Compound
- 1 tablet of Strepsils Plus contains 1.2 mg of dichlorobenzyl alcohol , 10 mg of lidocaine hydrochloride and 600 mcg of amylmetacresol . Additional substances: sodium saccharinate, tartaric acid, levomenthol , anise oil, peppermint oil, quinoline yellow dye, liquid sucrose, indigo carmine , liquid dextrose.
- 1 dose of Strepsils Plus topical spray contains 290 mcg of amylmetacresol , 580 mcg of dichlorobenzyl alcohol and 780 mcg of lidocaine hydrochloride . Additional substances: citric acid, 96% ethanol, carmazine edicol, sodium hydroxide, glycerol, saccharin, levomenthol, sorbitol 70%, anise oil, peppermint oil, water, hydrochloric acid.
Pharmacological authorities
Pharmacodynamics.
Amylmetacresol and 2,4-dichlorobenzyl alcohol act as an antiseptic, and lidocaine is a local anesthetic. Strepsils Plus is an antiseptic combination drug with a local anesthetic effect. Active across a broad spectrum of gram-positive and gram-negative microorganisms in vitro
; Repair the antifungal action in the same way.
Pharmacokinetics.
2,4-dichlorobenzyl alcohol is metabolized in the liver to the formation of hypuric acid, which is visible in the liver. Data for elimination of amylmetacresol daily.
Lidocaine is easily absorbed by mucous membranes. The period of withdrawal from plasma becomes approximately two years.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Multicomponent antiseptic drug for local use in ENT pathology and dentistry. Has antimicrobial and local analgesic effects. Demonstrates activity against many gram-positive and gram-negative microorganisms in the laboratory, and also has an antifungal effect.
Natural medicinal additives in the composition of the drug have a softening effect on inflammatory mucous membranes.
Pharmacokinetics
Due to negligible absorption into the systemic circulation, pharmacokinetic data are not provided.
Features of good stagnation
Do not overdo the prescribed dose.
If symptoms of illness persist for more than 3 days, are accompanied by high temperature, headache or other symptoms, additional correction of treatment regimens is necessary.
Do not put the drug immediately before taking it to prevent the skin from getting lost in the cold due to the local anesthetic effect of iceocaine.
The local analgesic effect of lidocaine can be caused by temporary numbness of the mouth and pharynx, and can also interfere with the process of forging.
Do not inhale the spray. Uniquely the loss in the eyes.
The duration of the treatment course should not exceed 5 days, otherwise this can lead to an imbalance of the normal microflora of the oral cavity with a risk of bacterial or fungal growth.
Repeated or trival treatment of the mucous membrane can lead to the development of systemic toxic effects of local anesthetics (damage to the central nervous system with blood vessels, cardiovascular insufficiency).
Athletes need to have respect for those who have the responsibility to avoid any substance that may cause a positive test result during anti-doping control.
Patients taking any other medications should consult a doctor before using the spray.
With care, we should treat illnesses with erosive and desquamative changes in the mucous membrane of the oral cavity, fresh wounds of large sizes in the oral cavity and pharynx.
Likarsky zasib mist barvnik karmoisin edikol (E 122). May cause allergic reactions.
This drug should be used with a low concentration of ethanol (alcohol), less than 100 mg/dose.
This medicinal purpose is to use sorbitol. If you have an intolerance to certain drugs, consult your doctor first and take this medication first.
Suspension during pregnancy or breastfeeding.
Vaginism
Research on animals is not enough to determine the level of toxicity. There is no or no amount of information about the provision of medicinal care to vaginal women. Crimea, a drug that mixes alcohol. It is not recommended to use Strepsils® Plus, oromucosal spray, during pregnancy.
Breast bath period
Lidocaine, its metabolites and alcohol are found in breast milk. It is unknown whether amylmetacresol and 2,4-dichlorobenzyl alcohol or their metabolites are excreted in breast milk. Rizik for newlyweds/newborns cannot be turned off. It is not recommended to take this medication during breastfeeding.
Fertility
Information about the impact on the reproductive function of people every day.
This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.
There was no information about the influx of keruvat into the building by motor transport or through other mechanisms.
Instructions for use Strepsils Plus (Method and dosage)
Strepsils Plus tablets, instructions for use
The tablets are intended to be dissolved and should not be swallowed or bitten.
Adults and children over 12 years of age are recommended to suck on 1 lozenge every two hours, but it is forbidden to take more than 8 pieces per day. The tablets need to be dissolved in the mouth until they are completely dissolved.
Spray Strepsils Plus, instructions for use
Strepsils Plus spray is prescribed only to patients over 12 years of age. Every 3 hours, spray 1 dose (which corresponds to 2 presses) in the area of the inflamed area. It is prohibited to use more than 6 doses per day. The duration of treatment should not be more than 5 days.
Strepsils Plus with anesthetic N16 lozenges
Compound
active ingredients
: lidocaine hydrochloride, amylmetacresol, 2,4-dichlorobenzyl alcohol
1 lozenge contains lidocaine hydrochloride 10 mg, amylmetacresol 0.6 mg,
2,4-dichlorobenzyl alcohol 1.2 mg
Excipients
: levomenthol, peppermint oil, star anise oil, tartaric acid, sodium saccharin, sucrose solution, glucose solution, yellow quinoline (E 104), indigo (E 132).
Dosage form
Lollipops.
Basic physical and chemical properties:
a round lollipop of a pale bluish-green color with an S embossed on both sides.
Pharmacotherapeutic group
Medicines used for throat diseases. Antiseptics. Dichlorobenzyl alcohol. ATX code R02A A03.
Pharmacodynamics
2,4-dichlorobenzyl alcohol and amylmetacresol have antiseptic properties. Lidocaine is an amide-type local anesthetic.
Pharmacokinetics
Lidocaine is easily and quickly absorbed from the mucous membrane. The half-life of the drug from blood plasma is approximately 2 hours.
Metabolism occurs in the liver to form the active metabolite, monoethylglycerylxylidine, which is then hydrolyzed to various metabolites, including glycinexylidide. These metabolites enhance both the therapeutic and toxic effects of lidocaine. Less than 10% is excreted unchanged by the kidneys. Metabolites are also excreted in the urine. Due to the insignificant absorption of amylmetacresol and 2,4-dichlorobenzyl alcohol into the blood, the drug is classified as a topical agent. Given this, the pharmacokinetic parameters of these components have not been studied.
Indications
Symptomatic treatment of infections of the mouth and throat, including severe sore throat.
Contraindications
An allergic reaction to any of the components of the drug or other amide local anesthetic drugs.
Do not use in patients with fructose intolerance, glucose-galactose, sucrose-isomaltose malabsorption syndrome.
Interaction with other drugs and other types of interactions
No clinically significant interactions of the drug with drugs from other groups have been identified.
Features of application
If symptoms of the disease persist for more than 3 days, are accompanied by high fever, headache or other phenomena, you should consult a doctor.
The drug may cause numbness of the tongue, so after taking the drug you should eat and drink with caution.
Patients with diabetes should note that 1 Strepsils® Plus lozenge contains approximately 2.6 g of sugar.
The drug should not be used immediately before or during meals to prevent food from entering the respiratory tract due to the local anesthetic effect of lidocaine.
The drug may cause mild transient taste disturbances, so caution should be exercised when consuming hot food and water.
The local anesthetic effect of lidocaine may cause temporary numbness of the mouth and throat and may also affect swallowing.
Use with caution in patients with erosive and desquamative changes in the oral mucosa, fresh large wounds in the oral cavity and pharynx.
Do not exceed recommended doses.
The ability to influence reaction speed when driving a vehicle or operating machinery
No effects on the ability to drive vehicles or operate machinery have been reported.
Use during pregnancy or breastfeeding
The safety of this medicine for use in pregnant women has not been established. Therefore, it is not recommended to use this drug during pregnancy and lactation, unless the patient is under supervision.
Directions for use and doses
Recommended for adults and children over 12 years old
.
Use 1 lozenge every 2 hours if necessary. The lollipop must be sucked until completely dissolved. Do not consume more than 8 lozenges within 24 hours. For elderly people there is no need to reduce the dose.
Children
Not recommended for use in children under 12 years of age.
Overdose
Given the form of the lozenges, accidental or intentional overdose is very unlikely. Overdose primarily causes excessive loss of sensation in the upper gastrointestinal tract and may result in symptoms of gastrointestinal discomfort. In this case, you must stop using the drug. Treatment of a potentially toxic overdose should be symptomatic and supportive, under medical supervision.
A significant overdose of lidocaine affects the nervous and cardiovascular systems and can also cause methemoglobinemia. Methemoglobinemia is treated with immediate administration of 1-4 mg/kg methylene blue intravenously.
Adverse reactions
The following adverse reactions have been observed during short-term use of 2,4 dichlorobenzyl alcohol and amyl methacresol in over-the-counter doses. In case of long-term treatment of chronic conditions, additional side effects may occur.
Adverse reactions that occurred with the use of 2,4-dichlorobenzyl alcohol and amylmetacresol are listed by organ system and frequency of their occurrence. The frequency of adverse reactions is determined as follows: very often (≥1/10), often (from ≥1/100 to <1/10), infrequently (from ≥1/1000 to <1/100), rarely (from ≥1/100). 10,000 to <1/1000), very rare (<1/10,000) and frequency unknown (cannot be estimated from available data). Within each group, the frequencies of adverse reactions are given in descending order of severity.
From the immune system
Not known: hypersensitivity, anaphylactic reactions, allergic reactions including rash, burning in the mouth or throat and swelling of the mouth and throat, urticaria, angioedema.
From the skin and subcutaneous tissue
Unknown: rash, itching.
From the gastrointestinal tract
Not known: nausea, oral discomfort, abdominal pain, stomatitis, dyspepsia, heartburn.
From the nervous system
Unknown: dysgeusia.
Best before date
3 years.
Storage conditions
Store at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Package
8 lollipops in a blister, 2 blisters in a cardboard box.
Vacation category
Over the counter.
Manufacturer
Reckitt Benckiser Healthcare International Limited.
Manufacturer's location and address of place of business
Nottingham Site, Thane Road, Nottingham, NG90 2DB, UK.
© Translation into Russian by the editorial team of apteka24.ua.
Source: “State register of medicinal facilities of Ukraine”, 2020.
Analogs
Level 4 ATC code matches: Falimint
Suprima-ENT
Ingalipt-N
Strepsils
Ingalipt
Theraflu LAR
Hexoral Tabs
Lisak
Efizol
Angilex
Kameton
Anzibel
Agisept
Yox
Lugol's solution with glycerin
Lugol
Laripront
Stopangin 2A
Stopangin
Septolete Neo
Rinza Lorsept Anesthetics , Hexoral Tabs extra .
Overdose
Overdosing can result in symptoms of discomfort in the side of the scolio-intestinal tract, such as nausea, nausea, vomiting, and can also cause extreme anesthesia in the upper respiratory tract and herbal tract. In this type of episode, it is necessary to administer the drug and carry out symptomatic treatment.
A significant overdose of iceocaine affects the nervous and cardiovascular systems and may also cause methemoglobinemia. Methemoglobinemia is treated with immediate administration of 1–4 mg/kg methylene blue intravenously.
Price, where to buy
The price of Strepsils Plus spray in Russia is 450-480 rubles, while a package of tablets No. 24 of the same name costs approximately 350-405 rubles.
In Ukraine, the spray can be purchased for 90-107 hryvnia, and the above package of tablets for about 73-85 hryvnia.
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
Pharmacy24
- Strepsils Plus 20 ml aerosol Famar Nederland B.V., Netherlands
93 UAH order - Strepsils Plus N16 lozenges with anesthetic for sore throat Reckitt Benckiser Healthcare International, Great Britain
67 UAH order
PaniPharmacy
- Strepsils plus Strepsils plus No. 16 UK, Reckitt Benckiser Healthcare International
79 UAH order
- Strepsils plus liquid Strepsils Plus aerosol 20ml Netherlands, Famar Nederland
104 UAH order
show more
Method of congestion and dosage
Maintain the lowest effective dose for the shortest period of time necessary to treat symptoms.
Considered to be older and older than 12 years old.
The interval between doses should be at least 2 years.
The children have grown up to 15 years of age
Grind the mouth and/or throat, pressing the two onto the saw, 1-6 times per serving.
Children from 12 to 15 pm
Grind the mouth and/or throat, pressing the two onto the saw, 1-4 times onto the bottom.
Stop the spray after taking the hedgehogs.
Remove the lid, turn the doors by pressing,
rozpilyuvach rosity mouth empty and/or throat
The bottle contains 20 ml, which is equivalent to 70 doses and 140 doses.
Children.
Not recommended for use in children under 12 years of age.
