Sinaflan ointment: what it helps with, features of hormonal use, side effects and contraindications, analogues, price

Sinaflan ointment belongs to the category of immunosuppressive drugs that suppress unwanted immune reactions of the body. Experts note that this drug is effective in combating the manifestation of inflammatory reactions and other abnormalities of the dermis and epidermis. The product has been actively used in dermatology for a long time, is prescribed for external use and belongs to the category of strong drugs that can, if used uncontrolled, lead to complications.

Along with positive reviews about the effectiveness of the ointment and examples of recovery in the most advanced cases, you should not rely only on the opinions of friends and relatives. The drug has contraindications, knowledge of which will protect you from serious consequences. Before use, you should not only read the instructions, but also consult a doctor. And in this article, we will talk about the features of the medicine, what Sinaflan ointment is used for, the subtleties of use and purpose.

Compound

1 g of liniment or ointment contains 0.25 mg of active ingredient.
The auxiliary ingredients in liniment include:

propylene glycol;
anhydrous lanolin ;
petrolatum;
pentanol;
stearic acid;
nipagin;
nipazole;
purified water.

Excipients in the ointment:

benzyl alcohol;
propylene glycol;
soft white paraffin;
ceresin;
lanolin.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

You can often hear the question of whether Sinaflan is hormonal or not. This is a hormonal drug, but this is the reason for its high effectiveness.

Fluocinolone acetonide binds to specific receptors in the cytoplasm of cells, which provokes an increase in mRNA synthesis. The result of exposure affects all metabolic processes in the cell.

Clinically significant effects include the following aspects of influence on the cell:

inducing the synthesis of lipocort proteins, including lipomodulin, which leads to inhibition of the activity of phospholipase A2, which is one of the factors in the progression of the inflammatory response;
stabilizes the cell membrane, which helps prevent swelling ;
increases the rate of protein catabolism;
reduces the migration of B and T lymphocytes and disrupts the interaction of these cells;
inhibits the accumulation of leukocytes and macrophages at the site of inflammation;
suppresses the effect of hyaluronidase, reduces the level of formation of arachidonic acid and leukotrienes;
affects the regulation of carbohydrate metabolism, reducing tissue glucose consumption, which can lead to an increase in its concentration in the blood ;
promotes the retention of sodium and water ions, provokes the excretion of potassium and calcium, reduces the ability to absorb calcium;
increases the synthesis of erythrypoietins.

This effect on metabolic processes in the cell contributes to a noticeable effect in those cases for which the medicine is used - for acne and other inflammatory skin lesions.

Pharmacokinetics

Fluocinolone acetonide easily penetrates into all layers of the skin, but accumulates in the stratum corneum (can be detected even 15 days after completion of treatment). It enters the bloodstream in small quantities.

Biotransformation occurs in the liver. In this case, inactive metabolites . Excretion occurs mainly due to the work of the kidneys.

Absorption of the drug occurs more intensely when treating children, when applied to large areas of skin, when used regularly, when applied to the face or damaged skin.

Main characteristics of Sinaflan ointment

Sinaflan is a glucocorticosteroid ointment manufactured only for external use for skin diseases:

Compound	0.025% fluocinol acetonide, lanolin, petrolatum, propylene glycol, ceresin
Release form	White or white-yellow ointment
How it works	Relieves inflammation, itching, eliminates rashes and peeling, fluid secretion in the affected areas
Dosage	Assigned individually
Indications	Acute and chronic skin pathologies of an allergic and non-microbial nature, accompanied by dryness
Contraindications	Skin infections, melanoma and other types of cancer, manifestations of tuberculosis, syphilis, mycoses, smallpox, gastritis and stomach ulcers, pyoderma
Is it hormonal	Yes, belongs to the group of glucocorticosteroids
Is it allowed during pregnancy and lactation?	No
Use for children	Acceptable after 2 years
Use in old age	Carefully
Features of use in childhood	With caution during puberty
Conditions for purchasing at a pharmacy	Over the counter
How to store	At a temperature of 12-15 degrees, protect from excess humidity
Best before date	2 years from date of manufacture
Manufacturer	OJSC Nizhpharm, LLC Atoll, OJSC Murom Instrument-Making Plant
Price in pharmacies	60-120 rub.
Analogs	Flucinar, Flutsar, Sinalar, Advantan, Momat

In addition to the listed manufacturers, the product is produced by ZAO Zelenaya Dubrava, AltaiVitamins, and OAO Biokhimik. Products from Nizhpharm are more expensive than others. Cheaper - Sinaf ointment from Belarus.

Sinaflan can be in the form of a cream, gel or liniment. The composition is enclosed in a metal tube, and the vessel itself is in a box. Each of them, regardless of the manufacturer and form, is accompanied by instructions that list the indications, prohibitions on use, the maximum permissible dose, and other nuances.

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Hormonal or not

Sinaflan is a hormonal ointment based on an artificially synthesized component. Its active ingredient is fluocinolone acetonide, which belongs to the group of glucocorticosteroids. It has an anti-inflammatory, anti-edematous effect, eliminates itching and burning, and returns the skin to its normal color.

In addition to fluocinolone, the composition includes lanolin, propylene glycol, ceresin, and petroleum jelly. These are auxiliary components that ensure the oily consistency of the drug, its preservation and absorption by tissues.

Is it possible during pregnancy and breastfeeding?

It is highly undesirable to use Sinaflan during pregnancy, as its effect on

the fetus has not been studied. But it is known that the drug can disrupt the balance of hormones in the female body.

Therefore, the doctor must decide whether it can be used by comparing and assessing the benefits of ointment treatment for the mother and the potential risks for the unborn child.

When breastfeeding, Sinaflan therapy is also rarely prescribed, and with it it is necessary to transfer the child to artificial formula. Cancellation of breastfeeding is necessary because it is unknown whether the active substance penetrates into milk.

Is it possible for children, elderly

Even if indicated, fluocinolone is practically not used for infants. It is extremely rare that ointment is prescribed at this age if there are indications and there is no effect from other means. For older children, the drug is not recommended until 2 years of age. But even then the ointment is prescribed for no longer than 5 days, always under the supervision of a doctor.

The drug is rarely prescribed to patients during puberty, as it can disrupt the natural balance of hormones, and therefore interfere with normal development.

Sinaflan is allowed for older people, but should be used with caution. Because at this age there are likely to be diseases in which the drug harms the condition of the skin, promoting atrophy. It can also lead to systemic disorders.

Contraindications

Contraindications to treatment with the drug:

intolerance to one of the components;
rashes from syphilis;
lupus;
diaper dermatitis;
psoriasis, if it affects a large area;
bacterial, viral and fungal skin infections;
pyoderma;
chicken pox;
herpetic rashes;
actinomycosis, blastomycosis, sporotrichosis;
skin cancer and benign formations on it;
open wounds at the affected areas;
trophic ulcer;
gastritis and stomach ulcers;
itching in the genital area and anus;
pregnancy and breastfeeding.

In all cases, the ointment will not only intensify the symptoms of the disease, but can also cause new complications.

Side effects

Even with correct use of the drug against this background, side effects may occur in the form of:

dryness of the treated area;
itching and burning in this area;
weakening of local immunity and, as a result, skin infection;
the appearance of acne;
skin atrophy.

With long-term use of the ointment, the following are likely:

loss or excess hair growth in the area;
formation of pigment spots;
purpura;
protrusion of the vascular network through the surface of the skin.

If the drug is applied to large areas of the body, it may cause:

gastritis or stomach ulcer;
diabetes;
stretch marks;
slow tissue healing after damage;
suppression of the immune system and, as a result, exacerbation of chronic ailments.

Price in pharmacies

Sinaflan costs from 60 to 120 rubles. The price depends on the volume of the tube; they come in 10 g and 15 g. It is also influenced by the place of purchase, as well as the manufacturer, although the compositions of the drug can be absolutely similar.

Indications for use

Why use Sinaflan ointment and dosage forms of the drug? For the treatment of various inflammatory skin lesions of non-infectious etiology.

What does Sinaflan ointment help with in most cases? You can list the following indications for the use of ointment, gel, cream and liniment:

eczema of various localizations;
psoriasis of the body and scalp;
atopic dermatitis;
seborrheic lesions;
lichen planus ;
itching of the skin of unknown etiology;
discoid form of lupus erythematosus ;
allergic rashes;
erythema multiforme ;
minor burns ;
neurodermatitis;
inflammation at the site of an insect bite.

What is it used for?

A topical hormonal drug is recognized as effective in the fight against non-microbial diseases and allergic manifestations on the skin, as a reaction to environmental irritants.

Sinaflan ointment is used:

to relieve itching;
to eliminate increased vascular permeability;
to reduce inflammatory processes;
to soothe the treated areas;
to prevent allergic reactions.

It is worth knowing what Sinaflan cream helps with. For medical reasons, it is considered effective in the fight against:

eczema;
toxoderma;
lupus erythematosus;
increased oiliness of the scalp;
lichen planus;
atopic dermatitis;
psoriasis;
diaper rash;
neurodermatitis;
hives;
itching of the skin;
external otitis media;
bone dyshidrosis;
insect bites;
mild sunburn;
thermal skin lesions of the 1st degree.

The therapeutic effect of Sinaflan ointment can be enhanced with the help of antifungal and antimicrobial drugs.

The medication is used as an antihistamine if appropriate symptoms are detected (minor rash, pustules and urticaria). For preventive purposes, in the absence of these clinical manifestations, the drug is not recommended.

Contraindications

It is prohibited to use ointment or liniment in such cases;

hypersensitivity to the active substance or auxiliary components of the drug;
skin diseases caused by an infectious agent: bacteria, virus or fungus;
lupus;
skin lesions that are a manifestation of syphilis ;
wound surface;
diaper rash;
precancerous skin conditions, tumors ;
the presence of a nevus on the area of skin where the medicine should be applied;
psoriasis that has progressed to plaque formation;
acne (the use of Sinaflan for acne, which is actually acne, can cause an exacerbation of the disease);
trophic ulcers on the lower extremities caused by varicose veins;
any use for children under 2 years of age;
use in ophthalmology and on the skin of the mammary glands is prohibited;
pregnancy and lactation .

Use in cosmetology

The drug Sinaflan is used in the complex treatment of acne caused by hormonal changes in the body. It is used in the treatment of rashes and pustules on the face, pink and acne. This is a good remedy for improving skin condition.

Cosmetologists prescribe Sinaflan ointment for exacerbation of acne to patients over 15 years of age. It should be applied pointwise with a cotton swab, avoiding contact with healthy areas of the epidermis. The medicine is discontinued according to the scheme drawn up by the doctor.

Side effects

The question of whether an ointment is hormonal or not is often due to the fact that it is known that hormonal drugs actively affect the entire body. This also applies to Sinaflan. Side effects are not very common, but they can be quite varied.

On the part of the skin and subcutaneous fatty tissue, the following may appear:

hives;
allergic contact dermatitis;
skin irritation;
peeling of the skin or rashes in the form of papules or spots at the site of application of the medicine;
hyperkeratosis;
furunculosis;
exacerbations of pathological skin conditions that were present at the start of treatment;
atrophic changes in the skin;
burning sensation;
itching;
steroid acne ;
folliculitis;
hair loss or excessive growth in the area where Sinaflan was applied;
pigmentation disorders.

From the digestive system (occurs when used on large areas of the skin):

gastritis;
steroid gastric ulcer .

From the endocrine organs:

increased blood glucose levels;
glucosuria;
in children – slower growth and development;
when applied to large areas of skin, the development of adrenal insufficiency , Itsenko-Cushing syndrome , and steroid diabetes mellitus .

From the immune :

allergic reactions;
hypersensitivity reactions;
decreased immunity ;
exacerbation of chronic diseases;
generalization of infectious lesions;
slowing down repair processes.

From the heart and blood vessels:

increased blood pressure ;
swelling.

When applied to the outer surface of the eyelids, there is a risk of developing cataracts and glaucoma .

Ointment for children

Experts say that a child’s body can react very violently to powerful external stimuli. An itchy surface is the cause of skin breakdown and the development of a bacterial infection. It is better to treat allergic manifestations in children in a timely manner with well-chosen drugs, among which are analogues of Sinaflan: Elokom, Advant, which include hormonal components, but in small doses.

However, Sinaflan itself is prohibited for use in children under 2 years of age.

Instructions for use of Sinaflan (Method and dosage)

Sinaflan ointment, instructions for use

The ointment is applied to the affected area 1 or 2 times a day and lightly rubbed in. The course of treatment for adults is up to 10 days, for children – no more than 5 days, for facial skin – no more than 1 day.

It is not advisable to use ointment under a bandage, with the exception of some forms of psoriasis . But in this case, it is very important to change it regularly.

The drug in the form of an ointment is recommended for use in dry forms of dermatoses .

Liniment Sinaflan, instructions for use

Liniment can be applied 2-4 times a day. The course of treatment is the same in duration as when using the ointment.

Do not use under a closed bandage, but can be applied to a small area of skin under an occlusive one.

It is advisable to use for dry dermatoses .

How to use Sinaflan cream or gel

Apply to affected areas 1-4 times a day. The course lasts no more than 2 weeks.

The cream is more often used for wet dermatoses , and the gel is used for lesions of the scalp.

Pharmacological properties

The main active compound, fluocinolone acetonide, is a synthetic derivative of glucocorticosteroids. This is a hormonal component, which after use is completely absorbed and penetrates into the deep layers. It inhibits the production of phospholipase and reduces the number of lymphocytes in the inflamed area.

When using Sinaflan ointment, the following pharmacological effect is observed:

reduction of burning and itching;
reduction of swelling;
improving blood supply to tissues;
reducing redness of the inflamed area.

When applied, the sensitivity of damaged skin receptors to adrenaline is restored, which provokes a narrowing of the capillaries. This enhances the outflow of excess fluid, improves cell nutrition, and increases the level of oxygen and nutrients. This accelerates the process of regeneration and restoration of the epidermis.

Fluocinolone acetonide enters the systemic circulation in small amounts. If overdosed or used incorrectly, it can cause adrenal suppression and lower corticosteroid levels. The substance undergoes metabolism in the liver and is excreted from the blood by the kidneys within 1-2 days.

Overdose

An overdose can easily occur when the medicine is applied to large areas of the skin, in case of long-term treatment, or when applied to particularly sensitive areas, such as the skin of the face. There is also a high risk when treating children with Sinaflan.

Possible symptoms of overdose:

swelling;
increased blood pressure ;
burning , itching at the site of application of the drug;
increased levels of glucose in the blood and urine;
Itsenko-Cushing syndrome.

Treatment for overdose is symptomatic. In this case, gradual withdrawal of Sinaflan is indicated.

Precautionary measures

When using the ointment you must:

avoid contact with eyes;
do not apply to the skin in the area of the mammary glands;
wear loose clothing, especially in areas where the product is applied;
people prone to atrophic skin changes should constantly monitor its condition;
do not be afraid of the doctor’s instructions to combine the drug with antimicrobial agents, sometimes this is necessary to prevent acne from worsening;
Towards the end of the course of therapy, reduce the dose of the drug (one-time volume or number of applications per day).

This is the only way to avoid the negative effects of the hormone, addiction, and adverse reactions.

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Despite the fact that the effect of Sinaflan occurs through the skin, it is quite strong. And you should not use ointment at the slightest redness or itching; it is better to choose a more neutral product. But even when you cannot do without the drug, and there is an obvious effect, you should not use it longer than prescribed.

Interaction

The drug interacts with many other medications, so caution is necessary when using at the same time:

with systemic glucocorticosteroids – the effectiveness of Sinaflan increases and the likelihood of developing side effects from its use increases;
with non-hormonal anti-inflammatory medications – the risk of developing both local and systemic adverse reactions of the body to each of the drugs increases;
with antihypertensive, antirhythmic drugs, diuretics, potassium supplements - the effectiveness of these medications decreases;
with diuretics (except potassium-sparing ones) – the likelihood of developing hypokalemia ;
with vaccines - an inadequate immune response is possible due to the fact that the immune system is weakened and is not able to synthesize the necessary antibodies in normal quantities;
with immunosuppressants – enhances the effect;
with immunostimulants - suppresses the effect of these drugs on the immune system.

Flucinar or Sinaflan - which is better?

Of the two drugs with the same active ingredient, Flucinar is perhaps better, since Sinaflan is produced in Russia and its quality is lower. Both products are based on a synthesized hormone, but the Polish ointment:

less likely to cause addiction during normal use;
provokes adverse reactions to a lesser extent;
Thanks to its gel consistency, it penetrates deeper into the skin;
makes it easier, without exacerbations, to stop using it after completing the course of therapy.

The differences between the drugs are determined by the quality of the active substance and the methods of its synthesis.

special instructions

When treating with Sinaflan, you must adhere to the following recommendations:

avoid getting the medicine into your eyes;
do not apply to wounds or breast skin;
it is strictly forbidden to exceed the recommended duration of treatment;
do not use with other topical medications;
it is undesirable to use under a bandage, since in this case the adsorption of the drug and the risk of developing systemic side effects increases;
If necessary, undergo a course of treatment several times, you need to take tests to monitor the functioning of the adrenal glands.

Use during pregnancy and childhood

The hormonal component can penetrate into the systemic circulation, so Sinaflan is not prescribed during the patient’s pregnancy. It affects the fetal adrenal glands, suppressing their work. For the same reason, the medicine is prohibited during breastfeeding.

Allergic dermatitis often occurs in young children. Sinaflan ointment is prescribed for the treatment of children from 2 years of age. It is used only in situations where other methods have proven ineffective. In most cases, doctors prefer to use new generation drugs with a safer composition.

Sinaflan's analogs

Level 4 ATC code matches:
Gistan N

Sinalar

Avecourt

Mesoderm

Momederm

Betazon

Silkaren

Elokom

Flucinar

Celestoderm

Cutivate

Advantan

Betamethasone

Beloderm

Mometasone Furoate

Uniderm

Momat

Analogues of Sinoflana:

Sinoflan-Fitofarm ointment (an analogue with an identical composition, manufactured by the manufacturer PJSC Fitofarm);
Flutsar-Darnitsa;
Flucederm;
Flucinar (gel and ointment).

Sinaflan liniment and ointment: what are the differences

Sinaflan in the form of liniment and ointment have the following differences:

in the first there is a higher volume of water, more additional components, it is characterized by a more liquid consistency, rapid but superficial absorption;
in the second form the structure is denser, so it lasts longer and penetrates deeper.

Given the differences, ointment is prescribed when the problem has reached a serious stage. Liniment is more suitable at the beginning of the development of the disease, with minor manifestations.

Sinaflan price, where to buy

The price of Sinaflan ointment and other dosage forms of this drug is low. In Russian pharmacies the cost is 10-90 rubles, depending on the form of release. In Ukrainian pharmacies, the price of medicine ranges from 10 to 30 hryvnia.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Sinaflan ointment 0.025% 15gOzon LLC
82 rub. order
Sinaflan ointment 0.025% tube 10 gAO Akrikhin
93 RUR order
Sinaflan-Akrikhin ointment for external use. approx. 0.025% tube 15gAO Akrikhin
114 RUR order
Sinaflan ointment 0.025% 10gAltaivitaminy JSC
38 rub. order
Sinaflan ointment for external application approx. 0.025% tube 10g JSC "Green Dubrava"
35 rub. order

Pharmacy Dialogue

Sinaflan ointment (tube 0.025% 15g)Biokhimik OJSC
46 RUR order
Sinaflan ointment (tube 0.025% 15g) Nizhpharm JSC
56 RUR order
Sinaflan ointment (tube 0.025% 10g) Nizhpharm JSC
52 RUR order
Sinaflan-Akrikhin ointment (tube 0.025% 10g) Akrikhin OJSC
72 RUR order
Sinaflan liniment (tube 0.025% 15g) Muromsky PZ
42 RUR order

Pharmacy24

Sinaflan 0.025% 15 g ointment
27 UAH. order
Sinaflan 0.025% 10 g ointment TOV DKP Pharm.Fabrika, Ukraine
20 UAH order
Sinaflan-Fitofarm 0.025% 15 g ointment PRAT "Fitofarm", Ukraine
21 UAH order

PaniPharmacy

Sinaflan ointment Sinaflan ointment 0.025% 15g Russia, Nizhpharm
35 UAH order
Sinaflan ointment Sinaflan ointment 0.025% 10g tube Ukraine, Zhytomyr FF LLC
27 UAH order
Sinaflan ointment Sinaflan ointment 0.025% 15g Ukraine, Fitofarm ChAO
24 UAH order

Useful video

Watch this video about the indications and features of using Sinaflan ointment: