Unfortunately, dermatitis and dermatoses of various origins are something that many people face, regardless of age, gender, nationality and other factors. Naturally, skin rashes bring a lot of difficulties into the patient’s life. Modern pharmacology, fortunately, offers a sufficient number of remedies that can relieve the external manifestations of the disease.
Canizon Plus is considered a good medicine for dermatosis. Doctors quite often recommend this particular ointment to their patients. This explains people’s interest in the drug “Canizon Plus”. Instructions for use, price, indications for use, restrictions and reviews - these are the main points that are worth reading.
pharmachologic effect
The effectiveness of Kanizon Plus is explained by its combined composition, which provides all the positive properties of the drug. The medicine can be used to achieve the following purposes:
- elimination of the inflammatory process on the surface of the skin,
- prevention of the development of allergic reactions that are explained by the negative impact of external or internal factors,
- destruction of fungal infection,
- elimination of pathogenic microflora, consisting of various pathogenic microorganisms.
Features of the action of each component
One of the components of the cream is gentamicin, an antibiotic that acts against a wide range of bacteria.
The substance belongs to the group of aminoglycosides. Many gram-negative organisms and bacteria are sensitive to gentamicin. The substance does not penetrate into the tissues, but concentrates only in areas where the inflammatory process is observed. Some pathogenic agents exhibit resistance to it, which must be checked before treatment .
Betamethasone is a glucocorticosteroid. It is thanks to this component that the cream has a vasoconstrictor and anti-inflammatory effect. The substance blocks the development of an allergic reaction, which is often observed during exacerbation of many dermatological diseases.
Betamethasone is easily absorbed into the skin. Maximum penetration into tissue is observed in areas with thin epidermis and in the presence of damage. With frequent application of the substance, its ability to be absorbed increases.
Clotrimazole is a component with an antifungal effect. It is used topically and belongs to the group of imidazoles. Under the influence of Clotrimazole, the cell membranes of fungi are destroyed, which is why they cannot continue to develop normally. The antimycotic has a wide spectrum of action: it has a destructive effect on mold microorganisms, Candida fungus, and dermatophytes.
Description of the drug
After application to damaged skin, Kanizon Plus exhibits antifungal, antibacterial and anti-inflammatory activity. It is used in the treatment of acute pathologies that can quickly affect healthy tissue. The drug is also used to treat chronic diseases that are dangerous due to painful relapses. In what cases is Kanizon Plus prescribed by dermatologists:
- allergic local reactions, the course of which is complicated by secondary infection;
- inflammatory skin lesions caused by pathogenic fungi and pathogenic bacteria;
- skin pathologies of a neurogenic-allergic nature, which have a chronic relapsing course.
The inclusion of a combination drug in treatment regimens allows you to avoid the use of several drugs at once. In this way, the pharmacological load on the body is reduced, as well as the likelihood of unwanted chemical interactions.
Clinical and pharmacological group
Kanizon Plus is a representative of the clinical and pharmacological group of drugs for external use with a combined composition. It belongs to antibacterial, antimycotic and hormonal agents.
pharmachologic effect
The therapeutic properties of Kanizon Plus ointment are provided by the combination of its active ingredients. The glucocorticosteroid betamethasone exhibits pronounced anti-inflammatory, antipruritic and decongestant activity.
It prevents the synthesis of prostaglandins and bradykinins from arachidonic acids by inhibiting cyclooxygenase. Due to this ingredient, inflammatory processes are stopped, microcirculation and blood circulation are normalized. Other components of Kanizon Plus are characterized by the following pharmacological properties:
- Gentamicin inhibits the activity of pathogenic bacteria. Upon contact with a bacterial cell, it prevents the production of specific proteins necessary for RNA replication. The impossibility of reproduction causes the death of infectious pathogens;
- Clotrimazole prevents the production of ergosterols by pathogenic fungi. As a result, the membranes lose their strength and gradually dissolve;
During the course of using the drug, metabolism accelerates. Damaged cells begin to receive nutrients necessary for their rapid regeneration. Applying the cream when the first symptoms appear allows you to speed up healing, avoiding irreversible damage to the skin.
Release form and composition
An Indian manufacturer produces Kanizon Plus in sealed aluminum tubes. Each contains 15 g of thick white cream that does not have a specific odor. The tubes are enclosed in cardboard boxes along with instructions for use. The active composition of the drug is represented by betamethasone dipropionate, gentamicin and clotrimazole. The thick creamy base is formed from the following ingredients:
- paraffin;
- cetostearyl alcohol;
- cetomacrogol;
- butylated hydroxytoluene;
- sodium hydrogen phosphate;
- chlorocresol;
- disodium edetate;
- propylene glycol;
- butylated hydroxyanisole;
- purified water.
Auxiliary ingredients prolong the action of the main components, and some of them have medicinal properties. Thus, propylene glycol exhibits weak antiseptic activity. And paraffin forms a thin film on the surface of the skin. Oxygen passes through it well, but pathogenic microorganisms are not able to penetrate.
Storage conditions and periods
Kanizon Plus should be stored at room temperature, in places protected from sunlight. The shelf life of the drug is 24 months. It shrinks after opening the aluminum tube. The product must be used within 3-4 weeks. The cream becomes unsuitable for therapy if its color, smell and (or) consistency changes. Small children should not have access to the place where the hormonal drug is stored.
Contraindications
The instructions for use of the drug warn about the following contraindications to its use:
- the presence of signs of syphilis on the skin,
- some diseases - herpes simplex, skin tuberculosis, chicken pox,
- the presence of open wounds on the surface of the dermis,
- the patient's age is less than two years,
- post-vaccination negative reactions manifested on the skin,
- individual intolerance to a certain component of the drug.
Canison is prescribed very carefully for the treatment of women in early pregnancy and for children of any age. It is not recommended for use with occlusive dressings or applied to too large areas of the body, which helps prevent overdose .
Pregnancy and lactation
The drug is not used in the 1st and 2nd trimester of pregnancy, although there is no data on the toxic effect of clotrimazole on the fetus. During the period before childbirth, it is possible to use Canizon in tablets and only on condition that the therapeutic effect is achieved.
If breastfeeding, this medication should only be used under the close supervision of a physician. It is forbidden to apply the product to the nipple area.
Contraindicated for use
in the first trimester of pregnancy.
Interactions with other drugs: Kanizon vaginal tablets 100 mg reduces the effect of polyene antifungal antibiotics (amphotericin, nystatin, natamycin, etc.).
Instructions for use
The drug is used externally only.
The cream should be applied in a thin layer to the areas of inflammation and to the skin around them. The method of use of the medicine is determined by the doctor based on the developing symptoms and the age of the patient.
How to use the drug for adults
According to the instructions, it is recommended to apply Kanizon twice a day - morning and evening. The drug must be used regularly to achieve the desired result. The duration of treatment is determined by the severity of the patient's condition. If after a month of intensive therapy there is no improvement, you should consult a doctor for additional examination. In this case, there is a possibility of an incorrect diagnosis.
How to use the cream to treat children
The drug is strictly prohibited for use by children under two years of age, regardless of the severity of the patient’s condition.
For older children, the use of the cream is possible, but only after consultation with a doctor. For therapy in children, the same scheme is used as for adults.
Treatment during pregnancy and lactation
During the first trimester of pregnancy, Canison Plus should not be used to treat any dermatological problems. It is at this time that the active development of the fetus occurs, and such interference can negatively affect this process.
At later stages, the use of the cream is possible, but must be agreed with the doctor. During lactation, Canison Plus is also used extremely carefully.
Properties
The drug "Kanizon" has the following properties:
- antifungal effect (by entering into chemical reactions, it affects fungal cells);
- antibacterial property - affects carinebacteria, streptococci, staphylococci. Clotrimazole enhances acid reactions in cells, therefore it has an antimicrobial effect;
- antiprotozoal (detrimental effect on amoebas);
- Trichomonacid (fights Trichomonas).
Regardless of the form of release, the medicine has small doses (since it is designed to affect a small affected area), as a result of which it is very difficult to overdose on this drug.
"Kanizon Plus" has several properties:
- antifungal;
- antimicrobial;
- anti-inflammatory;
- antiallergic.
Overdose
Long-term use of large doses of the drug is unacceptable, since it contains glucocorticosteroids. They are able to suppress the functioning of the adrenal glands, which leads to their insufficiency and the development of Cushing's syndrome.
Long-term use of gentamicin provokes the active growth of pathogens that are not sensitive to it. As a result, a superinfection may occur, requiring refusal of treatment with Canizon and the appointment of other more suitable drugs. No negative reactions to exceeding the dosage were observed. Usually, only systematic use of the drug more often than permitted in the instructions causes harm.
An overdose of Clotrimazole is impossible.
Storage conditions
In a dry place, at a temperature not exceeding 25 °C.
Release form: Kanizon is available in the form of: - vaginal cream, - ointment or cream for external use, - vaginal tablets of 100 mg, - 1% solution for external use.
Store at a temperature not exceeding 25 °C in a place protected from light, dry and out of reach of children.
The shelf life of vaginal tablets, solution and cream is 3 years.
When storing the product:
- the temperature in the storage room should be no more than 25 degrees, and for ointments and creams - no more than 20 degrees;
- Do not freeze;
- It is recommended to keep away from children.
Available without a prescription.
In a dry place, protected from light, at a temperature not exceeding 25C.
Do not freeze.
Keep out of the reach of children.
The drug should be stored in a dry, dark place at temperatures below 30 °C, and not frozen.
All forms of Canison are available without a prescription. The drug should be stored in a dark place at a temperature of up to 20 degrees for solution, up to 25 degrees for tablets and cream. The shelf life of the cream is 3 years.
Adverse reactions
The following side effects may occur when using this medicated cream:
- feeling of burning and itching,
- change in the normal pigmentation of the treated areas of the body,
- increased skin dryness,
- atrophic processes on the surface of the epidermis,
- secondary infection, difficult to treat,
- weeping,
- erythema,
- folliculitis, acne,
- the appearance or intensification of signs of dermatitis on the treated areas of the body,
- Excessive hair growth.
If minor skin irritation is observed during treatment with Canizon, there is no need to stop it. Usually, unpleasant symptoms disappear on their own within 2-3 days.
Analogs
Undoubtedly, Kanizon has analogues:
- Clotrimazole (cream, ointment and vaginal tablets). The cheapest analog in price;
- Candida (solution, tablets, powder, cream, vaginal gel);
- Clotrimazole-Akrikhin (solution);
- Candide-b6 (tablets);
- Imidil (cream for external use, vaginal tablets);
- Triderm (ointment and cream for external use);
- Antifungol (vaginal tablets);
- Candibene (cream, solution, vaginal tablets).
Treatment with the antifungal agent "Kanizon" promotes rapid recovery from fungal infections, and the reasonable price will pleasantly surprise you and will not put a dent in your pocket.
The price for "Kanizon Plus" is slightly higher than for the regular "Kanizon". This is explained by a more universal range of applications, thanks to the composition of several main components.
You can replace Kanison with the drugs Metroxan, Imidil, Chlorquinaldine, Aquapax, Immard, Lorinzol, Combutol, Avrazor, Tagera, Isoniazid - Ferein, Naxogin, Antifungol and Batsimex.
Only a specialist can choose an analogue. It is not recommended to replace the drug with an analogue yourself, as this can lead to serious consequences
Metroxan, Imidil, Chlorquinaldine, Aquapask, Immard, Lornizol, Combutol, Avrazor, Tagera, Isoniazid-Ferein, Naxogin, Antifungol and Batsimex.
special instructions
Avoid contact of Canizon Plus with your eyes.
It is recommended to interrupt treatment with the drug and begin appropriate therapy in case of growth of resistant microflora, development of irritation, sensitization and development of superinfection during treatment.
Side effects noted with systemic administration of glucocorticosteroids can also occur with their local use, especially in children.
To avoid side effects typical of gentamicin and glucocorticosteroids when used systemically, the drug should not be applied to open wounds and damaged skin, especially in children.
In case of long-term treatment with Kanizon plus, its abolition should be carried out gradually.
Indications
Each form of drug release has its own indications. The solution (drops) and cream are used for external treatment of the skin and oral cavity. Vaginal tablets are used to treat fungal infections of the genitals and sexual diseases caused by pathogenic microorganisms.
Kanizon cream and solution are used for:
- simple, allergic dermatitis with complications caused by secondary infection;
- atopic dermatitis, diffuse neurodermatitis;
- eczema, pyoderma;
- dermatomycosis, dermatophytosis, lichen versicolor, candidiasis of the skin in the groin area and in the folds;
- simple chronic lichen and limited nechrodermatitis.
After applying the cream, it is not allowed to use accclusive dressings. Avoid contact of the product with the eyes.
Tablets are used to diagnose the following pathologies:
- colpitis;
- vulvovaginal candidiasis;
- candidal balanitis (inflammation of the glans penis in men);
- superinfections, including mixed ones, caused by microorganisms sensitive to clotrimazole;
- sanitization of the vagina to prepare for childbirth.
The tablets cannot be taken orally during menstruation. Both sexual partners should take treatment at the same time, which will prevent relapse of the disease.
