Children, especially those who attend schools and preschools, very often catch various viral diseases, including the flu. A fairly popular drug for the prevention and treatment of influenza in children is the drug Orvirem, which we will consider in detail in this article.
What is Orvirem syrup for children, what is stated in its instructions for use, what analogues of this product are available, and what reviews customers leave about it - read on.
Pharmacodynamics and pharmacokinetics
The active ingredient rimantadine hydrochloride is located in the matrix cells of sodium alginate , which causes a gradual release of the active components from the product. At the same time, the toxic effect of rimantadine and the possibility of allergic reactions are minimized.
In turn, the active substance blocks the process of fusion of the virus shell with endosomal membranes , gene transfer. does not occur from the virus to the cytoplasm of the cell of genome transcription ).
The substance stimulates the production of antibodies to fight the virus and catalyzes the processes of interferon induction . Thanks to rimantadine, cytokines decreases and, as a result, detoxification the antigenic load decreases .
Orvirem syrup for children 0.2% fl. 100ml 60497
Description
From Orvirem®, which is a polymer compound of rimantadine with sodium alginate, the active substance is not released immediately, which causes a gradual release of rimantadine into the blood, its prolonged circulation in the body, a constant concentration of the drug in the blood, and a decrease in the toxic effect of rimantadine. Active against strains of influenza A virus. It has an antitoxic effect in acute respiratory viral infections and influenza caused by type B virus. Orvirem® selectively interacts with the transmembrane viral protein M2, which functions as a proton pump. It prevents a decrease in the pH of endosomes, blocks the fusion of the virus shell with endosome membranes and thus prevents the transfer of viral genetic material into the cell cytoplasm. Inhibits the exit of viral particles from the cell, i.e. interrupts the transcription of the viral genome. Thus, it has a direct antiviral effect. Stabilizes the system of formation of sIgA (secretory immunoglobulin A), as the first level of protection, in the nasopharyngeal mucosa. Promotes the induction of interferon as a second level of protection. Orvirem® helps to normalize the subpopulation composition of immunocompetent cells and, accordingly, improves their functional activity and strengthens the cellular component of immunity. Has a detoxifying effect. Reduces the levels of pro-inflammatory cytokines IL-8 and TNF-α, reduces the antigenic load on immunocompetent cells, and quickly stops inflammatory reactions. When prescribing Orvirem® to sick children with diabetes, it should be taken into account that the syrup contains 60% sugar.
Compound
Syrup for children 1 teaspoon (5 ml) active substance: rimantadine hydrochloride 10 mg excipients: sodium alginate; sugar; dye E122; purified water in dark glass bottles of 100 ml; 1 bottle in a cardboard pack.
Application
Prevention and treatment of influenza and ARVI in children over 1 year of age. The drug is usually well tolerated. While taking Orvirem®, nausea, flatulence, anorexia, headache, skin rash, itching, and urticaria may extremely rarely occur. Rimantadine reduces the effect of antiepileptic drugs. Enhances the effect of caffeine; aspirin and paracetamol reduce the concentration of rimantadine in the blood. Orally, after meals, with water, according to the following regimens: Treatment regimen Age Days of administration 1st 2nd 3rd 4th 1–3 years 2 teaspoons 3 times 2 hours .spoons 2 times 2 teaspoons 2 times 2 teaspoons 1 time 3–7 years 3 teaspoons 3 times 3 teaspoons 2 times 3 teaspoons 2 times 3 teaspoons 1 time 7–14 years 4 hours .spoons 3 times 4 teaspoons 2 times 4 teaspoons 2 times 4 teaspoons 1 time Prophylactic regimen Age Daily dose Dosage regimen Duration of administration 1–3 years 2 teaspoons 1 time per day 10–15 days 3–7 years 3 teaspoons 1 time per day 10–15 days 7–14 years 4 teaspoons 1 time per day 10–15 days 1 teaspoon = 5 ml. The maximum daily dose is 5 mg of rimantadine per 1 kg of body weight. Efficacy The criteria for assessing the preventive effectiveness of the tested drug was its ability to prevent disease during an outbreak of influenza or ARVI of another etiology in a team. Preventive effectiveness was also judged by its effect on viral shedding in hospitalized children with influenza and by the frequency of development of nosocomial acute respiratory infections among them. As a result of the studies, preventive effectiveness: excellent - 71.6%, satisfactory - 11.9%, unsatisfactory - 16.5%. Systematic administration of the drug to prevent influenza reduces the incidence of the disease by 4–5 times in organized groups. The criteria for assessing the therapeutic effectiveness of the drug were the duration of the main clinical symptoms of the disease (temperature reaction, intoxication and catarrhal symptoms in the nasopharynx), the speed of disappearance of pathological changes in laboratory parameters, if any developed at the onset of the disease, the development or absence of complications, as well as certain adverse reactions in response to his introduction. When treating influenza and acute respiratory viral infections, it reduces the time of manifestation of the main symptoms of the disease by 3.1–3.6 days. The duration of the temperature reaction, symptoms of intoxication, as well as catarrhal symptoms in the nasopharynx are significantly reduced. Peripheral blood counts normalize faster. Indicators of specific and nonspecific immunity improve. In case of late treatment and relapses of the disease, the use of Orvirem® reduces the duration of the disease by 2 times and prevents the development of complications. The drug has proven its safety: - no significant changes were detected in the dynamics of peripheral blood parameters in children of the compared groups; - no pathological changes were detected in the urine; — there is no increase in allergic mood in both children with high and normal levels of IgE in the blood serum, which confirms clinical data on the absence of any allergic reactions to its administration. increased sensitivity to rimantadine and other components of the drug; age up to 1 year; acute and chronic diseases of the liver, kidneys; thyrotoxicosis; diabetes; pregnancy; lactation.
Possible product names
- Orvirem syrup for children 0.2% fl 100ml
- ORVIREM SYRUP 2 MG/ML 100 ML
- ORVIREM 0.002/ML 100ML SYRUP FOR CHILDREN
- ORVIREM SYRUP FOR CHILDREN 2 MG/ML 100 ML. (REMANTADINE) X1
- ORVIREM (RIMANTADINE) SYRUP FOR CHILDREN 0.2% FL 100ML
- ORVIREM (REMANTADINE) SYRUP CHILDREN (FROM 1 YEAR) 0.2% FL. 100ML B
- (Orvirem) Orvirem syrup for children 0.2% fl 100ml
Instructions for Orvirem (Method and dosage)
The drug is prescribed orally, after meals. The maximum daily dose of syrup is 5 mg per kg of weight.
One teaspoon usually contains 5 ml of medicine.
Instructions for children during prevention:
- children from one to three years are prescribed 10 ml per day (2 spoons);
- children from three to seven years old – 15 ml;
- children from seven to 14 years old – 20 ml.
Instructions for use of Orvirem for the treatment of viral diseases
From one to three years of age:
- on day 1 – 3 doses of 10 ml;
- on days 2 and 3 – 2 doses of 10 ml;
- on day 4 – once 10 ml.
From three to seven years:
- on day 1 – 3 doses of 15 ml;
- in 2 and 3 – 2 doses of 15 ml;
- on day 4 – once 15 ml.
Children from 7 to 14 years old:
- first day – 3 doses of 20 ml;
- second and third - 2 doses of 20 ml;
- fourth - once 20 ml.
Operating principle
Orvirem is one of the antiviral drugs, since its active substance rimantadine has a detrimental effect on the influenza virus group A (it is the most widespread, and the diseases caused by it are the most severe). So, rimantadine:
- prevents the penetration of the genetic material of a pathogenic virus into the cytoplasm of a healthy cell;
- prevents the spread of viral particles throughout the body, blocking their exit from infected cells.
The most pronounced therapeutic effect from taking this drug is observed in those patients who began to use it within the first 7 hours after the first signs of the disease were detected. If you start taking this remedy at all 1 - 2 days before the first symptoms appear, then, according to studies, the disease may not occur at all, or may occur in an extremely mild form.
Analogs
Level 4 ATC code matches: Rimantadine
Rimantadine
Remavir
Remantadine, Arbimax, Rimantadine, protfenoloside, Yodantipyrine, aperflu, novirin, cytokine, Arbidol, algirem, avonex, Amizon, anaferol, Tamiflu, interferon.
Indications
Indications for the use of this medication are the prevention and treatment of group A influenza in children. Thus, prevention with this drug is advisable for:
- contact with a sick person at home;
- regularly being in a closed group during the active spread of various diseases;
- influenza epidemics.
Orvirem price (where to buy)
Syrup for children is relatively inexpensive.
On average, the price of Orvirem for children is about 170 rubles per 100 ml.
- Online pharmacies in RussiaRussia
ZdravCity
- Orvirem syrup for children
2mg/ml 100mlOlifen Corporation CJSC/OJSC Pharmstandard-Leksredstva RUB 268 order
Composition and release form
On the pharmaceutical market, this medication is presented in one single dosage form - a viscous pink syrup with a sweet strawberry flavor. This syrup is sold in dark glass bottles of 100 ml.
The main active ingredient of the drug Orvirem is rimantadine hydrochloride, which accounts for 2 mg per 1 ml of syrup. In addition, the product we are considering includes the following additional components: sodium alginate, food coloring, sugar, purified water.
Contraindications, possible side effects, overdose
Taking the drug we are considering is contraindicated if:
- individual intolerance to at least one of its components;
- various kidney and liver diseases;
- thyrotoxicosis (a condition in which the amount of hormones produced by the thyroid gland increases);
- fructose intolerance;
- under one year of age;
- pregnancy;
- breastfeeding.
With caution and only with the permission of a doctor, Orvirem can be used for children with:
- epilepsy, since the risk of an attack when using it increases;
- diabetes mellitus
Among its possible side effects are:
- nausea, vomiting, abdominal pain, flatulence;
- headache, dizziness, sleep disturbances, difficulty concentrating;
- rash, itching, urticaria;
- hyperbilirubinemia, etc.
To date, no cases of overdose with the syrup we are considering have been identified.
Reviews
Olga:
As an independent drug, Orvirem is quite weak (the doctor told me so), but in complex therapy for the treatment of influenza it is what is needed. With it, all unpleasant symptoms go away much faster.
Marina:
For example, we were prescribed this drug when my one-year-old son caught a rotavirus infection. We drank for 5 days, everything is fine. Thanks to its pleasant taste, my son took it without problems.
Snezhana:
This syrup did not help my child either in preventing or treating the virus. Perhaps it’s just not ours.
Caroline:
My husband and I have been saving ourselves with Remantadine for many years for any manifestations of viral diseases, and then I found out that a similar drug exists for children - Orvirem syrup. An excellent remedy for the prevention and treatment of influenza. But there is one caveat: the syrup must be taken as soon as possible after the appearance of at least some hint of the flu, otherwise it will not be effective.
Catherine:
We bought this drug purely by chance: the pharmacist recommended it to us instead of the medicine that was prescribed to us, but it was not available. We drank it strictly according to the scheme given in the instructions. By the way, this is one of the few medications that a child agrees to take voluntarily (it’s tasty, yes). Improvements became noticeable on the third day, and then the disease completely receded.
