Droperidol Instructions for use, contraindications, composition and price

Indications for use

• Surgery: induction of anesthesia, premedication, potentiation of general and regional anesthesia; neuroleptanalgesia (simultaneously with fentanyl); providing a sedative effect, eliminating vomiting and pain in the postoperative period, vomiting and nausea during surgical and diagnostic procedures;
• Therapy: shock and pain in injuries, severe attacks of angina, myocardial infarction, hypertensive crisis, pulmonary edema;
• Psychiatric practice: hallucinations, psychomotor agitation.

Reviews from patients and doctors about the drug Droperidol

Feedback from patients and doctors is mostly positive.

The only condition is the task and purpose of prescribing the drug .

Until recently, in medical practice, specialists tried to prescribe newer drugs, but their increased negative effect on the heart and nervous system of patients forced them to return to the drug Droperidol.

Reviews from doctors:

1. Vasiliev R.O., cardiologist . For hypertensive crisis in complex therapy, Droperidol is the best medicine.
2. Nikiforova P.R., neurologist . Droperidol can cause severe agitation in the patient; therefore, special attention should be paid to the clinical picture of the patient’s behavior and should be prescribed only in hospital treatment.

reviews :

1. Michael. 27 years. I was coded for alcohol addiction. They called a doctor to the house. They injected various drugs Disol, Pyridoxine. Droperidol helped. Although before this the results were zero.
2. Elena . 21 years old. I am 1.5 months pregnant. Severe toxicosis. Droperidol was prescribed. After a week of use, the gag reflexes went away. Tests showed that everything was fine with the fetus.

Advice from patients

At the hospital I was prescribed Droperidol. Treatment with the drug went well. There were no side effects.

At home, without calculating the dose, my neighbor injected me with the drug. I began to feel severe shortness of breath and my heart began to pound. As a result, I again (by calling an ambulance) ended up in the hospital for 2 weeks.

Be careful when taking the drug, and it is still better to use it under the supervision of specialists than to use it yourself.

Pros and cons of the drug

The above positive aspects include the fact that the drug:

• can be used for veterinary purposes;
• the drug is dispensed according to a doctor's prescription.

Contraindications

• Coma;
• Extrapyramidal disorders;
• Increased QT interval on ECG;
• Severe depression;
• Hypokalemia;
• C-section;
• Arterial hypotension;
• Age up to 2 years;
• Hypersensitivity to the components of the drug and morphine derivatives.

The use of Droperidol by pregnant women is possible only in cases where the expected benefit to the health of the mother is higher than the potential risk to the fetus. If it is necessary for women to use the drug during lactation, breastfeeding should be stopped.

Droperidol

Active substance:

Droperidol*

Pharmgroup:

Neuroleptics

Directions for use and dosage

The dose of Droperidol is determined individually, taking into account the nature of the disease, age, general physical condition, body weight, drugs used simultaneously, and the type of anesthesia to be performed.

For premedication, adults are administered 2.5-5 mg of Droperidol intramuscularly 15-45 minutes before the start of surgery; children - at the rate of 100 mcg/kg.

For adults, the drug is prescribed in a dose of 15-20 mg (intravenously) for induction of anesthesia. For children, intravenous (at a dose of 200-400 mcg/kg) or intramuscular (at a dose of 300-600 mcg/kg) administration is possible.

To maintain anesthesia during long-term operations, repeated intravenous administration of Droperidol at a dose of 2.5-5 mg is possible.

In the postoperative period, adults are prescribed 2.5-5 mg intramuscularly every 6 hours.

Pharmacodynamics and pharmacokinetics

Pharmacological group of Droperidol - antipsychotics of the butyrophenone . The duration of action of the drug does not exceed 2-3 hours, but the effect of the drug occurs quickly and is quite strong. The medicine has the property of potentiating the effect of sleeping pills and painkillers on the body. It has antishock and antiemetic activity.

Droperidol has an adrenolytic effect by blocking central dopamine receptors , anticholinergic activity . The drug greatly reduces blood pressure and has antiarrhythmic and cataleptogenic activity.

When intravenously , it appears within 3-5 minutes, reaching its maximum level after half an hour. About 90% of the active substance binds to blood plasma proteins. Its metabolites are excreted through the kidneys, in their original form - with urine and feces.

Side effects

When using Droperidol, it is possible to develop disorders of certain body systems:

• Central nervous system: drowsiness, dysphoria in the postoperative period and, conversely, when using high doses - fear, motor excitability, anxiety; rarely – extrapyramidal symptoms; in some cases in the postoperative period – depression, hallucinations;
• Cardiovascular system: tachycardia and moderate arterial hypotension (usually no special therapy is required); in very rare cases - arterial hypertension (most likely when combined with fentanyl or other parenterally administered analgesics);
• Digestive system: dyspepsia, loss of appetite, nausea; rarely – transient liver dysfunction, jaundice;
• Allergic reactions: rarely - dizziness, anaphylactic reactions, trembling, bronchospasm, laryngospasm.

special instructions

Droperidol should only be used in hospital settings.

The drug should be prescribed with caution to patients with functional disorders of the kidneys and liver, depression, epilepsy, as well as in conditions preceding an epileptic seizure.

In case of pheochromocytoma, tachycardia and severe arterial hypertension may develop after administration of Droperidol.

During therapy, the possibility of developing severe arterial hypotension must be anticipated. The drug can also cause a decrease in pressure in the pulmonary artery, which must be taken into account during diagnostic and surgical procedures. Patients receiving Droperidol need careful medical supervision.

The initial dose of the drug should be reduced in elderly, exhausted and physically weakened patients. When increasing the dose, you should be guided by the effect obtained.

Droperidol should be prescribed in a lower dose when used concomitantly with drugs that have a depressant effect on the central nervous system. Accordingly, after Droperidol, the doses of such drugs are also reduced.

The use of Droperidol in high doses (25 mg or more) can lead to sudden death in patients with cardiac arrhythmias due to alcohol withdrawal, hypoxia, or electrolyte imbalance.

In surgical practice, when using the drug, it is necessary to carefully monitor the parameters of the physiological state of the body. When performing epidural or spinal anesthesia, it is possible to develop a blockade of the sympathetic nervous system and intercostal nerves, which, in turn, can lead to difficulty breathing, the development of arterial hypotension and dilation of peripheral vessels.

To avoid the occurrence of orthostatic hypotension, it is recommended to be careful when transporting the patient and to avoid sudden changes in body position.

While Droperidol is in effect and for 24 hours after its use, it is necessary to avoid performing potentially hazardous work that requires rapid psychomotor reactions and high concentration.

Droperidol Instructions for use, contraindications, composition and price

Home \ Medicines \ Injection solutions \ Droperidol

Droperidol solution d/in 2.5 mg/ml fl 2 ml pack. cont. cell N5.

Dosage form

Solution for intravenous and intramuscular administration

Compound:

Active substance: droperidol - 2.5 mg

Excipients: tartaric acid - up to pH 3.3 (about 1.5 mg), water for injection - up to 1 ml.

Description of the dosage form:

Transparent colorless or slightly colored liquid

Pharmacological group

Antipsychotic (neuroleptic) drug

Pharmacological (immunobiological) properties

Antipsychotic drug (neuroleptic), butyrophenone derivative. It also has sedative, antishock, antiemetic, hypothermic, hypotensive and antiarrhythmic effects. The antipsychotic effect is due to the blockade of dopamine D 2 receptors of the mesolimbic and mesocortical systems. The sedative effect is due to the blockade of adrenergic receptors in the reticular formation of the brain stem. Droperidol enhances the duration and intensity of the action of hypnotics, narcotic and non-narcotic analgesics, local anesthetics, anticonvulsants and alcohol. The antiemetic effect is due to the blockade of dopamine D2 receptors in the trigger zone of the vomiting center. The hypothermic effect is due to the blockade of dopamine receptors in the hypothalamus. Droperidol dilates peripheral vessels and reduces total peripheral vascular resistance; reduces pulmonary artery pressure (especially if it is significantly increased) and reduces the pressor effect of adrenaline. Reduces the incidence of arrhythmias caused by adrenaline, but does not prevent cardiac arrhythmias of other etiologies.

Has strong cataleptogenic activity.

When administered intravenously or intramuscularly, the effect occurs within 5-15 minutes, the maximum effect is achieved after 30 minutes; the sedative effect lasts 2-4 hours, the total duration of action on the central nervous system is 12 hours.

Pharmacokinetics

The time to reach maximum plasma concentration is 15 minutes. Plasma protein binding is 85-90%, half-life is 120-130 minutes. Metabolism - in the liver. Excreted by the kidneys in the form of metabolites - 75%, unchanged by the kidneys - 1%, through the intestines - 11%.

Indications

Premedication before general anesthesia, induction of anesthesia, potentiation of the effect of drugs during general and local anesthesia.

Neuroleptanalgesia (in combination with narcotic analgesics, often with fentanyl). Providing a sedative effect, preventing nausea and vomiting during diagnostic and surgical procedures.

Pain and vomiting in the postoperative period, psychomotor agitation, hallucinations. Pain syndrome; pain shock due to injuries.

Contraindications

Increased individual sensitivity to the drug, coma, extrapyramidal disorders, cesarean section, hypokalemia, arterial hypotension, pregnancy, children (up to 3 years).

Carefully

Liver and/or renal failure, alcoholism, decompensated chronic heart failure, epilepsy, depression.

Use during pregnancy and breastfeeding

Use during pregnancy is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus. During treatment with the drug, breastfeeding should be stopped.

Directions for use and doses

The administered dose of droperidol should be determined individually, taking into account the patient's age, body weight, general physical condition, the nature of the disease, concomitantly used medications, and the type of anesthesia to be performed.

Droperidol is used intramuscularly and intravenously. When administering the drug, vital physiological functions of the body should be monitored.

P remedication. Droperidol is administered intramuscularly 30-60 minutes before surgery at a dose of 2.5-10 mg (1-4 ml). The dose is determined individually.

General anesthesia. For induction of anesthesia, Droperidol is used intravenously at a dose of 2.5 mg (1 ml) per 10 kg of body weight in combination with narcotic analgesics and/or agents for general anesthesia. In some cases, smaller doses may be used. The total dose of droperidol is determined individually.

During surgery, the maintenance dose of droperidol is 1.25-2.5 mg (0.5-1.0 ml) intravenously.

The use of droperidol in diagnostic procedures without general anesthesia. Droperidol is administered intramuscularly at a dose of 2.5-10 mg (1-4 ml) 30-60 minutes before the procedure. Additionally, droperidol can be administered intravenously at a dose of 1.25-2.5 mg (0.5-1 ml). (Some procedures, like bronchoscopy, require local anesthesia.)

Local anesthesia. To provide additional sedative effect, Droperidol is administered intramuscularly or intravenously slowly at a dose of 2.5-5 mg (1-2 ml).

To relieve hypertensive crises. Droperidol is administered in a dose of 2.5-5 mg (1-2 ml) intravenously or intramuscularly, if necessary, simultaneously with other drugs. Injections can be repeated after 45-90 minutes.

Use of droperidol in pediatric practice. For premedication, children over 3 years of age are prescribed Droperidol at a dose of 100-150 mcg/kg body weight. For induction anesthesia intravenously at a dose of 200-400 mcg/kg body weight or intramuscularly at a dose of 300-600 mcg/kg body weight.

Side effect

Moderate decrease in blood pressure and tachycardia, which can be stopped without special therapy.

Possible dysphoria, drowsiness in the postoperative period and, on the contrary, when using higher doses - anxiety, motor excitability, fear; extrapyramidal symptoms, which should be relieved with anticholinergic drugs.

Anaphylaxis, dizziness, tremor, laryngospasm, bronchospasm.

Increased blood pressure and tachycardia - with the combined use of droperidol with fentanyl or other narcotic analgesics administered parenterally.

In the postoperative period, hallucinations and depression are possible.

Overdose

Overdose symptoms are due to the pharmacological action of the drug. The decrease in blood pressure is eliminated by analeptics and sympathomimetic drugs. Treatment of extrapyramidal symptoms is carried out with m-anticholinergic drugs.

In case of respiratory failure, oxygen should be given and artificial ventilation provided. Careful monitoring of the body's condition is necessary for 24 hours. The patient should be warmed and warm solutions should be introduced into the body. If a severe or prolonged decrease in blood pressure develops, infusion therapy should be used to avoid hypovolemia.

Interaction

Droperidol enhances the effect of other drugs that depress the central nervous system (barbiturates, tranquilizers, narcotic analgesics, general anesthesia). This should be taken into account when choosing drug doses: the dose of droperidol should be reduced if other central nervous system depressants have been used, and, conversely, the doses of other central nervous system depressants should be reduced after the use of droperidol.

Droperidol antagonizes the pressor action of epinephrine and other sympathomimetic agents.

Droperidol potentiates the effect of antihypertensive drugs.

Because droperidol blocks dopamine receptors, it may inhibit the action of dopamine receptor agonists.

When used concomitantly with droperidol, anticonvulsants may require an increase in the dose of the latter.

special instructions

Droperidol is used only in hospital settings.

When using droperidol, one should anticipate the possibility of lowering blood pressure and have means for its timely correction.

Patients receiving droperidol should be under medical supervision. Initial doses of droperidol should be reduced in elderly and physically weakened patients. When increasing the dose of the drug, you should be guided by the effect already obtained. It should be borne in mind that the doses of narcotic analgesics used in conjunction with droperidol should be reduced.

Droperidol rarely causes neuroleptic malignant syndrome.

In the preoperative period, diagnosing neuroleptic hyperthermia is difficult. Appropriate therapy (eg, dantrolene) should be initiated immediately if there is an increase in temperature, increased heart rate, and increased carbon dioxide production.

High doses of droperidol (25 mg or more) in patients at risk of arrhythmia due to hypoxia, electrolyte imbalance or alcohol withdrawal can cause sudden death.

With some types of conduction anesthesia (for example, spinal, epidural), blockade of intercostal nerves and sympathetic innervation may develop, which, in turn, complicates breathing, contributes to the dilation of peripheral vessels and a decrease in blood pressure. Droperidol, in turn, also affects blood circulation; Therefore, in cases where droperidol is used in addition to these types of anesthesia, the anesthesiologist should anticipate possible changes and carefully monitor vital signs.

A decrease in blood pressure may be accompanied by hypovolemia, so infusion therapy is necessary to prevent it. The patient should be positioned to improve venous flow to the heart. During spinal or epidural anesthesia, it is necessary to ensure that the patient’s head does not hang down - this position enhances the effect of anesthesia and impairs venous circulation.

To avoid orthostatic hypotension, care should be taken when transporting the patient; do not quickly change the position of his body.

Droperidol may reduce pulmonary artery pressure. This should be kept in mind during surgical and diagnostic procedures to determine further treatment for the patient.

In patients with pheochromocytoma, after administration of droperidol, a sharp increase in blood pressure and tachycardia may be observed.

Influence on the ability to drive vehicles and control mechanisms that require increased concentration of attention

When treated with the drug, patients are not recommended to perform work for 24 hours that requires a quick reaction and is associated with risk, for example, driving vehicles.

Release form

Solution for intravenous and intramuscular administration 2.5 mg/ml.

2 ml, 5 ml in neutral glass ampoules.

10 ampoules each along with a knife for opening ampoules or an ampoule scarifier and instructions for use in a cardboard box.

5 ampoules each in a blister pack made of polyvinyl chloride film and printed varnished aluminum foil. 2 contour blister packs along with a knife for opening ampoules or an ampoule scarifier and instructions for use in a cardboard pack. When using ampoules with notches, rings and dots, do not insert an ampoule scarifier or a knife for opening ampoules.

Storage conditions

In a place protected from light at a temperature of 8 to 25 ° C.

Keep out of the reach of children.

Shelf life: 2 years

Droperidol solution d/in 2.5 mg/ml fl 2 ml pack. cont. cell N5 ,

Price: 65.20 rub. Manufacturer: Moscow Endocrine Plant, Russia

! The scientific information provided is general and cannot be used to make a decision about the possibility of using a particular drug.

Drug interactions

When using Droperidol simultaneously with certain medications, undesirable effects may occur:

• Drugs that have a depressant effect on the central nervous system (benzodiazepine derivatives, anesthetics, opioid analgesics, hypnotics): increased depressant effect on the central nervous system;
• Antihypertensive drugs: potentiation of their action;
• Epinephrine and other adrenergic and sympathomimetic drugs: manifestation of antagonism in their relation;
• Dopamine agonists, including bromocriptine, lisuride and levodopa: inhibition of their action.

Analogs

Level 4 ATC code matches:
Haloperidol Decanoate

Haloperidol

The most common analogues of the drug: nitrous oxide, Ketamine, Medxenon, Sodium hydroxybutyrate, Predion, Propovan, Propofol Fresenius, Diprivan, XeMed, Pofol, Proviv, Rekofol .