Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Simethicone is a chemically inert substance with surface activity and antifoaming effect. In the intestinal lumen it acts as an antifoam: it reduces the tension of gas bubbles. The released gases are absorbed by the intestinal walls, and some are excreted naturally due to intestinal peristalsis. Simethicone acts on the surface of gas bubbles without affecting the mucous membrane and without being absorbed. By removing bubbles, digestion and absorption of nutrients are normalized. Use before ultrasound and x-ray examinations prevents the occurrence of artifacts that cause gas bubbles. Does not contain sugar, so it can be used for diabetes .
Pharmacokinetics
Not absorbed in the intestines, excreted unchanged.
Indications and contraindications
Espumisan is sold without a doctor's prescription. However, before giving it to a newborn baby, you should consult a specialist . You should not give medicine to your baby without reason or in large quantities. "Espumizan Baby" is indicated for adults and children in a number of cases listed below:
- The newborn is capricious and cries when the tummy is touched.
- A child or adult exhibits signs of gas accumulation in the gastrointestinal tract.
- Increased gas formation is observed, which is associated with functional dyspepsia.
- Acute poisoning with shampoo, dishwashing detergent and other substances that contain foaming components.
In addition, you should take the medicine before undergoing diagnostic tests in the abdominal area. Due to this, the ultrasound image is clearer, so the diagnostic result is considered more correct.
The medicine is contraindicated if a person has an individual intolerance to the components included in its composition. Espumisan should also be avoided in case of intestinal obstruction , as well as inherited fructose intolerance. For children under six years of age, only Espumisan Baby is suitable, and Espumisan El can be given to older children.
Both drugs are suitable for use during pregnancy and lactation. Side effects of the drug may occur in people with hypersensitivity to its components. In this case, an allergy is possible. If any allergic reaction occurs, you should immediately consult a doctor. Medical diagnosis is also necessary if the baby’s colic does not go away within 3-4 days.
An overdose of Espumisan is impossible, since the simethicone contained in it is chemically inert.
Indications for use
- treatment of flatulence of any origin (including in the postoperative period);
- functional dyspepsia ;
- aerophagia;
- intoxication with surfactants (as an antifoam).
Indications for use also include the use of the drug in preparation for diagnostic studies (ultrasound, X-ray examination of the gastrointestinal tract, gastroscopy).
Espumisan tablets, instructions for use (Method and dosage)
How to take Espumisan? To eliminate flatulence, adults and children over 6 years old - 2 capsules 3-5 times a day after meals with a small amount of liquid. To prepare for diagnostic tests - 2 capsules three times the day before the test and 2 capsules on the day of the test, without drinking water. In case of poisoning with detergents with foaming agents - 10-20 capsules in one dose for adults, children over 6 years old - 3-10 capsules. The instructions for use of Espumisan contain information that the drug can be taken for a long time, since it is chemically inert and does not cause adverse reactions.
For adults, tablets are a more acceptable form of release because they are convenient to take at work or in public places. It is more difficult to give tablets or capsules to children, not to mention the fact that this is generally impossible for newborns. There is an emulsion for them. Children are given Espumisan 40 - an emulsion in 100 ml bottles with a measuring spoon or Espumisan L in bottles with a dropper. Infants - 25 drops added to a bottle or given from a spoon after breastfeeding three times a day. Children from 1 to 6 years old - 25 drops 3-5 times a day, older children - 30-50 drops 3-5 times. Shake the bottle before use.
Release form and composition
The dosage form of Espumisan L is an emulsion for oral administration: white, with the smell of banana (in dark glass bottles of 30 ml with a dropper dispenser and a measuring cap included, 1 set in a cardboard box).
Composition of 1 ml emulsion:
- active substance: simethicone – 0.04 g;
- auxiliary components: purified water – 0.778 245 g; sorbic acid – 0.001 060 g; sodium hydroxide – 0.000 708 g; sodium citrate – 0.004 445 g; sodium chloride – 0.000 708 g; liquid sorbitol – 0.211 655 g; acesulfame potassium – 0.000 318 g; banana flavoring – 0.004 233 g; carbomer – 0.006 35 g; glyceryl monostearate 40-55 – 0.004 02 g; macrogol stearate – 0.006 56 g.
Espumisan's analogs
Level 4 ATC code matches:
Disflatil
Mint tablets
Kuplaton
Espumisan Baby
Espumisan L
Espumisan 40
Bobotik
Dill water
Pepsan-R
Sub Simplex
Infacol
Plantex
Bebinos
Dicetel
Meteospasmil
Romazulan
What can replace this drug if it is temporarily unavailable in the pharmacy? You will be offered similar drugs: Bobotik , Sab Simplex , Meteospasmil , Disflatil , Simikol , Bebicalm . These substitutes, except for Bebicalm, have the same active ingredient, but in different doses.
What is the price of analogues? 30 capsules of Meteospasmil can be purchased for 408-580 rubles. Disflatil and Simikol are currently not available in pharmacies. Cheap analogues of Espumisan: Bobotik and Sub Simlex 30 ml costing 222-274 rubles.
As you can see, this is not the only drug that eliminates increased gas formation in the intestines. Which drug should you prefer?
What is better Espumisan or Bobotik?
The drug Bobotik contains the same active ingredient. The peculiarity of drugs based on simethicone is that they do not affect the functioning of the gastrointestinal tract, are not absorbed and are excreted unchanged. In the case of prolonged colic in children, the best solution is drugs based on this. The above products differ in the content of the active substance in 1 ml - 66 mg (Bobotik) and 40 mg (Espumizan), based on this, the effectiveness of the first is greater. It is also convenient in dosage - 8 drops per dose is enough for a baby. Does not contain sugar. Manufacturer: Medana FARMA, Poland.
What is better Espumisan or Sub Simplex?
Sab Simplex is also a product based on simethicone. Judging by the dosage (1 ml of this drug contains 69.19 mg of simethicone), it can be assumed that the effectiveness will be higher. A convenient bottle with a dropper allows you to accurately count 1 dose for an infant - 15 drops. What does Sub Simplex help with? Eliminates infant colic during the period of adaptation to new food. To achieve the effect, it is better to use it at the time of pain. Since the drug does not cause side effects, it can be used almost constantly as long as it is needed. Does not contain dyes, can be used during pregnancy. From a well-known manufacturer - Pfizer Inc., USA.
Meteospasmil or Espumisan - which is better?
Meteospasmil is a combination drug containing not only simethicone, but also the myotropic antispasmodic alverine , which reduces the tone of the intestinal muscles. Therefore, it eliminates belching, nausea, colic and abdominal pain associated with increased gas formation. Taking this into account, and also taking into account that the content of simethicone in 1 capsule is much higher (300 mg), we can conclude that this drug is more effective. However, it can only be used by adults and for no more than 4 weeks; allergic reactions are possible; it is not recommended for use during pregnancy. Manufacturer: Laboratoires MAYOLY-SPINDLER (France).
What is better Espumisan or Bebicalm?
Babycalm is a dietary supplement consisting of essential oils: anise, dill, mint. Designed for children from the first days of life. It has a carminative, antispasmodic, sedative, and antibacterial effect. As you can see, the composition is different. The emulsion should be prepared by yourself by adding boiled water to 15 ml of a mixture of essential oils up to the mark indicated on the bottle, and store it in the refrigerator. The kit includes a pipette dispenser. Children of the first year of life are given 10 drops from a spoon before each feeding (even if there are 10 or more). The emulsion should not be added to a bottle with the formula, as the child may refuse to eat due to the pronounced odor. You should start with 2-3 drops and monitor the child’s condition. The summary contains warnings that rash and itching may occur. Reviews about this dietary supplement are different: some help, others consider it useless. From the reviews we can conclude that the drug must be given for a long time (a month), even if the colic and bloating have stopped. In this case, drops are not given at every feeding.
Espumisan during pregnancy
Can pregnant women use this drug? The instructions provide for the use of the drug by pregnant and lactating women. The drug is non-toxic, safe and can be used at any stage of pregnancy, since the active substance does not have a systemic effect. The dosage and frequency of administration do not differ from the general recommendations for administration - to combat flatulence, take 2 capsules 4-5 times a day. Practice shows that the drug is well tolerated and no negative effects are noted. If you are still concerned about the presence of dyes in the capsules, and you are prone to allergic reactions, use traditional medicine (decoction of dill and fennel seeds).
Notes
- Colic Medication. Prashant G Deshpande, MD; et.al.
- COLIC MYTHS AND FACTS
- Wade S., Kilgour T.
Infantile colic: Clinical Review (English) // BMJ: journal. - 2001. - Vol. 323. - P. 437. - doi:10.1136/bmj.323.7310.437. - Infantile colic: a systematic review of medical and conventional therapies. Hall B, Chesters J, Robinson A. J Paediatr Child Health. 2012 Feb;48(2):128-37. doi: 10.1111/j.1440-1754.2011.02061.x. Epub 2011 Apr 7. Review. PMID 21470331
Reviews about Espumisan
The well-known drug Espumisan helps with bloating, since it is constantly advertised. Reviews about Espumisan are mostly positive and this is justified. First of all, it is used to treat flatulence of any etiology, it acts only in the intestines and is not absorbed, it can be used for a long time, can be combined with other drugs and is suitable for the whole family. For some it helps more, for others less, but this depends on the severity of flatulence and its causes (dysbiosis and chronic gastrointestinal diseases or simply flatulence of alimentary origin after eating grapes or cabbage). If taking the drug does not help, you need to be examined by a gastroenterologist to find out the cause of flatulence. Some claim that the drug is effective the first two weeks from the start of treatment.
Espumisan price, where to buy
You can buy the drug in Russian cities at any pharmacy. The cost of the drug in capsules and drops differs slightly. The price of Espumisan in tablets (capsules) 40 mg No. 50 ranges from 370 rubles. up to 442 rub. Considering that the recommended dose is 6-8 capsules per day, then one package will last on average for a week. How much does Espumisan cost in emulsion? The cost of a 100 ml bottle is 385 - 711 rubles. With the recommended intake of 30 ml per day, the drug will be enough for 3-4 days. You can easily purchase the drug in Ukraine. The cost of the drug in capsules is practically the same in pharmacies in different cities: Kharkov (114-131 UAH), Dnepropetrovsk (115-143 UAH), Kyiv (120-152 UAH)
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Espumisan Extra granules 125 mg sachet 14 pcs. Hermes Pharma Ges.m.b.H.
RUB 323 order - Espumisan Baby drops for internal use. approx. 100mg/ml vial. 50mlBerlin-Chemie AG
RUR 556 order
- Espumisan Baby drops for internal use. approx. 100mg/ml 30mlBerlin-Chemie AG
RUB 423 order
- Espumisan capsules 40 mg 50 pcs. Catalent Germany Eberbach GmbH/Berlin-Chemie AG.
RUR 454 order
- Espumisan capsules 40 mg 25 pcs. Catalent Germany Eberbach GmbH/Berlin-Chemie AG.
RUB 284 order
Pharmacy Dialogue
- Espumisan Extra granules 125ml No. 14Hermes
RUB 353 order
- Espumisan Baby drops 100mg/ml 50mlBerlin-Chemie AG/Menarini
RUB 588 order
- Espumisan (caps. 40 mg No. 50)Berlin-Chemie AG/Menarini
RUR 548 order
- Espumisan Baby (drops 100 mg/ml fl. 30 ml) Berlin-Chemie AG/Menarini
RUR 454 order
- Espumisan (caps. 40 mg No. 25)Berlin-Chemie AG/Menarini
320 rub. order
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Pharmacy24
- Espumisan L 40 mg/ml 30ml emulsion
111 UAH. order - Espumisan N50 capsules R.P.Scherer GmbH & Co. KG/Berlin Chemie AG (Menarini Group), Nimecchina/Nimecchina
150 UAH order
- Espumisan No. 25 capsules Berlin Chemi AG, Nimechchina
88 UAH order
PaniPharmacy
- Espumisan capsule Espumisan caps. 40 mg No. 25 Germany, Berlin-Chemie
98 UAH order
- Espumisan capsule Espumisan caps. 40 mg No. 50 Germany, Berlin-Chemie
171 UAH order
- Espumisan L liquid Espumisan L emul. 40mg/ml 30ml Germany, Berlin-Chemie
130 UAH order
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What is the difference between “Espumizan El” and “Baby”
In pharmacies you can find “Espumizan El” in the form of syrup, which is also prescribed by doctors for intestinal colic in babies.
What is the difference between them? They differ in dosage, composition, and cost. So, in “Espumizan El” there are 40 mg of simethicone in 25 drops of solution, and in “Espumizan Baby” - 100. Therefore, a special children’s drug removes gases from the intestines faster. However, it must be borne in mind that such a substance cannot be used for more than a month after opening . At the same time, “Espumizan El” is usable for six months. "Espumizan Baby" costs about 40% more.