Mechanisms of development and symptoms of measles in children and adults


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A visual guide to diseases.

Since the beginning of 2021, more than 5,000 people have contracted measles, according to the Ministry of Health. It's no wonder that people panic when they see a rash on themselves or their children, reports lifter

Of course, not every skin rash is a sign of measles. For example, in the USSR there was a diagnosis of “measles rubella” - this non-existent medical term denoted various viral exanthemas (that is, rashes of infectious origin).

Causes of the disease

The etiology of measles is well studied. The disease is caused by an RNA virus belonging to the group of large myxoviruses. It first received its description in 1954. Four years later, Russian researchers under the leadership of Anatoly Aleksandrovich Smorodintsev isolated the virus from the nasopharynx and blood of sick people.

This marked the beginning of scientific work to create a vaccine in our country. Thanks to vaccination, the incidence rate has dropped sharply. Vaccinations and antibiotic therapy have made measles curable.

The measles virus has the appearance of an irregular sphere with a diameter of 120 to 250 nm. It has a complex antigenic structure. The stability of the virion in the external environment is low. The pathogen is sensitive to ultraviolet and visible light. In droplets of saliva on which the sun shines, it dies within half an hour. When it dries out, it dies instantly.

The virus can be isolated from the blood or swabs from the nasopharynx of sick people during the catarrhal period and in the first hours of the rash phase. Weakened strains are used to create measles vaccine.

After the first vaccination, 85% of children develop immunity. To ensure 100% immunization, revaccination is carried out.

You cannot get measles twice. If a person has been ill, antibodies are produced to the pathogen. They last a lifetime.

Routes of infection

Measles is an anthroponotic pathology (the source of infection is exclusively a sick person). Susceptibility is almost 100%. The only ones who have protection against the measles virus are newborn babies who have received antibodies from their mother. Provided that the mother had measles before pregnancy or was vaccinated. Until the age of three months, the baby will not get sick, having innate immunity.

By 6–10 months of age, children can become infected and develop measles. Those babies to whom antibodies were not transmitted (the mother was not sick or was not vaccinated) are susceptible to infection from birth. Infection of the fetus during the antenatal period (pregnancy) is possible.

The main route of transmission of the disease is airborne droplets. The infectiousness of the patient begins from the last days of the incubation period, persisting in the catarrhal period and with the appearance of a rash. From the fifth day from the onset of the rash, the child is considered non-infectious.

The virus spreads when someone who is sick sneezes, talks, or coughs. The method of transmission through things or third parties is practically excluded, since virions quickly die outside the human body. However, there have been cases where the measles pathogen could be transferred over significant distances within the same building through the ventilation system.

Therefore, if a carrier of infection is in a kindergarten, he can infect children not only from his group.

The pathogenesis of measles consists of stages:

  • fixation of the virus at the entrance gate (mucous membranes of the upper respiratory system);
  • spread of virions into the submucosal layer and further into the lymphatic system;
  • reproduction in lymph nodes;
  • entry into the bloodstream;
  • damage to various organs (spleen, liver, tonsils, gastrointestinal tract, bone marrow, etc.
    );
  • an increase in viral intoxication, skin damage in the form of characteristic rashes, a weakening of the body’s defenses;
  • the occurrence of complications.

The main pathogenetic mechanism is damage to all lymphoid tissue. Bacterial infections often occur against the background of reduced immunity.

Historical fact! Before medicine had antibiotics, measles was known as the “baby plague.” It claimed millions of lives.

In his video, Dr. Komarovsky talks in detail about this disease:

How does measles manifest in children under one year of age?

  • Up to three months, infants do not get measles, as they receive innate immunity from their mother.
  • Up to six months, the likelihood of getting sick in infants is small for the same reason. When breastfeeding, natural immunity lasts longer.
  • In a child under one year old, measles often develops atypically, with mild symptoms. In this case, the temperature rises slightly, catarrhal signs and spots in the mouth may be absent. The rash appears all over the body at once and disappears much faster.
  • The mild form that affects young children does not exclude the development of adverse consequences in them.

Stages of the disease

There are 4 stages of measles:

  1. incubation period;
  2. catarrhal stage;
  3. rashes;
  4. pigmentation.

The onset of the disease is acute. A number of authors consider the catarrhal period to be prodromal. Its duration is on average 3–4 days, with possible deviations from one day to a week.

The early stage of the disease is manifested by two syndromes - intoxication and catarrhal.

Then follows the stage of rashes. Its duration does not exceed 3–4 days. The extent of clinical manifestations will depend on the severity of the disease. With a smooth course of the disease, the pigmentation stage will be a recovery.

The state of immunosuppression (measles anergy) can persist for 3–4 weeks or longer. How long the decline in immunity lasts depends on the individual characteristics of the child. At this time, the risk of developing a bacterial or fungal infection is very high.

The classification of measles is as follows:

  • by severity: mild, moderate and severe;
  • by typicality: typical and atypical;
  • downstream: smooth and non-smooth.

Most often, the disease typically occurs in mild or moderate form. If there are no complications, it will last no more than ten days. By the end of the disease, persistent post-infectious immunity will begin to form.

The percentage of atypical forms is low (no more than 5–7%). These include: abortive, erased, asymptomatic, mitigated, hypertoxic and hemorrhagic. The last two variants are observed in adolescents with weak immune systems and adults. They are severe and can be fatal.

Symptoms of the disease

Typical measles in children has characteristic symptoms. It starts off sharp.

Stage 1

Signs of intoxication and catarrhal inflammation appear. Initial symptoms include a dry, annoying cough, nasal congestion, sometimes with moderate mucus discharge.

The temperature rises within the subfebrile range. On the first day of illness, local manifestations will be scanty: slight redness and looseness of the oropharyngeal mucosa.

Stage 2

On the second or third day of the catarrhal period, the signs of measles become more pronounced. The cough intensifies and can be sharp and rough. Conjunctivitis begins to appear. Swelling of the eyelids, hyperemia, and photophobia are observed. Quite large spots of dark red color are visible on the soft palate. The cheek mucosa is swollen, hyperemic, loose.

Stage 3

1–2 days before the onset of the rash, Belsky–Filatov–Koplik spots can be seen. This symptom is specific to measles. If the child opens his mouth, characteristic small whitish dots bordered by a red rim will appear in the area of ​​the small molars, on the cheeks, gums and inner surface of the lips.

These spots do not merge. They look like pimples and are areas of dead epithelium. Often their appearance is accompanied by a grayish coating on the gums and tongue. Gastrointestinal dysfunction may develop due to the introduction of the virus into the intestinal mucosa.

Stage 4

Symptoms of intoxication in the catarrhal phase will be moderate or mild. Body temperature does not rise above 38°C, less often - 39°C. A sick child experiences malaise, weakness, loss of appetite, and headaches. If early complications develop, the baby’s well-being will be significantly worse. By the end of the catarrhal period, the child has a characteristic appearance: a puffy face, swollen eyelids, tears in the eyes, snot flowing from the nose.

Stage 5

On the fourth or fifth day of illness, a rash begins. Changes in the oral cavity persist. The patient is bothered by a runny nose. The cough becomes more frequent, sometimes painful. The throat becomes sore. Hoarseness may occur due to damage to the larynx. In children of the younger age group, especially infants, dyspeptic disorders are possible.

Intoxication increases. The thermometer shows high values ​​(from 38.5 to 40°C). There may be severe headache, delirium, vomiting, increased heart rate, decreased blood pressure and other symptoms. Lymphadenopathy is observed.

The exanthema will appear within 3–4 days, strictly in stages. The transformation into pigmentation will be just as consistent. The first elements of the rash appear behind the ears and on the nose. Then they spread to the chin, neck, and upper shoulder girdle. On the second day, the exanthema covers the skin of the torso, and on the third - the upper and lower extremities. The rashes are initially spotty, then they grow, merge and become maculopapular.

Stage 6

After 2–3 days from the appearance of the first elements of the rash, the period of pigmentation begins. Pigmented areas appear in the same sequence: head, body, limbs. You can observe the following picture: pigmentation is visible on the face and upper body, and a bright rash is visible on the arms and legs. This distinctive feature of the rash helps in making a differential diagnosis.

Stage 7

With a smooth course of the disease, the pigmented elements will gradually disappear.

By the seventh to ninth day, the symptoms of catarrhal symptoms will disappear. In severe forms and the addition of a secondary infection, the duration of the disease will increase. This will not be a smooth course of measles. The nature of the symptoms will depend on the location and etiology of the complications.

Important! If your child shows any symptoms of the disease, you should contact your pediatrician. The doctor will make a diagnosis and explain to the parents what to do and how to treat the baby.

Atypical forms

Atypical forms that occur easily include:

  • Abortive (cut off) begins typically. On the first or second day the rashes stop. The rash is small, single, and does not affect the limbs. Body temperature rises slightly on the first day of the rash or remains normal.
  • Mitigated disease is even milder and does not have the characteristics of measles.
  • Erased.
  • Asymptomatic.

Such variants of the disease develop in children who received gammaglobulin or blood products during the incubation period. In isolated cases, atypical measles will be detected in those who have undergone active immunization or without objective reasons.

Hypertoxic and hemorrhagic forms are extremely rare. The first option is characterized by severe intoxication. The temperature rises to high levels and can last for several days. Symptoms of acute cardiovascular failure (shortness of breath, tachycardia, cyanosis of the nasolabial triangle, etc.) and meningoencephalitis (impaired sensitivity, severe headaches, etc.) appear.

In the hemorrhagic variant of the disease, against the background of general intoxication, numerous hemorrhages are observed in the epidermis, mucous membranes and internal organs.

Blood is present in stool and urine. The prognosis is unfavorable, the patient's death is possible.

Possible complications

What's scary about measles is its complications. Russian scientists have proven that the measles virus leads to the suppression of local and general immunity. Against this background, pathogenic and opportunistic flora begin to attack the weakened body.

More often, complications arise and are severe in young children, as they are very susceptible to bacterial infections. The baby is at risk:

  • with malnutrition;
  • with a lack of vitamins and microelements, in particular patients with rickets;
  • having chronic foci of infection and various somatic diseases;
  • bottle-fed infant.

Complications of measles are classified depending on:

  1. origin: own and secondary;
  2. terms of development: early and late;
  3. the organ that is affected (heart, lungs, eyes, brain, etc.).

Internal measles complications (otitis, laryngitis, bronchitis, pneumonia, diarrhea) will appear in parallel with the main clinical signs and weaken along with them. The exception is measles encephalitis. It develops on the third to fifth day after the first rash.

Encephalitis and meningoencephalitis are extremely rare. Inflammation of the brain can occur with any form of the disease. More often it is diagnosed in severe cases and in adult patients. Deaths with encephalitis reach 25%. During recovery, residual effects may persist (paresis, memory loss, dementia, etc.).

Secondary complications can occur during any period of the disease. Their consequences can be deadly. When they develop in the early stages, they are difficult, aggravating the course of measles. The occurrence of late complications is indicated by the persistence of temperature after the onset of the period of pigmentation or its new rise.

Secondary complications from the respiratory system often manifest themselves as laryngitis and pneumonia. Bacteria that cause inflammatory processes in the lungs: pneumococcus, streptococcus, staphylococcus, mycobacterium tuberculosis.

Disturbances in the digestive system are often manifested by various stomatitis. A number of pathogens can cause intestinal inflammation (salmonella, shigella, staphylococcus, etc.). The clinical picture will depend on the characteristics of the microorganism.

The eyes, inner ear, skin, urinary system and other organs may be affected. If the etiological factor is identified in time and antibacterial therapy is started, the risk of negative consequences is reduced.

Important! If complications occur, the patient should be examined by a doctor. For emergency indications, hospitalization and treatment in a hospital are performed.

Diagnostics

A doctor must diagnose the disease. Sometimes parents, after looking at a photo on the Internet of what a child with measles looks like, draw the wrong conclusions. They may confuse this pathology with other diseases. Incorrect diagnosis and erroneous treatment can lead to death.

Clinical and epidemiological data and laboratory tests are important for diagnosing measles.

The latter include:

  • blood analysis;
  • virus isolation by immunofluorescence;
  • determination of antibody titer in the blood (immunoglobulins M and G);
  • cytological examination (morphology) of a nasal smear or sputum.

An antibody test allows you to distinguish measles from other pathologies and determine the stage of the disease. Antibodies of class M are responsible for acute measles infection, IgG indicate a previous illness or that the person has been vaccinated. A general blood test will show a low level of white blood cells.

Differential diagnosis is carried out with the following diseases: colds, ARVI, allergies, urticaria, infectious mononucleosis, scarlet fever, rubella, chickenpox and other pathological conditions.

During the catarrhal period, measles should be recognized among other infections that are caused by a virus (influenza, parainfluenza, adenovirus or rhinovirus infection). During the period of rashes, a false diagnosis can be made, without distinguishing measles rash from enteroviral exanthema, drug-induced disease or scarlet fever.

The following features of the rash will help determine whether it is measles or allergies: elements of an allergic rash will appear first on one part of the body, then on another, changing their shape. They will be varied (spots, pimples, blisters, papules). They may hurt and itch. Itchy skin almost always accompanies allergies.

When to see a doctor

Measles (symptoms in adults, a photo of which shows rashes on the skin and mucous membranes, every medical worker must know and keep in mind) can be diagnosed by a general practitioner, but consultation with an infectious disease specialist and laboratory tests may be required if it proceeds atypically.

The disease begins abruptly, and if the temperature exceeds 39 ºС and the symptoms of intoxication are very pronounced, a doctor is called to the house, especially if there is a suspicion of contact with a person with measles. In the typical course of the disease, treatment can be done at home.

The exception is for patients whose isolation is difficult to ensure - for example, those who stay in closed groups (military units, orphanages and boarding schools), as well as when adequate care is impossible and poor living conditions. Hospitalization of such patients occurs according to epidemiological indications, regardless of the severity of measles.

Patients with immunodeficiencies, severe (hypertoxic or hemorrhagic measles) or complicated course of the disease, and pregnant women are subject to mandatory hospitalization for measles. Even if treatment is carried out at home, medical supervision is required to prevent or timely monitor complications.

Treatment methods

In the treatment of patients with measles, an important place is occupied by the creation of conditions that exclude secondary infection and the development of complications. If the patient cannot be isolated or there is a severe form of the disease, the child will be in the hospital.

If the baby is at home, you need to minimize his contact with other people. It is important to provide proper care. Strictly monitor the hygiene of the patient and the room in which he will live during his illness.

At home, you should constantly wash your baby’s hands and face with baby soap, rinse your eyes with clean boiled water, and clean your mouth after eating (give babies more fluids to drink). During a fever, you should not break bed rest and swim. Nutrition should be complete and gentle.

There is no specific treatment for measles. Measles immunoglobulin can be given during the incubation period only to unvaccinated people with confirmed contact with a sick person.

Drug therapy is used depending on symptoms and complications. The doctor makes the appointments. He decides which product, how much and how often to use.

Important! Each medicine has its own contraindications, so any drug cannot be given (administered) without a doctor’s recommendation. This may harm the baby. For example, aspirin should not be used to treat measles.

  • At high body temperatures, antipyretics are used (paracetamol, Nurofen, etc.). For purulent conjunctivitis, a 20% solution of sodium sulfacyl and similar drugs are dripped into the eyes. Do rinsing with strong tea or baking soda. It is recommended to treat the skin with synthetic tannin (Delaskin).
  • Nasal congestion is eliminated using a 2% solution of protargol or vasoconstrictor drops. For purulent discharge, anti-inflammatory antibacterial ointments can be applied and physiotherapy can be performed. An obsessive cough can be cured using herbal decoctions and special mixtures.
  • Bacterial complications should be treated with antibiotics. The doctor writes out a diagram indicating the drugs and their doses. Infants are prescribed medicine in the form of drops or suspension. Adult children are prescribed tablets.
  • If there are sores on the skin, they need to be smeared with antiseptics and antimicrobials. Treatment of mucous membranes is carried out very carefully, especially in young children. The sooner antibacterial therapy begins, the greater the chance that the complication will be completely cured.
  • Together with antibiotics, immunostimulants, vitamins (especially C and A), and antiviral drugs are used. It is possible to prescribe physiotherapeutic methods.

Traditional medicine for measles

  • After eating, it is useful to gargle and gargle with chamomile decoction. This will help avoid such an unpleasant complication as stomatitis and speed up the healing of spots on the palate. To prepare chamomile infusion, pour boiling water over a tablespoon of dried flowers and heat for 10 minutes. in a water bath.
  • Linden decoction, dry raspberry tea, and cranberry juice have antipyretic properties.
  • A warm bath (34-35 °C) with the addition of bran will help relieve peeling after a rash. You should take this bath for no more than 10 minutes.

Prevention

Nowadays, vaccination is considered the main preventive measure. A live measles vaccine (LMV) has been developed, which, along with Pentaxim (an analogue of DPT), is included in the vaccination table in accordance with the relevant order. The measles vaccination is given at one year of age.

There is no side effect in the form of a local reaction to the administration of the drug. A general vaccination reaction occurs in 10–13% of children as a short-term infectious process (mitigated measles). There is no risk of infection for contacts. It is extremely rare for an allergic reaction to occur.

Most people develop a strong immune response after the first vaccination. The second vaccination is given at 6 years of age. LCV can be used in preschool educational institutions as an anti-epidemic agent if a measles outbreak has been recorded. In this case, children two years old and older who have not had measles before, are unvaccinated and have no contraindications to vaccination are subject to vaccination. Those who were in contact with an infectious child no later than 5 days ago should be vaccinated.

Passive immunization (prevention with gammaglobulin) helps protect children who cannot be vaccinated from the disease. It is used to prevent the spread of the virus when it is introduced into children's healthcare facilities. Only children who do not have antibodies to measles can be protected in this way.

Important! Dr. Evgeniy Olegovich Komarovsky and authoritative representatives of world pediatrics advise getting vaccinated against dangerous diseases. Parents who refuse to protect their child through vaccination must understand that such a position threatens the health and life of their child.

Listen to his detailed opinion on this matter:

The rules of nonspecific prophylaxis are as follows:

  • recognize the endemic situation;
  • promptly identify sources of infection;
  • isolation of sick people (from the onset of the disease to the fifth day of rash, if there is pneumonia, the period is increased to 10 days);
  • act according to the protocol (the room where the patient was is ventilated for 30–45 minutes, no disinfection is required);
  • Children who have been in contact with the source of infection and have not received gammaglobulin are subject to quarantine for 17 days; those who received it are subject to quarantine for 21 days;
  • All preschoolers, upon admission to kindergarten, must provide a vaccination certificate and be examined by a doctor;
  • place information stands “What is measles and why is it dangerous” with photographs and medical articles in preschool educational institutions and children's healthcare facilities.

You need to protect yourself from measles by getting vaccinated. This is an effective and safe way. If a one-year-old baby has contraindications for vaccination, contact with sick people should be avoided, since infection occurs through airborne droplets.

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If a girl or boy in the next building has measles, they will not pose a danger as long as they are not in close proximity. In close contact, infection will occur.

In recent years, cases of measles among adolescents and adults have increased. This indicates the need for serological testing to determine antibodies in older people.

Vaccination

The most common vaccine is the MMR vaccine, which immunizes against measles, mumps, and rubella. Two doses of the MMR vaccine reduce the risk of getting one of these infections by about 97 percent.

The MMR vaccine is first given to children at approximately 12 to 15 months, and a second, booster dose is given between four and six years of age. The vaccine has contraindications, read more about the side effects of the MMR vaccine.

There is another vaccine called MMRV, which protects against measles, mumps, rubella and chickenpox. This vaccine is currently only licensed for use in children aged 12 months to 12 years.

Answers to frequently asked questions

Is it possible to walk with measles?

A sick child should not walk outside.

Is it possible to bathe a child with measles?

You cannot wash yourself or go to the pool while you are sick. It is dangerous to bathe a small child for several weeks after measles. A wet baby with a weakened immune system may again catch an infection or catch a cold.

Is it possible to get measles again?

You cannot get measles a second time. If a person has been ill once, the virus will be destroyed again by the antibodies of the immune system.

Can a parent get infected from a child?

The short answer is yes, it can.

Is it possible to protect yourself from measles with a disposable mask?

On this issue, doctors explain that a disposable mask does not provide absolute protection against the measles virus.

Infectious mononucleosis.

With mononucleosis, rashes appear in approximately 10% of patients. Moreover, the rash immediately covers the entire body (with measles, remember, it spreads from top to bottom).

READ ALSO: Armpit rashes - what are they, reasons, how to treat armpit rashes

If a patient with mononucleosis received a penicillin antibiotic (this is a medical error, alas, not uncommon in our area), the likelihood of a rash increases to 90%. This rash is called ampicillin and indicates an allergy to the antibiotic.

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