Neo-Theophedrine - description of the drug, instructions for use, reviews

Composition Teofedrin-N

The composition of Teofedrin-N includes the following active substances: theophylline , paracetamol , phenobarbital , cytisine , caffeine , ephedrine hydrochloride , belladonna extract .
Additional ingredients: potato starch, stearic acid, calcium stearate, povidone.

Thus, the composition of Theophedrine characterizes it as a combination drug.

Sales and storage

You can purchase Teofedrine only with a prescription from a doctor.

Since the tablets are recognized as a potent drug, you can purchase Teofedrine medication at a pharmacy with a prescription from a doctor. Selling in the public domain may mean that this is a fake; in such cases, it is recommended not to risk your health and contact the Federal Service for Supervision of Health Care.

Theophedrine instructions call for storing the drug in a cool and dry place, excluding direct sunlight on the tablets. The shelf life of the drug is 2 years.

Pharmacodynamics and pharmacokinetics

Theophedrine-N is a combination medicine that has bronchodilator and antispasmodic properties .

The bronchodilator effect is caused by a combination of theophylline and caffeine with ephedrine and the m-anticholinergic atropine .

Phenobarbital , which is part of the drug, has a depressant effect on the nervous system.

As a result of the action of the drug, the lumen of the bronchi increases, blood pressure in the pulmonary circulation decreases, coronary vessels renal blood flow activates of heart contractions increases . The drug also acts to a moderate extent as diuretic .

In addition, the medicine has antipyretic and analgesic properties, since it contains paracetamol . It is well absorbed from the gastrointestinal tract when orally as tablets. Maximum plasma is reached after 60 minutes. Metabolites of paracetamol are excreted within 1-4 hours. This occurs primarily through the kidneys. The plasma half-life is 3 hours. This time may increase in case of renal / liver failure and drug overdose.

The maximum concentration of theophylline in the blood is observed after 150 minutes. The half-life is 11 hours.

The main active ingredient in belladonna leaf extract is atropine . It binds to blood after oral administration by 18%. About half of the dose taken is excreted unchanged through the kidneys.

Ephedrine is characterized by a good degree of absorption in the digestive tract. The required therapeutic level is maintained in plasma. Ephedrine is biotransformed in the liver. It is excreted mainly in the urine.

Composition, release form and action of Teofedrine

The drug Teofedrine is available in the form of white tablets with inclusions, in the shape of a cylinder, coated with an enteric film. Sold in blisters of 10 pcs., 1 or 2 blisters per package.

Each tablet contains: 0.1 g theophylline, 0.02 g phenobarbital, 0.2 g paracetamol, 0.02 g ephedrine, caffeine, cytisine, belladonna extract, and other excipients. Caffeine and Theophylline have a bronchodilator effect, Paracetamol has an anti-inflammatory, antispasmodic and antipyretic effect. Also, the action of the medication is aimed at relaxing the muscles of the bronchi, stimulating breathing, dilating blood vessels, reducing pressure in the respiratory organs and increasing renal blood flow. The latter allows you to quickly remove toxins and breakdown products from the body.

Features of the blood supply to the kidneys

The active ingredients are quickly absorbed into the walls of the stomach, enter the blood plasma and have the desired effect. They are completely eliminated from the body 12 hours after entering the body.

Contraindications

The contraindications are as follows:

• hypersensitivity to the main and additional components;
• angina pectoris;
• heart rhythm disturbances;
• prostatic hyperplasia;
• lactation;
• pregnancy;
• arterial hypertension;
• childhood;
• chronic heart failure;
• violation of coronary circulation ;
• angle-closure glaucoma;
• hyperthyroidism;
• epilepsy and other convulsive conditions .

The product should be used with caution in the following cases:

• renal and liver failure ;
• problems with urination;
• diabetes mellitus;
• tendency to develop drug dependence.

Possible side effects

The occurrence of side effects when using Theophedrine is quite rare, but not excluded. If the body is weak, it may react to the drug by causing the following ailments:

• increased heart rate and heaviness in the chest;
• sudden tachycardia;
• difficulty breathing;
• heartburn and heaviness in the stomach;
• nausea and vomiting;
• dyspepsia;
• the occurrence of aching headaches or severe migraines;
• increased emotional arousal;
• insomnia and detached state;
• decreased or complete lack of appetite;
• problems with urination and dull pain in the kidneys;
• dry mouth;
• increased sweating;
• allergy.

If one or more manifestations are detected, it is important to stop taking Teofedrine, then immediately consult a doctor and replace the medicine with another.

During the course, it is not recommended to drive vehicles or perform other activities that require high concentration - the active substances can affect brain function and reaction speed.

Instructions for use Teofedrin-N (Method and dosage)

The instructions for Teofedrine indicate that the medicine is administered orally . It is an auxiliary drug for preventing attacks of bronchial asthma . Single dose – 2 tablets. If necessary, take the medicine 2-3 times a day. But the maximum daily dosage should not exceed 3 tablets.

Instructions for using Teofedrin-N for preventive purposes indicate that you need to take half a tablet or one tablet per day after meals. It is advisable to do this in the morning or afternoon to avoid insomnia .

The duration of taking the tablets depends on the characteristics of the disease and the therapeutic effect of the drug.

Analogs

If you find side effects of the medication while taking the pills, Theophedrine has analogues that are worth paying attention to. The most famous means with a similar effect are recognized:

• Triphedrine,
• Askofen-P,
• Bronholitin,
• Diprophylline,
• Bronchophylline,
• Teobiolong,
• T-Fedrin,
• Theotard.

The listed agents have a similar chemical composition and act on the body in a similar way.

Remember: each medicine has individual contraindications and may have a separate list of side effects. It is strictly forbidden to replace one remedy with another on your own; the consequences can be unpredictable.

Overdose

The following symptoms of overdose are likely: manifestations of acute intoxication (nausea, pain in the stomach, epileptoid seizures , vomiting , insomnia , blurred vision). Ephedrine in high doses causes an increase in blood glucose.

The dose of ephedrine that leads to death is 1 g.

Symptoms of paracetamol appear when taking more than 10–15 g, so their development is impossible due to the presence of other active substances among the components of the drug.

As therapy, patients are prescribed gastric lavage and induce vomiting. Treatment is symptomatic.

Reviews

Evaluations from real customers indicate that the use of Theophedrine has a good bronchodilator effect and helps relieve spasms in bronchitis and asthma, however, over the age of 60 years, the drug is poorly tolerated and causes ailments in the form of multiple side effects.

The price of Teofedrine ranges from 150 to 550 rubles.

Interaction

The content of theophylline in the blood increases when taking beta-blockers , Carbamazepine , Cimetidine , antibiotics , MAO inhibitors , , indirect anticoagulants , Furosemide , Verapamil , fluoroquinolones , hormonal contraceptives . Thus, the likelihood of side effects increases.

The effect of belladonna leaf extract is reduced by the influence of m-cholinomimetics and anticholinesterase drugs.

Anticoagulants enhance the effect of paracetamol . The likelihood of developing its hepatotoxic effect increases when combined with barbiturates , Carbamazepine , Zidovudine , Phenytoin , Rifampicin and other inducers of microsomal liver enzymes .

The interaction of ephedrine and MAO inhibitors leads to severe hypertensive crises due to inhibition of the metabolism of these vasopressor substances. Ephedrine also reduces the effect of opioid analgesics and other drugs that have a depressant effect on the nervous system.

Combination with non-selective beta-blockers reduces the bronchodilator effect of Teofedrine-N.

Interaction with other drugs

There are a number of pharmaceutical drugs, the action of which enhances the effect of the use of Theophedrine. There, the risk of side effects and unexpected reactions of the body increases. These include antidepressants, hormonal contraceptives, beta-blockers, antibiotic groups of drugs, anticoagulants, glucocorticosteroids.

Anticoagulants

Anticoagulants increase the activity of paracetamol, ephedrine provokes uncontrolled surges in blood pressure and enhances the effect of MOA inhibitors, the increased activity of which inhibits metabolism and makes it difficult to remove half-life products from the body. The kidneys work under increased load, which can cause pain and activation of inflammatory processes.

The use of Theofedrine can be dangerous if thoughtlessly combined with other medications; for safe treatment, the course must be adjusted by a specialist.

special instructions

The drug should not be taken simultaneously with alcoholic beverages. Patients prone to regular consumption of alcohol-containing beverages should be aware that when taking Theophedrine-N and ethanol together, the risk of liver toxicity increases.

The drug should not be prescribed to patients with diabetes mellitus, since ephedrine can increase metabolism and lead to increased blood glucose levels.

Since Teofedrin-N contains potent components, during treatment you must be careful when driving and performing other types of work that require high concentration and quick reaction.

Features of the use of Teofedrine

Theophedrine should not be taken in the evening, as it may disturb the usual state of sleep. During the period of taking the drug, it is necessary to completely avoid alcohol consumption.

This drug should be used with caution in the treatment of diabetes mellitus. Due to the activity of the drug, the level of glucose in the chemical composition of the blood increases. During the period of taking this drug, intellectual and labor activities and driving of vehicles should be limited.

The side effects of Teofedrine are enhanced when the drug is used together with beta-blockers, indirect anticoagulants, fluoroquinolones, furosemide, cimetidine, carbamazepine, verapamil, antibiotics, hormonal contraceptives, MAO inhibitors.

Paracetamol in Theophedrine can lead to intoxication of the body when used together with liver enzyme inducers and barbiturates. Ephedrine weakens the effectiveness of tranquilizers and analgesics. The bronchodilator effect of the drug is reduced when taken simultaneously with beta-blockers.

Rifampicin reduces the concentration of theophylline in the blood, and oleandomycin, ciprofloxacin and erythromycin increase it. Theophedrine reduces the therapeutic effect of doxycycline and its absorption. The use of Theophedrine in treatment in combination with lincomycin is unacceptable.

Co-administration of Teofedrine with antiepileptic and psychotropic drugs should be avoided. The effect of antihypertensive drugs, oral contraceptives and antidepressants when taken together with Theophedrine is usually reduced, and the effect of sleeping pills and diuretics may be increased.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use Neo-Theophedrine, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Neo-Theophedrine is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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