Compound
1 gram of cream, spray and dermgel (gel) of Lamikon includes 10 mg of terbinafine as an active ingredient.
Additional ingredients of the cream: soft white paraffin, phenylethyl and cetostearyl alcohol, sodium hydroxide, mineral oil, macrogol 20 cetostearyl ether, poloxamer 407, propylene glycol, purified water.
Additional ingredients of the spray: propylene glycol, benzoic acid, macrogol 20 cetostearyl ester, disodium edetate, poloxamer 407, water for injection.
Additional ingredients of dermgel: gasoline alcohol, butylated hydroxytoluene, sorbitan laurate, isopropyl myristate, polysorbate 20, ethanol 96%, sodium hydroxide, carbomer 974P, purified water.
1 tablet of Lamikon contains 250 mg of terbinafine as an active ingredient.
Additional tablet ingredients: sodium starch glycolate, microcrystalline cellulose, anhydrous colloidal silicon dioxide, corn starch, magnesium stearate, hydroxypropyl methylcellulose.
Precautions when taking Lamikon
The drug Lamikon is intended for external (local) use only, so in no case should it be used internally. You should be careful not to allow the drug to come into contact with the mucous membrane of the eyes.
If the drug is used in the form of a spray, then you should be especially careful about inhaling drug vapors and try to avoid them
You should be very careful when treating pregnant women with Lamicon. The use of Lamikon in this category of patients must be carried out under strict control of their health status and only according to indications. Self-treatment with this medication during pregnancy is not recommended.
Studies have shown that when the drug is used by women during lactation, only a small amount of its active substance is excreted in breast milk. Therefore, in the presence of small areas of skin lesions, the use of Lamikon should not cause a systemic effect on both the mother’s body and the baby’s body.
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Total votes: 11
First vote: 03/12/2013 Last vote: 05/15/2016
If you have experience using this drug, please describe it in the reviews section about Lamicon - with this you can help many of our readers who are just planning to use it.
Remember that this material is only a brief description of Lamikon? in free presentation. Consultation with a doctor before taking it is required. Do not self-medicate under any circumstances - this can only harm yourself. Good health to you!
Pharmacodynamics and pharmacokinetics
The antifungal substance terbinafine is an allylamine that is active against a fairly large number of fungal strains . The fungicidal effect of terbinafine, in adequate concentrations, extends to molds, dermatophytes, and some dimorphic fungi. Regarding yeast fungi, depending on their type, terbinafine exhibits fungicidal or fungistatic effectiveness.
The mechanism of action of Lamikon is a specific inhibition, in the membrane of fungal cells, of the early stage of sterol biosynthesis . The consequence of this effect is the intracellular accumulation of squalene and ergosterol deficiency , which leads to the destruction of fungal cells.
The effect of terbinafine is manifested through the process of inhibition, in the membranes of fungal cells, of the enzyme squalene epoxidase , which belongs to the cytochrome P450 . Lamikon has no effect on the effects of other drugs, as well as on the metabolism of hormones. When applied externally (locally), the absorption of terbinafine is less than 5% of the applied dose, and therefore its systemic exposure is negligible.
When applied externally, Lamikon is absorbed in a very small amount, begins its action almost immediately and remains effective for a short time, about 7-14 days. The fungicidal effect of terbinafine, due to the preservation of its required concentration in the stratum corneum of the epidermis obtained during treatment, continues for 7 days after discontinuation of the external agent.
When taking Lamikon tablets internally, terbinafine accumulates in nails, hair, and skin, in concentrations that provide its fungicidal effects. Absorption of the drug in tablet form is about 70%, with absolute bioavailability of approximately 50%.
After taking one 250 mg tablet, after 90 minutes a Cmax in the blood of 1.3 mcg/ml is observed. Compared with a single dose, at steady state, the Cmax of terbinafine is approximately 25% higher, with a 2.3-fold increase in blood AUC. Effective T½ approximately 30 hours. Food intake has little effect on the bioavailability of Lamikon and does not require dose adjustment.
Terbinafine is 99% bound to plasma proteins. The drug quickly penetrates the dermis and accumulates in the stratum corneum. It is also secreted by the sebaceous glands and is found in high concentrations in hair, hair follicles and skin . In the first weeks of treatment it penetrates into the nail plates .
The metabolism of terbinafine occurs quite quickly, with the participation of cytochrome P450 . After the biotransformation , inactive metabolites of Lamikon are excreted mainly by the kidneys.
With pathologies of the kidneys and/or liver, the rate of elimination of terbinafine slows down, which makes its concentration in the blood higher.
Pharmacological properties
Terbinafine is the active ingredient of Lamicon. It belongs to allylamines. This component is known in medicine for its wide spectrum of action. It is quite active against various infections that affect the skin, hair and nail plates.
If the substance is used in low concentration, it will have a fungicidal effect against molds, dimorphic fungi and dermatophytes. The manifestation of fungistatic activity against pathogenic pathogens is also not excluded.
Terbinafine has a pronounced stimulating effect at the initial stage of synthesis in the cell of the fungal pathogen. As a result of this, he experiences a lack of ergosterol and squalene. Such changes lead to the sudden death of pathogenic microflora.
If the drug is taken orally against the fungus, there is an accumulation of its active component in the nail plates, skin and hair.
Indications for use
All local dosage forms of Lamikon (cream, spray, gel) are intended for the treatment of:
- fungal infections of the skin caused by fungi of the genus Microsporum , Trichophyton , Epidermophyton ( dermotophytosis of the groin, feet, trunk, etc.);
- pityriasis versicolor (pityriasis versicolor) caused by exposure to Malassezia (Pityrosporum) fungi ;
- candidiasis of the skin, caused by fungi of the genus Candida .
The oral form of the drug Lamikon - tablets is used for therapy:
- fungal infections of the skin , in cases where the concentration of lesions, their prevalence or severity are a sufficient reason for oral treatment;
- mycoses of the scalp and onychomycosis (damage to the nails).
Tablets are not prescribed for the treatment of versicolor (pityriasis versicolor) .
Pharmacodynamic parameters
When applied externally, the active substance from Lamikon cream (spray, gel) is absorbed (up to 6%) into the epidermal layers, hair follicles, sebaceous and sweat glands. Here, terbinafine accumulates and has a fungicidal effect for another 7-14 days after cessation of treatment.
Oral administration of Lamiconot fungal tablets is accompanied by penetration (up to 70%) of the active component into the systemic bloodstream. The substance quickly binds to the protein components of the plasma, penetrates the nail plates, hair shafts, and skin. Its half-life is up to 30 hours - metabolites are excreted by the kidneys and liver.
Terbinafine causes the death of fungi from the dermatophyte family, dimorphic and mold strains. At sufficient concentration, it inhibits the viability of mold parasites. The use of ointment, cream, spray Lamikon is advisable if there are indications:
- skin damage by dermatophyte fungi;
- dermatophytosis inguinal, feet, trunk;
- candidiasis of the skin;
- detection of multi-colored lichen.
Lamikon antifungal tablets are taken systemically as monotherapy or complex therapy for the diagnosis of the following diseases:
- damage to the hairy parts of the body by mycoses;
- dermatomycosis, trichophytosis of smooth skin, perineum;
- candidiasis in hard-to-reach areas of the body;
- fungal nail infection - onychomycosis.
Preparations of the Lamiconot fungus series are complete medicines that are used exclusively as prescribed by the treating mycologist (dermatologist). Independent uncontrolled use of the product is fraught with serious consequences.
Side effects
When using external forms of the drug, local reactions may occur, such as: burning or peeling of the skin , itching , irritation and pain , pigmentation disorders , crust formation, erythema in the treated area, and others. These reactions rarely lead to cessation of therapy and generally resolve spontaneously.
It is necessary to distinguish the above reactions from some possible similar allergic manifestations : skin itching , urticaria , rash (including bullous ), which are observed quite rarely, but often require discontinuation of treatment. In this regard, if any side effects are detected, you should inform your doctor.
Eye irritation has also been observed following accidental exposure to terbinafine.
latent fungal infection may worsen .
Therapy using Lamikon tablets is usually tolerated without serious side complications, although in some cases the following manifestations are possible:
Blood system:
- agranulocytosis;
- neutropenia;
- pancytopenia;
- thrombocytopenia.
The immune system:
- Lyell's syndrome;
- anaphylactoid reactions (including angioedema );
- Stevens-Johnson syndrome;
- systemic and cutaneous symptoms of lupus erythematosus ;
- photosensitivity.
Nervous system:
- taste disorders;
- headache;
- hypoesthesia;
- dizziness;
- paresthesia.
Gastrointestinal organs:
- feeling of a full stomach;
- dyspepsia;
- loss of appetite;
- nausea;
- diarrhea;
- stomach ache.
Skin and subcutaneous tissues:
- mild skin reactions ( urticaria , rash );
- exacerbation of psoriasis or psoriasis-like rashes;
- acute exanthematous generalized pustulosis (very rare);
- hair loss (with unproven cause-and-effect relationship).
Musculoskeletal system:
- myalgia;
- arthralgia.
Hepatobiliary system:
- increased levels of liver enzymes;
- hepatobiliary dysfunction (mainly cholestatic );
- Isolated cases severe liver pathologies jaundice , cholestasis , hepatitis ) have been described.
Are common:
- feeling tired (very rare).
Overdose
One of the symptoms of an overdose is headache
"Lamicon" cream or its other form can lead to an overdose. It usually occurs when the patient takes the wrong dose of pills.
The following symptoms indicate an overdose:
- Impaired flow of bile,
- Stomach ache,
- Headache,
- Change in taste,
- Nausea,
- Diarrhea,
- Loss of interest in food.
For an overdose, symptomatic treatment is proposed, which includes mandatory gastric lavage and sorbent intake.
Instructions for use
The instructions for Lamikon spray, cream and gel suggest the use of these dosage forms only externally. Before using external products, you should first clean and dry the affected areas of the skin.
Depending on the pathogen and severity of the lesion, Lamikon cream, instructions for use, recommend applying 1-2 times throughout the day. Lamikon spray is also applied 1 to 2 times, while Lamikon dermgel is applied once a day.
The cream and gel are applied to the affected skin and adjacent areas of the skin in a thin layer and lightly rubbed in. If infections are accompanied by diaper rash, for example in the groin area, between the fingers, under the mammary glands, between the buttocks, etc., the treated areas can be covered with gauze, especially at night.
The spray, in an amount sufficient for visible moisturizing, is sprayed onto areas of the skin affected by fungi , as well as onto healthy adjacent skin.
The duration of treatment with the use of local agents, depending on its severity, usually takes from 7 to 14 days.
Relief from the symptoms of the disease is usually observed after a few days. For therapy to be effective, it is necessary to strictly adhere to the drug application regimen, not skip the next application and not stop treatment earlier than the recommended period, as this can lead to relapses.
Elderly patients do not require dose adjustments of topical medications.
Lamikon tablets are prescribed to adults and children over 6 years of age, weighing more than 20 kilograms. Taking the pills is continued for a period of time sufficient for the complete disappearance of the symptom of the disease , depending on its severity and nature.
The recommended dose of Lamicon in the form of tablets for adults is 250 mg, for children weighing from 20 to 40 kilograms - 125 mg, over 40 kilograms - 250 mg.
The duration of treatment for skin candidiasis , trichophytosis of the skin and perineum is generally from 2 weeks to 1 month, for dermatomycosis of the feet from 2 weeks to 1.5 months.
Fungal diseases of the scalp , most often found in children, can be treated in recommended doses for 4 weeks.
Therapy for onychomycosis usually takes 1.5 months for fingernails and 3 months for toenails. In case of reduced growth of nail plates , the course of treatment may require a longer time.
Application of external agents
Before applying Lamikon ointment, the skin is washed and dried with napkins or a towel. The medicine is applied 1-2 times a day in a thin layer, evenly distributed and gently rubbed in. The oily texture of the ointment creates a protective layer on the surface of the skin. It contains a sufficient amount of active substance for a long-term fungicidal effect. It is advisable to use the drug in the form of an anti-fungal ointment at any stage of skin mycoses, including advanced forms. In the treatment of onychomycosis, the cream is applied to previously softened, trimmed or filed nail plates and adjacent soft tissues.
Lamicon Dermgel against fungus has a light texture, non-greasy consistency, and is quickly absorbed. The product is applied once a day, recommended for mycoses of smooth skin, feet, and interdigital areas.
Lamicon spray for nail fungus is non-contact and is convenient for treating hard-to-reach or large areas. The product irrigates the affected nail plates and the surrounding skin. The spray produces a drying effect and is recommended in the presence of exudative (inflammatory) processes. Before the procedure, it is recommended to make soap-soda or salt baths for your feet. Trim softened nail plates and rough cuticles, treat the affected area with a spray. Regular application 1-2 times a day.
The duration of treatment is determined by the complexity of the disease.
Interaction
No interactions of Lamikon cream, gel and spray with other medications have been identified.
When taking tablets, it is possible to increase the clearance of terbinafine with the parallel use of inducers of its metabolism and decrease the clearance with the use of cytochrome P450 inhibitors . This combination of drugs requires adjustment of the dose of Lamikon.
Terbinafine has no effect on the clearance of Digoxin or Antipyrine of Desipramine by 82% and reduces the clearance of Cyclosporine .
Rifampin doubles the clearance of terbinafine .
Lamicon has little effect on the change (in one direction or the other) in the clearance of drugs metabolism occurs with the participation of cytochrome P450 , such as: Terfenadine , Tolbutamide , Triazolam or oral contraceptives .
Taking Lamikon tablets reduces the clearance of intravenously administered caffeine by 19%.
Terbinafine is able to suppress CYP 2D6-mediated metabolism, which may have clinical significance for drugs metabolized by this enzyme: β-adrenergic receptor blockers , tricyclic antidepressants , SSRIs, antiarrhythmic drugs, MAO inhibitors .
Side effects of the drug Lamikon
Tablets: feeling of heaviness and pain in the epigastric region, taste disturbance, loss of appetite, nausea, diarrhea, cholestasis, neutropenia, skin allergic reactions. Cream, spray: skin redness, itching or burning sensation may sometimes occur at the sites where the drug is applied, but these phenomena rarely lead to the need to stop treatment. These side effects should be distinguished from allergic reactions, which occur infrequently and the development of which requires discontinuation of treatment. Special instructions for the use of the drug Lamikon: tablets: patients with impaired renal function (creatinine clearance less than 50 ml/min and serum creatinine level more than 300 µmol/l) should receive half the usual dose of the drug. It is necessary to constantly monitor patients receiving concomitant treatment with terbinafine with drugs that are predominantly metabolized with the participation of the cytochrome 2D6 enzyme (tricyclic antidepressants, β-adrenergic receptor blockers, selective serotonin reuptake inhibitors and MAO type B inhibitors), if the drug used has a small range of therapeutic concentrations. Cream, spray: clinical experience with the use of terbinafine cream or spray during pregnancy is very limited, so this drug should be prescribed during this period only for strict indications. When carrying out local treatment, it is unlikely that the small amount of terbinafine that is absorbed through the skin will have an adverse effect on the fetus. According to reference data, terbinafine passes into breast milk. However, any negative effect on the child when the cream is used by the mother during breastfeeding is unlikely, since systemic absorption of the drug through the skin is negligible. When spraying a spray or applying a cream, avoid getting the drug into the eyes and respiratory tract. If the drug accidentally gets into your eyes, rinse them immediately with running water. For lichen versicolor, oral terbinafine is ineffective, unlike topical application. Systemic use for onychomycosis is justified in the case of total damage to most nails, the presence of severe subungual hyperkeratosis, and the ineffectiveness of previous local therapy. During treatment (after 2 weeks and at the end of treatment), it is necessary to carry out antifungal treatment of shoes, socks and stockings.
special instructions
Lamikon cream, gel and spray are intended exclusively for external use.
Avoid contact of external products with the eyes, and in case of unintentional contact, rinse with sufficient amount of running water.
In order to prevent mycosis reinfection, it is necessary to regularly change underwear, do not wear poorly breathable or too tight clothes, dry problem areas thoroughly after washing, and always use a clean individual towel. Do not walk barefoot if you have mycosis of the feet. Spray socks, tights, etc., as well as the inside of shoes.
Lamicon tablets are not recommended for use in patients with active or chronic liver damage .
Since the drug has some hepatotoxicity , liver condition should be assessed even in healthy patients.
If nausea of unknown etiology, fatigue , anorexia , vomiting , right-sided abdominal pain, jaundice , light-colored stool or dark urine are detected, the patient must inform his doctor and stop taking the pills. Then the condition of the liver is assessed.
If skin rashes , therapy is canceled until the cause of these phenomena is determined.
For any pathological change in the blood while taking Lamikon, you need to consider changing treatment.
When creatinine clearance is less than 50 ml/min, oral terbinafine .
Contraindications and restrictions
Lamikon should not be used for renal and hepatic insufficiency.
The medicine is suitable only for those patients who have no contraindications to taking it. “Lamicon” should not be treated by people who have hypersensitivity to the components of the medication. Also, therapy based on this drug is not suitable for patients with renal or liver failure, malignant tumors and metabolic disorders in the body.
During pregnancy and breastfeeding
Doctors do not recommend that pregnant and lactating women use the drug for therapeutic or prophylactic purposes.
In childhood
Treatment with Lamicon is suitable for young children over three years of age.
In old age
The manufacturer does not provide information about the specifics of using Lamicon in the treatment of patients in the older age group.
For impaired renal function
If a patient has been diagnosed with kidney problems, then he should select the minimum dosage of a drug with an antifungal effect.
For liver dysfunction
People with chronic damage to an internal organ are strongly recommended to consult with their doctor about selecting an individual dosage.
Reviews about Lamikon
Reviews about the effectiveness of external forms of the drug Lamikon (cream, spray, dermgel), when used against fungi sensitive to terbinafine , are mostly positive. The drug begins to act within a few days and leads to the complete disappearance of the manifestations of the fungal disease by the end of the course of therapy, which most often lasts 7-14 days.
In case of severe damage, for more effective and faster treatment, it is preferable to use a combination of dosage forms of the drug, for example, parallel taking of tablets and application of a cream, spray or gel. to treat the inside of shoes to prevent reinfection . Reviews about the tablets of this drug, subject to all doctor’s recommendations and taking into account indications and contraindications, are also positive and indicate the high effectiveness of this drug.
Negative reviews about Lamicon found on user forums may be associated with the use of the drug to treat fungi that are insensitive to it or the incorrect use of its dosage forms. If therapy is interrupted earlier than the recommended time, even with visible improvement, relapses of the disease are possible, and if the rules of personal hygiene associated with fungal infections are not followed, the fungi can spread to other parts of the body.
Therefore, if you suspect the presence of a fungal infection, it is necessary to accurately determine its causative agent in order to prescribe adequate and effective, in this case, treatment, which can only be recommended by a dermatologist.
It is worth paying attention to the fact that on the Internet you can often find instructions for Lamikon ointment, a description of its action, reviews of the ointment, recommendations for its use, etc., which do not correspond to reality. At this time, Lamikon produces the drug only in the form of cream, spray, dermgel and tablets. All other dosage forms of the drug described are erroneous and most likely are the result of a lack of understanding of the differences between the bases of ointment, cream and gel.
Directions for use and dosage
Lamicon can be used to treat children and adults. If your body weight is more than 40 kg, Lamicon tablets should be taken 1 piece no more than 1 time within 24 hours. In this case, 1 tablet of Lamikon contains 0.25 g of terbinafine.
In the case when the child’s weight is less than 40 kg, he is prescribed half a Lamikon tablet once a day.
If the patient suffers from onychomycosis, the total treatment time with the drug can be up to 6 weeks or 3 months. If dermatomycosis or skin candidiasis is detected, the course of treatment is 2-6 weeks.
Lamicon ointment can be used to treat children over 12 years of age. You can use it no more than 1-2 times a day. Before starting the procedure for applying the drug to the skin, it must be thoroughly cleaned of dirt and wiped dry. Lamikon ointment should be applied to the affected parts of the body in a thin layer. The frequency of applying Lamikon ointment to the skin, as well as the general course of treatment with this product, is determined only by the attending physician in each specific case.
Lamikon spray is prescribed strictly for external use. Before using Lamikon spray, the affected area of the skin is well cleansed and moisturized. After the manipulations are completed, the spray is sprayed onto a specific place on the body. The frequency of use of Lamikon spray and the duration of treatment is determined only by the doctor and depends on the nature and type of the disease.
Reviews about Lamikon show that if you abruptly stop treatment with Lamikon, you can provoke a relapse of the disease.
Lamikon price, where to buy
The cost of the drug Lamikon in Ukraine varies depending on its dosage form. On average, the cream can be purchased for 60 hryvnia, dermgel for 65 hryvnia and Lamikon spray for 75 hryvnia. The price of tablets of the drug varies from 130 to 160 hryvnia for 14 pieces.
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
Pharmacy24
- Lamikon 15 g cream PAT "Farmak", Ukraine
80 UAH. order - Lamikon 1% 25 g spray PAT "Farmak", Ukraine
105 UAH order
- Lamicon Dermgel 1% 15 g gel PAT "Farmak", Ukraine
81 UAH order
- Lamikon 0.25 g No. 14 tablets PAT "Farmak", Ukraine
130 UAH order
PaniPharmacy
- Lamikon cream Lamikon cream 1% 15g Ukraine, Farmak OJSC
86 UAH order
- Lamicon dermgel gel Lamicon Dermgel gel 1% tube 15g Ukraine, Farmak OJSC
96 UAH order
- Lamikon liquid Lamikon spray 1% 25g Ukraine, Farmak OJSC
118 UAH order
- Lamicon tablets Lamicon tablets. 250 mg No. 14 Ukraine, Farmak OJSC
148 UAH order
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Features of the drug
Lamikon is considered one of the most popular antifungal drugs today. Thanks to the thoughtfulness and balance of the composition, it copes well with almost all manifestations of lesions: the tendency of the epidermis to increased dryness is eliminated, improvements in the condition of the skin are found in the form of an increase in its protective properties, manifestations of fungal activity are minimized - skin erosion, peeling, rashes, increased sensitivity , separation of the nail plate in case of infection of the nail plate by fungus.
Thanks to several dosage forms, the positive manifestations and effects of the drug can be significantly expanded. Complex treatment allows to minimize the negative impact of the fungus on the patient’s health.
Dosage forms
The following medicinal types of the drug are available for sale:
- tablets - presented in the form of dragees, coated with a white coating that quickly dissolves under the influence of saliva and gastric juice. The tablets are packaged in a polymer blister, 10 pieces each. The blister is located in a cardboard package with attached instructions.;
- Lamikon gel has a particularly high degree of effectiveness due to the slightly increased content of the active substance in it, as well as the high penetrating ability of this dosage form when applied to the skin. The gel has a uniform consistency, packaged in aluminum tubes of 15 g, as well as in cardboard packaging;
- the ointment is also well absorbed by the skin, does not leave a greasy residue after application and provides excellent results due to the high content of the active substance;
- the cream has a uniform consistency, light yellow color, is quickly absorbed and is most often used when it is necessary to apply to hard-to-reach areas of the skin;
- The spray allows you to spray the active substance over the largest possible area of the affected skin; its absorption is also considered high. The spray is packaged in 25 g bottles.
All types of the drug cope well with the manifestations of fungus due to their rational composition and high content of the active component. The composition of dosage forms may vary slightly, but the active ingredient in them is the same.
Composition of Lamicon
The active ingredient of all varieties of Lamicon is terbinafine, which prevents the active proliferation of fungus on the surface of the skin and nail plate, destroys intercellular membranes, which leads to their death.
Depending on the type of drug, the composition may include the following additional components:
- for cream - cetostearic alcohol, soft white paraffin, purified water, propylene glycol, sodium hydroxide, cetostearic ether, mineral oil;
- the spray contains propylene glycol, disodium edetate, benzoic acid, water for injection;
- for the gel, additional components are polysorbate, purified water, gasoline alcohol, carbomer, ethanol;
- The outer shell of the tablets contains colloidal silicon oxide, purified water, sodium hycerate, microcrystalline cellulose, corn starch.
All types of the drug have proven themselves in the treatment of various fungal infections, since the effect is on the root cause of the disease, while simultaneously removing the consequences of the disease.
Price
The cost of the medicine is important to the buyer, and the price of Lamicon can be considered relatively affordable for all groups of the population: the price of the gel from different sellers ranges from 120 to 190 rubles per bottle, tablets from 135 to 185 rubles per package, ointments and creams - from 89 to 135 rubles per package.
