Daflon 500: instructions for use, analogues, reviews, cost

pharmachologic effect

Daflon 500 is used for various diseases associated with circulatory disorders and pathologies of blood vessels.

Action of the drug:

• prevents the formation of blood clots in the lumen of blood vessels;
• reduces fragility and permeability of capillary walls;
• increases elasticity, firmness and tone of blood vessels;
• leads to a decrease in blood viscosity;
• activates lymphatic drainage;
• eliminates puffiness, pain, swelling, fatigue and heaviness in the lower extremities.

general information

Daflon 500 (instructions in Russian are always included) is available in the form of capsules coated with a special shell. The tablet contains the active substance of plant origin (diosmin) in terms of 450 mg and hesperidin (50 mg).

The agent in question allows you to stabilize the structure of the venous walls, speed up the flow of blood, and reduce the filling of the affected areas of the vein with blood. Simply put, blood moves through the veins in different directions: using the laws of gravity, as well as the work of the heart and leg muscles. If the vein loses its elasticity, the valves are disrupted, resulting in changes in the blood circulation process.

In this case, the vein increases in size, complications arise in the form of swelling, inflammation, ulcers and pain. The action of the medicine in question is precisely aimed at blocking the destructive process and restoring the correct functioning of the vascular system.

Pharmacodynamics of the drug

Daflon tablets help reduce the viscosity of leukocytes, which prevents them from sticking to the walls of blood vessels. This reduces the likelihood of blood entering the paravenous tissue.

Regular use of the medicine stimulates the diffusion of oxygen in the tissues of the epidermis and inhibits the formation of red “webs”. Daflon eliminates the feeling of heaviness and reduces swelling of the lower extremities, helps get rid of cramps.

The use of Daflon reduces the risk of postoperative complications and improves the patient’s overall well-being.

The maximum concentration of the drug is observed 13-15 minutes after taking the tablet. Daflon is excreted from the body 24 hours after oral administration.

Peculiarities

As the instructions say, the indications for Daflon and analogs for use have a very wide range associated with the treatment of venous vessels. Completing the course does not require any special conditions. However, while taking the capsules, you should not stay in the sun for a long period or take long walks. You need to monitor your weight.

In rare cases, it is prescribed to wear compression knitted underwear, which allows you to activate blood circulation in the legs. It is worth noting that to achieve quick and better results in treatment, it is necessary to adhere to complex therapy. Along with taking medications, it is recommended to maintain a healthy lifestyle, following all the recommendations of your doctor.

Indications for use

Phlebeurysm;

• various forms of venous insufficiency;
• lymphedema, trophic ulcers;
• acute and chronic form of hemorrhoids;
• prevention of varicose veins;
• cramps, swelling of the legs.

The pharmacological agent is highly effective in the treatment of hemorrhoids - after just a few doses it normalizes the condition of the blood veins in the anal area, reduces the size of hemorrhoidal cones and nodes, and also helps stop bleeding.

What diseases does it help with?

It is important to note that recently diseases have become “younger” - some have a hereditary predisposition, while others, due to professional needs, spend a lot of time on their feet, standing in one place.
This leads to vein diseases:

• chronic venous insufficiency;
• varicose veins;
• varicothrombophlebitis;
• reticular (“cosmetic”) varicose veins;
• deep vein thrombosis;
• haemorrhoids.

The prevalence of lymphovenous diseases reaches 40% among the population aged 20-60 years. At first, the disease may be virtually asymptomatic and not cause concern.

But despite this, it is important not to wait for the transition to severe stages and to engage in timely diagnosis and prevention.

Reviews and recommendations from doctors and patients

Many doctors claim that Daflon is effective in treating varicose veins and hemorrhoids. Its advantages:

• strengthening the walls of blood vessels, improving their tone and elasticity;
• reducing the size of hemorrhoids;
• stopping bleeding from hemorrhoidal veins;
• activation of blood circulation in the lower extremities;
• preventing the development of blood clots.

Patients note that the use of the drug relieves heaviness and pain in the legs.

Attention!

This information does not constitute official instructions for use of the drug. The main characteristics of the drug Daflon are described here. Before purchasing and using the medicine, consult your doctor and read the instructions from the manufacturer.

Analogs

The main and direct analogue of Daflon 500 is Detralex.

1. It is Detralex that has the same composition (micronized purified flavonoid fraction, consisting of 450 mg of diosmin and 50 g of hesperidin) and has a similar effect.
2. Thanks to the components of Detralex, patients can observe significant improvements in the vascular system.
3. For many, even in the later stages of varicose veins, the process of thrombosis slows down, swelling and pain disappear. Detralex can be effectively combined with other methods of treating the disease, then the recovery process will be faster.

Detralex is much easier to buy in Russia, although its cost is not much different from the price of Daflon.

Other analogues, which contain the same active components, include:

• Venarus
• Venozol

Please note that even the packaging design of Detralex and Daflon 500 are similar

Venarus has a similar effect to Detralex and Daflon. However, despite this, there are a number of differences:

1. After taking Venarus, side effects appear more often.
2. Detralex and Daflon contain a micronized fraction, so the action develops much faster; Venarus does not have such a fraction (only diosmin and hesperidin).
3. Venarus is non-toxic and therefore safe.
4. Venarus costs much less - approximately 420-750 rubles per package. The price depends on the number of tablets in the package.

Venozol, unlike other analogs of Daflon and Detralex, is a dietary supplement that contains diosmin and hesperidin. The action is the same. Venozol is not a medicine, but a dietary supplement, an extract of red grape leaf.

The manufacturer produces the drug in the form of gel, cream and capsules. The price of this analogue is also significantly lower than that of Daflon. For example, the cost of capsules No. 36 is 294 rubles, and the cost of cream, 50 ml is 108 rubles.

Since it is not a drug, it is less toxic and has virtually no side effects, which is an advantage.

Cheap partial analogues

Phlebodia 600 – contains diosmin 600 mg . Indicated for varicose veins, the effect develops quickly. Adverse reactions are rare. Price – from 500 to 1500 rubles.

Vasoket - contains diosmin . The indications are the same. Price – from 630 to 825 rubles.

Anistax - dietary supplement, bioflavonoid . Produced in Germany in tablet form. The effect develops quickly. Price – from 500 to 1500 rubles.

Troxevasin is a derivative of rutin . Significantly improves the condition of the venous walls, relieves pain and swelling. Produced in the form of a gel, solution for injection, capsules. Price – from 153 to 500 rubles. (depending on the release form).

Anavenol is a combined venotonic . Available in tablet form. The drug is effective, adverse reactions develop more often, such as bleeding, dizziness, and nausea. Price from 120 to 180 rub.

Side effects

Hypersensitivity of the body to the components of the drug is extremely rare. It may manifest itself with the following symptoms:

• Disorders of the gastrointestinal tract (nausea, diarrhea, vomiting, pain in the lower abdomen).
• Allergic manifestations on the skin in the form of dermatitis or urticaria.

Disturbances in the functioning of the central nervous system (dizziness, weakness, headache)..

The use of Daflon tablets (the instructions and reviews confirm this) very rarely produces side effects, patients generally tolerate the medicine well. There are no dangerous cases of overdose; even if minor disorders are observed, treatment should not be stopped.

Pharmacokinetics

When taken orally, it is absorbed into the gastrointestinal tract quite quickly. After a single oral administration, it was noted that the curve of Daflon concentration in blood plasma immediately over time is characterized by a biphasic character.

The initial peak concentration from the moment of administration is fixed after 15 minutes, after which the concentration begins to slowly decrease, four hours after the moment of application a new round of increasing levels is observed, reaching an equilibrium concentration 5–8 hours after taking the drug, then the levels decrease even after 24 h are practically not detected. Almost 90% of the administered dose of diosmin is eliminated within 48 hours.

Selective accumulation of diosmin in the area of ​​venous vessels reaches a maximum 9 hours after taking the drug and continues for the next 96 hours.

It is excreted from the body mainly in feces, about 14% in urine. T1/2 - 11 hours. Daflon undergoes active metabolism, as evidenced by the presence of phenolic acids in the urine.

A word to consumers

Reviews from patients who have already had the opportunity to use Daflon in practice.

When the first unpleasant sensations in my legs began to appear, I did not attach any importance to them. But then my feet began to fill up like pads, painful discomfort appeared in my legs, and a red mesh appeared on the skin of my lower leg, I realized that I couldn’t do without the help of a specialist.

The therapist prescribed me Daflon 500. I completed a two-month course of treatment according to the regimen of two tablets a day. To be honest, I didn’t even expect such an effect. My leg problems are completely gone, no pain or swelling. I can’t even believe that pills can work such miracles.

Svetlana, 45 years old

I have long suffered from chronic hemorrhoids, sedentary work, difficult childbirth and heredity. At the first unpleasant symptoms of an exacerbation, I start taking Daflon 500 tablets.

The medicine helps instantly, but most importantly it frees you from all the unpleasant symptoms of this disease for a long time.

Nina, 38 years old

What is the difference?

First of all, the fundamental difference concerns the composition. The amount of active substance is the same - 450 mg, but the difference concerns the second part of the substance - 10% of the total amount . The auxiliary components are also different. This results in a significant difference in price.

The drugs are produced by different companies, albeit under the same license. Thus, Detralex is an exclusively foreign drug, and Daflon is a cheaper analogue produced in the CIS countries.

According to the results of angiostereometric studies, Detralex has a positive effect on blood flow somewhat faster than Daflon does. The reason for this is the increased concentration of starch and talc, with which Detralex is absorbed faster and more efficiently.

Question of acquisition

The drug is sold in pharmacies only with a doctor's prescription. Daflon should be stored in a dry and dark place at a temperature not exceeding 30°C. The shelf life of the tablets is 4 years.

In addition to Daflon, there are drugs that have the same composition and have similar therapeutic effects. These include:

All of the medications listed are cheaper analogues of the French drug Daflon. In theory, they are all no different at all, but in practice it is difficult to establish the difference, since there is no information about the technological nuances of their production.

• Indications for use
• Mode of application
• Contraindications
• Overdose
• Pregnancy
• Interaction with other drugs
• Storage conditions
• Compound
• Additionally

Daflon is a medication for the symptomatic treatment of hemorrhoids and chronic venous diseases. Pharmacological action of Daflon The active components of Daflon are subjected to a high-tech grinding process, which increases their bioavailability and clinical effectiveness. The advantage of Daflon compared to other medications used for venous diseases is its complex effect: The active components of Daflon have a vasoconstrictor effect on the walls of the veins and help to increase venous tone, and, consequently, reduce venous distensibility. This increases venous outflow and reduces venous congestion, which is observed against the background of chronic venous disease. In addition, according to recent studies, the active components of Daflon protect venous valves from inflammation and destruction, which prevents further progression of chronic venous disease; Daflon significantly improves lymphatic drainage and also increases the total number of functional lymphatic capillaries; The active components included in Daflon tablets improve microcirculation, reducing the migration and activation of leukocytes at the capillary level, which leads to a decrease in the release of inflammatory mediators in the form of free radicals. Against the background of chronic venous disease, Daflon, according to the instructions, alleviates the severity of most symptoms of the disease, which manifest themselves in the form of pain, heaviness in the legs, cramps and swelling. Relief of symptoms contributes to significant improvement in quality of life in chronic venous disease. In addition, according to studies, Daflon tablets are effective in acute hemorrhoidal attacks. At the same time, relief of symptoms (pain, bleeding and discharge) is observed from the second day of treatment, which makes it possible to reduce the use of painkillers. Also, the use of Daflon, according to reviews, reduces the risk of postoperative bleeding and reduces healing time in the postoperative period.

Price

The cost varies depending on the region of the Russian Federation. The statistics are presented below in table form. As it decreases from European countries, the price increases, since the drug is imported and is brought from France.