Triampur compositum n50 tablet price 432 rubles in Moscow, buy Triamterene instructions for use, reviews in the online pharmacy

Pharmacodynamics and pharmacokinetics

The two main active components of the drug - triamterene and hydrochlorothiazide - are moderately strong diuretics. Their pharmacodynamic and clinical features have been very well studied. The substances mutually enhance each other’s effects on the body, especially on the water and electrolyte balance in the body.

Triamterene enhances the process of removing sodium ions from the body, reduces the intensity of loss of potassium and hydrogen , and belongs to the group of potassium-sparing saluretics . The substance inhibits the exchange of sodium for potassium and hydrogen, which usually occurs in the terminal parts of the distal tubules. However, a small amount of sodium is excreted, and the drug does not affect the process of urea .

Hydrochlorothiazide reduces the intensity of a similar process in the initial part of the distal tubules . The excretion of potassium, chlorine, water and sodium ions is enhanced. The drug also has the ability to inhibit carbonic anhydrase , which can lead to excessive excretion of bicarbonate . The primary effect of the drug is associated with increased excretion of electrolytes , and the secondary effect is associated with stimulation of urea .

The drug contains a combination of active components in a ratio of one to two ( hydrochlorothiazide and triamterene ), which significantly enhances the effectiveness of the product. Their opposite effect on kaliuresis leads to the desired effect of neutralizing the potassium balance and compensating it.

When taking the medicine orally, the active components are absorbed in the gastrointestinal tract (80%). The bioavailability of thiazide is approximately 70%, triamterene – 50%. 2/3 of hydrochlorothiazide and 60% of triamterene . After 1 hour the diuretic effect begins to appear, after a maximum of 4 hours its maximum is reached and lasts up to 12 hours, depending on the dose taken. The hypotensive effect is more stable and can last another day. The half-life is approximately 7 hours for hydrochlorothiazide and 4 to 7 for triamterene.

Thiazide is not metabolized and is excreted by the kidneys almost unchanged. Triamterene, on the contrary, undergoes metabolic reactions in the liver. Its main metabolite, 4-hydroxytriamterene, is also pharmacologically active and is excreted from the blood after 3 hours with bile or through the kidneys.

"Dyazide"

The main active ingredients in the Triampur analogue Diazide are triamterene and hydrochlorothiazide. It is produced by the manufacturer in capsule form. Capsules are packaged in packs of 100 and 1000 pieces.

The main indications for its use are:

Hypertension, including those provoked by hypokalemia.
Edema syndrome, provoked by a chronic form of cardiac failure, including accompanied by hypokalemia.

The use of "Dyazide" is contraindicated during pregnancy, chronic, acute forms of renal failure, anuria, hyperkalemia, hypersensitivity to active or auxiliary substances in the composition of the medication.

Indications for use Triampur Compositum

Why is the drug prescribed? This product is used:

to reduce blood pressure in arterial hypertension ;
for edema caused by heart, kidney or liver diseases, in cases where it is necessary to avoid the loss of potassium from the body.

Also an indication for the use of the drug is heart failure . The medicine is prescribed as part of complex therapy with cardiac glycosides to avoid potassium loss and stimulate the removal of excess fluid from the body.

Analogs

Analogues of Triampur compositum contain similar substances and the mechanism of action on the body. Despite this, before replacing one drug with another, you should consult your doctor, as indications, contraindications and side effects may differ.

A drug	Active substance	Manufacturer	price, rub.
Diuretidine	Hydrochlorothiazide, triamterene	Bulgaria, Balkanfarma-Dupnitsa AT	400
Triamzid	Hydrochlorothiazide, triamterene	Ukraine, Kharkov, PJSC "Red Star"	300
Moduretic	Amoloride hydrochloride, hydrochlorothiazide	Netherlands, Merck Sharp and Dome B.V.	1200

Contraindications

The medicine is contraindicated:

with increased individual sensitivity to the components of the product or the group of sulfonamides ;
with severe disorders of the kidneys and liver;
with anuria , acute glomerulonephritis , disturbances in water and electrolyte balance ;
for lactose intolerance ;
for newborns and children under 14 years of age;
for chronic alcoholism ;
with kidney stones;
for diabetes and gout ;
pregnant and lactating women;
folic acid deficiency .

Side effects

The drug has been well researched. During clinical trials and judging by patient reviews, the following reactions may occur:

hemolytic anemia , thrombocytopenia , agranulocytosis , aplastic anemia , leukopenia , neutropenia , megablastic anemia ;
lethargy , dry mucous membranes, headache, drowsiness , convulsions , collapse , depression , paresthesia , disorientation , mood changes;
ataxia , increased heart rate, arrhythmia , changes in the electrocardiogram , decreased blood pressure ;
loss of consciousness, lightheadedness;
violations of orthostatic regulation ;
dry eyes, disturbances in color perception; myopia ;
pulmonary edema, pneumonia and respiratory distress syndrome ;
pancreatitis , increased levels of liver enzymes, cholecystitis , jaundice ;
skin rashes, urticaria , vasculitis , itching and allergic reactions to light;
nausea, epigastric , constipation , vomiting, intestinal obstruction (symptoms do not appear if you take the tablets after meals);
increased kidney activity;
muscle cramps , muscle deformation, hypotonia of skeletal muscles;
shock , vasculitis , anaphylactic and anaphylactoid reactions, exacerbation of lupus ;
increased fatigue, weakness, impotence , decreased libido and sexual function, general weakness;
development of Steven-Johnson syndrome , hepatic coma , latent diabetes ;
possible deterioration of prediabetic and diabetic conditions , hyperkalemia , hyperglycemia , metabolic acidosis , hyponatremia , increased blood cholesterol creatinine .

"Triam-Co"

It is an analogue of Triampur. The main active substances in its composition are: triamterene, hydrochlorothiazide. The manufacturer produces the medicine in the form of tablets; the tablets are packaged in blisters. Each of them holds 10 tablets. Each box contains 3 blisters.

As the instructions indicate, the Triampur analogue is indicated for use in the presence of the following pathological conditions in the patient:

Edema syndrome of various origins (premenstrual edema, liver cirrhosis, nephrotic syndrome, chronic forms of heart failure).
Arterial hypertension.

The medicine should not be used if the patient has the following contraindications:

Childhood.
Hyperkalemia.
Anuria.
Severe kidney and liver dysfunction, increased sensitivity to substances in the medication.

This remedy should be used with caution if the patient has impaired liver function, kidney function, gout, or diabetes mellitus. In older age, lower adjusted doses should be used.

While using Triam-Co, the following side symptoms may develop: allergic manifestations, photosensitivity, increased levels of glucose, urea, creatinine, uric acid in the blood, headache, paresthesia, weakness, dizziness, tachycardia, hypercalcemia, hypomagnesemia, hypochloremia, hyponatremia, convulsions, hyperkalemia, hypokalemia, dry oral mucous membranes, diarrhea, vomiting, attacks of nausea.

If these symptoms occur, you should consult a doctor.

Triam-Co should be taken for the treatment of arterial hypertension once a day, 1 tablet. If the drug is well tolerated, the dosage is increased fourfold. For the treatment of edematous syndrome, it is recommended to take 1 tablet twice a day.

Triampur, instructions for use (Method and dosage)

The dosage and duration of taking the drug should be determined by the attending physician on an individual basis.

If the course of treatment with the drug is long, then you should not suddenly stop taking the pills. The dose should be reduced gradually.

The tablets are taken after meals, without splitting or chewing.

Instructions for use Triampur Compositum for adults

For the treatment of arterial hypertension , the initial dosage is 4 tablets per day, divided into 2 doses. Then, after some time, the dosage is reduced to 2 tablets per day (in one or two doses). If the patient additionally takes other medications that lower blood pressure, then the daily dosage is 2 pieces per day.

To treat edema , at the beginning, take 4-8 tablets per day, in 2 doses. Maintenance dosage – 1 tablet per day, or 2 every other day, or 4 tablets per day.

As a complex therapy for the treatment of heart failure, patients are prescribed 2 tablets per day (up to 4, depending on test results).

For kidney disease, a dose adjustment should be made. If the concentration of creatinine in the blood serum is 1.5-1.8 mg per 100 ml or the clearance is 50-30 ml per minute, then the daily dosage should not exceed one tablet.

"Zaroxolin"

It is a cardiac drug that is used to treat cardiovascular diseases. This is a diuretic, similar in action to thiazide diuretics. Within an hour, the effect of the drug most often appears, and after about 2 hours it reaches its peak activity. Lasts about a day.

The drug is used in the treatment of hypertension as a diuretic.

The initial dosage of the drug "Zaroxolin" is 5 mg per day, after two weeks you can take the same dose every other day. For renal failure - 5-20 mg in several doses. For heart failure - 5-10 mg.

Overdose

in blood pressure occurs , up to orostatic collapse .

With long-term use of high doses of the drug, dehydration , electrolyte imbalance , nausea, weakness, and vomiting are observed.

At the first symptoms of an overdose ( weakness, confusion, heart rhythm disturbances, nausea ), you should immediately stop taking the drug. In especially severe cases, alkalosis , acidosis , adynamia , spasms and overexcitation .

a specific antidote . In this regard, gastric lavage, enterosorbents , and symptomatic therapy are performed.

You should carefully monitor the patient's condition and adjust the electrolyte and water balance in the body, blood sugar levels, and blood pH .

If hypovolemia , drinking plenty of fluids is indicated to avoid crystallization of the drug in the kidneys. It is recommended to administer an isotonic solution of sodium bicarbonate , and for hyperkalemia - glucose and insulin .

Victims with kidney failure may require hemodialysis . bradycardia occurs that cannot be treated, a pacemaker .

If blood pressure reaches a critical minimum and shock , it is recommended to administer potassium, sodium and magnesium in the form of an electrolyte solution .

Interaction

When combined with diuretics, phenothiazines , vasodilators, antihypertensive drugs, ethanol and barbiturates , the hypotensive effect is enhanced.

Concomitant use with methyldopa increases the likelihood of hemolysis .

The risk of kidney disease increases if you combine the drug Triampur Compositum with indomethacin .

The diuretic effect and the blood pressure lowering effect are enhanced if the drug is taken with non-steroidal anti-inflammatory drugs . Salicylates increase the load on the central nervous system.

You should combine lithium and medicine with caution, as the load on the heart increases; Both drugs are cardiotoxic .

The effect of curare-like muscle relaxants is enhanced when combined with the drug.

ACE inhibitors , when combined with the drug, contribute to a sharp decrease in blood pressure, especially in the first days of therapy.

The absorption capacity of the drug is reduced if it is taken together with colestipol or cholestriamin .

Potassium salts, potassium -sparing diuretics and ACE inhibitors, when combined with the drug, contribute to the development of hyperkalemia , and glucocorticosteroids , chlorpropamide and laxatives – hypokalemia .

The drug weakens the effect of drugs for gout , hypoglycemic drugs , norepinephrine and adrenaline .

Triampur Compositum and beta blockers increase the risk of impotence .

When Triampur is combined with quinidine, the elimination of the latter from the body slows down, and the effect of cytostatics on the bone marrow increases.

special instructions

The medicine should be taken with caution and strictly under the supervision of a doctor:

patients with stones ;
patients with diabetes mellitus ;
with a deficiency or suspected deficiency of folic acid in the body;
with liver and kidney dysfunction.

3 days before testing for diabetes mellitus or studying the functions of the kidneys or thyroid gland , the medicine should be discontinued.

If one of the regular doses of the drug was missed, you cannot use a double dose.

During therapy you should drink enough fluids.

If you wear contact lenses, there is a high probability that the mucous membrane of your eyes will need additional hydration.

In order to prescribe the drug to children, not enough research has been conducted. In this regard, the drug is not used in pediatrics.

While taking the medication, you should constantly monitor the levels of potassium, sodium, uric acid, chlorine, creatinine and glucose.

Caution should be exercised when operating machinery and vehicles due to a decrease in reaction speed. The effect is especially pronounced when taking alcohol, increasing the dose, starting treatment, or replacing the medication with analogues.

Withdrawal syndrome

The antihypertensive drug Triampur is addictive in rare cases. Addiction can occur when the drug is taken incorrectly or the prescribed course is violated. When taking the drug, it is necessary to monitor the salt balance and replenish it. Monotherapy with Triampur diuretic tablets for blood pressure can lead to withdrawal syndrome.

When getting used to it, the previous dosage may seem insufficient to the patient. But you cannot increase the dose without a doctor’s prescription, as this can lead to impaired renal response and kidney failure.

Discontinuation of the drug involves a gradual reduction in dose. Upon withdrawal, the patient should drink plenty of fluids and take vitamins containing magnesium and sodium.