Libexin - cough tablets, instructions for use, analogues, reviews

Indications for use

What are Libexin tablets for? This drug is used for:

• surgical intervention on the pleura;
• pulmonary infarction;
• pleuropneumonia;
• exudative and dry pleurisy ;
• emphysema;
• flu;
• bronchial asthma;
• chronic and acute bronchitis ;
• any non-productive cough ;
• cough at night in patients with heart failure .

Excess of dosage and negative reactions

Libexin is a drug with minor effects on the central nervous system. If recommended dosages are exceeded, drowsiness, fatigue and poor attention may occur. Patients who work daily in positions that require increased concentration should strictly follow the doctor's recommendations.

Possible adverse reactions:

• numbness and dryness in the mouth;
• nausea, vomiting;
• allergic rash, itching.

Compliance with the doctor's instructions helps to minimize the risk of developing these unpleasant reactions.

Libexin price, where to buy

The price of Libexin in Russia is on average 340 rubles. In Ukraine, the drug can be purchased for an average of 45 hryvnia.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Libexin Muco syrup 5% 125mlUniter Liquid Manufacturing/A.
  Nattermann & See GmbH RUR 543 order
• Libexin tablets 100 mg 20 pcs. Chinoin

  RUR 553 order

• Libexin Muco syrup for children. 2% 125mlUniter Liquid Manufacturing/A.Nattermann & See

  RUR 501 order

Pharmacy Dialogue

• Libexin (100 mg tablet No. 20)Chinoin

  RUR 589 order

• Libexin Muko (syrup for adults 5% 125ml)Unither

  602 rub. order

• Libexin Muko (syrup for children fl. 2% 125ml)Sanofi Aventis

  RUR 562 order

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PaniPharmacy

• Libexin tablets Libexin tablets.
  100 mg No. 20 Hungary, Chinoin 68 UAH. order

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Compound

Libexin tablets are a monocomponent medicine. The active ingredient of the drug is prenoxdiazine. This compound remains a synthetically developed molecule that has beneficial effects on both the ciliated epithelium of the bronchi and individual muscle fibers located around the respiratory tract.

In addition to prenoxdiazine, the chemical composition of the drug contains the following auxiliary components:

• glycerol;
• talc;
• corn starch;
• povidone;
• magnesium stearate and lactose monohydrate.

The mechanism of action of the corresponding drug is based primarily on the inhibition of peripheral sensory receptors in the respiratory tract, which are irritated and provoke cough.

Libexin has three key effects on the patient's respiratory tract:

1. Local anesthesia. By reducing the sensitivity of the epithelium lining the respiratory tract, the severity of cough decreases;
2. Dilatation of the bronchi (bronchodilation). Due to the effect on the muscle fibers located around the respiratory tract, air movement accelerates, coughing occurs better;
3. Inhibition of the functional activity of the center responsible for the cough reflex, located in the brain. The peculiarity of Libexin remains its weak effect on the central nervous system, due to which the drug gently eliminates cough without the formation of drug dependence.

The complex effect of the drug on the human respiratory tract allows it to be used in everyday practice without a high chance of progression of undesirable consequences.

Side effects

Side effects are indicated according to their frequency: very often (≥ 1/10), often (from ≥ 1/100 to < 1/10), infrequently (from ≥ 1/1000 to < 1/100), rarely ( ≥ 1/10000 to < 1/1000), very rare (< 1/10000), unknown (cannot be estimated based on actual data).

On the side of the scilicointestinal tract

Rarely: dry mouth and throat.

Unknown: glandular-intestinal side effects (gastralgia, constipation) may occur (in < 10% of cases), which occur during the course of taking it.

On the side of the immune system

Rarely: allergic reactions.

On the side of the respiratory system, chest and mediastinum

Unknown: bronchospasm.

Information about suspected adverse reactions

Reporting suspected adverse reactions after drug registration is an important procedure. This allows you to continue to control the “measles/risk” relationship for your medicinal purpose. Medical professionals are asked to report any suspected adverse reactions to the State Expert Center of the Ministry of Health of Ukraine.

Side effects

Reviews from patients indicate that in most cases Libexin is well tolerated, but in some cases it has side effects.

Thus, against the background of the use of Libexin, the following undesirable effects from the body may appear:

• Fatigue and mild sedation (this is how the nervous system can react when taking the drug in high doses);
• Dry throat and/or mouth, stomach pain, nausea, tendency to constipation, temporary numbness and, as a result, loss of sensitivity of the oral mucosa (possible side effects from the gastrointestinal tract);
• Skin rash and angioedema (allergic reactions).

It is worth noting that side effects from the nervous system in the form of sedation and fatigue appear when therapeutic doses are exceeded, but these symptoms themselves disappear a few hours after taking the drug.

Cases of overdose with Libexin have not been reported in medical practice. Presumably, increased severity of sedation and weakness is possible.

Overdose: what should be done?

If the patient adheres to the doctor’s recommendations regarding the frequency of administration and quantity, he is definitely not in danger of overdosing. When a person ignores the prescription and independently increases the daily dose with the duration of the course, negative consequences are inevitable.

Uncontrolled and prolonged intake of prenoxdiazine leads to its accumulation in the human body. The first warning signs are nausea, along with dizziness, lethargy, itchy skin, and so on. Despite the manufacturer's statement that this medicine can be safely given to children, this must be done with caution and under the strict supervision of pediatricians.

The child’s body’s reaction to even minor overdoses can be unpredictable, from barely perceptible weakness to the appearance of Quincke’s edema. Many people mistakenly believe that if unpleasant symptoms appear, they can do nothing at all, and that it will be enough to simply stop taking it. But this is not always the case. You can’t ignore your body’s signals; you should rush to see a doctor!

You need to pay attention to manufacturers

Few people read what is written on the packaging of the drug. The annotations are still more or less scanned, but no one pays attention to what is indicated in small print at the end. But this is in vain. There are often situations when the same medicine, but from different manufacturers, differs in the degree of effectiveness, and radically.

Careful study of the information written on the packaging helps to avoid disappointment. The drug "Libexin" is produced in Budapest. Foil blisters contain twenty tablets of 100 milligrams.

An analogue syrup “Libexin Muko” is produced (France). The volume of bottles for adults is 125, 200 and 300 milliliters, for children - 125 and 200. They are equipped with an aluminum screw cap. The package includes a measuring cup.

special instructions

For alcoholism, epilepsy, liver diseases, injuries or diseases of the brain, it should be taken into account that Libexin Muco syrup contains 1.64% ethanol, which in terms of a measuring cup (1 dose = 15 ml) is 0.2 g.

Patients on a low-carbohydrate diet and patients with diabetes are advised to take into account that the sucrose content in 1 measuring cup of syrup is 6 g; in 1 measuring spoon of syrup for children – 3.5 g.

When following a salt-free or low-salt diet, the sodium content in 1 measuring cup of syrup should be taken into account as 0.097 g.

It is not recommended to use Libexin Muco in patients with fructose intolerance, sucrase/isomaltase deficiency, or glucose-galactose malabsorption syndrome, since the syrup contains sucrose.

Impact on the ability to drive vehicles and complex mechanisms

During drug therapy, when driving vehicles or engaging in other potentially hazardous activities, caution must be exercised due to the possible development of side effects such as dizziness and weakness. Patients taking Libexin Muco syrup must remember that the presence of ethanol in its composition can reduce concentration and affect the speed of psychomotor reactions

Patients taking Libexin Muco syrup must remember that the presence of ethanol in its composition can reduce concentration and affect the speed of psychomotor reactions.

Impact principle

The main effect in eliminating dry cough is achieved due to the influence of the main component of the drug - Prenoxydiazine - on peripheral cough receptors.

This impact is expressed in the following directions:

• local anesthesia, which prevents the passage of impulses to the nerve endings, which leads to a decrease in irritation;
• subtle decrease in breathing rate;
• dilatation of the bronchi, facilitating the release of sputum when coughing.

The effect of the drug Libexin Muco is similar to Codeine in suppressing the central nervous system. However, prenoxydiazine is not classified as a drug that causes addiction and dependence on the drug.

The influence of the main active component slightly inhibits the transmission of nerve impulses to receptors, which guarantees the safety of using Libexin syrup from the age of two. This cough medicine is recommended for inflammatory diseases such as chronic bronchitis.

Contraindications

Absolute:

• Diseases accompanied by abundant bronchial secretion;
• Glucose-galactose malabsorption, lactase deficiency, galactose intolerance;
• The period after inhalation anesthesia;
• Hypersensitivity to the drug.

Libexin should be used with extreme caution when treating children.

During pregnancy and lactation, the drug is prescribed only after a careful assessment of the intended benefits and possible risks.

Pharmacological authorities

Pharmacodynamics.

Dyucha rechovina prenoxdiazine hydrochloride to repair antitussive action for rakhunok:

• local anesthetic action: reduces the agitation of peripheral sensory (cough) receptors;
• bronchodilator action: suppresses baroreceptors, which affects the cough reflex;
• a slight decrease in the activity of the respiratory center, but does not cause suppression of the respiratory system.

The dizziness subsides and the phlegm begins to spread.

The anti-cough effect lasts for 3-4 years.

Pharmacokinetics.

This liquid is absorbed quickly and extensively from the intestines. The maximum concentration in serum is reached within 30 weeks after stagnation; Therapeutic rhubarb can be maintained for 6-8 years.

Vin is moderately bound to blood plasma proteins throughout the first year – by 55-59%.

The training hour becomes 2.6 years.

A significant part of the dose taken is metabolized in the liver, about 1/3 of the part is excreted unchanged. In addition, 4 metabolites are excreted.

Zhovchovidlenya plays the most important role in the first 12 years of drug metabolism. 93% are excreted within 24 years after stagnation. 50-74% of the administered dose is excreted in feces, and 26-50% is excreted within 72 years after fasting.

Interaction with other drugs

Libexin is a drug that can be used in tandem with other medications. Hungarian tablets demonstrate good results when used together with antibiotics. Antibacterial drugs suppress the activity of the pathogenic pathogen, and prenoxdiazine eliminates cough.

Important! Libexin should not be combined with mucolytics and expectorants (Ambrobene, Gedelix, Pectolvan, others). Against the background of stimulation of the secretion of liquid mucus, stagnation of sputum occurs, leading to a deterioration in the patient's condition.