaria)

Active ingredients

• Codeine
• Caffeine
• Metamizole sodium
• Paracetamol
• Phenobarbital

Disease class

• Phantom limb syndrome with pain
• Acute upper respiratory tract infection of multiple and unspecified localization
• Sciatica
• Myalgia
• Neuralgia and neuritis, unspecified
• Fever of unknown origin
• Headache
• Other constant pain
• Surgical practice
• Dysmenorrhea, unspecified

Clinical and pharmacological group

• Not indicated. See instructions

Pharmacological action

• Anti-inflammatory
• Antipyretic
• Sedative
• Analgesic (non-narcotic)

Pharmacological group

• NSAIDs - Pyrazolones in combinations
• Opioid narcotic analgesics in combinations

pharmachologic effect

The tablets have a combined composition and have antipyretic, analgesic, antimigraine and vasodilating effects. The medication is able to eliminate the symptoms of influenza , acute respiratory infections, and colds.

Caffeine stimulates brain activity, in particular psychomotor centers. The active substance increases performance (mental and physical), reduces the severity of feelings of fatigue and drowsiness , has an analeptic effect, and enhances the effect of analgesics.

Codeine has an analgesic effect by changing the emotional perception of pain, which is achieved by stimulating the antinociceptive system. Suppression of the excitability of the cough center provides an antitussive effect of central origin. Compared to Morphine, the active component is less likely to cause respiratory depression, nausea, miosis, and constipation (when opioid receptors are activated in the intestinal lumen, smooth muscle tissue relaxes, sphincter spasm decreases, and peristalsis decreases). Codeine can enhance the effect of analgesics.

Paracetamol is a non-narcotic analgesic. The mechanism of action is based on blocking cyclooxygenases-1,2 in the nervous system. The antipyretic and analgesic effect is achieved by influencing the centers of thermoregulation and pain.

Metamizole Na belongs to the group of NSAIDs. It has antipyretic and analgesic effects. An antispasmodic effect is observed on the smooth muscles of the biliary and urinary tract.

Phenobarbital has sedative, antiepileptic, muscle relaxant and hypnotic effects.

Side effects

allergic responses , thrombocytopenia (decreased number of blood cells - platelets ), dizziness are rarely observed . With long-term therapy, pathology of the kidneys and renal system may develop, and bronchial asthma attacks may become more frequent. When the medication is abruptly discontinued, withdrawal symptoms are recorded, manifested mainly by headaches . Long-term use may be accompanied by a gradual decrease in the effectiveness of the drug.

Nervous system:

• irritability;
• limb tremors;
• headache;
• fast fatiguability;
• anxiety;
• impaired coordination of movements.

The cardiovascular system:

• agranulocytosis;
• extrasystole;
• arterial hypotension;
• cardiopalmus;
• hemolytic anemia.

Digestive tract:

• constipation;
• epigastric pain;
• vomit;
• anorexia;
• dry mouth;
• diarrhea syndrome;
• changes in liver function.

Bronchospasm is rarely observed. If other negative reactions are registered, consultation with a doctor and independent discontinuation of the drug Sedalgin is required.

Indications and restrictions

The drug is indicated for painful sensations of any location and intensity. This remedy relieves symptoms such as:

• 
  fever, including ARVI;

• arthralgia;
• dysmenorrhea;
• myalgia;
• neuralgia;
• sciatica;
• various types of pain (burn, traumatic, dental, rheumatic, migraine).

However, against the background of the positive dynamics of the drug’s effect on the body, there are a number of contraindications that must be taken into account when prescribing tablets:

• pregnancy;
• breastfeeding the baby;
• myocardial infarction;
• children under 12 years of age;
• hypersensitivity or intolerance to any substance included in the medication;
• renal or liver failure;

• 
  anemia;

• arrhythmia;
• leukopenia;
• glaucoma;
• bronchial asthma;
• hypertension (intracranial);
• depressed breathing;
• alcohol intoxication.

This medication is prescribed with extreme caution to elderly patients, as well as people with gastric or duodenal ulcers. Considering these contraindications, you should not use Sedalgin Neo without the prescription of a specialist, much less self-medicate.

Interaction

Anxiolytics, sedatives and all medications that depress the functioning of the nervous system can lead to increased sedative effect of Sedalgin Neo and depression of the respiratory center (a life-threatening condition). The drug enhances the effect of alcohol-containing drinks on psychomotor reactions. Metamizole displaces hypoglycemic drugs, indirect anticoagulants, indomethacin, and glucocorticosteroids from binding to proteins, increasing their activity. Oral contraceptives , antidepressants and Allopurinol increase the toxicity of Metamizole Na by changing its metabolism in the hepatic system. The effect of the active component is reduced when taking inducers of microsomal liver enzymes. An increase in toxic effect is observed during treatment with other non-narcotic analgesics.

General information

The drug is prescribed by specialists from medical institutions for frequent pain, fever, flu, severe and prolonged cough. It has proven itself well as an analgesic, antipyretic, and sedative. But due to its strong effect, the medicine is not recommended for use in children under twelve years of age, as well as in pregnant and breastfeeding women, since it contains phenobarbital, which negatively affects the condition of the fetus and the child’s body.

Drug group, INN

Sedalgin Neo belongs to the combined analgesic drugs with the international nonproprietary name Codeine + Caffeine + Metamizole sodium + Paracetamol + Phenobarbital. Finds its application when:

• neuralgia;
• frequent migraines;
• neuritis;
• colds (flu, ARVI), accompanied by acute attacks of coughing, high fever;
• various types of pain (dental, migraine, postoperative), trauma, rheumatism, burns;
• dysmenorrhea.

Analogs

Level 4 ATC code matches:
Phenacetin

Combiflu

Chlorphenamine

Coldflu

Calpol

Fervex

Panadol Extra

Panadol for children

Panadol

Solpadeine

Efferalgan

Milistan

Coldrex Maxgripp

Coldrex Hotrem

Coldrex

AntiGrippin

Unispaz

Pentalgin Plus

Rapidol

Maxicold

• Sedal-M;
• Quintalgin;
• Santoperalgin.

Sedalgin-Neo

Active substance:

Codeine, Caffeine, Metamizole sodium*, Paracetamol*, Phenobarbital*

Pharmgroup:

Opioid narcotic analgesics in combinations