Prohibited during pregnancy
Prohibited during breastfeeding
Prohibited for children
Has restrictions for older people
Has limitations for liver problems
Has limitations for kidney problems
Clopixol is an antipsychotic drug used to treat schizophrenia, bipolar disorder, and cognitive decline. The drug first appeared on the market back in 1964 and currently continues to be actively prescribed by psychiatrists. It has three trade names on the market - Clopixol, Clopixol Depot and Clopixol-Acufaz.
Pharmacological properties
"Clopixol" is an antipsychotic that has an exceptional inhibitory effect. Depending on the dosage, it can be used as a sedative, indispensable in the treatment of acute manifestations of psychosis. Using its inhibitory effect on the patient, experts prescribe it for all types of anxiety, hostile states, aggression or excessive agitation.
There are different types of the drug that have different degrees of impact on the patient’s psyche, but contain the same active substance. Their purpose depends on the clinical picture of the disease, the patient’s medical history and the stage of treatment of the disease. There are three forms of the drug:
- "Clopixol";
- "Clopixol-acufase";
- "Clopixol depot".
A single dose of Clopixol-Acufaz has a quick and effective effect on the patient’s psyche and can reduce psychotic symptoms for a period of up to 2-3 days. As a rule, 1-2 injections are enough to achieve the required therapeutic effect.
Due to the pronounced addictive effect of zuclopenthixol, these injections are prescribed in the first stage of treatment until a calm state is achieved. After this, you can reorient the patient to take the tablet form of the medication.
The nonspecific sedative effect of Clopixol tablets occurs 2 hours after ingestion, the maximum level of effect is reached after 7-8 hours, then the reaction slows down, subsides and becomes less pronounced with a second dose.
The therapeutic effect of Clopixol Depot in comparison with Clopixol tablets is more prolonged, which helps to achieve positive dynamics when treating patients who do not always follow the doctor’s instructions. This type of drug prevents frequent relapses if the patient interrupts therapy.
Indications for use
The dosage form "Clopixol" according to the instructions is used for any psychotic manifestations accompanied by hallucinations, paranoia, delusions, and disruptions in mental activity. Similar symptoms are characteristic of acute and chronic schizophrenia, manic-depressive psychotic state, mental retardation accompanied by psychomotor agitation, senile dementia with signs of spatial orientation failure and confused consciousness.
In the initial period of therapeutic measures to relieve acute manifestations of psychosis (including cases of mania) and the chronic type in the acute stage, “Clopixol-acufaz” is usually prescribed.
The scope of use of "Clopixol Depot" is limited to schizophrenia in any form of its manifestation, accompanied by hallucinations, delusions, and mental disorder. The drug of this form helps to relieve the state of agitation, hostility and aggressiveness.
Analogues of the drug
In case of severe individual intolerance to the drug, you can use one of the analogues of Clopixol. Among the most popular are Clozapine, Ketilept, Quetiapine and Haloperidol. Let's look at them in more detail:
Clozapine is an atypical antipsychotic. Its undoubted advantage is that it does not cause extrapyramidal disorders or drug-induced parkinsonism. Even among atypical antipsychotics, it is the safest. It is easy to find on the market under the name Azaleptin.Chemically, Clozapine has a similar structure to both tranquilizers and antidepressants. Unfortunately, it has a rather dangerous side effect - it reduces the number of granulocytes up to agranulocytosis. Therefore, it is not used as a first-line remedy, but only in case of ineffectiveness of other antipsychotics.
- Ketilept is an atypical antipsychotic that acts as an antagonist of neurotransmitter receptors in the brain. Used in the treatment of schizophrenia and bipolar disorders. Not used in children under 18 years of age due to lack of clinical data.
The increased risk of suicide must be taken into account. An influx of suicidal thoughts in a patient may go undiagnosed for a long time. Ketilept dosage regimens depend on the individual sensitivity of the patient.
Quetiapine is an atypical antipsychotic prescribed to patients with acute and chronic schizophrenia, major depressive disorder and other mental disorders. It is prescribed orally 2 times a day. May cause drowsiness, dyspepsia, sedation, decreased blood pressure.Based on the results of modern experimental studies, one can judge an increased risk of malignant neoplasms in mice administered Quetiapine. It is similar in effectiveness and frequency of side effects to Haloperidol.
- Haloperidol is a synthetic antipsychotic for parenteral and oral use. Its main feature is the possibility of use not only in adults, but also in children. Effectively relieves mania, paranoid psychoses, hyperactivity, aggression, and tendency to self-harm in mentally retarded people. Contraindicated in patients with heart failure, parkinsonism, ventricular arrhythmia.
Dosage forms and composition. Storage rules
"Clopixol" is sold in biconvex film-coated tablets. In accordance with the concentration of the main component, their colors differ:
- pale pink (dosage 2 mg);
- pink-brown (dosage 10 mg);
- red-brown (dosage 25 mg).
In cross section, all tablets are white. They are packed in plastic bubbles of 50-100 pieces, the outer packaging is a cardboard box.
The active ingredient of the drug is zuclopenthixol dihydrochloride. Among the excipients, it is possible to use castor oil, potato starch, lactose monohydrate, glycerol, microcrystalline cellulose, copovidone, talc and magnesium stearate. The outer capsule may contain hypromellose, macrogol, iron oxide and titanium dioxide.
The active ingredient of “Clopixol Depot” is zuclopenthixol decanoate, and “Clopixol-acufaz” is zuclopenthixol acetate. These dosage forms are available in glass ampoules filled with liquid for intramuscular use. "Clopixol Depot" is a transparent, oily liquid substance of a yellowish tint, bottled in transparent 1 ml ampoules of colorless material, packaged in cardboard boxes.
Preparations containing zuclopenthixol are stored at a temperature of no more than + 25 degrees. The expiration date is written on each medicinal unit. Packages with “Clopixol depot” and “Clopixol-acufaz” must be protected from the penetration of light rays and placed out of the reach of children and pets.
Clopixol price, where to buy
The cost of this medicine depends on the form of release. The average price of Clopixol tablets is as follows:
- 2 mg tablets 50 pieces – 240 rubles;
- tablets 25 mg 100 pieces – 1550 rubles;
- tablets 10 mg 50 pieces – 460 rubles.
The cost of Clopixol-Acufaz is approximately 2100 rubles.
The price of Clopixol Depot for one ampoule per package is about 370 rubles, for 10 ampoules per package – 3200 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Clopixol depot solution for intramuscular injection.
oil 200mg/ml 1mlLundbeck RUB 223 order - Clopixol depot solution for intramuscular injection. oil 200mg/ml 1ml 10 pcs.Lundbeck
RUR 2,022 order
- Clopixol tablets p.p.o. 10mg 50 pcs Lundbeck
RUB 277 order
- Clopixol tablets p.p.o. 2mg 50 pcs.Lundbeck
65 rub. order
- Clopixol-acufase solution for intramuscular injection. oil 50mg/ml 1ml 5 pcs.Lundbeck
RUB 1,409 order
Pharmacy Dialogue
- Clopixol (2 mg tablet No. 50) Lundbeck
240 rub. order
- Clopixol Depot (amp. 200 mg/ml 1 ml No. 1) Lundbeck
RUR 384 order
- Clopixol Depot (amp. 200 mg/1 ml No. 10) Lundbeck
RUB 2,058 order
- Clopixol (tab. 10 mg No. 50) Lundbeck
RUB 292 order
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Pharmacy24
- Clopixol 2 mg No. 100 tablets H. Lundbeck A/S, Denmark
216 UAH order - Clopixol-depot 200 mg 1 ml N10 solution for injection H. Lundbeck A/S, Denmark
1412 UAH order
- Clopixol 10 mg No. 100 tablets H. Lundbeck A/S, Denmark
344 UAH. order
- Clopixol-Acufase 50 mg 1 ml N10 solution for injection H. Lundbeck A/S, Denmark
1930 UAH order
Instructions for use of "Clopixol" and its dosage forms
The dosage and regimen of taking the drug is determined by a specialist. He analyzes the clinical picture of the course of the disease, calculates the required amount of active substance required by the patient per dose.
Clopixol tablets are prescribed orally, dividing the daily dose into several parts. In the first phase of treatment, it is recommended to take the medicine in small portions, observing how the patient’s body reacts. Gradually the amount of medication is increased until a positive result occurs.
In case of acute manifestations of schizophrenia, mania and severe agitation, the patient is prescribed 10-50 mg of the drug per day. The initial dose can be divided into 10-20 mg with a cycle of 2-3 days and increased to 75 mg. The maximum you can take per day is up to 150 mg.
Instructions for use of "Clopixol" contain detailed information about the dosage of the drug for a particular disease, but self-administration of the drug is unacceptable. The sedative effect of Clopixol can cause addiction to the main active ingredient.
If signs of a psychotic disorder are moderate, you can start with 20 mg, and if necessary increase by 10-20 mg daily with a break of 2-3 days.
In the treatment of chronic forms of mental disorders, a supporting effect is achieved by daily intake of 20-40 mg. It is permissible to use 10 mg of Clopixol at a time. Instructions for use of the drug allow dividing the dose into 2-3 doses.
To reduce agitation in patients diagnosed with mental retardation, 6-20 mg per day is sufficient; if necessary, it can be increased to 25-40 mg.
In case of confusion in patients suffering from senile disorders, 2-6 mg to 10-20 mg per day is prescribed.
The instructions for use of Clopixol tablets indicate that the best time to take the drug is in the evening before bedtime. In this case, the side effects of the drug are reduced and the sedative effect increases.
Clopixol-acufaz ampoules are prescribed as intramuscular injections into the gluteal region. Injections cannot be used for a long time. Most often, a dose of 1-3 ml is recommended. Repeated manipulation is carried out after 2-3 days. To maintain the desired effect, along with intramuscular administration of the drug, it is recommended to take Clopixol tablets orally. The attending physician may decide to replace the drug with intramuscular administration of Clopixol Depot.
According to the instructions for use, Clopixol Depot ampoules are most often used in the maintenance phase of therapy in dosages of 200-400 mg (1-2 ml) with an administration frequency of 2-4 weeks. Increasing the portion of the active substance or reducing the interval between administration of the drug is allowed only on the recommendation of the attending physician.
During treatment, it is possible to switch from taking one form of the drug "Clopixol" to another. Intramuscular injections can be replaced by taking tablets orally and vice versa. Zuclopentaxol decanoate has a dosage-dependent sedative effect. The instructions for use of Clopixol Depot ampoules contain information about a possible transition to this drug from Clopixol-Acufaz tablets or injections. In this case, the sedative effect may be reduced. The active component of Clopixol Depot is broken down when it enters the body. Its maximum concentration in blood serum is recorded after 7 days of administration. Half-life occurs after 3 weeks. After a second course, this period increases to 3 months.
When switching to the use of tablets or depot form, you should adhere to the following scheme:
- When switching to tablet form - 40 mg 2-3 days after the last injection. It is recommended to divide the dose into several doses. If necessary, the dosage can be increased by 10-20 mg over 2-3 days.
- When switching to the depot form - 1-2 ml after administration of zuclopenthixol acetate. The medicine is administered intramuscularly every 2-4 weeks. If necessary, the dose can be increased or the intervals between injections shortened.
The instructions for using Clopixol for injections indicate the possibility of mixing injectable forms with zuclopenthixol in one syringe. After such a procedure, Clopixol Depot is prescribed individually. A local reaction to injections may occur, so it is recommended to administer no more than 2 ml of solution at a time. Large doses can be divided into two doses.
The main condition for carrying out therapeutic manipulations is compliance with the recommendations of the instructions for use of “Clopixol” and compliance with the doctor’s prescriptions.
Contraindications and effects on other medications
The instructions for Clopixol contain a list of contraindications for use. It is not recommended to use the drug in cases of acute forms of alcohol and barbiturate intoxication, exposure to opioid analgesics, or coma.
"Clopixol" can increase the sedative effect of drugs that depress the central nervous system. The simultaneous use of this drug with “Guanethidine” and dosage forms of a similar direction is unacceptable, since the antipsychotic drug interferes with their effects.
Taking Klopixol reduces the effectiveness of adrenergic drugs. Use with Metoclopramide and Piperazine increases the possibility of extrapyramidal symptoms (impaired muscle activity).
Contraindications
This drug is contraindicated in acute alcohol intoxication , as well as acute intoxication with opioid analgesics and barbiturates , coma , hypersensitivity to the components of the drug.
In addition, it is not advisable to prescribe it during pregnancy and lactation .
Overdose
Taking into account some reviews, the instructions for use of “Clopixol” indicate cases of overdose. This mainly applies to oral administration. An overdose of an injectable drug is unlikely. Changes in ECG parameters and arrhythmias may occur.
If you experience drowsiness, convulsions, low blood pressure, shock, hypothermia or hyperthermia, you should immediately seek medical help. Before the doctors arrive, you need to rinse your stomach and take the sorbent. It is worth paying attention to maintaining respiratory function and heart function. The simultaneous use of adrenaline drugs is not allowed, as this can lead to a decrease in blood pressure. For convulsions, the patient can be given a Diazepam tablet.
Side effects
The instructions for use of Clopixol contain indications of the presence of side effects of the drug. It can manifest itself in various systems of the body. Before starting treatment, consultation with a specialist is necessary.
On the part of the central nervous system, drowsiness, lethargy, and impaired accommodation (the ability of the eyes to change focal length) may occur. This is especially often observed at the initial stage of taking the medicine. With long-term treatment, the patient may experience dyskinesia (impaired coordination). In both cases, it is necessary to reduce the dose of the drug.
In the area of the cardiovascular system, dizziness, tachycardia, and hypotension (low blood pressure) may appear.
Clopixol may have an effect on the digestive tract and urinary system: a feeling of dry mouth, constipation, functional disorders of the liver are less common, and urinary retention is possible.
If these and similar symptoms occur, medical attention is necessary; it is important to provide it in time to prevent coma.
Possible negative effects of Clopixol
Side effects are dose-dependent; when they occur, try to reduce the dosage of the drug. They are most pronounced at the beginning of therapy and decrease as the course of treatment continues. The most typical side effects are extrapyramidal disorders and drug-induced parkinsonism. The most common pathological manifestations occur:
- increased heart rate, tachycardia;
- disturbances of accommodation, decreased visual acuity;
- dizziness, imbalance;
- shortness of breath, nasal congestion;
- anuria, oliguria, polyuria;
- drowsiness, hyperkinesia, hypokinesia, akathisia;
Akathisia - dry mouth, hypersecretion of saliva;
- constipation, diarrhea, dyspepsia, nausea;
- nervousness, anxiety, sleep disturbances, decreased libido, insomnia, depression;
- myalgia;
- hyperhidrosis, scabies;
- increased appetite, weight gain;
- fatigue, constant feeling of tiredness and depression.
Rarely occurring side effects include the following:
- increased blood pressure, unhealthy blush on the face;
- erectile disfunction;
- apathy, increased libido, nightmares;
- pyrexia, thirst, skin reaction at the injection site;
- impaired glucose tolerance, hyperglycemia;
- trismus, torticollis, muscle rigidity;
- hyperprolactinemia;
- jaundice, cholestatic hepatitis;
Cholestatic hepatitis - ringing in the ears, hypersensitivity;
- horizontal or vertical nystagmus, mydriasis;
- abdominal pain, flatulence;
- anaphylaxis;
- dryness of the groin area;
- rashes, pigmentation disorders, purpura, dermatitis, photosensitivity reactions;
- changes in the QT interval on the ECG;
- neuroleptic malignant syndrome;
- decrease in the number of leukocytes, granulocytes, neutrophils, platelets in the blood;
- parkinsonism;
- speech disorders;
- migraine.
If the patient experiences hyperthermia or hypothermia, drowsiness, extrapyramidal disorders, convulsions, and even impaired consciousness (even coma), an overdose of Clopixol should be suspected.
There is no etiological treatment for overdose, so the set of emergency measures is standard: it is necessary to perform gastric lavage as quickly as possible and administer intravenous drips of norepinephrine to avoid shock. Seizures are treated with benzodiazepines, and extrapyramidal disorders are treated with antiparkinsonian drugs (Soleron).
Special instructions when using Clopixol
It is not advisable to take the drug during pregnancy and breastfeeding. There is evidence that when the mother was treated with antipsychotic drugs, breastfed children showed signs of intoxication (overexcitability, tremor, lethargy).
A doctor can prescribe this drug to patients with chronic hepatitis, diseases of the cardiac system, and for seizures. But in this case, strict monitoring of health status is required in order to make a timely decision to reduce the dose of the drug.
When taking antipsychotics, including those containing zuclopenthixol, the instructions for use warn of a possible risk of developing neuroleptic malignant syndrome with a fatal outcome. If symptoms such as hyperthermia (overheating of the body), profuse sweating, impaired clarity of consciousness, tachycardia, muscle weakness appear, the medication should be stopped and consulted with your doctor to prescribe symptomatic and supportive treatment.
Clopixol may affect the ability to drive a vehicle and operate complex machinery. According to the instructions for use of Clopixol tablets, caution must be exercised at the beginning of treatment until a reaction to the components of the drug is detected.
Patients under 18 years of age should take special control over the use of Clopixol. In the treatment of elderly people, minimal doses of the drug are used.
Medicinal analogues and generics
Full and group analogues of Clopixol are produced by pharmaceutical companies in Denmark, the USA, Europe and Japan. Such well-known ones as “Actavis”, “Egis”, “Lek”, “Hexal”, “Teva”, “Zentiva” offer all known dosage forms.
In the instructions for use, the drugs “Clopixol depot” and “Clopixol-acufase” are named as complete analogues of “Clopixol”. They are available in injection forms and contain the same active ingredient – zuclopenthixol.
Analogs for therapeutic effects on the body include drugs containing risperidone as the main active component: “Rispolept Konsta”, “Risperidon”, “Ridonex”, “Rileptide”, “Torendo”, “Risset”. The similarity in the action of these generics is 60-70%.
In a smaller range (50-60%) are dosage forms containing the active ingredients haloperidol, olanzapine, chlorpromazine and chlorprothixene, flupenthixol: “Truxal”, “Chlorprothixene”, “Fluanxol”.
Reviews of Clopixol
As a rule, patients leave reviews about Clopixol in the form of an injection solution. They note that the course of use of this drug is very convenient, since injections are rarely given. It's much easier than constantly taking pills.
However, some advantages of this medicine are also noted in the tablet form. For example, the fact that you don’t need to go to the doctor. The patient takes the medicine on his own, so there is no need to coordinate his plans with the injection schedule.
Reviews of Clopixol Depot and a similar drug in tablet form also note some undesirable effects. Typically, patients report apathy and decreased libido. Extrapyramidal disorders are sometimes described .
However, there is no doubt about the effectiveness of this remedy. The main thing is to take it strictly as prescribed by your doctor. For any dose adjustments or changes in condition, you should definitely contact a specialist.
