Troxevasin: instructions for use of ointment and gel, review and reviews

Active substances and release form

Ointment (gel) Troxevasin has two forms of release: the first is a gel, and the second is capsules for oral administration.

Troxevasin gel has a light brown, honey-like color. The consistency of the product is watery, making it easy to apply to the skin. The medicine has no smell.

The composition of Troxevasin gel includes several active ingredients. The value of ointment for veins is represented by several of its components.

1. Troxerutin is the main active ingredient in the drug. It is obtained by a semi-synthetic method, in contrast to the existing natural analogue of rutin. The component helps increase the elasticity of vascular walls, which prevents the development of varicose veins.
2. Trolamine is a component necessary to relieve pain in the legs. After application, the drug quickly and in maximum concentration penetrates the tissues and relieves severe pain in the affected veins and tissues.
3. Carbomer is a component necessary for uniform application of the composition. Thanks to the substance, the gel is easily distributed over the skin, does not roll off and is effectively absorbed. The component also ensures uniformity of the ointment and complete mixing of all active ingredients in the composition.
4. Benzalkonium chloride is an antiseptic that destroys most pathogenic bacteria before they penetrate into the deep layers of tissue. If there are problems with veins on the skin, most patients may develop wounds and lesions, the infection of which is prevented by the component, preventing the formation of ulcers.
5. Disodium edetate dihydrate is a substance that thins the blood and prevents the development of blood clots. It also helps improve blood flow due to a decrease in its viscosity and prevents the worsening of stagnant processes.

Purified water, which is an auxiliary component in the medicine, is necessary to dissolve the active ingredients. Troxevasin ointment contains almost no components that can cause an overdose.

Description of the drug

Troxevasin belongs to the angioprotectors and venotonics used in the complex treatment of pathologies of the vascular system. Its main purpose is to correct blood microcirculation. For effective therapy, it is important to decide on some points at the preliminary stage - to establish what troxevasin helps with, and how to properly administer it into the body.

The drug, regardless of its form, is indicated for hemorrhoids accompanied by itching, pain, and chronic venous insufficiency. The active ingredients of the drug provide pronounced decongestant, antioxidant and anti-inflammatory properties.

Pharmacological group and action

Cream (ointment, gel) troxevasin is a compound based on bioflavonoids with the main active element troxerutin. The drug belongs to the pharmacological group of microcirculation correctors and angioprotectors.

When acting locally on problem areas of blood vessels, the drug provides:

• relieving inflammation from the inside of the capillary walls, strengthening them;
• increasing the elasticity of vascular walls;
• leveling the likelihood of blood clots;
• elimination of excess swelling;
• weakening of painful symptoms characteristic of varicose veins and venous insufficiency;
• normalization of nutrition of tissues localized near blood vessels.

The active substance of the drug is concentrated in the endothelial layer of venules and penetrates deeply into the structure of blood vessels. Troxerutin neutralizes the negative effects caused by oxidation processes at the cellular level and protects membrane structures from damage.

Troxevasin eliminates congestion in blood vessels.
In fact, it inhibits hydroxyl radicals, lipid peroxidation and the oxidative properties of incoming oxygen. This ensures a pronounced antioxidant effect. The main component of the drug suppresses the aggregation activity of erythrocytes, the synthesis of pain mediators during inflammation, and prevents the adhesion of neutrophils.

Release form and composition

The pharmaceutical product in question is presented in 2 forms - gel and encapsulated composition. Gel (2%) is used exclusively externally and is available in aluminum tubes of 40 g.

Capsules (300 mg) are sealed in plastic blisters and are intended for oral administration. Regardless of the form, the medicine is packaged in a cardboard box and comes with an insert with detailed annotations and instructions for use.

Questions about what is better, troxevasin ointment or gel, are meaningless, since the drug is available exclusively in gel form. Many patients call it an ointment, despite the absence of this form in principle. In this case, ointment and gel are synonymous.

The composition of troxevasin includes 1 main substance - troxerutin (on average up to 20 mg for every 1 g of product), as well as a number of auxiliary components.

Additional ingredients (per 1 g):

• purified water – up to 960 mg;
• trolamine – no more than 7 mg;
• carbomer – about 6 mg;
• benzalkonium chloride – up to 1 mg;
• edetate disodium – about 0.5 mg.

The specific form of the drug is prescribed by the attending physician, and depends on the characteristics of the localization, the course of the pathogenic process, and the chosen treatment regimen.

pharmachologic effect

Troxevasin ointment has anti-edematous, anti-inflammatory and tonic effects. The gel is also prescribed in the complex treatment of venous problems, especially when varicose veins and superficial thrombophlebitis occur. The ointment helps reduce capillary fragility and improves blood microcirculation, which provides tissues with adequate nutrition.

The venotonic effect is achieved by increasing the tone of the walls of blood vessels, which, under the influence of the drug, restore their healthy smoothness and necessary elasticity.

Excessive vascular permeability is also eliminated, which reduces swelling. Due to the venotonic effect, it is possible to get rid of blood flow disorders and blood stagnation.

The anti-inflammatory properties of the gel make it possible to eliminate the pathological process in the walls of blood vessels. Relieving swelling further contributes to this, relieving the affected area of ​​pathological pressure. Swelling subsides due to the removal of fluid from the tissues that accumulates in the intercellular space. Venous blood, which penetrates there due to the increased permeability of the vascular wall, is also removed from the tissues.

Indications for use

Indications for the use of Troxevasin gel are varied. Use the ointment as the main medicine or as a component of complex therapy in the following cases:

varicose veins of the lower extremities (recommended to be combined with a course of taking Troxevasin capsules);

1. thrombophlebitis of superficial veins;
2. venous insufficiency of the legs, which causes swelling, pain and increased fatigue;
3. insufficient tissue trophism against the background of venous insufficiency, manifested by pale skin, the appearance of bruises and a decrease in the healing rate of minor wounds;
4. haemorrhoids;
5. varicose dermatitis;
6. hemorrhagic diathesis;
7. a pronounced decrease in sensitivity of the lower extremities in the morning after sleep;
8. night cramps of the calf muscles;
9. increased load on the veins and vessels of the legs (standing and sedentary work, excess weight);
10. prevention of vein diseases;
11. viral infections that lead to increased permeability and fragility of blood vessels;
12. bruises accompanied by profuse hematomas and swelling;
13. trophic ulcers, including diabetic ones.

Troxevasin has indications for use primarily for persons aged 18 to 50 years who have an initial degree of vascular impairment, or for the prevention of vascular pathologies. If necessary, it is allowed to use Troxevasin for bruises and swelling in case of injuries and from 15 years of age. In this case, it is necessary to especially strictly observe the conditions for using the ointment, which are indicated in the instructions or given by the doctor.

During pregnancy, the ointment is prescribed by a doctor if a woman experiences severe congestion in the pelvic area, legs, or develops hemorrhoids.

It is not recommended to prescribe medication on your own when carrying a child.

Therapeutic effects, pharmacodynamics and pharmacokinetics

Types of effects Troxevasin has on veins and capillaries:

• tonic;
• tread.

The drug reduces the size of the pores between the cells of the endothelial layer of blood vessels, makes red blood cells more elastic, and also reduces their aggregation.

In chronic venous insufficiency, Troxevasin reduces the manifestations of trophic disorders, such as swelling, pain, and cramps. The drug also helps relieve symptoms of hemorrhoids, eliminating itching in the anal area and bleeding.

A positive effect on the walls of capillary vessels and the rheological properties of blood helps to slow down the development of retinopathy, which is observed in diabetes mellitus.

The contents of the capsules are absorbed in the intestines by only 10-15%. The maximum concentration is reached 120 minutes after taking the medication. It is mainly excreted through the intestines, partly by the kidneys.

Side effects and contraindications

It is not allowed to use the drug in the following cases:

• intolerance to the components of the drug (hypersensitivity to the drug);
• first trimester of pregnancy - Troxevasin for legs during pregnancy can only be prescribed by a doctor and mainly from the 2nd month, when the placenta has already formed, protecting the fetus from most of the negative effects of the drug;
• peptic ulcer of the stomach and duodenum - there is a risk that even local blood thinning will provoke bleeding, which poses a danger to the patient’s life. This especially applies to the use of ointment for the treatment of hemorrhoids. When treating leg diseases, the use of ointment is usually allowed, but in a minimal dosage;
• gastritis in acute form - similar to the previous one;
• severe renal failure - some of the components of the ointment are excreted by the kidneys, and additional stress on the diseased organ can cause a deterioration in the condition;
• wounds in which a purulent process is present - Troxevasin will not help against suppuration, and the pathology must first be treated with antibiotics.

Troxevasin ointment is not used for children under 15 years of age due to its active effect on the body, which can negatively affect the patient.

Side effects from the drug are extremely rare. They develop more often if a large amount of gel is applied, which cannot be completely absorbed.

Instructions

Registration number: P N012713/01 Trade name: Troxevasin® International nonproprietary or generic name: troxerutin Dosage form: capsules

Composition: 1 capsule contains: active ingredient: troxerutin 300.0 mg; excipients: lactose monohydrate 47.0 mg, magnesium stearate 3.0 mg. capsule shell: body - quinoline yellow dye (E 104) 0.9%, sunset yellow dye (E 110) 0.039%, titanium dioxide (E 171) 3%, gelatin up to 100%; cap - quinoline yellow dye (E 104) 0.9%, sunset yellow dye (E 110) 0.039%, titanium dioxide (E 171) 3%, gelatin up to 100%.

Description Hard cylindrical gelatin capsules No. 1, body - yellow, cap - yellow. Contents of capsules: powder from yellow to yellow-green, the presence of conglomerates is allowed, which are destroyed by light pressure with a glass rod. Pharmacotherapeutic group: venotonic and venoprotective agent ATC code: C05CA04

Pharmacological properties: Troxevasin contains at least 95% troxerutin. Troxerutin selectively accumulates in the endothelial layer of blood vessels, penetrates deep into the subendothelial layer of the venous wall, creating higher concentrations there compared to surrounding tissues. Prevents damage to cell membranes caused by oxidative reactions. The antioxidant effect is manifested in the prevention and elimination of the oxidative properties of oxygen, suppression of lipid oxidation and protection of the vascular endothelium from the oxidative effects of hydroxyl radicals. Troxerutin reduces increased capillary permeability and has a venotonic effect. The cytoprotective effect is the result of suppressing the activation and adhesion of neutrophils, reducing the aggregation of erythrocytes and increasing their resistance to deformation, and reducing the release of inflammatory mediators. Troxerutin increases venous-arterial reflux and increases the time of refilling of veins, improves microcirculation and microvascular perfusion. Troxerutin reduces pathological changes associated with venous insufficiency: swelling, pain, improves tissue trophism. Due to its effect on the permeability and resistance of capillary walls, troxerutin helps slow the progression of diabetic retinopathy. The effect of troxerutin on the rheological properties of blood helps prevent the development of retinal vascular microthrombosis.

Pharmacokinetics Absorption After oral administration of a radioactively labeled drug, the absorption of 14C-O-(β-hydroxyethyl)-rutosides in humans is about 10-15%. The maximum concentration in blood plasma (Cmax) is achieved within 1-9 hours. Within 120 hours, concentrations remain detectable; the decrease in concentration is bioexponential. Distribution: Bonding with blood plasma proteins is 27-29%, and accumulates in the largest quantities in the endothelium. Does not penetrate the blood-brain barrier. It penetrates the placental barrier slightly and is excreted in minimal quantities in breast milk. Biotransformation Metabolized mainly through o-glucuronidation in the liver. Excretion Excreted mainly through the intestines and to a lesser extent by the kidneys.

Indications for use: — Chronic venous insufficiency. — Postthrombotic syndrome. — Trophic disorders in varicose veins and trophic ulcers. — As an auxiliary treatment after sclerotherapy of veins and removal of varicose veins. - Hemorrhoids (pain, exudation, itching and bleeding). — As an auxiliary treatment of retinopathy in patients with diabetes mellitus, arterial hypertension and atherosclerosis.

Contraindications: - Hypersensitivity to rutosides or other components of the drug. — Pregnancy (I trimester). — Peptic ulcer of the stomach and duodenum. — Chronic gastritis in the acute phase. — Children under 18 years of age (experience of clinical use is insufficient). - Breastfeeding period. — Rare hereditary galactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome.

With caution - In case of renal failure (with long-term use). — Pregnancy (II and III trimesters).

Use during pregnancy and breastfeeding The use of the drug during the first trimester of pregnancy is contraindicated. The possibility of using the drug during the second and third trimester of pregnancy is determined by the doctor and is possible only if the expected benefit to the mother outweighs the potential risk to the fetus. If it is necessary to use the drug in the second and third trimesters of pregnancy, you should consult your doctor. It is excreted in minimal quantities in breast milk. The use of the drug during breastfeeding has not been studied.

Directions for use and dosage: Orally, during meals. Capsules should be swallowed whole with plenty of water. For chronic venous insufficiency and its complications, for the symptomatic treatment of hemorrhoids, at the initial stage of treatment, 1 capsule (300 mg) is prescribed 2-3 times a day (600-900 mg), depending on the severity of the symptoms. The effect usually develops within 2 weeks. Treatment is stopped after symptoms and swelling disappear. In case of recurrence of symptoms, treatment is resumed at the same dose or the dose is reduced - 1 capsule 2 times a day (600 mg). The achieved effect lasts for at least 4 weeks. The course of treatment averages 3-4 weeks. For diabetic retinopathy, the drug is used in a dose of 1800-3000 mg, 6-10 capsules (2 times a day, 3-5 capsules (1800-3000 mg)). The course of treatment averages 3-4 weeks. The need for longer treatment is determined after consultation with a doctor and individually.

Side effects The frequency of occurrence of adverse reactions is given in accordance with the WHO classification: very often (≥1/10), often (≥1/100, ˂1/10), infrequently (≥1/1000, ˂1/100), rarely ( ≥1/10000, ˂1/1000), very rare (˂1/10000), frequency unknown (cannot be estimated based on available data). Immune system disorders: very rarely - anaphylactic shock, anaphylactoid reactions, hypersensitivity reactions (for example, skin rash). Nervous system disorders: very rarely - headache, dizziness. Vascular disorders: very rarely - hyperemia (“flushes”), ecchymosis. Gastrointestinal disorders: rarely - nausea, pain and discomfort in the stomach, dyspepsia, flatulence, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract. Disorders of the skin and subcutaneous tissues: rarely - itching, rash, urticaria. Other: very rarely - feeling of fatigue. If undesirable reactions occur, you should consult a doctor.

Overdose In case of overdose, the following symptoms may appear: agitation, nausea, headache, flushing of blood to the face. Treatment: It is necessary to rinse the stomach, take activated charcoal, and, if necessary, carry out symptomatic treatment. In case of overdose of the drug, you should immediately consult a doctor.

Interaction with other drugs There are no established drug interactions.

Special instructions When treating superficial thrombophlebitis or deep vein thrombosis, the use of the drug does not exclude the need to prescribe anti-inflammatory and antithrombotic therapy. Troxerutin is ineffective for edema caused by concomitant diseases of the liver, kidneys and heart. If during the period of use of the drug the severity of the symptoms of the disease does not decrease or the symptoms of the disease become more severe, you should immediately consult a doctor. There is insufficient experience with the use of the drug in children under 18 years of age. When using the drug independently, you should not exceed the maximum duration and recommended doses.

Effect on the ability to drive vehicles and machines. Taking the drug does not affect motor and mental reactions, does not interfere with the control of vehicles and other complex mechanisms.

Release form Capsules 300 mg. 10 capsules per blister made of PVC/Al foil or PVC/PVDC/Al foil. 5 or 10 blisters along with instructions for use in a cardboard box.

Storage conditions At a temperature not exceeding 25 °C. Keep out of the reach of children!

Shelf life: 5 years. Do not use after the expiration date.

Conditions of release Dispensed without a prescription.

Manufacturer Balkanfarma-Razgrad AD, blvd. April Uprising, 68, 7200, Razgrad, Bulgaria.

The organization that accepts consumer complaints is Teva LLC, 115054, Moscow, st. Valovaya, 35, tel., fax Internet address: www.teva.ru

TROX-RU-00151-Cons

Application

Instructions for use of Troxevasin include several ways to use the medicine. Always clean the area being treated before applying the gel. In most cases, the composition is applied in the morning and evening and gently rubbed into the sore spot with light, non-pressing movements. There should be no bleeding wounds in the areas treated with the gel, which will bleed more due to the action of the ointment.

After applying the ointment, hands should be washed thoroughly. It is unacceptable to allow the gel to come into contact with mucous membranes or eyes. When this happens, you must immediately rinse the affected area with cool running water. If after this the unpleasant sensations persist, then seeking medical help is required.

Cost of the drug

To find out how much Troxevasin gel costs, just look at any pharmacy. This product is produced by various manufacturers and is available in all pharmacies. On average, the price varies between 70–150 rubles.

The products are manufactured by two companies in the world. The first, the Icelandic Actavis Group, produces only capsules for internal use. The second, a Bulgarian pharmaceutical company, produces both gel and tablets. The cost of the gel does not exceed 90–150 rubles, and the capsules will cost customers 350 rubles. for 30 pcs.

There is also an analogue of Troxevasin gel. This is Troxerutin, which is produced by various manufacturers; its cost will vary - depending on the manufacturing company, as well as the pricing policy of the pharmacy. As for the updated drug, the price of Troxevasin Neo gel is already much higher than its predecessor. The cost of the drug is already 250–350 rubles.

For hemorrhoids

Hemorrhoids are caused by varicose veins of the hemorrhoids. Troxevasin ointment, used for hemorrhoids, allows you to get rid of congestion in the problem area of ​​the colon and promotes the retraction of nodes. The manufacturer guarantees equal effectiveness of the drug for both external and internal hemorrhoids. Inflammation in the affected area does not prevent the medicine from working.

The product should be applied in the morning and evening, after the intestines have been emptied, and the problem area has been washed with warm water and wiped dry with a towel. Troxevasin ointment for hemorrhoids is carefully rubbed into the sore spot in a circular motion until completely absorbed. Relief is observed after 10 days of regular use of the product.

In addition to rubbing, the ointment can also be used in the form of applications to the affected area. To do this, a gauze swab is soaked in the drug and applied to the anal area for 15-20 minutes. This use of the drug allows you to speed up the healing process of damaged tissue.

Troxevasin for hemorrhoids, according to the instructions for use, can be prescribed even to pregnant women from the second trimester, as well as to elderly patients. The drug is particularly effective at the initial stage of damage.

As an independent, only medicine for hemorrhoids, using the gel is not effective. It is a component of complex therapy.

Reviews

Rosa, 34 years old, Birobidzhan
The ointment was recommended by the doctor who has been treating me for the last 4 months (chronic inflammation of hemorrhoids). For the first 3 weeks, everything was great - the inflammation stopped, and the formations themselves were reduced in size by half. But by the beginning of week 4 everything was back to normal. I think this gel is more suitable for local problems rather than chronic pathologies. The best analogue of troxevasin, in my opinion, is Toxerutin. This drug costs 2 times less, and the effect is much longer lasting. Now I only use it for treatment. The result makes me happy, but it’s too early to talk about a complete cure.

Maria, 49 years old, Stavropol

I can’t imagine my life without Troxevasin. This is a real godsend for women, especially those who, due to life circumstances, are exposed to frequent stress. I use the ointment mainly for cosmetic purposes - I remove bags under my eyes, and I also apply it to my legs to relieve the fatigue accumulated during the working day. Now even my son, who is into martial arts, uses the gel. I think every home should have such a useful and universal medicine.

Ignat, 36 years old, Kazan

I purchased Troxevasin gel at the pharmacy because I was looking for a remedy for varicose veins. I am very tired of this disease. I read reviews on forums and websites and decided to buy. The girl at the pharmacy recommended another drug, but settled on this one. As such, the effect of the drug is “0”. There is only a slight cooling after applying it to the skin, and this is where the healing effect ends. It is much safer and more profitable to consult a doctor who will prescribe adequate treatment, rather than buy at your own peril and risk.

Read further:

Troxevasin or troxerutin – which is better to choose, similarities and differences, professional opinions and customer reviews

Troxevasin for bruises and contusions: instructions and recommendations for use, review of effectiveness, analogues and reviews

Viferon ointment: instructions for use for children under one year of age, recommendations and reviews

Troxevasin ointment for hemorrhoids: how to use, official instructions, review of analogues and reviews

Gel Troxevasin neo: composition, instructions for use for adults and children, review of analogues and reviews

Troxevasin (review) from 200 rub.

Overall

4.2

• Efficiency
• Price
• Safety
• Availability

Pros

• Well absorbed
• Without smell
• Efficiency

Cons

• Yellowness after use

For varicose veins

Troxevasin ointment is used primarily for varicose veins. The drug is used as the main one in the initial stages of the disease and for its prevention. If the disease is advanced, then the gel is included in complex therapy.

Apply the ointment to the limbs with massage movements in the direction from the foot to the thigh, which improves blood circulation and gets rid of the stagnant effect. It is recommended to rub in Troxevasin in the morning even before the patient gets out of bed.

Troxevasin should be used for the veins and vessels of the legs at the first manifestations of varicose veins, such as swelling and heaviness in the limbs. To enhance the therapeutic effect, it is useful to combine the drug with vitamin C, which strengthens the vascular walls and prevents the progression of the disease.

Using Troxerutin gel

The presented gel form of the drug is intended for external use only. Many patients are interested in the differences between Troxerutin gel and ointment. The first option is presented in a more liquid form, which is very convenient when applying the drug to a large area of ​​skin.

The product is absorbed quickly enough, and therefore quickly brings relief to the patient. Like the instructions for Troxevasin Neo gel , recommendations for the use of a standard drug are sufficient

The remedy should be used only on the recommendation of a doctor who examines the patient, assesses his condition, and then may prescribe the remedy.

The standard application regimen is as follows: rub the product into the damaged area 2 times a day. This should be done before bed, as well as in the morning, before work or vigorous activity.

In order for the composition to be perfectly absorbed and have a quick positive effect, it is recommended to rub it in with light massage movements without pressure for 10 minutes. This has an excellent therapeutic effect, allows you to relieve swelling, and ensure excellent blood microcirculation.

The course of treatment, depending on the patient’s condition and the doctor’s recommendations, can reach 7–14 days, in some situations the period can be extended.

For bags under the eyes

Age bags under the eyes and bruises are a problem for 80% of women. It is associated with vascular disorders, for which the gel is also used. Troxevasin ointment helps solve the problem of bags under the eyes. The light texture of the drug ensures its rapid penetration into tissues without traumatic effects. With regular application of the gel, the capillaries are toned, and their walls, becoming stronger, no longer allow plasma to pass into the surrounding tissues, due to the accumulation of which edema develops.

To get rid of edema, Troxevasin is applied in a thin layer in the morning and evening and is not rubbed in, as pressure on the tissue will lead to even greater damage. The first visible results appear after a week of therapy. The course takes 30 days.

If there are bruises or spider veins under the eyes (rosacea), then before starting treatment you should consult a doctor, since the phenomenon may be a symptom of a serious illness. If the problem is only vascular, then Troxevasin gel is prescribed. The drug should be applied to the skin 2-3 times a day, rubbing with the index finger without pressure until completely absorbed. There is no limitation on the duration of therapy, and it continues until the bruises and vascular network disappear. If itching or rashes appear after using the ointment, this indicates intolerance to it, and the drug must be replaced with an analogue.

Analogs

Analogues of Troxevasin ointment are of interest to patients mainly because of the price. The main replacement for the gel, which costs 2-3 times less, is troxerutin. There are no differences in the action of the drugs, and the results from their use are completely the same. The indications for use are also the same. The gels differ only in their auxiliary components, and not in their active ingredients. The analogue can be used for a long period of time.

Other analogues of Troxevasin have a higher price. The main ones are:

• liaton,
• venoruton,
• venopaginol.

It is not recommended to replace the drug with analogues on your own due to various contraindications. If you want to use a different drug, you should consult your doctor.

Troxevasin, despite all its effectiveness, is primarily a prophylactic agent and has a pronounced therapeutic effect only when vascular problems begin to develop.

Contraindications

There are also a number of prohibitions on the use of the composition. It is often well tolerated, but the presence of acute infectious pathology in the area of ​​application does not allow the use of the product. You cannot use the composition if you have an individual intolerance to the composition. Patients under 18 years of age are at risk, and therefore it is worth consulting with a doctor about the possibility of using the drug.

Particular attention is paid to the use of Troxevasin gel during pregnancy. It is not recommended to use the product in the early stages. The doctor can prescribe the drug only in the second or third trimester.