How to properly store Tobrex

Compound

The therapeutic effect of Tobrex eye drops is explained by tobramycin. In addition to this, the medication includes the following additional components:

• alkyldimethylbenzylammonium chloride;
• orthoboric and sulfuric acid;
• sodium sulfate;
• sodium chloride;
• tyloxapol;
• water;
• sodium hydroxide.

Overdose and side effects

If you administer an excess amount of medication, rinse your face and eyes with water.
Overdose symptoms are not observed even with simultaneous use or ingestion of a whole bottle of medication. Some patients experienced keratitis, redness of the whites, increased lacrimation, itching and swelling of the upper eyelids. You should rinse your eyes with cold running water or chamomile decoction. Secondary undesirable effects include the following:

• headache;
• discomfort in the eyes;
• pain and cramps;
• protein hyperemia;
• visual disturbances;
• dryness or increased tearing;
• hives;
• rashes.

pharmachologic effect

Tobramycin is an aminoglycoside antibiotic. It has a wide spectrum of antimicrobial activity. The antibiotic disrupts protein biosynthesis and the permeability of the cytoplasmic membrane of bacteria, which causes the death of microorganisms.

The following pathogenic agents are sensitive to it:

• staphylococci;
• streptococci;
• coli;
• Klebsiella;
• hemophilus influenzae;
• Neisseria;
• Pseudomonas aeruginosa;
• enterobacteria;
• proteas;
• Moraxella;
• Acinetobacter.

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How can Tobrex be replaced if necessary?

Let's consider other antibacterial drugs used in the treatment of ophthalmic diseases in newborns.

One of the most popular drugs prescribed to infants for bacterial eye infections for many years is Albucid (sodium sulfacyl). This drug has proven itself in the fight against gram-positive and gram-negative microorganisms. However, over time, there has been a significant increase in bacterial resistance to the action of Albucid. In addition, the drug stings strongly when instilled into the eyes.

Drugs from the floxinalone group, along with aminoglycosides, are used in newborns. Among the diverse range of medicines in this group, Floxal stands out as the most effective. The drug retains its antibacterial effect for 5–6 hours and is used from the first minutes of the baby’s life.

Vitabact antibacterial drops have proven themselves in the treatment of bacterial eye infections in newborns. The drug is often prescribed for dacryocystitis.

Sometimes pediatricians prescribe Ciprofloxacin (Tsiprolet, Tsipromed) to newborns. Bacterial resistance to it develops very slowly, which means it is highly effective.

However, according to the instructions, this group of drugs is contraindicated in children under 1 year of age, so they should be used with caution

Wash the eyes with a cotton pad soaked in the prepared solution in the direction from the outer corner to the inner one.

In addition to antibacterial therapy for infectious eye diseases, washing and removing pus discharged from the eyes plays an important role. The following are used as rinsing agents:

• chamomile decoction or drunken tea;
• furatsilin solution (you can buy ready-made at the pharmacy or dilute it yourself - 1 tablet in half a glass of water);
• In hospitals, boric acid 2-4% is also used to wash the eyes.

Additionally, the doctor may prescribe ointment. When treating newborns, Erythromycin ointment is used.

Indications for use

Eye drops are used for bacterial infections of the eye and its appendages:

• inflammation of the edges of the eyelids;
• conjunctivitis;
• keratoconjunctivitis;
• inflammation of the cornea of ​​the eye;
• blepharoconjunctivitis;
• anterior uveitis.

Tobrex drops are used to prevent infections that may occur after eye surgery.

Indications and contraindications

Instructions for use recommend using drops for conjunctivitis, blepharitis, keratitis, uveitis and other bacterial infections. In children under one year of age, Tobrex 2x is prescribed for the treatment of purulent dacryocystitis. Aminoglycosides can be instilled after surgery or injury to prevent infectious complications. For severe inflammation or allergies due to redness of the eyes, combined ointments with glucocorticoids are effective.

The drug is not used to relieve allergy symptoms.

Antibiotics based on tobramycin are not prescribed for the treatment of viral and allergic diseases. Contraindications also include the following pathologies and conditions:

• intolerance to the components of the drug;
• history of anaphylactic shock or angioedema;
• dehydration;
• severe renal failure;
• pathologies of the vestibulo-cochlear nerve;
• diseases of the auditory and vestibular analyzer;
• myasthenia gravis;
• Parkinson's disease;
• prematurity of children;
• pregnancy;
• elderly age.

Instructions for use

The instructions for use of Tobrex eye drops recommend the selection of an individual course of eye treatment depending on the severity of the infection. If the signs of the disease are not very pronounced, then the medicine should be instilled every 4 hours, 1 or 2 drops into each conjunctival sac.

When the infection is severe, Tobrex drops should be instilled, 2 drops every hour.

The course of therapy, depending on the etiology of the disease, can last from several days to several weeks.

During treatment, the following should be considered:

1. To prevent contamination of the tip of the dropper bottle and eye drops, avoid contact of the medication with the eyelids or periorbital area.

2. After using the drug, the dropper bottle must be tightly closed.

3. If, in addition to Tobrex, other drugs are prescribed in the form of eye drops or ointments, then the time interval between instillations should be 5 minutes. In this case, eye ointment should be added last.

4. If systemic aminoglycosides are prescribed with eye drops, their plasma levels must be monitored to maintain the required systemic concentration of the antibiotic.

5. To ensure that eye drops do not lose their medicinal properties, they must be stored at a temperature of 8-30 degrees for 36 months from the date of release, but after opening the bottle they can only be used for 28 days.

6. If you accidentally drop more medicine into your eyes than necessary, they should be rinsed with plenty of water.

7. If you accidentally take eye drops orally, you should consult a doctor who, if necessary, will prescribe symptomatic treatment.

8. It is not advisable to use contact lenses during therapy. The drug contains benzalkonium chloride, which can change the color of soft contact lenses and cause eye irritation.

9. If the patient does not want to give up wearing lenses, then they must be removed before instilling the medication and reinserted only a quarter of an hour after instillation of the drug.

10. Caution must be exercised when prescribing Tobrex and systemic aminoglycosides simultaneously, as this increases the risk of systemic side effects.

11. When instilling the drug, temporary blurred vision may occur, so drivers and people working in hazardous industries should be careful. They must wait until their vision is fully restored and only then begin their activities.

How safe is it to use the product?

The safety of the drug for the baby’s health is a priority issue for parents

When talking about the safety of using an antimicrobial drug in newborns, we should first of all highlight the possibility of a systemic effect on the baby’s body. As noted above, the insignificant concentration of the active substance in Tobrex drops, as well as compliance with the doctor’s recommendations regarding the duration of use of the drug, minimize the entry of tobramycin into the bloodstream.

Parents of babies under one year old should be very attentive to any unusual manifestations that arise during the treatment process. So, you should immediately stop taking the drug and consult a doctor if you notice the following symptoms:

Individual intolerance to the components of the drug (allergy). Expressed in redness, swelling, burning, itching of the skin and mucous membranes, lacrimation. Stinging in the eyes. Hyperemia of the eyelids. Chemosis is inflammation of the conjunctiva. Deterioration of vision (passing). The appearance of small ulcers on the cornea. Nausea. Cramps. Disorders of the urinary system. Hearing impairment.

Separately, it should be noted that a side effect of long-term use of the drug is superinfection, which appears for several reasons:

acquisition of resistance by pathogens to a certain type of antibiotic due to unreasonably long treatment; immaturity of the immune system of a newborn child; addition of a fungal infection.

An overdose of Tobrex drops is extremely rare. Of course, a large dose of an antibiotic will leave a mark on the immune system of any person: be it an adult or a child. However, an overdose of an antibiotic will not cause tangible and immediate consequences.

When prescribing a drug to a newborn, the doctor must take into account its interaction with other medications that the baby is already taking. Thus, due to the tyloxapol contained in Tobrex, it is incompatible with tetracycline drugs.

Among the direct contraindications to the use of the drug indicated in the instructions are confirmed allergies and hypersensitivity to its components.

Side effects

Tobrex eye drops may cause the following adverse reactions:

• headache;
• lacrimation;
• conjunctival injection;
• allergic and anaphylactic reactions, including nettle fever, rashes, itching, Stevens-Johnson and Lyell syndrome
• eye irritation;
• discomfort, dryness, itching and pain in the eye;
• swelling of the eyelids and conjunctiva;
• dry skin;
• inflammation and erosion of the cornea;
• erythema of the eyelids;
• blurred vision, blurred vision;
• loss of eyelashes and eyebrows;
• leukopathy;
• skin inflammation.

If eye drops are used for a long time, they can cause the growth of microorganisms that are insensitive to the antibiotic. If superinfection develops, another antimicrobial agent should be prescribed.

Severe side effects such as nephrotoxicity, ototoxicity and neurotoxicity develop when the patient receives additional oral tobramycin.

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special instructions

With long-term use of Tobrex, like other antibiotics, excessive growth of resistant microorganisms, including fungi, is possible. If superinfection occurs, adequate treatment should be prescribed.

Patients using contact lenses should remove them before using the drug and put them back no earlier than 15 minutes after the procedure.

The bottle with drops and the tube with ointment must be closed after each use.

In the event of a temporary decrease in vision clarity, it is not recommended to drive a car or engage in other activities associated with increased concentration until normal eye function is restored.

Analogs

Complete analogues of Tobrex drops are available for sale:

1. Tobrex 2x. The medicine is available in the form of eye drops, which differ from Tobrex in the composition of the auxiliary components, which allows them to be used in case of mild infection, 1 drop twice a day, and in severe cases, 1 drop four times a day. As additional ingredients, the drug contains: mannitol, tween, boric and sulfuric acid, xanthan, caustic soda, water, trometamol, benzododecinium bromide. In addition, the shelf life of the medication is 24 months, and after opening the bottle, the drug can only be used for 4 weeks. And the medicine should be stored at temperatures up to +5 to +25 degrees.
2. Tobrosopt. This is a Polish medicine that is available in the form of eye drops. They also contain tobramycin as the main component. But the drug differs from Tobrex in the composition of auxiliary ingredients. Tobrosopt is recommended for bacterial eye infections in children over 2 months of age. In case of individual intolerance, they can cause allergies, which are manifested by swelling, tingling, redness of the conjunctiva. In case of an overdose of the drug, it can provoke punctate keratitis, itching of the eyelids, lacrimation, redness of the conjunctiva. If these signs appear, it is recommended to immediately rinse the eyes with saline solution. Eye drops should be stored at temperatures up to 25 degrees for 24 months. Once the bottle is opened, they must be used within 4 weeks.
3. Tobriss. This is an Indian remedy that comes in eye drops. They differ from Tobrex in the composition of inactive components. Tobriss can be used in children older than 2 months for bacterial eye infections. The Indian drug must be stored at a temperature not exceeding 30 degrees for 24 months, but after opening the bottle, the drops are good for 30 days.

In addition, partial analogues of the drug Tobrex, such as Tobradex, are commercially available. The medication is available in eye drops that, in addition to tobramycin, contain the glucocorticosteroid dexamethasone.

HSC relieves inflammation and signs of allergy and has a desensitizing effect. Due to dexamethasone, Tobradex, unlike Tobrex, has more contraindications and adverse reactions.

It should not be used in children under 12 years of age or in women who are breastfeeding.

They are contraindicated in the following pathologies:

• allergy to the composition of the medicine;
• viral, mycobacterial, fungal eye infections;
• condition after removal of a foreign object from the cornea.

During pregnancy they can be used with caution.

They can provoke the following undesirable reactions:

• pain, irritation, dryness and discomfort in the eyes;
• allergy;
• glaucoma;
• keratitis;
• redness and swelling of the conjunctiva;
• sensation of a foreign object in the eyes;
• blurred vision;
• swelling of the eyelids;
• itching and erythema of the eyelids;
• cataract;
• pupil dilation;
• photophobia;
• headache;
• runny nose;
• laryngospasm;
• dysgeusia;
• slower wound healing;
• fungal diseases of the cornea.

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If the therapeutic dosage of the medication is exceeded, it can cause swelling of the eyelids and their redness, precise keratitis, redness of the conjunctiva, and lacrimation. In case of overdose, you need to rinse your eyes and, if necessary, use symptomatic therapy.

Tobradex should be stored at a temperature of +8-+27 degrees for 24 months from the date of release. After opening the bottle, the medicine can also only be used for 4 weeks, like Tobrex drops.

Release form

Tobrex is available in the form of drops, as well as an ointment - it should be white or cream in color. The ointment is applied to the inner surface of the eyelid in the form of a strip. Due to its thick texture, the drug retains its bactericidal effect longer, however, this form is used mainly for adults. A combination of ointment and drops is possible.

Tobrex drops are produced in plastic dropper bottles with a volume of 5 ml. This amount of solution is quite enough for a course of treatment. The solution is transparent and may have a slightly yellowish tint. In addition to tobramycin, the solution contains excipients: boric acid, sodium sulfate, sodium hydroxide, etc.

Tobrex 2X drops are also on sale. This drug is almost the same in composition as its analogue, but has a thicker consistency. This is due to the presence of xanth gum among the ingredients of the drug. Thanks to this component, the medication stays in the conjunctival sac longer and has time to work more effectively. In this case, the dose of Tobrex 2X drops should be reduced by 2 times compared to regular Tobrex.

Reviews

Angela, Moscow.

The doctor prescribed Tobrex drops for his son for conjunctivitis. They are packaged in a convenient 5 ml plastic bottle with a Drop-Tayner® dispenser, thanks to which it is possible to accurately dose the medicine. Conveniently, the drops do not need to be stored in the refrigerator and their shelf life after opening the bottle is 4 weeks. I also liked that the drug does not burn the eyes. Even if conjunctivitis is only in one eye, the medicine must be instilled into both eyes. It is also important to complete the course of treatment to the end, otherwise microorganisms will appear that are resistant to the drug and the disease may return again. My son had no unwanted reactions, the drops helped quickly.

Lyudmila, Kazan.

My daughter had an inflamed eyelid, and the doctor prescribed Tobrex drops for her, but unfortunately they did not work for us. We took them for 4 days and the eye became very swollen, inflamed and closed completely. In addition, the drug caused discomfort to the child; when instilled, the daughter felt a strong burning sensation. After 4 days we stopped using the drops and the swelling gradually subsided. The doctor prescribed another medication.

Anastasia, Veliky Novgorod.

Tobrex eye drops are a prescription drug and should not be self-medicated.

Tobrex for runny nose

Sometimes pediatricians recommend putting eye drops into the nose. This is due to the fact that these drugs dry out the mucous membrane that lines the nasal passages. Most often, Tobrex (or analogues) is prescribed if a child has green snot and a runny nose that does not go away for more than 7 days. As a rule, sinusitis, sinusitis, and sinusitis are treated in this way. This rhinitis is bacterial in nature, and topical antibiotics are ideal to combat it.

However, to achieve maximum effect, before instilling Tobrex into your nose, you should rinse your nasal passages with saline solution. Then clear the nose of mucus using an aspirator if the baby cannot blow his nose on his own.

Drug price

The average price of Tobrex is 270 rubles.

ATTENTION! The information posted on our website is for reference or popular information and is provided to a wide range of readers for discussion. Prescription of medications should be carried out only by a qualified specialist, based on the medical history and diagnostic results

Problems with the health of children's eyes are a common cause of concern for young mothers. The modern range of medicines for the fight against eye diseases is represented by many drugs, but when it comes to treating newborn children, the list of drugs is greatly reduced. Not every drug can cope with the problem; often young mothers, under the supervision of a doctor, have to search for a suitable drug for months using a “brute force” method.

Very often, pediatricians prescribe Tobrex to children, an antibiotic that has proven its effectiveness in the fight against ophthalmological diseases. The peculiarities of its use in newborns should be known to every modern mother who is faced with inflammatory eye diseases in her baby.

Description of the drug Tobrex: group of drugs, active ingredient

Tobrex drops - a broad-spectrum antibiotic

The drug Tobrex is an antibacterial drug (antibiotic) from the group of aminoglycosides. The active component that provides the highly effective therapeutic effect of the drug is tobramycin. Its action is based on inhibiting the production of protein by pathogenic bacteria, which leads to their complete disappearance.

However, Tobrex is not able to affect all types of pathogens: if the eye disease is caused by anaerobic bacteria or chlamydia, the drug will be powerless. The drug is weakly effective in the fight against enterococci.

Tobrex has proven itself best in the treatment of ophthalmic diseases caused by the proliferation of the following harmful bacteria:

streptococcus; staphylococcus; Klebsiella; enterobacter; coli; Pseudomonas aeruginosa.

The local action of the antibiotic ensures its complete excretion in the urine unchanged, so the overall effect on the body is minimal. The proportion of the active substance in the drug is small: 1 milliliter of solution contains 3 milligrams of tobramycin. All this, as well as prescribing a course of treatment that is appropriate for the child’s age, allows the drug to be used from the first days of the baby’s life.

Tobrex for conjunctivitis

Tobrex is used to treat bacterial conjunctivitis, i.e. caused by bacterial flora and not viruses, because Antibiotics have no effect on viruses, and other medications are prescribed to treat viral conjunctivitis.

Against the background of viral conjunctivitis, a bacterial infection can also occur - such conjunctivitis can be treated with Tobrex in combination with other drugs.

Other medications are also used to treat allergic conjunctivitis; Tobrex is ineffective in these cases.

Therefore, it is not recommended to self-medicate for conjunctivitis, because Only a doctor can determine the cause.

The doctor determines both the dose (frequency of instillation) and the duration of the course of treatment.

More about conjunctivitis