Lipin Biolic 500 mg lyophilisate for emulsion - Pharmstandard-Biolek: price, instructions, reviews. Buy Lipin Biolic 500 mg lyophilisate for emulsion in Ukraine

Release form and composition

Lipin is produced in the form of a lyophilisate for the preparation of an emulsion: an amorphous mass of light yellow or white color with a characteristic odor (in bottles or vials of 100, 250 or 500 mg, 1 bottle or vial in a cardboard pack or 3 vials in a cardboard pack as a set with NEBULISER inhaler).

The composition of 1 bottle (bottle) includes:

Active ingredient: lecithin – 100, 250 or 500 mg (as standard lecithin);
Auxiliary component: lactose.

Safocid

The drug Safocid is a pharmacological group of combined drugs with antifungal, antibacterial and antiprotozoal therapeutic effects.
The drug is used to treat infectious pathologies caused by pathogens sensitive to the active components of the drug.

In this article we will look at why doctors prescribe Safocid, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Safocid can be read in the comments.

Indications and contraindications for use

Before you learn how to take the medicine, you need to understand in what cases a gynecologist or urologist prescribes it, as well as what contraindications there are. The drug is recommended for use if there is a history of several infections in the genitourinary system:

Fungal infection;
Chlamydia;
Gonorrhea;
Bacterial form of vaginosis;
Trichomoniasis, etc.

Safocid is a powerful antibacterial agent that consists of three substances; accordingly, it has a fairly extensive list of medical contraindications. Contraindications for the drug are divided into absolute - use is strictly prohibited; relative - it is permissible to use, but with extreme caution.

Use in the following situations is strictly prohibited:

Disturbance of the central nervous system;
Severe form of liver failure;
Time of bearing a child, lactation period;
Pathologies of the circulatory system;
Renal failure;
Organic intolerance to the active components of the drug;
Children under 18 years of age.

Important: Safocid is prescribed with extreme caution for arrhythmia, as there is a risk of developing ventricular arrhythmia.

Due to medical contraindications, sometimes the use of medication is not advisable, so many are interested in what to replace Safocid with? There is no complete analogue that would include three active components.

Analogs that have an antifungal effect include: Abaktal, Unidox Solutab, Tetracycline with nystatin, Ericicline, Ofor and other medications. These analogues have a lesser effect, so they are used for a long time to destroy the fungus. Alternatively, you can take the active ingredients in tablet form separately. In other words, Fluconazole + Azithromycin + Secnidazole.

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Indications for use

Lipin is prescribed as part of complex treatment of the following diseases:

Cardiology: unstable angina and acute myocardial infarction;
Pulmonology: syndrome of chronic and acute respiratory failure of any origin in adults and children, including newborns with respiratory disorders associated with perinatal hypoxia and birth asphyxia;
Obstetrics: intra-abdominal fetal hypoxia, late gestosis;
Gastroenterology: active hepatitis (acute and chronic), liver cirrhosis, chronic non-calculous cholecystitis, nonspecific ulcerative colitis;
Nephrology: polycystic disease, acute and chronic pyelonephritis, diabetic nephropathy, glomerulonephritis, renal failure.

Safocid

Directions for use and dosage

Lipin is used orally, intravenously, rectally and inhaled.

The liposomal emulsion should be prepared immediately before use. To do this, the bottle (vial) is kept for 30 minutes at room temperature. To prepare an emulsion for intravenous administration, a 0.9% solution of sodium chloride for injection or infusion, preheated to 36 °C, is added to it in a ratio of 10:1 (per 100 mg of lyophilisate - 10 ml of solution). When preparing an emulsion for inhalation, a ratio of 100:2 is used (per 100 mg of lyophilisate - 2 ml of solution). Then the bottle should be shaken until a homogeneous white emulsion is formed (about 2 minutes).

When preparing the emulsion for rectal use and oral administration, you can use boiled or distilled water.

Lipin should not be used in the same syringe or inhalation device with other inhalation or parenteral solutions.

Pulmonology: For inhalation use, 10-15 mg/kg body weight is usually prescribed for 1 inhalation. Frequency of application – 1-2 times a day (in severe cases – 3 times a day), course duration – 5-10 days.

For newborns with respiratory distress syndrome, the drug is prescribed 3-4 times a day in doses of 25-100 mg/kg body weight. The optimal duration of inhalation is 3-4 minutes, the duration of the course is 4-5 days (if necessary, it can be extended to 10-12 days).

It is possible to connect the inhaler to the breathing circuit of a ventilator (artificial lung ventilation). When carrying out inhalation, you need to use aerosol-type inhalers or ultrasonic inhalers. The use of vapor aerosol inhalers is prohibited.

Obstetrics: For gestosis, Lipin is administered intravenously slowly.

The duration of the course is determined by clinical manifestations and can vary from 3 to 10 days.

Gastroenterology: For acute or chronic active hepatitis, chronic non-calculous cholecystitis and liver cirrhosis, Lipin is taken orally 2 times a day, 1000 mg. Course duration is 18-21 days. In severe cases of the disease, the lyophilisate is dissolved in a 5% glucose solution and administered intravenously in the same dose. The duration of the course is 10 days. During therapy, it is possible to change the method of administration of Lipin.

In the treatment of nonspecific ulcerative colitis, the drug is used in the form of microenemas in a single dose:

Days 1-10: 1000 mg;
Days 11-20: 500 mg.

Frequency of use – 2 times a day, course duration – 20 days.

Nephrology: In the treatment of chronic and acute pyelonephritis, Lipin is administered intravenously in a dose of 10-20 mg/kg body weight once a day simultaneously with antibacterial agents. Course duration is 3-4 days.

In the treatment of chronic pyelonephritis, glomerulonephritis, diabetic nephropathy at the stage of chronic renal failure, Lipin is administered intravenously in the same dose simultaneously with standard basic therapy. The duration of the course is 14 days.

Safocid

Safocid is a combined set containing an antifungal drug, an antibiotic and an antibacterial drug with antiprotozoal activity. Fluconazole is an antifungal agent that has a highly specific effect, inhibiting the activity of fungal enzymes dependent on cytochrome P450. Blocks the conversion of lanosterol in fungal cells to ergosterol; increases the permeability of the cell membrane, disrupts its growth and replication. Fluconazole, being highly selective for fungal cytochrome P450, practically does not inhibit these enzymes in the human body (in comparison with itraconazole, clotrimazole, econazole and ketoconazole, it suppresses cytochrome P450-dependent oxidative processes in human liver microsomes to a lesser extent). Does not have antiandrogenic activity. Active against opportunistic mycoses, incl. caused by Candida spp. (including generalized forms of candidiasis due to immunosuppression), Cryptococcus neoformans and Coccidioides immitis (including intracranial infections), Microsporum spp. and Trichophyton spp.; for endemic mycoses caused by Blastomyces dermatidis, Histoplasma capsulation (including immunosuppression). Azithromycin is a broad-spectrum antibacterial agent, an azalide, which acts bacteriostatically. By binding to the 50S ribosomal subunit, it inhibits peptide translocase at the translation stage, suppresses protein synthesis, slows down the growth and reproduction of bacteria, and in high concentrations has a bactericidal effect. Active against extra- and intracellular pathogens. Microorganisms sensitive to azithromycin: aerobic gram-positive microorganisms - Staphylococcus aureus (methicillin-sensitive strains), Streptococcus pneumoniae (penicillin-sensitive strains), Streptococcus pyogenes; aerobic gram-negative microorganisms – Haemophilus influenzae, Haemophilus parainfluenzae, Legionella pneumophila, Moraxella catarrhalis, Pasteurella multocida, Neisseria gonorrhoeae; anaerobic microorganisms – Clostridium perfringens, Fusobacterium spp., Prevotella spp., Porphyromonas spp.; other microorganisms – Chlamydia trachomatis, Chlamydia pneumoniae, Chlamydia psittaci, Mycoplasma pneumoniae, Mycoplasma hominis, Borrelia burgdorferi. Microorganisms with acquired resistance to azithromycin: aerobic gram-positive microorganisms - Streptococcus pneumoniae (penicillin-resistant strains and strains with average sensitivity to penicillin). Microorganisms with natural resistance: aerobic gram-positive microorganisms - Enterococcus faecalis, Staphylococcus aureus (methicillin-resistant strains), Staphylococcus epidermidis (methicillin-resistant strains); anaerobic microorganisms – Bacteroides fragilis. Cases of cross-resistance between Streptococcus pneumoniae, Streptococcus pyogenes (group A beta-hemolytic streptococcus), Enterococcus faecalis and Staphylococcus aureus, including Staphylococcus aureus (methicillin-resistant strains) to erythromycin, azithromycin, other macrolides and lincosamides have been described. Secnidazole is an antimicrobial bactericidal agent - a synthetic derivative of nitroimidazole. Active against obligate anaerobic bacteria (spore- and non-spore-forming), causative agents of some protozoal infections: Trichomonas spp., Giardia lamblia, Entamoeba histolytica. Not active against aerobic bacteria. Interacts with the DNA of a microbial cell, causing disruption of the helical structure, strand breakage, suppression of nucleic acid synthesis and cell death. Causes sensitization to alcohol (teturam-like effect).

Indications for use: Indications for the use of the drug Safotsid are: combined uncomplicated sexually transmitted infections of the genitourinary tract, such as trichomoniasis, chlamydia, fungal infections, as well as specific cystitis, urethritis, vulvovaginitis and cervicitis accompanying them.

Directions for use: Take Safocid All 4 tablets included in the blister are taken simultaneously one hour before a meal or 2 hours after a meal.

Side effects

When used in therapeutic doses, Lipin is usually well tolerated.

During therapy, palpitations, headaches, urticaria and other allergic manifestations may occur.

In some cases (after intravenous administration of Lipin), the following may develop:

General reactions: fever, tremors of the extremities, decreased blood pressure, weakness, vomiting, pain in the lumbar spine, shooting in the thoracic and lumbar spine;
Local reactions: pain along the vein.

If these disorders develop, Lipin should be discontinued and symptomatic therapy prescribed.