Let's consider what effect Coficil Plus has on the human cardiovascular system: does it increase or decrease blood pressure, why is this drug needed and who will benefit from taking it?
Coficil Plus is a drug with analgesic and antipyretic effects, used to eliminate spasms, normalize body thermoregulation, and relieve pain (headache, dental, muscle). Available in the form of tablets for internal use.
Pharmacodynamics and pharmacokinetics
Multicomponent product.
Acetylsalicylic acid has an antipyretic and anti-inflammatory effect, reduces pain, and also moderately suppresses platelet and thrombus formation processes, improves perfusion at the site of inflammation.
Paracetamol has an analgesic, antipyretic and weak anti-inflammatory effect, which is associated with its effect on the thermoregulation center and a weak ability to suppress the biosynthesis of prostaglandins.
Caffeine increases the excitability of the spinal cord, vasomotor and respiratory centers, dilates the kidneys, blood vessels of the muscles, brain, heart, and reduces platelet aggregation; reduces the feeling of fatigue, drowsiness , increases performance.
In this combination, it has almost no stimulating effect on the brain, but helps regulate cerebral vascular tone and accelerate perfusion.
Description and procedure
Coficil Plus is a combination medicine based on ASA (acetylsalicylic acid) and is classified as an analgesic drug. Due to its complex composition, it is also classified as a non-steroidal anti-inflammatory and psychostimulant drug. Release form: tablets, packaging: blisters of 10 pieces; boxes with two blisters inside (20 pieces) are also available for sale. , "Ozone", "Pharmstandard" and others. The minimum price for 10 tablets is 10 rubles.
The main substance of the composition is ASA in an amount of 300 mg, the tablets also include 100 mg of paracetamol, 50 mg of caffeine.
ASA has a pronounced antipyretic effect, helps normalize temperature, and also reduces pain and has an anti-inflammatory effect. Pain caused by inflammation decreases more quickly when taking Coficil than pain of other origins.
ASA also has the ability to optimize blood microcirculation, improve its rheological properties, and reduce platelet aggregation, resulting in blood thinning.
Caffeine is a natural substance that moderately increases the reflex excitability of neurons in the spinal cord, vascular system, and respiratory center. It has the following actions:
- dilates blood vessels (muscular, cerebral, coronary, renal);
- activates motor activity, mental and physical performance;
- reduces drowsiness, fatigue;
- reduces platelet aggregation;
- improves mood.
The dosage of caffeine in Coficil Plus tablets is low, so when taken in recommended quantities it does not provide a pronounced psychostimulating effect, but it normalizes vascular tone and accelerates blood flow. With moderately low blood pressure, the use of tablets will have a normalizing effect and eliminate headaches.
Paracetamol is a non-narcotic analgesic that acts by weakly blocking COX-1-2 in the central nervous system, and also affects the thermoregulation center of the brain. Paracetamol's ability to inhibit prostaglandin synthesis is weak, so its anti-inflammatory effect is insignificant. This also determines the advantages of paracetamol, since due to the nature of its work it does not have a negative effect on the gastrointestinal tract or water-salt metabolism.
Contraindications
- Lesions of the digestive tract of an erosive-ulcerative nature.
- "Aspirin" asthma.
- Hypersensitivity.
- Bleeding from the digestive organs.
- Hemophilia.
- Hypoprothrombinemia.
- Vitamin deficiency K.
- Pregnancy or lactation .
- Severe coronary heart disease.
- Kidney failure.
- Lack of glucose-6-phosphate dehydrogenase.
- Severe arterial hypertension.
- Glaucoma.
- Sleep disorders.
- Portal hypertension.
- Surgical interventions with expected bleeding.
- Increased excitability.
- Hemorrhagic diathesis.
- Age up to 15 years.
It is recommended to take Coficil-Plus with caution if you have gout or liver disease.
Contraindications
The medicine should not be taken if allergic reactions are observed from taking ASA or other non-steroidal PS, especially those that are manifested by a combination of urticaria, asthma attacks, and hay fever. Acid negatively affects the gastrointestinal mucosa, so contraindications also include:
- erosion;
- ulcers (for a course of treatment - even in remission);
- acute gastritis.
The drug thins the blood and can be harmful in any form of bleeding, especially gastrointestinal. It is also strictly prohibited for various diseases of the blood system and a number of functional disorders - hemorrhagic diathesis, hemophilia, low levels of prothrombin and platelets, vitamin K deficiency. The same group of contraindications includes thrombocytopenic purpura, von Willebrand disease. Serious degrees of kidney and liver dysfunction also determine a ban on taking Coficil.
The drug is contraindicated in portal hypertension, severe hypertension, and aortic aneurysm. Due to the presence of caffeine, it can harm people with sleep disorders, various panic and anxiety disorders, and hyperexcitability. It is prohibited to treat with tablets for ischemic heart disease, after myocardial infarction, during pregnancy (1st and 3rd trimesters), and while breastfeeding. In the second trimester, you can only take pills once! The drug is also contraindicated for children under 15 years of age.
Side effects
Nausea, gastralgia, hepatotoxicity , vomiting, erosive-ulcerative lesions of the digestive system, tachycardia , allergic reactions , nephrotoxicity , increased blood pressure , bronchospasm.
dizziness , tinnitus, weakened platelet aggregation, hypocoagulation, deafness, headache , Reye's syndrome , hemorrhagic syndrome are possible .
Adverse reactions
Coficil Plus may cause adverse reactions. They usually occur when the medication is taken incorrectly/uncontrolled. Among them are the following conditions:
- decreased appetite;
- anorexia;
- nausea;
- vomit;
- stomach ulcer, duodenal ulcer;
- blurred vision;
- dizziness;
- nosebleeds;
- spasms, convulsions;
- liver dysfunction;
- nervous disorders;
- insomnia;
- blood clotting disorder;
- allergic reactions (skin rash, itching).
If adverse reactions occur, the drug should be discontinued. The patient must immediately consult a doctor and undergo laboratory tests.
Instructions for use Coficil-Plus (Method and dosage)
Instructions for use Coficil-Plus prescribes taking the drug orally, during or after meals, 1 tablet every four hours; for pain, take 1-2 tablets; the usual daily dose is 3-4 tablets, the highest daily dose is 8 tablets. The duration of therapy should not exceed 7-10 days.
The medicine should not be taken for more than five days as an analgesic and for more than three days as an antipyretic. Other dosages and patterns of use are determined by the doctor.
Indications for use
Typically, the drug is recommended to be taken for pain of mild to moderate severity - it does not treat sharp, severe pain. Adults can drink it for migraines and headaches of vascular origin. The medicine will help with toothache if it is caused by caries, pulpitis, mini-operations for resection, cyst removal, or dental implantation.
Among the indications for Coficil are pain in the muscles - myalgia, as well as manifestations of neuralgia after hypothermia and for other reasons.
Tablets can be used for joint pain caused by arthrosis, arthritis and other pathologies. Also, the indications for use of Coficil Plus indicate pain due to osteochondrosis, lumbago and radiculitis, sciatica and radicular syndrome. The drug will help with painful menstruation - algomenorrhea.
At elevated temperatures it can also be used, but with some restrictions. Indications include colds and acute respiratory infections of bacterial etiology, sore throat and other infections of non-viral origin. In adults over 18 years of age, it is permissible to use the drug for viral infections under the supervision of a specialist.
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Overdose
Signs of overdose: nausea, ringing in the ears, gastralgia, vomiting, dizziness, lethargy, collapse, drowsiness , bronchospasm , convulsions, difficulty breathing, anuria , respiratory acidosis , bleeding.
Treatment of overdose: monitoring pH balance and electrolyte balance; depending on the level of metabolism, the use of sodium citrate, sodium lactate or sodium bicarbonate is recommended.
Interaction
Combined use with other anti-inflammatory non-steroidal drugs, Methotrexate increases the likelihood of developing undesirable effects.
Reduces the effectiveness of Spironolactone, Furosemide, antihypertensive and anti-gout drugs that promote the evacuation of uric acid.
Metoclopramide enhances the absorption of Paracetamol .
Salicylamide, barbiturates, Rifampicin, antiepileptic drugs and other inducers of microsomal oxidation enhance the synthesis of toxic derivatives of Paracetamol , which affect liver function.
The simultaneous use of Paracetamol and ethanol increases the risk of hepatotoxic effects.
Under the influence of Paracetamol, the half-life of Chloramphenicol is extended fivefold.
Caffeine enhances the absorption of ergotamine.
special instructions
With long-term use of the drug, monitoring of blood counts and liver condition is necessary.
Children are prohibited from being prescribed medications containing acetylsalicylic acid , since in case of infection they can increase the risk of Reye's syndrome ( encephalopathy , vomiting, hepatomegaly ).
Acetylsalicylic acid in small doses weakens the evacuation of uric acid.
Acetylsalicylic acid has a teratogenic effect.
Effect on pressure
Coficil Plus increases blood pressure, the effect is short-term, lasting no more than 2 hours. This effect of the drug is due to the fact that it contains caffeine.
Caffeine dilates blood vessels, increasing circulation. Due to this, blood pressure increases. In addition, acetylsalicylic acid in combination with paracetamol helps remove excess fluid, thin the blood, and relieve inflammation. The result is that the work of the cardiovascular system is stabilized, the patient’s condition returns to normal.
However, the hypertensive effect of Coficil Plus is not comparable to the effect of antihypertensive drugs. It increases blood pressure by no more than 10 mm Hg. Art. Therefore, it is not advisable to take it during a hypotensive attack. But if, with a sharp decrease in pressure, there are no special medications at hand, you can take them to avoid the onset of a crisis or coma. After this, you must definitely call a doctor at home.
Analogs
Level 4 ATC code matches:
Acetylsalicylic acid
Aspirin-S
Citropak
Aspirin
Citramon
Farmadol
Askofen-P
Cefekon N
Aquacitramon
Upsarin UPSA
Citrapack
Alca Prim
Thrombopol
Citrapar
Askofen-P, Aquacitramon, Acepar, Migrenol Extra, Acifein, Citramarin, Citramon Ultra, Citramon P, Citrapar, Excedrin.
Price, where to buy
The price of a package of drug No. 10 in Russia is 9-10 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Koficil-Plus tablets 10 pcs. JSC Pharmstandard (ICN) Leksredstva Kursk
7 rub. order - Koficil-Plus tablets 20 pcs. Pharmstandard-Leksredstva OJSC
33 rub. order
