Dona - instructions, indications, composition, method of application

Pharmacological authorities

Pharmacodynamics.

The active ingredient is aminomonosaccharide glucosamine sulfate, which is present in the human body and is combined with sulfates for the biosynthesis of hyaluronic acid, synovial acid and glycoses. noglycans of the main substance of the subglobular cartilage.

The mechanism of action of glucosamine sulfate is stimulation of the synthesis of glycosaminoglycans and, apparently, carbon proteoglycans. In addition, glucosamine exhibits anti-inflammatory effects, increasing the process of degradation of the subglobular cartilage, which is primarily responsible for the reduction of its metabolic activities, thereby inhibiting the activity of interleukin 1 (IL-1), so on one side, it responds to the symptoms of osteoarthritis, and on the other – to the deterioration of structural destruction of the corners, about which to compare the data of long-term clinical studies.

The effectiveness of glucosamine sulfate against osteoarthritis is obvious already after 2-3 days of treatment.

The results of clinical studies of continuous treatment over a period of 3 years indicate a progressive improvement in its effectiveness, depending on symptoms and an increase in the structural deterioration of the joints, which is confirmed before I'll help x-ray.

Glucosamine sulfate demonstrated good tolerability. No significant effect of glucosamine sulfate on the cardiovascular, respiratory, autonomic or central nervous systems was identified.

Pharmacokinetics.

90% of the dose of glucosamine sulfate is absorbed directly from the scolio-intestinal tract, passes through biological barriers and penetrates the tissue, especially the tissue of the subglobular cartilage. Bioavailability – 26%. Renewal period – 68 years.

Contraindications

Every medication has its own contraindications, and Dona was no exception. However, the number of contraindications to the use of Dona is quite narrow, and you can encounter them quite rarely.

Contraindications to the use of the drug:

• period of pregnancy and breastfeeding;
• age under 12 years;
• intolerance to the components of the drug;
• intolerance or hypersensitivity to lidocaine;
• diseases of the excretory system, for example, phenylketonuria;
• neurological diseases, such as epilepsy;
• Cardiac diseases, such as heart failure.

Interactions with other medicinal drugs and other types of interactions

There appears to be evidence of a possible drug interaction with glucosamine, but an increase in MNR (international normalization) was observed when oral vitamin K antagonists were administered. Therefore, patients who want to overcome the antagonism of oral vitamin K should carefully follow the initiation of glucosamine therapy. Supplemental treatment with glucosamine may enhance the absorption and therefore the concentration of tetracyclines in the blood system. The clinical significance of this interaction is probably limited.

In view of the fact that there is little evidence about the possible interaction of glucosamine, particular attention should be paid to any modification of the reaction to changes in the level of concentration of the concomitantly induced drugs. karskikh zabіv in syrovatsі blood.

Dona - a drug for joints: composition, in what form is it available, how to take it?

The drug has many advantages. It significantly alleviates the patient’s condition and has a beneficial effect on the course of the metabolic process in the cartilaginous component of the articular tissue. After the necessary course of therapy with the drug, motor activity is restored, health improves, and the destruction of building material in the joints slows down.

The main active component of the dosage form is glucosamine sulfate. It is considered one of the best chondroprotectors in pharmacy. The element is a salt of the aminosaccharide glucosamine. The substance has a low molecular weight. Salt is able to activate regenerative reactions at the cellular level of cartilage tissue and restore the permeability of joint capsules.

How to treat joints

This active component reduces pain in the affected areas, is able to stop inflammation, prevents the development of joint deformation, and improves their motor ability.

Your doctor may prescribe medication for the following joint problems::

• At various stages of development of primary and secondary arthrosis.
• Osteoarthrosis, osteochondrosis, diseases of the shoulder joints, in particular periarthritis.
• Destruction of the cartilaginous matter of the posterior part of the patella.

For ease of use, pharmacists produce the drug in three forms available for use: ampoules, pills, powders. The ampoules contain salt and solution, which, after mixing, are directly intramuscularly administered to the patient. The packaged form contains 1500 milligrams of the active ingredient. One ampoule contains 400 milligrams of active salt.

Treatment regimen

When prescribing Dona, medical specialists can use different treatment regimens . Much depends on the form of the drug used and on the degree of pathology in the patient. It is recommended to use the powder as follows: the package is diluted in a small volume of liquid, stirred and taken twenty-five minutes before meals . The period of use is from one and a half to three months. If the disease is advanced, then the use of the medicine is repeated after a short break.

Inflammation of the knee joint. Don's tablets

It is recommended to take the pills twice a day . It is advisable to take the tablets while eating and wash them down with one glass of liquid. The therapeutic course can last from four to six weeks. A noticeable improvement in health occurs after just two weeks of taking the pills.

Intramuscular injections are recommended for patients three times a week ; the course of therapy can last one to one and a half months. Before making an injection, mix the powdery mass and solution, and only then administer the product.

IMPORTANT: In difficult cases, the specialist recommends comprehensive treatment. More precisely, a combination of injections, pills or powder. Such methods are most effective in the treatment of diseases of joints and cartilage tissue.

The success of treatment depends on individual characteristics. Some people experience relief within half a month after starting treatment. The patient will have a lasting effect for almost eight weeks. The patient will not feel pain during this period even without taking medications.

Features of good stagnation

Before administering the drug, it is necessary to consult a doctor to exclude the possibility of illness in the case of other treatment methods.

Patients with impaired glucose tolerance should exercise caution when taking glucosamine. Patients with cervical diabetes are advised to closely monitor the level of cervix in the blood and, if necessary, increase insulin requirements before the start and periodically continue the treatment.

In patients with a known risk factor for cardiovascular diseases, it is recommended to monitor the level of blood lipids; Hypercholesterolemia.

When treating asthma, the drug should be administered with caution, as such patients may be more susceptible to developing allergic reactions to glucosamine, which may worsen the symptoms of their illness.

Powder for oral administration contains aspartame, which is similar to phenylalanine, which is unsafe for patients with phenylketonuria.

1 sachet contains 6.6 mmol (151 mg) sodium. This should be taken to the satisfaction of patients who are undergoing controlled treatment instead of sodium.

Powder for oral administration containing sorbitol. For patients who suffer from intermittent fructose intolerance, this pharmaceutical form is not recommended.

Immobilize the body under the supervision of a doctor for patients with impaired liver function or with thrombophlebitis.

Suspension for children and children.

Glucosamine should not be administered to children and children (up to 18 years of age), since the safety and effectiveness of the drug for such patients has not been established.

Treatment for summer patients.

No specific follow-up studies have been conducted on the part of summer patients, but, based on clinical evidence, there is no need for adjusted dosage in this category of patients.

Treatment for patients with nitric and/or liver insufficiency.

For patients with impaired liver and/or liver function, dosing recommendations cannot be given, as no further follow-up has been carried out.

Suspension during pregnancy or breastfeeding.

If you use the drug during pregnancy or breastfeeding every day, you should not use the drug in this category of patients.

This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.

Testing of the infusion of the drug for the presence of ceruvate in a car or other mechanisms was not carried out. Be careful when using transport means and work that requires respect. Once you experience drowsiness, sleepiness, confusion or blurred vision, the use of vehicles and other mechanisms are blocked.

Brief description of the medicine

Unfortunately, the spine, bones and joints often suffer from a variety of diseases. It is almost impossible to completely cure such diseases. The main thing that needs to be done in such situations is to slow down the processes that destroy the tissue of bones, joints and spine.

In addition, it is necessary to provide damaged tissues with nutrients, restore the weakened body with a special diet and medical procedures.

Experts often prescribe the use of Don's medicine for the treatment of joints and spine. A number of questions arise. What is Dona, and what does this medicine help with? How does the drug work, how to take it correctly? What diseases does Dona fight, and what does the instructions say about contraindications? Below you can find answers to these important questions.

Dona is a drug from the group of chondroprotectors. Glucosamine is the main active component of the drug. The medicine is presented in the form of injections, tablets or powder for drinking solutions. Experts have conducted research for many years and found that Dona powder helps:

1. Replenish the lack of certain nutrients necessary for joint tissues.
2. Restore cartilage tissue.
3. Prevent the development of benign and malignant neoplasms.
4. Reduce pain.
5. Restore joint shock absorption.
6. Increase the production of intra-articular synovial fluid.
7. Restore mobility to the affected joint.

These properties of Dona make it possible to prescribe the drug for the treatment of the musculoskeletal system and normalization of its functions.

Don's medicine delivers special substances to the body using injections, tablets, etc. These components, firstly, stop inflammation processes , and secondly, destroy aggressive enzymes that negatively affect joint cartilage. Thus, the drug helps the cartilage pads recover quickly.

As for bone diseases, the medicine promotes the accumulation of calcium in the body and the formation of calcium compounds necessary for bone structures.

Don's drug is used to treat diseases that affect not only the joints, but also the spine. The reason is that Dona has anti-inflammatory properties of a non-steroidal drug , and not only acts as a chondroprotector.

Practical evidence allows this drug to be prescribed for the treatment of many diseases.

Method of congestion and dosage

Stop inside.

Adult and summer age patients:

Instead of 1 sachet, equivalent to 1500 mg of glucosamine sulfate, dissolve in a bottle of water and take 1 time per day, within an hour.

Glucosamine is not indicated for the treatment of acute pain symptoms. Relief of symptoms (especially pain relief) may occur only after a few episodes of fasting, and in several episodes - longer.

If no improvement in symptoms has occurred after 2-3 months of use, it is necessary to re-evaluate the treatment.

What is Dona

Dona is a medicine whose action is aimed at stimulating regenerative processes in cartilage tissues.
The drug has analgesic, anabolic and anti-inflammatory properties. In addition, the medicine may have a chondroprotective effect and reduce cortisol levels.

Dona has a positive effect on the synthesis of nutrients (for example, calcium) and mediators that are required for the regeneration of damaged tissues. The drug allows the necessary substances to accumulate in the joint area. This property of the drug helps eliminate pain, as well as stop inflammation and tissue degeneration processes.

Dona is available in different forms:

• ampoules for injections;
• ointment;
• powder;
• pills.

Side effects

The most common side effects associated with glucosamine supplementation are fatigue, abdominal pain, dyspepsia, flatulence, constipation, diarrhea, headache, and drowsiness. The identified adverse reactions are usually transient and mild in severity.

Criteria for assessing the frequency of development of an adverse drug reaction:

On the side of the immune system:

unknown frequency – allergic reactions (hypersensitiveness);

on the side of the nervous system:

often – headache, drowsiness; frequency is invisible - confused;

from the side of the organs:

frequency of the unknown - discord with the dawn;

from the side of the judiciary:

infrequently - red;

on the side of the respiratory organs, chest and mediastinum:

frequency of unknown – asthma, exacerbation of asthma;

on the side of the grass system:

often - abdominal pain, flatulence, dyspepsia, diarrhea, constipation, boredom, unknown frequency - vomiting;

on the side of the hepatobiliary system:

frequency of the unknown – zhovtyanitsa;

from the side of the skin and under the skin:

infrequently - exanthema, itching, erythema, visipanna; frequency unknown - angioneurotic swelling, kropiv'yanka;

underground discord:

often - heavy, frequency unknown - swelling, peripheral swelling;

tracking results:

the frequency of the unknown is the increase in the level of liver enzymes.

Frequency unknown - patients with blood diabetes may experience negative effects on blood sugar monitoring.

There have been reports of isolated spontaneous episodes of hypercholesterolemia, but no causal link has been established.