The drug Antigrippin-ANVI represents a pharmacological group of medications for the symptomatic treatment of acute respiratory viral pathology and influenza. It is available in the form of capsules of 2 types, containing various active ingredients. The medication is used for adults and adolescents over 15 years of age. Use is contraindicated for certain pathological conditions affecting the stomach, intestines, blood system, as well as for pregnant and breastfeeding women.
Compound
- Composition of one capsule A of the drug Antigrippin-ANVI: 300 mg of ascorbic acid , 250 mg of acetylsalicylic acid , 20 mg of rutoside (in the form of trihydrate ). Additional substances: calcium stearate , potato starch. Ingredients of gelatin capsules: yellow quinoline dye, black diamond dye, azorubine dye, proprietary blue or blue brilliant dye, gelatin, titanium dioxide.
- One capsule B contains: 20 mg diphenhydramine hydrochloride , 250 mg metamizole sodium monohydrate , 100 mg calcium gluconate monohydrate. Additional substances: calcium stearate, potato starch. Ingredients of gelatin capsules: titanium dioxide , gelatin.
Consumer Reviews
Instructions for use of Antigrippin-Anvi are required reading. In it you can learn about when and in what dose you should use the drug to obtain the best therapeutic result.
According to consumer reviews, this medicine is quite effective in eliminating the symptoms of colds and flu, and also quickly lowers body temperature. To prevent adverse reactions, this medication should be taken in dosages strictly recommended by your doctor for no more than 3-5 days in a row.
The main disadvantage of the drug "Antigrippin-Anvi" is that it has a large number of contraindications.
Release form
The drug Antigrippin-ANVI includes capsules of two types:
- capsules A are usually green, hard; contents - a mixture of amorphous and crystalline mass of light yellow color with a slight green tint, the presence of lumps is possible;
- capsules B are usually white and also hard; contents - a mixture of small granules and white powder, the presence of a yellow tint or lumps is allowed.
Ten capsules A in a contour package and ten capsules B in a contour package; one package of each capsule in a paper pack.
Indications for use
The main medical indication for the use of the medication is infectious and inflammatory pathology, accompanied by an inflammatory, allergic reaction, fever and other signs of intoxication.
for adults
Reducing the severity of clinical manifestations (symptomatic therapy) of colds, acute viral pathologies, including influenza, parainfluenza.
for children
Antigrippin-ANVI capsules are not intended for use in pediatric practice. The drug can be used for adolescents over 15 years of age for the same indications as for adults.
for pregnant women and during lactation
The drug is not used for pregnant and breastfeeding women, as the active ingredients have a negative effect on the body of the developing fetus and infant.
Pharmacodynamics and pharmacokinetics
Combined drug.
Ascorbic acid regulates redox reactions, carbohydrate metabolism, tissue regeneration processes, blood clotting, and increases the body's resistance.
Acetylsalicylic acid (aspirin) has antipyretic, analgesic, anti-inflammatory, and antiplatelet effects.
Rutoside (or rutin ) is a powerful angioprotector . Reduces capillary permeability, symptoms of inflammation, stabilizes the vascular wall. Reduces aggregation and increases deformation of red blood cells.
Diphenhydramine has antiallergic and anti-edematous effects. Reduces vascular permeability, relieves hyperemia and swelling of the nasal mucosa, manifestations of hypersensitivity reactions in the respiratory tract.
Metamizole sodium has analgesic, antipyretic and minor anti-inflammatory effects associated with inhibition of prostaglandin .
Calcium gluconate regulates the exchange of phosphorus and calcium, has an antiallergic effect, and reduces vascular permeability. In the treatment of allergic diseases, its use in conjunction with antihistamines is recommended.
Pharmacological group
The drug Antigrippin-ANVI belongs to the group of drugs used for the symptomatic treatment of inflammatory diseases. The therapeutic effects are due to the active components of the drug:
- Acetylsalicylic acid is a non-steroidal anti-inflammatory drug that reduces the concentration of inflammatory mediators prostaglandins, thereby reducing the severity of pain and inflammatory reaction, and normalizing body temperature during fever.
- Rutin is an angioprotector, improves the functional state of microcirculatory structures, reduces the permeability of their walls, reduces the inflammatory reaction and tissue swelling.
- Vitamin C – has an antiviral effect, improves metabolism in cells, strengthens blood vessels.
- Diphenhydramine is an antihistamine that has antiallergic and decongestant effects.
- Metamizole sodium - reduces the intensity of prostaglandin synthesis, due to which it has an anti-inflammatory and anti-edematous effect.
- Calcium gluconate – reduces the severity of allergic reactions, and also normalizes the permeability of the walls of microcirculatory vessels.
Due to the effects of the active components of the drug, Antigrippin-ANVI capsules help reduce the severity of inflammatory and allergic manifestations.
Contraindications
The drug has the following contraindications for use:
- bleeding from the digestive tract;
- bronchial asthma and diseases accompanied by bronchospasm;
- erosive and ulcerative changes in the digestive tract;
- tendency to bleed;
- pronounced changes in liver or kidney function;
- hemorrhagic diathesis ( thrombocytopenic purpura, hemophilia, thrombocytopenia, hypoprothrombinemia, telangiectasia, von Willebrand disease );
- hereditary hemolytic anemia anemia caused by deficiency of glucose-6-phosphate dehydrogenase );
- suppression of hematopoiesis ( neutropenia, agranulocytosis, leukopenia );
- dissecting aortic aneurysm;
- hypercalcemia, hypercalciuria;
- portal hypertension;
- calcium nephrolithiasis;
- sarcoidosis;
- overdose of cardiac glycosides;
- lack of vitamin K ;
- age less than 15 years;
- pregnancy and lactation ;
- deficiency of glucose-6-phosphate dehydrogenase ;
- hypersensitivity to any of the components of the drug.
It is recommended to prescribe Antigrippin-ANVI with caution for gout, urate nephrolithiasis, hyperuricemia, peptic ulcer, decompensated cardiac failure.
Possible side effects
In case of overdose or intolerance to the components, an allergic reaction may develop. If a rash, redness of the skin, problems with bowel movements (diarrhea), or bronchospasm appears, treatment should be stopped immediately. It is prohibited to use Antigrippin Anvi if during therapy the patient’s blood pressure rises, tachycardia, or discomfort in the kidneys or liver occurs.
Contraindications for taking capsules include pregnancy, breastfeeding, and childhood (under 15 years). Particular caution should be exercised in the presence of concomitant diseases of the gastrointestinal tract and cardiovascular system (ulcer, gout, nephrolithiasis).
Side effects
- Phenomena from the digestive system: gastralgia, anorexia, diarrhea, bleeding, erosive and ulcerative changes , vomiting, nausea, liver failure.
- Phenomena from the system: increased pressure, tachycardia .
- Phenomena from the genitourinary system: renal failure.
- Allergic phenomena: angioedema , rash, bronchospasm.
Side effects observed when using the drug for longer than one week
- Nervous system effects: headache , dizziness .
- Phenomena from the organs of hearing and eyes: tinnitus, visual impairment, deafness.
- Phenomena from the hematopoietic system: thrombocytopenia, leukopenia, agranulocytosis.
- Respiratory system effects: bronchospasm.
- Allergic phenomena: possible development of anaphylactic shock , Lyell's syndrome or Stevens-Johnson syndrome.
- Phenomena from the blood coagulation system: hypocoagulation , weakening of platelet aggregation, hemorrhagic syndrome.
- Phenomena from the genitourinary system: papillary necrosis of the kidneys, interstitial nephritis , impaired renal function, anuria , oliguria, proteinuria, red coloration of urine.
- Other phenomena: the development of Reye's syndrome is possible in children ( metabolic acidosis, hyperpyrexia , vomiting, mental changes, liver damage).
Overdose
Symptoms of overdose: vomiting, nausea, sweating , stomach pain, pale skin, tachycardia ; with a slight overdose, ringing in the ears may occur; in case of severe overdose - collapse , drowsiness , convulsions , difficulty breathing, bronchospasm, anuria , progressive respiratory paralysis , bleeding.
Therapy: gastric lavage, use of activated charcoal and saline laxatives ; If seizures , intravenous diazepam ; if necessary, perform forced diuresis or hemodialysis .
Interaction
When used together with indirect anticoagulants, heparin, reserpine, hypoglycemic agents and steroid hormones, their effect is enhanced.
When used simultaneously with Furosemide, Spironolactone, uricosuric and antihypertensive drugs, their effectiveness is reduced.
The drug enhances undesirable reactions of glucocorticosteroids , methotrexate derivatives, sulfonylureas, non-opioid analgesics and non-steroidal anti-inflammatory drugs.
Ascorbic acid enhances the absorption of iron preparations in the intestine.
When used simultaneously with barbiturates, zidovudine, antiepileptic drugs, rifampicin and alcohol-containing drugs, hepatotoxicity increases .
Metamizole sodium stimulates the effects of alcoholic beverages.
Tricyclic antidepressants, Allopurinol and oral contraceptives alter the metabolism of metamizole and increase its toxicity.
The simultaneous use of Metamizole with Cyclosporine reduces the level of the latter in the blood.
Tranquilizers and sedatives stimulate the analgesic effect of the drug.
When used together, Thiamazole sodium and Melphalan increase the risk of leukopenia.
X-ray contrast agents, Penicillin and colloidal blood substitutes should not be used while taking Metamizole sodium.
Interaction with other drugs
The active components of the drug may interact with other drugs:
- Increased activity of heparin.
- Reduced activity of diuretics.
- Increased negative reactions of glucocorticosteroids.
- Increased negative effects on the liver when used simultaneously with rifampicin, barbiturates, and antiepileptic drugs.
- Increased effects of alcohol.
- Increased analgesic effect of metamizole when combined with sedatives and tranquilizers.
special instructions
With long-term use of the drug, it is necessary to perform an analysis of peripheral blood and indicators of liver condition.
Acetylsalicylic acid in small doses reduces the evacuation of uric acid - this can provoke an exacerbation of gout.
During the period of use of the drug, patients should avoid drinking alcoholic beverages due to the increased risk of bleeding from the digestive system.
Taking ascorbic acid by patients with intensively metastasizing cancer can cause a worsening of the process.
During the period of use of the product, driving should be avoided.
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Antigrippin-ANVI, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Antigrippin-ANVI is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Level 4 ATC code matches:
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Antigrippin , Antigrippin-Maximum, FluZiOZ-F, AntiFlu Kids.
Antigrippin-ANVI price, where to buy
The price of a package of the drug in Russia is 112-130 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Antigrippin-ANVI caps.
No. 20 Pharmproject JSC 155 rub. order
Applications and dosages
The drug is intended for oral administration, 2 capsules (green and white) at a time. It is recommended to take the medicine after meals; the duration of the course of therapy should not exceed 3-5 days.
for adults
The therapeutic dosage for adults is 2 capsules (green and white) 2-3 times a day. After the condition improves, the capsules are stopped.
for children
Antigrippin-ANVI capsules are not used in children. For adolescents over 15 years of age, the drug is prescribed in the same dosage as for adults.
for pregnant women and during lactation
The drug is contraindicated for pregnant and breastfeeding women.
