Pharmacodynamics and pharmacokinetics
The effect of this combination drug is due to its components, which are a glucocorticosteroid, an aminoglycoside antibiotic and an antifungal agent.
The use of betamethasone dipropionate helps to inhibit the concentration of leukocytes , the formation of lysosomal enzymes and a number of anti-inflammatory mediators in the area of inflammation. In this case, phagocytosis is inhibited, vascular-tissue permeability is reduced and the occurrence of inflammatory swelling is prevented.
Gentamicin, which is a broad-spectrum antibiotic Its action is directed against the causative agents of many primary and secondary bacterial infections of the skin, namely: gram-negative and gram-positive bacteria. However, anaerobes, fungi and viruses are not sensitive to this substance.
The antifungal effect of the drug is provided by clotrimazole. In this case, the synthesis of ergosterol, which makes up the cell membrane of fungi, is disrupted.
Activity is manifested against the most common fungi: Trichophyton rubrum, Epidermophyton floccosum, Candida albicans and so on.
Contraindications
It is not recommended to use Akriderm GK cream or ointment if:
- hypersensitivity to it;
- skin tuberculosis;
- cutaneous syphilis;
- skin post-vaccination reactions;
- chicken pox;
- herpes simplex;
- lactation;
- children under one year of age;
- otitis externa.
Reviews
Natalya, Chekhov
I can confirm from my own experience that Akriderm GK is safe for children. At the age of 3, my daughter was diagnosed with allergic dermatitis to pollen. The allergist advised lubricating the skin with this cream before immunotherapy. It helped very quickly, after a day my child’s skin was almost completely cleared.
Evgenia, Chelyabinsk
I used Akriderm GK ointment to treat neurodermatitis. As soon as I got a little nervous, the skin became covered with red spots and swollen. The ointment was used together with antiseptics and sedatives. There have been no relapses for several months now, but I keep a tube in my medicine cabinet at home just in case.
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Akriderm GK (review) from 390 rub.
Description
A drug with antibacterial and anti-inflammatory effects. Effective in treating dermatitis and other skin problems.
Overall
4.4
- Efficiency
- Price
- Safety
- Availability
Pros
- Efficiency
- Wide spectrum of action
- Without smell
- Quickly absorbed
Cons
- Price
- Hormonal
Side effects
The use of GCS often causes side effects such as burning, irritation, excessive dry skin, hypertrichosis, folliculitis, acne , hypopigmentation, dermatitis , and so on.
Long-term use, especially under occlusive dressings, can cause prickly heat, maceration or atrophy of the skin, secondary infection, and purpura.
Children should be treated with extreme caution to avoid the occurrence of systemic undesirable effects such as hyperglycemia, glucosuria , suppression of the adrenal cortex, Cushing's syndrome , etc.
Instructions for use Akriderm GK (Method and dosage)
Akriderm GK ointment instructions for use recommend applying it externally only. In this case, the product is applied in a fairly thin layer to the affected areas of the skin. This needs to be done 2 times every day.
It should be noted that the instructions for use for Akriderm GK cream contain the same therapeutic regimen. But it is also possible for a doctor to prescribe individual treatment, depending on the severity of the disease. Mild cases allow the use of the cream only once a day, and more severe cases, on the contrary, increase the frequency of use.
The duration of therapy usually depends on how effective this remedy was in a particular case, and can be 2-4 weeks.
In the absence of a positive result for a long time, it is necessary to clarify the diagnosis.
special instructions
The appearance of symptoms of sensitivity, skin irritation and other undesirable symptoms caused by the use of the drug requires abandoning this therapy and choosing another suitable remedy.
Long-term treatment, application of cream or ointment to large skin surfaces, use of occlusive dressings and therapy in children can cause systemic absorption of GCS.
This external remedy can be used in the treatment of children over one year of age, but only on the recommendation and under the close supervision of a specialist, which will avoid systemic side effects. It has been established that applying Akriderm GK cream or ointment over large areas for a long time leads to inhibition of the hypothalamic-pituitary-adrenal system, hypercortisolism, decreased excretion of hormone and increased intracranial pressure.
In addition, with prolonged application to the face, atrophic changes often occur, compared to other areas of the skin. For this reason, you should adhere to the standard therapeutic course, which is 5 days.
It is contraindicated to use any form of the drug in ophthalmology, avoiding accidental contact not only with the eyes, but also with mucous membranes.
pharmachologic effect
Indications for the use of Akriderm GK ointment include pathologies accompanied by acute or chronic inflammation. To suppress it, betamethasone is included in the product. The glucocorticosteroid inhibits the enzyme cyclooxygenase, preventing the production of mediators of pain and inflammation - prostaglandins and bradykinins. It also significantly limits the migration of leukocytes to inflammatory foci. The glucocorticosteroid stabilizes lysosomal membranes and reduces capillary permeability. The antibiotic gentamicin also has an anti-inflammatory effect. It is active against the following pathogens:
- Proteus;
- staphylococci;
- coli;
- streptococci;
- Klebsiella;
- shigella;
- salmonella.
Thanks to the effects of gentamicin, the growth and reproduction of bacteria quickly slows down. The presence of an antibiotic in the ointment or cream allows not only to eliminate the bacterial infection, but also to prevent its occurrence. The antimycotic drug clotrimazole prevents the production of ergosterol by pathogenic yeast-like fungi. They need this compound to build cell membranes. Ergosterol deficiency leads to a gradual decrease in the number of fungi on the skin.
Analogues of Akriderm GK
Level 4 ATX code matches:
Rederm
Losterine
Akriderm SK
Akriderm
Akriderm Genta
Elokom S
Diprosalik
Belosalik
Triderm
Kanizon Plus
Betasalik
Triacutan
Momat-S
The main analogues are represented by the following drugs: Triderm and Kanison.
At the same time, the price of analogues varies between 470-720 rubles.
Reviews about Akriderm GK
According to many users, this external remedy is one of the most effective. Although reviews of Akriderm GK cream are more common than ointment reviews. In any case, each form of this drug is prescribed to treat a variety of skin diseases and usually patients notice improvement within a couple of days.
It should be noted that in addition to positive reviews, you can also find reports of side effects. Symptoms that indicate intolerance or sensitivity to this drug are usually described: increased redness, peeling, development of inflammation, and so on.
In addition, patients often report that the drug helps only while you use it, and soon after discontinuation, the symptoms of the disease return again.
The reason for this is, most likely, that Akriderm GK helps suppress the manifestations of the disease, but still does not affect the disease itself. Therefore, in addition to the drug that alleviates the patient’s condition, the main treatment of the source of the health disorder must also be carried out.
In any case, it is not recommended to use this remedy without the prescription of a specialist. In addition to the fact that therapy may simply be useless, it is possible that severe complications may arise, which usually require long-term treatment.
Clinical and pharmacological group
Akriderm GK is part of a broad pharmacological group of glucocorticosteroids in combinations. All these drugs are prescribed by dermatologists for complex treatment of skin pathologies in children and adults. Akriderm GK has proven itself especially well in the treatment of dermatoses of allergic origin.
Drugs from the group of combined glucocorticosteroids may contain several active ingredients:
- antifungal agents;
- antibiotics from various groups;
- non-steroidal anti-inflammatory drugs;
- regeneration stimulants.
This allows you to start treatment without waiting for laboratory results. If Akriderm GK is prescribed to a small child, then the parents always ask the doctor whether it is a hormonal ointment or not. The drug contains the glucocorticosteroid betamethasone dipropianate. The synthetic hormonal compound exhibits antiexudative and antiedematous activity.
Akriderm GK price, where to buy
The price of Akriderm GK cream is 130-400 rubles.
The price of Akriderm GK ointment is 350-650 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Akriderm GK ointment 15gAO Akrikhin
RUB 508 order - Akriderm gk ointment 30g n1AO Akrikhin
RUR 729 order
- Akriderm GK cream 30gAO Akrikhin
RUB 802 order
- Akriderm GK cream 15gAO Akrikhin
460 rub. order
Pharmacy Dialogue
- Akriderm GK ointment (tube 15g) Akrikhin OJSC
500 rub. order
- Akriderm GK ointment (tube 30g) Akrikhin OJSC
RUR 796 order
- Akriderm GK cream (tube 30g) Akrikhin OJSC
RUR 801 order
- Akriderm GK cream (tube 15g) Akrikhin OJSC
490 rub. order
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Release form and composition
The drug is produced by the Russian pharmaceutical factory Akrikhin. The primary packaging of Akriderm GK is an aluminum tube that may contain 15.0 or 30.0 g of the drug. The screw cap has a protrusion for quick and safe opening. The secondary packaging of the drug is a cardboard box with detailed instructions for use inside.
On pharmacy counters there are two dosage forms of the product for local application, differing in composition:
- Akriderm GK ointment is a transparent gel-like substance with a yellowish tint;
- Akriderm GK cream is a white pasty mass.
The qualitative and quantitative composition of the active ingredients of the ointment and cream is identical.
The content of auxiliary ingredients varies. There are a few of them in the ointment - paraffin, petroleum jelly and propylparaben. And the cream is supplemented with sodium edetate and propylene glycol. The composition of active ingredients determines the therapeutic effect of Akriderm GK:
- glucocorticosteroid betamethasone;
- aminoglycoside group antibiotic gentamicin;
- antifungal agent clotrimazole.
Components for forming the base enhance and prolong the effect of the ingredients. They also provide rapid transdermal and transepidermal penetration of compounds into inflammatory lesions.
