Pharmacodynamics and pharmacokinetics
The active component of the drug, Flumethasone , is a synthetic bifluorinated corticosteroid intended for external use. The substance has anti-inflammatory , antiallergic , antipruritic , decongestant and vasoconstrictor effects. By acting on the skin, the drug helps prevent the marginal accumulation of neutrophils , reducing inflammatory exudate and the production of lymphokines, inhibits the migration of macrophages, reduces the processes of infiltration and granulation, and so on.
Clioquinol or iodochlorooxyquinoline is a derivative of 8-hydroxyquinolines. Its activity is manifested against yeast fungi, dermatophytes, and gram-positive bacteria. In addition, the antiexudative effect of Flumethasone .
The combined effect of Flumethasone and Clioquinol suppresses the development of various inflammatory and allergic reactions on skin surfaces, which can be complicated by bacterial or fungal infections.
Thanks to its fatty base, the ointment has a softening and water-repellent effect, which is provided by a protective film that protects the skin from moisture. This drug is suitable for use by patients with dry and thin skin.
After applying the product to the skin, its active substances penetrate the stratum corneum. In this case, flumethasone pivalate is not absorbed into the bloodstream and does not have a systemic effect. Increased absorption occurs as a result of frequent use of the ointment or its application to large areas of the skin. This can also be expected when using the product on the face, in skin folds, in places of damage to the epidermis, under an occlusive dressing. It should be noted that in children the effect of the substance is especially pronounced. Clioquinol in the ointment is absorbed through the skin, binding to blood plasma proteins.
The active substances are slightly metabolized in the skin structure. Mostly this process occurs in the liver. The components are then excreted from the body in urine or bile.
Mechanism of operation
The effectiveness of the drug is due to the properties of the substances on which Lorinden is made.
- Flumethasone, a synthetic component, prevents the accumulation of neutrophils in the focal area, which reduces the activity of inflammatory exudate and the production of lymphokines. The anti-inflammatory effect is complemented by an antipruritic and antiallergic effect. The substance relieves swelling and promotes vasoconstriction.
- Clioquinol - enhances the effect of the active component, destroys different types of fungi. In combination with flumethasone, it prevents the development of complications of fungal and bacterial infections.
- Salicylic acid – the substance has anti-inflammatory, antiparakeratosis and keratolytic effects. The non-steroidal anti-inflammatory drug transports flumethasone into the layers of the epidermis, thereby increasing the therapeutic effect of the ointment. The acid helps restore the protective functions of the skin and is active in the fight against pathogenic bacteria.
When the medicine is applied to the affected area of the skin, there is a decrease in the production of leukotrienes and prostaglandins, which is achieved by inhibiting the activity of phospholipase A2 and slowing down the release of arachidic acid.
These processes create favorable conditions for the reduction of the basic substance of connective tissue, weakening proliferative and exudative reactions in the layers of the epidermis.
Contraindications for use
This drug is not prescribed for:
- skin tuberculosis;
- viral skin lesions, such as chickenpox or herpes ;
- syphilis with manifestations on the skin;
- precancerous conditions and skin tumors;
- perioral dermatitis ;
- period after vaccination;
- acne;
- trophic ulcers caused by varicose veins ;
- under 10 years of age;
- hypersensitivity.
Lorinden during pregnancy and lactation
The drug has not been tested on pregnant and breastfeeding patients, so Lorinden is not prescribed .
The exception is when the mother's health is at risk.
- In medical practice, the ointment is contraindicated in the 1st trimester of pregnancy.
- are not treated during lactation .
The manufacturer advises using the drug with extreme caution when breastfeeding (provided the treatment is short-term, not exceeding 3 days).
Side effects
The use of the drug Lorinden C can cause: burning, stretch marks, folliculitis , itching and dry skin. Long-term use leads to the development of: purpura, skin atrophy , telangiectasia, pigmentation disorders, local hirsutism . When the product is applied to large areas for a long time, side effects characteristic of GCS may occur.
Overdose
Data from studies of the drug indicate rare cases of symptoms characteristic of intoxication.
The risk of overdose occurs if the ointment is used incorrectly or if it is used for a long time.
To relieve alarming signs of intoxication, symptomatic therapy is used. For further treatment, another drug is selected or oral medications are prescribed.
Interaction
The simultaneous use of Lorinden S and other external agents is not permissible. When the drug is applied to large areas of the skin, the absorption of Flumethasone can reduce the effect of insulin , other hypoglycemic agents, antihypertensive drugs and anticoagulants. In addition, the risk of negative effects of anticholinergic drugs, anabolic steroids, oral contraceptives, androgens, estrogens, antipsychotics, azathioprine , bucarban, diuretics, nitrates, tricyclic antidepressants, antihistamines, cardiac glycosides increases. The immunosuppressive effect of this drug requires refraining from vaccinations and immunizations.
Instructions for use
Before you start treating the affected area of the skin, it is recommended that you familiarize yourself in detail with the information about what the product helps with and how to use it correctly.
Particular attention is paid to the contraindications . This will help avoid the development of complications and unpredictable reactions.
Rules for using hormonal drugs:
- The medicinal composition should only be used externally;
- distribute the ointment over the affected area of the skin in a thin layer;
- at the initial stage of therapy, treatment is carried out 2-3 times. per day, after the appearance of positive dynamics, the frequency of procedures is reduced to 1-2 r. in a day;
- the duration of the course of treatment is determined by the doctor, but in any case does not exceed 14 days;
- the daily dose should not exceed 2 g of ointment;
- if the focal area is located at the point of contact of the skin with clothing, a gauze bandage should be applied;
- when signs of hyperkeratosis are detected or when the upper layer of the epidermis is thickened, it is recommended to apply ointment under an occlusive dressing (one procedure every 1-2 days);
- For adolescents, the medicine is prescribed with caution to all areas of the skin except the face.
Analogs
In modern pharmacology, there are analogues of this drug: Flumethasone, Lorinden, Lorinden A. Drugs similar in action include: Dexamethasone, Prednisolone, Diprospan, Methylprednisolone , etc.
Precautionary measures
During treatment with Lorinden, it is recommended to observe the following precautions:
- During the procedure, you should avoid contact of the drug with the skin of the face and mucous membranes.
- Changing the treatment regimen or course duration on your own is strictly prohibited. The hormonal drug is used exclusively for its intended purpose, subject to compliance with all doctor’s instructions. Otherwise, the risk of systemic side effects increases.
- If after completion of treatment a secondary infection forms on the skin, a more powerful agent is used for treatment.
- In old age, with atrophic changes in the structure of the epidermis, the ointment is prescribed with caution.
- A course of therapy exceeding 10 days is fraught with the development of microflora resistance to the substance clioquinol.
- The active components of the ointment do not have a negative effect on psychomotor function, brain activity, or physical condition.
Reviews of Lorinden S
As reviews of Lorinden S show, this external remedy is one of the most popular. It is prescribed for a wide variety of skin lesions, and in most cases, it turns out to be very effective.
However, some patients report that the positive effect of the drug lasts only for a while, that is, it simply inhibits the development of unwanted symptoms. After stopping the use of Lorinden S, patients begin to experience the same disorders again.
According to experts, this treatment result was noted when prescribing an external remedy without sufficient examination by specialists, since often people do not even know exactly what Lorinden S ointment is for. Also, many reviews of the ointment contain information that patients often use the drug on their own without contacting to the doctor. Therefore, in such cases, one should not exclude either a temporary cessation of the symptoms of the disease or the development of all kinds of side effects.
Price and varieties
You can buy a topical hormonal product at a pharmacy or by placing an order in an online store.
The cost of one tube is 365-398 rubles . The medicine is dispensed with a prescription sheet.
Depending on the combination of constituent substances used by the manufacturer, the following types of dermatological products are produced:
- Lorinden A (with vitamin A);
- Lorinden S (with salicylic acid).
Both drugs are used in the fight against skin diseases, but taking into account the excipients, a high therapeutic effect can be obtained with the correct selection of ointments for specific problems.
The composition, enriched with vitamin A, has a keratolytic (softening) effect. Ointment with salicylic acid works well in the treatment of fungal infections.
Lorinden S price, where to buy
In Moscow pharmacies, the price of Lorinden C ointment for external use varies between 242-308 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Lorinden S ointment 15gJelfa SA
RUR 447 order
Pharmacy Dialogue
- Lorinden S (ointment tube 15g)Jelfa
490 rub. order
show more
Pharmacy24
- Lorinden C 15 g ointment Farmzavod Elfa A.T., Poland
111 UAH order
PaniPharmacy
- Lorinden C ointment Lorinden C ointment 15g Poland, Jelfa
126 UAH order
show more
Compound
The basis of the composition is the substance flumethasone pivalate .
For better absorption of the medicine by the tissues and cells of the epidermis, the main component is supplemented with vitamins and chemical compounds (propylene glycol, anhydrous lanolin, white petroleum jelly, etc.).
External signs: opaque dense creamy substance of whitish color. Packaged in tubes with a capacity of 15 g.
