Disseminated intravascular coagulation syndrome (DIC syndrome)

Causes

DIC is not a separate disease; it occurs after certain actions. The most common causes of internal combustion engine:

• acute infections;
• different types of shock;
• injuries, including from surgery;
• cancer;
• disorders during pregnancy and childbirth;
• diseases of the heart and blood vessels, inflammation of internal organs.

It follows from this that the threat of the syndrome exists in most serious illnesses and terminal conditions (resuscitation actions).

Thrombosis: normal or pathological?

In order to understand what the cause is and what are the mechanisms of occurrence of such a severe disorder as DIC syndrome, you need to know the main stages of blood coagulation.

A person is constantly faced with the risk of possible injuries, from minor scratches or cuts to serious wounds, so nature provides a special protective mechanism - thrombosis, that is, the formation of a blood clot at the site of vessel damage.

There are two oppositely directed systems in the body - coagulation

and
anticoagulant , the correct interaction of which promotes thrombus formation if necessary, as well as the liquid state of blood in the vessels in the absence of any damage.
These hemostatic systems play a very important protective role. Blood clot formation

When the integrity of the vascular wall is violated, the coagulation system is activated, a whole cascade of reactions of which leads to the formation of a thrombus (a clot in the lumen of a vessel or chamber of the heart). Plasma proteins, in particular fibrinogen, as well as platelets, coagulation factors produced in the liver, and various enzymes are directly involved in this. The result is the formation of a blood clot that closes the defect in the vascular wall and prevents further bleeding.

To maintain the fluid state of the blood and prevent the uncontrolled formation of blood clots, there are specific antithrombotic mechanisms

, realized by the action of so-called
anticoagulants
- substances that prevent the occurrence of massive thrombosis (plasma proteins, proteolytic enzymes, endogenous heparin). In addition, an obstacle to thrombosis is rapid blood flow and so-called fibrinolysis, that is, the dissolution of the fibrin protein and its removal from the vascular bed with the help of enzymes circulating in the blood plasma and secreted by leukocytes, platelets and other cells. The remains of fibrin after its destruction are absorbed by leukocytes and macrophages.

When the interaction of the components of the hemostatic system changes in various diseases and injuries, discoordination occurs in the work of the coagulation and anticoagulation systems , which contributes to massive uncontrolled thrombus formation along with bleeding. These mechanisms form the basis of the pathogenesis of DIC syndrome, which is a life-threatening complication.

Symptoms

DIC syndrome is divided into several forms:

• Acute (duration from several hours to several days, occurs during injuries, sepsis, operations, blood transfusions).
• Subacute (lasts up to several weeks, occurs against the background of chronic infections, autoimmune diseases).
• Chronic (duration up to several years, occurs with severe heart disease, vascular disease, lung disease, kidney disease, diabetes mellitus).
• Recurrent.
• Latent.
• Lightning fast (develops in a matter of minutes, most often during pregnancy and childbirth).

In DIC syndrome, the main damage occurs to organs with a developed network of capillaries (lungs, skin, brain, etc.). The signs of the disease are most noticeable on the skin. The manifestations are as follows:

• specific rash;
• necrosis.
• Other symptoms:
• dyspnea;
• pulmonary edema;
• impaired urine production;
• acute renal failure;
• neurological disorders;
• numerous bleedings.

Disseminated intravascular coagulation syndrome (DIC syndrome)

Disseminated intravascular coagulation syndrome (DIC) is a condition characterized by disturbances in the blood coagulation system. In this case, depending on the stage of DIC, multiple thrombi (blood clots) form in the vessels of various organs or bleeding occurs.

The blood coagulation system includes platelets and coagulation factors (specific proteins and inorganic substances). Normally, blood clotting mechanisms are activated when there is a defect in the vessel wall and bleeding. As a result, a thrombus (blood clot) forms, which clogs the damaged area. This protective mechanism prevents blood loss due to various injuries.

Disseminated intravascular coagulation syndrome occurs against the background of other serious diseases (for example, complications during childbirth and pregnancy, severe injuries, malignant tumors and others). At the same time, a significant amount of coagulation factors is released from damaged tissues, which leads to the formation of multiple blood clots in various organs and tissues. This impedes blood circulation in them and, as a result, causes their damage and dysfunction.

A large number of blood clots leads to a decrease in the number of blood clotting factors (they are consumed during the formation of blood clots). This reduces the blood's ability to clot and leads to bleeding (hypocoagulation stage).

DIC syndrome is a serious complication and threatens the patient's life. It is necessary to carry out urgent therapeutic measures aimed at treating the underlying disease (against the background of which DIC syndrome occurred), preventing the formation of new blood clots, stopping bleeding, restoring the deficiency of coagulation factors and blood components, and maintaining impaired body functions.

Synonyms Russian

Consumption coagulopathy, defibration syndrome, thrombohemorrhagic syndrome.

English synonyms

Disseminated intravascular coagulation, consumption coagulopathy, defibration syndrome.

Symptoms

Symptoms of disseminated intravascular coagulation syndrome depend on the stage of the disease.

At the stage of increased blood clotting, multiple blood clots form in various organs.

With blood clots in the vessels of the heart and lungs, these and other symptoms may occur:

• chest pain (can spread to the left arm, shoulder, back, neck, jaw, upper abdomen);
• dyspnea;
• feeling of lack of air;
• cold sweat;
• nausea;
• vomit.

Signs of blood clots in the veins of the legs:

• leg pain;
• redness;
• heat;
• swelling.

With thrombosis of cerebral vessels, acute cerebrovascular accident (stroke) can develop. He is accompanied by:

• headache;
• loss of consciousness;
• nausea, vomiting;
• speech disorders;
• muscle weakness or immobility of an arm or leg on one side;
• muscle weakness or immobility on one side of the face;
• numbness predominantly on one side of the body.

The formation of blood clots in the vessels of other organs (for example, kidneys) leads to their damage and dysfunction (renal failure).

The amount of blood clotting factors gradually decreases, as they are consumed in the process of forming multiple blood clots. As a result, DIC enters the stage of hypocoagulation (reduced blood clotting). This may cause bleeding.

Symptoms of internal bleeding (into various internal organs and tissues):

• blood in the urine - as a result of hemorrhage in the bladder, kidneys;
• blood in stool – bleeding in the gastrointestinal tract (for example, in the stomach, small intestine);
• severe headache, loss of consciousness, convulsions and other manifestations - with hemorrhage in the brain.

Symptoms of external bleeding:

• prolonged bleeding even from minimal skin lesions (for example, from the injection site);
• bleeding from the nose, gums;
• prolonged heavy menstrual bleeding in women;
• pinpoint hemorrhages on the skin (petechiae).

Thus, the manifestations of disseminated intravascular coagulation syndrome are diverse and depend on the stage of DIC syndrome and the predominant damage to certain organs.

General information about the disease

Disseminated intravascular coagulation syndrome is a disorder in the blood coagulation system that develops against the background of various serious diseases.

The reasons for the development of DIC syndrome may be:

• complications during pregnancy and childbirth (for example, placental abruption, fetal death, severe blood loss and others);
• sepsis is a serious disease in which the infection circulates in the blood and spreads throughout the body;
• severe injuries, burns, in which a large amount of substances from destroyed cells enter the bloodstream, the endothelium (the inner wall of blood vessels) is damaged; these and other mechanisms can cause activation of blood coagulation processes;
• malignant tumors - the mechanism of development of disseminated intravascular coagulation in malignant tumors has not been fully studied; according to researchers, some types of malignant tumors (for example, pancreatic adenocarcinoma) can release substances into the blood that activate blood coagulation processes;
• Vascular disorders – vascular diseases such as aortic aneurysm (an enlargement of a vessel that threatens to rupture) can cause a local increase in coagulation (blood clotting). Once in the bloodstream, activated coagulation factors lead to disseminated intravascular coagulation throughout the body;
• poisonous snake bites.

Thus, these conditions can cause the release of a large number of blood clotting stimulants into the blood, resulting in the formation of blood clots in the vessels of various organs. This can lead to disruption of the blood supply to the lungs, kidneys, brain, liver and other organs. In the most severe cases, severe dysfunction of several organs occurs (multiple organ failure).

Gradually, the level of blood clotting factors decreases, as they are consumed during the formation of blood clots. As a result, the blood's ability to clot is sharply reduced. This may lead to bleeding. The severity of bleeding can vary from small hemorrhages on the skin (petechiae) to massive bleeding from the gastrointestinal tract, hemorrhages in the brain, lungs and other organs.

Disseminated intravascular coagulation syndrome can be acute or chronic. In acute DIC syndrome, after a short phase of hypercoagulation (increased blood clotting), hypocoagulation (decreased blood clotting) may develop. In this case, the main manifestations will be the occurrence of bleeding and hemorrhages in various organs.

In chronic DIC, the formation of blood clots comes to the fore. Cancer is a common cause of chronic disseminated intravascular coagulation syndrome.

Disseminated intravascular coagulation syndrome is a serious complication. According to various researchers, the presence of DIC syndrome increases the risk of death by 1.5 - 2 times.

Who is at risk?

Risk groups include:

• women who have serious complications during pregnancy and childbirth (for example, placental abruption)
• patients with sepsis (a serious condition in which infection spreads through the bloodstream throughout the body)
• persons with severe injuries, burns
• persons with malignant tumors (for example, prostate adenocarcinoma)
• persons who have been bitten by poisonous snakes.

Diagnostics

Laboratory diagnostics play a key role in the diagnosis of disseminated intravascular coagulation syndrome. Determining blood coagulation parameters is also of great importance in the treatment of DIC syndrome. The following laboratory tests are carried out:

• Coagulogram. Analysis of the blood coagulation system. Blood clotting is a complex process involving many components. Assessment of coagulation parameters includes several indicators: APTT (Activated partial thromboplastin time), INR (International Normalized Ratio), prothrombin index, antithrombin III, D-dimers, fibrinogen and others. In case of DIC syndrome, a comprehensive assessment of these indicators is required. Activated partial thromboplastin time (aPTT). Shows the time it takes for a blood clot to form when certain chemicals are added to blood plasma (the liquid part of the blood). An increase in this indicator indicates hypocoagulation, that is, a decrease in the ability of blood to clot (tendency to bleed), a decrease in this indicator indicates an increased risk of thrombosis (formation of blood clots).
• Prothrombin index (PI). Prothrombin is a protein that is produced in the liver. It is a precursor to thrombin, a protein necessary for blood clotting. The prothrombin index shows the ratio of the clotting time of a healthy person's plasma to the clotting time of a patient's plasma. This indicator is expressed as a percentage. An increase in this indicator indicates increased blood clotting; a decrease indicates a decrease in the blood’s ability to form a blood clot.
• International normalized ratio (INR). An indicator of the blood coagulation system. An increase in this indicator is observed with a decrease in the ability of blood to clot. It is an important parameter when treating with drugs that affect the blood coagulation system.
• Antithrombin III. It is a natural substance that reduces blood clotting. During the thrombus formation stage, the amount of antithrombin decreases. Using this indicator, one can indirectly judge the severity of DIC syndrome.
• Fibrinogen. Fibrinogen is a protein that is necessary for the blood clotting process. During the stage of increased blood clotting in DIC syndrome, a decrease in fibrinogen levels is observed.
• D-dimers. D – dimers are one of the end products of the breakdown of fibrinogen (a protein involved in blood clotting). An increase in the level of D-dimers indicates activation of thrombus formation. The level is increased during the hypercoagulation stage of DIC syndrome.

• Thrombin time. The time it takes for fibrin (the protein needed to form a blood clot) to form a clot when an enzyme (thrombin) is added. An increase in this indicator is observed with hypocoagulation (decreased blood clotting ability).
• General blood analysis. This indicator allows you to determine the number of main blood components: red blood cells, hemoglobin, platelets, leukocytes. With DIC syndrome, there may be a decrease in the number of platelets.

Assessment of kidney and liver function:

• Serum creatinine. Creatinine is formed in the muscles and then enters the blood. Participates in metabolic processes accompanied by the release of energy. It is excreted from the body in urine through the kidneys. When kidney function is impaired, the level of creatinine in the blood increases.
• Urea in serum. Urea is the end product of protein metabolism. It is excreted from the body by the kidneys and urine. Urea levels increase when kidney function is impaired.
• Alanine aminotransferase (ALT). Alanine aminotransferase is an enzyme that is found in many cells of the body, mainly in liver cells. When liver cells are damaged, this enzyme enters the blood. An increase in the level of this enzyme is observed with liver damage.

Research:

Diagnosis of DIC syndrome is based on clinical data and laboratory tests. Various studies may be necessary to diagnose the underlying disease and complications that have arisen. The need for and scope of research is determined by the attending physician.

Treatment

Treatment tactics for disseminated intravascular coagulation syndrome depend on the causes of its occurrence, the severity of the patient’s condition and other factors.

Acute disseminated intravascular coagulation syndrome is a serious condition that threatens the patient's life and requires intensive treatment measures. Treatment can be aimed at eliminating the causes that caused DIC syndrome (the underlying disease), preventing the formation of blood clots in the vessels, stopping bleeding, restoring the normal volume of blood and its components. To do this, transfusions of fresh frozen plasma (the liquid part of blood taken from a donor), blood components, intravenous administration of various solutions, drugs that affect blood clotting, and other medications can be used.

Prevention

There is no specific prevention of disseminated intravascular coagulation syndrome.

Recommended tests

• Coagulogram No. 3 (PI, INR, fibrinogen, ATIII, APTT, D-dimer)
• Thrombin time
• General blood analysis
• Serum creatinine
• Urea in serum
• Alanine aminotransferase (ALT)

Literature

• Dan L. Longo, Dennis L. Kasper, J. Larry Jameson, Anthony S. Fauci, Harrison's principles of internal medicine (18th ed.). New York: McGraw-Hill Medical Publishing Division, 2011. Chapter 116. Coagulation Disorders. Disseminated Intravascular Coagulation.
• Mark H. Birs, The Merk Manual, Litterra 2011. Chapter 17, p. 694. Disseminated Intravascular Coagulation.

Diagnostics

The clinical picture plays an important role in making a diagnosis. With serious damage to internal organs, the diagnosis is obvious. But in subacute and chronic forms, the symptoms are not so bright.

In addition to the clinical picture, clinical research data are important to establish a diagnosis:

• general blood test;
• general urinalysis;
• coagulograms (testing blood for clotting);
• blood smear analysis;
• enzyme immunoassay (search for possible infections).
• Internal organs are also examined for damage.

Pathogenesis

DIC syndrome is a variant of coagulopathy, in which there is a particularly clear imbalance between the coagulation, anticoagulation and fibrinolytic systems of the body.

A feature of DIC syndrome is disseminated, scattered, multiple formation of blood clots and fibrin clots, essentially where hemostasis is not required.

Etiological factors lead to hypercoagulation, the formation of small loose fibrin clots or microthrombi in almost the entire microcirculatory system. They are immediately dissolved by the fibrinolytic system. New blood clots and new clots are formed and all the main factors of the coagulation system are gradually depleted - platelets, prothrombin, fibrinogen.

Hypocoagulation develops due to consumption coagulopathy. If the integrity of the vascular wall is compromised somewhere, a blood clot cannot form. At the same time, there are anticoagulant substances in excess, which makes bleeding difficult to stop. Fibrin clots and microthrombi formed in microvessels block tissue blood flow, cause tissue ischemia, and disrupt the function of such vital organs as the heart, lungs, and kidneys.

Prevention

Preventive measures are associated with identifying the risk group (people with low levels of antithrombin III, erythrocytosis). The risk group also includes people with chronic diseases (diabetes mellitus, pyelonephritis, etc.), the elderly, etc.

A successful result in the treatment of DIC syndrome depends entirely on the experience of medical personnel and doctors, as well as on the speed of their reaction. Remember that only qualified specialists are able to provide the necessary assistance for DIC syndrome. Contact the SM-Clinic in St. Petersburg for treatment.

Treatment

Due to the multifactorial origin of consumption coagulopathy, which complicates a variety of diseases and pathological conditions, there is currently no uniform treatment strategy for DIC syndrome .
However, taking into account the characteristic stages and features of the course, the main approaches to the prevention and treatment of such a dangerous complication have been identified. It is important to eliminate the causative factor that caused the development of thrombohemorrhagic syndrome as early as possible, this will be etiotropic

direction of treatment:

1. Adequate antibiotic therapy for purulent-septic complications;
2. Timely replenishment of circulating blood volume during blood loss;
3. Maintaining the function of the cardiovascular system and blood pressure during various types of shock;
4. Prevention of complications and timely surgical care in obstetric practice;
5. Adequate pain relief in case of various injuries and traumatic shock, etc.

Main directions of pathogenetic

and
symptomatic
treatment:

• Anticoagulant therapy;
• The use of fibrinolytics and antifibrinolytic drugs depending on the phase of the disease;
• Replacement infusion therapy;
• Improving the rheological properties of blood, using drugs to normalize microcirculation;
• Extracorporeal detoxification.

An important principle in the treatment of DIC syndrome is the use of anticoagulant therapy . Most often, heparin is used for these purposes, which restores normal blood clotting, prevents the formation of blood clots and helps remove existing ones, thereby improving the function of affected tissues and organs.

To eliminate the deficiency of blood coagulation factors, replacement infusion therapy is performed. The optimal drug for these purposes is fresh frozen plasma. Along with it, heparin and protease inhibitors can also be administered (they reduce enzyme activity and prevent the development of hypocoagulation, prevent the development of shock - contrical, gordox).

To improve microcirculation in tissues, aspirin, trental, chimes, etc. are used, as well as the introduction of rheological solutions (reopolyglucin, voluven).

Extracorporeal detoxification methods - plasmapheresis, cytapheresis, hemodialysis - are very important in the complex therapy of DIC syndrome.

In general, the treatment of DIC syndrome is a very complex task , and sometimes the decision on the regimen of drugs and their dosages must be made in a matter of minutes.

It is necessary to treat DIC syndrome in stages, since the prescription of a particular drug entirely depends on the patient’s state of hemostasis at a particular point in time. In addition, constant laboratory monitoring of blood coagulation, acid-base balance, and electrolyte balance should be carried out.

Emergency care consists of relieving pain, combating shock, establishing infusion therapy, and administering heparin in the first phase of DIC.

Patients who have been diagnosed with thrombohemorrhagic syndrome or are at high risk of developing it should be immediately hospitalized and placed in the intensive care unit.

Mortality in thrombohemorrhagic syndrome, according to various sources, reaches 70% in stage III, and in chronic cases – 100%.

Prevention

This dangerous complication consists, first of all, in the earliest possible treatment of the diseases that led to its occurrence, as well as in restoring blood circulation and microcirculation in organs and tissues. Only early initiation of therapy and correct tactics contribute to the normalization of hemostasis and further recovery.

Treatment of other diseases starting with the letter - D

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