Compound
The active ingredient is biperiden hydrochloride, the content in one tablet is 2 mg. The drug also contains the following components:
- microcrystalline cellulose;
- corn and potato starch;
- calcium hydrogen phosphate dihydrate;
- magnesium stearate;
- copovidone;
- talc;
- purified water.
Particular attention should be paid to lactose monohydrate, which is a potent allergen for patients with glucose-galactose disorders.
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Akineton, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Akineton is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Pharmacological properties
Antiparkinsonian drug, penetrates the blood-brain barrier. Blocks central M-cholinergic receptors, inhibits the transmission of excitation in the autonomic nervous system. It affects the neurons of the striatum, the activity of which decreases.
Intended for oral administration. Quickly stabilizes the patient's condition, eliminates tremor of the limbs, muscle rigidity, and catalepsy. The anticholinergic effect of the peripheral plan is manifested at an insignificant level.
"Akineton": overdose
Take this medicine strictly as directed by your doctor. An overdose of biperiden can lead to negative consequences. At the same time, it is impossible to predict in advance which organ will be at risk.
Most often, patients experienced the following consequences of an overdose:
- the pupils reacted very slowly to light;
- mucous membranes became excessively dry;
- the skin became covered with red spots;
- increased heart rate;
- hyperemia;
- diseases of the central nervous system;
- disturbances of coordination, memory and thought processes.
Pharmacokinetics (principle of action)
When used once, bioavailability does not exceed 30–40%. The maximum daily dosage should not exceed eight tablets (16 milligrams). High solubility and binding to blood plasma proteins (90–94%) ensures good penetration of the active substance into organs and tissues. The required concentration is achieved after 15–40 hours. Akinetone is released only in the form of derivative compounds: piperidine and bicycloheptane.
Eating does not affect the absorption of the active and excipients. Akineton penetrates well into all biological fluids of the body. Absorbed from the gastrointestinal tract and metabolized in the liver, excreted by the body in feces and urine within 24 hours. In people over 65 years of age, this time can increase to 38–40 hours, which is associated with reduced renal function characteristic of this age.
Release form and composition
Akineton is available in the form of flat, cylindrical, white tablets and in the form of a clear solution for injection.
Each tablet contains two milligrams of biperiden hydrochloride, the main active ingredient. The auxiliary components included in the tablets are: microcrystalline cellulose, potato and corn starch, calcium hydrogen phosphate dihydrate, lactose manohydrate, copovidone, magnesium stearate, distilled water, talc.
The tablets are packaged in blisters of ten or twenty pieces.
In the solution for injection, one milliliter contains five milligrams of biperiden lactate, the main active ingredient. And the auxiliary components in the solution include: sodium lactate and distilled water. The solution for injection is packaged in ampoules of one milliliter. One package contains five ampoules with injection solution.
Indications for use
Recommended for the correction of extrapyramidal disorders, it is effective and has a “mild” effect. Oral administration of Akineton and its analogues in tablets (Benzac, Mendylex, Biperidine) is indicated:
- adult patients with Parkinson's disease;
- with a complex of extrapyramidal disorders caused by taking antipsychotics (tremor, dystonia, tics, chorea, myoclonus, cardiopathy, etc.);
- in case of intoxication with phosphorus-containing substances or nicotine.
When prescribing Akineton, the doctor takes into account its effect on cognitive function. It is recommended to avoid uncontrolled use.
Storage rules
Please note that buying this drug is not so easy. Before going to the pharmacy, you definitely need to see a doctor and get a prescription from him.
The medication must be stored in the right conditions, otherwise it will lose its effectiveness and be hazardous to health.
Tablets and ampoules should be stored at a temperature not exceeding 25 degrees Celsius, away from sunlight and children.
If the correct storage conditions are observed, Akineton can be used for five years from the date of manufacture.
How to take the drug (dosage)
Attention! Self-medication is unacceptable! Before use, you should carefully study the instructions for use. It is strongly recommended that you adhere to the information contained in it!
Taking Akineton tablet.
2 mg No. 50 is prescribed before or after eating, and the tablets are washed down with a large volume of water. Therapy begins with small doses, increasing them over time to maximum values. In this case, the occurrence of undesirable symptoms is taken into account. Parkinsonism syndrome
Start with 1 mg (0.5 tablet) once or twice every 24 hours. The amount increases every day by 2 mg (1 capsule). For prevention, take from 2 to 16 mg/day. The total amount of the drug is divided into equal portions.
Extrapyramidal symptoms in patients of different age groups caused by the action of antipsychotics
To correct neuroleptic treatment, taking into account the severity of the clinical picture, the recommended maximum daily dose is:
- adults - 1–4 mg (0.5–2 tablets);
- children and adolescents 3–15 years old—1–2 mg.
In case of intoxication,
the Manufacturer recommends the drug based on the individual state of the body at the time of administration. Use in childhood is indicated in short therapeutic courses.
To prevent side effects in the gastrointestinal tract, the drug Akineton tab. 2 mg is taken immediately after eating. The duration of the course is determined by the severity of clinical symptoms. Abrupt withdrawal of the drug is not allowed - it begins with a dose reduction.
Who should use it?
The drug "Akineton" is very often prescribed in the following cases:
- poisoning with phosphorus-containing or nicotine substances;
- in the presence of parkinsonism syndrome in adults;
- for extrapyramidal syndromes caused by antipsychotics or other similar drugs. In this case, the medication is prescribed to both children and adults.
Side effects
In the first days of using Akineton, side effects may appear, which also appear with a sharp increase or decrease in dosage.
- Central nervous system : weakness and drowsiness, unexplained fatigue, anxiety, dizziness. Possible muscle spasms, headache, insomnia, irritability. Some patients experience euphoria, complemented by hallucinations, speech and memory disturbances.
- Vision : photophobia, glaucoma, accommodative disorders.
- Digestive system : pain in the epigastric region, constipation. Sometimes there is an increase and thickening of the salivary glands, which leads to a decrease in the volume of fluid secreted, thirst, and a change in taste sensations.
- Cardiovascular system : arterial hypotension, sinus rhythm disturbances.
- Urinary organs : difficulty urinating may occur.
Increased sensitivity may develop, which is typical for older people with disorders of the central nervous system and a tendency to epilepsy.
Patients with tardive dyskinesia, which develops due to systemic use of antipsychotics, are at risk. The drug enhances the manifestations of erratic movements of a choreo-like nature.
special instructions
The drug is prescribed with special caution to pregnant women and people of the older age group suffering from organic brain failure. In these cases, consultation with a medical specialist is mandatory!
Abuse of the drug is extremely rare, which is manifested by increased mood and the onset of euphoria after ingestion.
With a long course, constant monitoring of intraocular pressure is necessary.
Side effects appear in the first few days after the start of treatment and/or when the dose is increased too quickly.
Reviews
Reviews from doctors and patients about this product confirm its effectiveness. However, everything depends on the correct dosage. You should not immediately take large doses, it is better to increase them gradually. Doctors strongly recommend monitoring your general health during the course of treatment: regularly see a doctor and get tested. According to the collected reviews, the drug is tolerated quite well. Side effects are extremely rare. Most often in case of overdose.
This drug has shown to be highly effective in the treatment of Parkinson's syndrome. Tremor in the limbs disappears very soon after starting use. The disadvantages include the high cost of the drug "Akineton". The price for tablets is about 600 rubles. But for injections you will have to pay about 900 rubles.
Despite many shortcomings, this medication still copes well with its tasks. When used correctly, the risk of developing negative consequences is extremely low. Strictly follow your doctor's recommendations, take your medicine on time, and very quickly you will be able to notice the first positive results. And if the drug does not suit you, do not worry, there is always the opportunity to find a replacement.
Interaction with other drugs
Simultaneous use of Akineton with antiallergic, psychotropic drugs, drugs against Parkinson's disease can cause the following side effects:
- disturbances in the functioning of the heart and blood vessels;
- increased dyskinesia when taking levodopa orally;
- Akineton in combination with ethanol has a negative effect on the central nervous system;
- neutralize the effect of metoclopramide (Metoclopramidum) and similar drugs on the gastrointestinal tract.
During therapy, the side effects of pethidine (an opioid agonist) on the central nervous system may increase.
Directions for use and dosage
In case of Parkinson's disease in severe form of Akineton, it is important for an adult patient to administer Akineton slowly, using intravenous droppers, or intramuscularly in small doses - two to four milliliters, which should be divided into several injections per day.
Taking Akineton in tablets begins with small dosages, no more than one milligram twice a day. Then, depending on the therapeutic effect, the dosage can be gradually increased to two milligrams twice a day. The maximum dosage of this drug should not exceed sixteen milligrams per day, divided into four doses.
A single dose of this drug can be prescribed in case of disorders of the body’s motor system:
- for children under one year of age, 0.2 ml intravenously;
- from one to six years, 0.4 ml intravenously;
- over ten years old, 0.6 ml intravenously;
- for adult patients, 0.5-1 ml intravenously (but not more than four ml per day).
If necessary, a repeat dose of Akineton is administered no earlier than thirty minutes after the first administration of the drug. If a side effect is observed, the administration of Akineton must be stopped.
Tablets of this drug are taken during food intake or immediately after it.
The duration of treatment is determined by the doctor and directly depends on the severity of the disease.
Discontinuation of the drug should occur gradually, by reducing the dosage.
Overdose
The effect of the drug is accompanied by dilation of blood vessels, a decrease in blood pressure, increased contraction of smooth muscles, and increased secretion of the salivary and sweat glands.
In case of an overdose (daily or one-time), a toxic effect occurs. Main symptoms:
- hyperemia;
- cardiac dysfunction;
- temperature fluctuations;
- psycho-emotional disorders (hallucinations, confusion, memory loss, overexcitation).
In some cases, collapse, cardiac arrest, depression of the respiratory system, and death are possible.
Treatment
A standard dosage of Physiostigmine, a reversible acetylcholinesterase inhibitor, is required. In emergency cases, resuscitation measures may be required.
