Write a review
Reviews: 0
Manufacturers: Chinoin Pharmaceutical and Chemical Works Private Co. Ltd.
Active ingredients
- Drotaverine
- A nicotinic acid
Disease class
- Vascular headache, not elsewhere classified
- Transient transient cerebral ischemic attacks [attacks] and related syndromes
- Encephalopathy, unspecified
- Atherosclerotic heart disease
- Atherosclerosis of the arteries of the extremities
- Thromboangitis obliterans [Berger's disease]
- Other specified peripheral vascular diseases
- Peripheral vascular disease, unspecified
- Narrowing of the arteries
- Other and unspecified circulatory system disorders
- Headache
- Menopause and menopause in women
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Hypolipidemic
- Vasodilating
Pharmacological group
- Vasodilators in combinations
- Myotropic antispasmodics
General information about the drug
Nikoshpan is included in the medicinal group of vasodilating agents. It improves peripheral and cerebral circulation. The main effects after using this product are increased cellular respiration, relief of spasm, pain and improvement of lipid metabolism in the body. The international nonproprietary name of Nikoshpan has not been established; it is included in the Comb drug group (combined drugs).
Release forms, composition and prices for the drug in Russia
The medicine is available in the form of tablets in a package of 50 pieces. Each of them contains 78 g of drotaverine hydrochloride and 22 mg of niacin. The following auxiliary components are used: lactose, magnesium stearate starch, talc and polyvidone. The average cost of Nikoshpan in Russia is presented in the table below (Table 1).
Table 1 – Cost of Nikoshpan
The price of such a medicine in pharmacies will depend on the region of sale. The highest cost for Nikoshpan is in the Far East, St. Petersburg and Moscow.
Pharmacodynamics
Nicotinic acid (water-soluble vitamin PP) is involved in tissue respiration and electron transfer in the respiratory chain. This substance is used for hyperlipidemia in combination with other drugs that regulate lipid metabolism. In high dosages, it allows you to control the amount of fats in the blood and promotes their elimination.
Niacin has its effect due to the formation of coenzymes in the body (the result of the processing of NAD+ and NADP), which take part in the transport of electrons in the respiratory chain and in tissue respiration.
Mechanism of action
Another component of this product is drotaverine hydrochloride, an isoquinoline derivative. The substance has an antispasmodic effect on vascular smooth muscle. The effectiveness of such a substance is determined by the suppression of PDE 4 (without suppression of PDE 3 and 5) and an increase in the level of cAMP, which, through the suppression of the enzyme myosin light chain kinase (MLCK), leads to relaxation of smooth muscles.
The influence of drotaverine extends to the smooth muscles of the genitourinary system, gastrointestinal tract, as well as biliary and vascular muscles. The vasodilating effect allows you to increase blood supply to tissues, which has a beneficial effect on the functioning of organs.
Pharmacokinetics
Vitamin PP is quickly distributed in the tissues of the body after it is absorbed from the gastrointestinal tract. It is excreted from the body mainly with feces and partly with urine. You should be aware that it can pass into breast milk, so Nikoshpan is contraindicated in pregnant women. This component is capable of being metabolized into uric acid and its derivatives.
Drotaverine hydrochloride is rapidly absorbed after both oral and parenteral administration. It binds to alpha lipoproteins, gamma globulins and albumin. In addition, it is able to bind to plasma proteins. The maximum concentration of this component in the blood serum is achieved 65 or 75 minutes after the tablet enters the patient’s body.
Characteristics of drotaverine
Drotaverine is metabolized in the liver. Already two days after use, it is almost completely eliminated from the human body in the form of metabolites with feces (partially - 30%) and urine (50%) unchanged. Currently, manufacturers do not have information about the interaction of drotaverine with niacin.
Description and instructions for the drug Nikoshpan
Nikoshpan is another remedy that dilates blood vessels.
Its action is based on a combination of two active components: drotaverine and vitamin PP (nicotinic acid). The first substance is widely used both as an independent drug and as the basis of such a well-known medicine as No-shpa. It reduces the intensity of calcium entry into smooth muscle cells, which provide the tone of internal organs, including blood vessels, intestines, bile ducts, and so on. As a result, this muscle relaxes and the tension in the vascular walls, intestinal walls and other organs subsides. Blood pressure decreases and spasms go away. The second component – nicotinic acid – protects and restores vascular health, normalizes the concentration of fats in the blood, and reduces its clotting. Thus, blood flow in the system of the smallest vessels improves, tissue nutrition is optimized. Nikoshpan is used for:
- Various vascular diseases. For example, endarteritis, vasospasm, and so on;
- Headache caused by vascular damage;
- Brain circulatory disorders;
- Other circulatory disorders associated with vascular diseases.
Nikoshpan is produced in tablet form. This remedy can be used for a long time, until the alarming symptoms completely disappear. The instructions for the drug recommend taking it three times a day.
Nikoshpan is contraindicated for:
Noticeable dysfunction of the liver, kidneys, heart.
Contraindications to taking Nicospan
There are often disputes in the medical community about whether the sale of this drug without a prescription is permissible. The fact is that there are a number of serious contraindications to its use. “Nikospan” cannot be used in the treatment of those patients who have problems with the kidneys, heart, liver, if the level of cholesterol in the blood is elevated, or if there is a predisposition to thrombosis, which the patient may not be aware of.
In addition, “Nikoshpan” is contraindicated; there is a tendency to arterial hypertension, that is, for those who often have high blood pressure. It can be tracked only with constant monitoring of readings. That is, before you start a course of taking Nicoshpan, you need to make sure that your blood pressure is normal.
This drug is also contraindicated for those who are intolerant to lactose or other components included in the Nikoshpan tablets. Allergy sufferers must carefully read the instructions for the drug, especially the section that describes the composition of the tablets. If the list contains a substance that can cause an attack, you should refuse therapy with this antispasmodic.
Composition, properties and release form of the drug Nikoshpan
The basis of Nikoshpan tablets is drotaverine hydrochloride, a common and relatively safe broad-spectrum antispasmodic. The second active substance is nicotinic acid (vitamin PP). Without it, the human body is unable to function properly. Most people use them as auxiliary components when forming tablets.
- talc and magnesium stearate,
- povidone and lactose,
- starch.
Drotaverine, entering the human body, has a direct effect on smooth muscles and the walls of blood vessels, relaxes them, thereby eliminating pain. Nicotinic acid accelerates microcirculation of all fluids in the body, including blood, normalizes the balance of their components, against which the general condition of a person improves and tone increases.
“Nikoshpan” goes on sale in plastic jars placed in a cardboard box. One transparent plastic bottle usually contains 50 tablets.
Side effects
Nikoshpan tablets can cause negative changes in the functioning of some organs. Such phenomena belong to the category of side effects that may go away on their own.
In some cases, especially when the severity of unpleasant symptoms becomes clinically significant, it is recommended to interrupt treatment with Nicospan and consult a doctor.
Most often, patients taking the medicine experience the following side effects:
dyspeptic disorders in the form of nausea and vomiting, gas formation, changes in stool (diarrhea or constipation);- pain in the epigastric region;
- dizziness;
- a sharp decrease in blood pressure;
- fainting;
- hyperemia and itching of the skin;
- difficulty falling asleep.
Reviews of "Nikoshpan" and its analogues
In their reviews of the drug “Nikoshpan”, both patients who are taking or have taken it, and medical specialists note its high effectiveness, the ability to take tablets as an ambulance for pain caused by spasms of smooth muscles.
Another significant advantage of “Nikoshpan” is that its main active ingredient is supplemented with nicotinic acid, which reduces the time for its absorption by the body and accelerates the penetration of the component into the body’s tissues.
The decision to replace Nikoshpan with its analogues must be agreed with the attending physician or pharmacist of the pharmacy chain. The drug is not a prescription, so a pharmacist can replace it. Most often, instead they offer such analogs of “Nikoshpan” as “No-Shpa”, “Drotaverine”, “Parnavel”, “Niacin” powder, “Vinoxin-VM” and others.
Similar drugs:
- No-Spa Oral tablets
- Vinoxin-mv (VINCAMINUM) Oral tablets
- Liprazidum 10 Oral tablets
- Magnesium sulfate Powder for oral suspension
- Magnesium sulfate Substance-powder
- Niacin (Niacyne) Substance-powder
- Lisinopril Oral tablets
- Platyphyllin Oral tablets
- Parnavel Oral tablets
- Diroton Oral tablets
** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Nikoshpan, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
Are you interested in the drug Nikoshpan? Do you want to know more detailed information or do you need a doctor's examination? Or do you need an inspection? You can make an appointment with a doctor - the Euro lab is always at your service! The best doctors will examine you, advise you, provide the necessary assistance and make a diagnosis. You can also call a doctor at home . Euro lab clinic is open for you around the clock.
** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Nikoshpan is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
If you are interested in any other drugs and medications, their descriptions and instructions for use, information about the composition and form of release, indications for use and side effects, methods of use, prices and reviews of drugs, or you have any other questions and suggestions - write to us, we will definitely try to help you.
Drug interactions
Despite the fact that Nikoshpan contains several active components, the list of drug interactions between tablets cannot be called extensive. Meanwhile, the medicine still interacts with some drugs:
- when taken simultaneously with contraceptives, Nikoshpan reduces their effectiveness;
- when taken together with oral hypoglycemic drugs, it reduces their effectiveness;
- when taken together with medications containing statins, Nikoshpan can provoke the development of skeletal muscle necrosis or myopathy;
- when used in conjunction with levodopa drugs, Nikoshpan reduces its effectiveness against the manifestations of Parkinson's disease.
In this regard, when prescribing Nikospan, the patient is recommended to inform the doctor about taking any medications, including those listed in the list above.
Arrhythmia is a violation of cardiac activity, deviations in the rhythm of heart contractions that are different in nature and origin. Find out more about symptoms and treatment:
- Modern methods of treating arrhythmia.
- Symptoms indicating cardiac arrhythmia.
